Gentiana lutea

• Index
• Plant Species
• Metabolite list (27)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Gentiana lutea
Genus	Gentiana
Family	Gentianaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Gentiana lutea
Linked NCBI taxonomy ID	38851
Linked level	species

Family

Family in NCBI taxonomy	Gentianaceae
ID	21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (27)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00030375	Gentioside					No. 1	No. 15
C00002957	Isogentisin		C018087			No. 3	No. 15
C00002954	Gentisin / 1,7-Dihydroxy-3-methoxyanthone		C037062			No. 3	No. 15
C00029665	alpha-Amyrone / alpha-Amirenone / Urs-12-en-3-one	CHEMBL518475	C073947			No. 13	No. 51
C00003738	beta-Amyrin / beta-Amirin / beta-Amyrine / beta-Amyrenol		C036380		0 / 4	No. 23	No. 51
C00003749	Lupeol / Lupenol / (+)-Lupenol	CHEMBL289191 CHEMBL459702	C010480	3 / 0 / 0	2 / 6	No. 23	No. 51
C00003737	alpha-Amyrin / alpha-Amyrine / alpha-Amyrenol					No. 23	No. 51
C00010604	Loganic acid	CHEMBL1081585 CHEMBL1079678 CHEMBL1356464 CHEMBL1452775	C002947	6 / 8 / 7		No. 64	No. 36
C00002953	Gentisein	CHEMBL361025		2 / 1 / 1		No. 71	No. 15
C00030150	Docosanal / n-Docosanal					No. 115
C00032306	Tetracosanal / 1-Tetracosanal / n-Tetracosanal					No. 115
C00030477	Hexacosanal					No. 115
C00002669	Pyrocatechuic acid / o-Pyrocatechuic acid / 2,3-Dihydroxybenzoic acid	CHEMBL1432	C009135	12 / 6 / 5	1 / 4	No. 817	No. 81
C00030213	Erythrodiol 3-O-palmitate					No. 923
C00029823	Betulin 3-O-palmitate					No. 923
C00032468	(+)-Gentiatriculin / Uvaol 3-O-palmitate					No. 923
C00003047	Linalool / (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol	CHEMBL25306 CHEMBL235672	C018584	6 / 8 / 2	35 / 4	No. 958	No. 34
C00000156	Carvacrol	CHEMBL281202	C073316	10 / 6 / 1	4 / 2	No. 969	No. 35
C00029674	alpha-Terpineol	CHEMBL447597 CHEMBL449810	C016775	3 / 16 / 11		No. 983	No. 35
C00003100	Swertiamarin	CHEMBL456138	C013270	1 / 0 / 0		No. 1348	No. 36
C00001135	Gentianose	CHEMBL175500 CHEMBL603717				No. 1765
C00029431	2,3',4,6-Tetrahydroxybenzophenone / 2,4,6,3'-Tetrahydroxybenzophenone	CHEMBL445711				No. 1837
C00003070	Amarogentin		C102609		1 / 3	No. 2478
C00031311	Scabran G3 / (-)-Scabran G3					No. 3327
C00029675	Vitamin E quinone / alpha-Tocopherolquinone	CHEMBL1223852 CHEMBL1254448		5 / 2 / 3		No. 3729
C00003082	Gentiopicrin / Gentiopicroside	CHEMBL508320	C012997	2 / 2 / 0	0 / 1	No. 3781	No. 36
C00010754	Gentiolactone / (+)-Gentiolactone					No. 7860

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000156 C00003047 C00029674	3 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000156 C00003047 C00029674	5 / 1
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00000156 C00003047	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00003047 C00003082	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003082 C00010604	2 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000156	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002669	2 / 2
P02545	Prelamin-A/C	Unclassified protein	C00029674	11 / 10
P08047	Transcription factor Sp1	Unclassified protein	C00003749	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00003047	3 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002953	1 / 1
P02768	Serum albumin	Secreted protein	C00002669	0 / 0
P49327	Fatty acid synthase	Transferase	C00002953	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00029675	0 / 1
P60033	CD81 antigen	Unclassified protein	C00010604	1 / 1
P11387	DNA topoisomerase 1	Isomerase	C00003749	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003749	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000156	0 / 0
P16581	E-selectin	Adhesion	C00002669	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002669	0 / 0
O75496	Geminin	Unclassified protein	C00003100	0 / 0
P22894	Neutrophil collagenase	M10A	C00002669	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00000156	0 / 0
P03956	Interstitial collagenase	M10A	C00002669	0 / 1
Q99700	Ataxin-2	Unclassified protein	C00002669	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00029675	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00002669	1 / 3
O75762	Transient receptor potential cation channel subfamily A member 1	Unclassified protein	C00000156	1 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000156	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000156	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003047	0 / 0
P14151	L-selectin	Adhesion	C00002669	0 / 0
P16109	P-selectin	Adhesion	C00002669	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00029675	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00029675	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00002669	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00029675	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00010604	4 / 3
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000156	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00010604	0 / 0
P08254	Stromelysin-1	M10A	C00002669	1 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00010604	1 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00010604	0 / 3

43 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002669
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00003749
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00003749
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00003047
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003047
1386	ATF2, CRE-BP1, CREB2, HB16, TREB7	activating transcription factor 2 (EC:2.3.1.48)	C00003047
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00003047
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00003047
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003047
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00003047
1028	CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	C00003047
1030	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	C00003047
1447	CSN2, CASB	casein beta	C00003047
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00003047
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003047
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00003047
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00003047
2335	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF	fibronectin 1	C00003047
1647	GADD45A, DDIT1, GADD45	growth arrest and DNA-damage-inducible, alpha	C00003047
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00003047
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00003047
3297	HSF1, HSTF1	heat shock transcription factor 1	C00003047
3320	HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	C00003047
3308	HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY	heat shock 70kDa protein 4	C00003047
3316	HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP	heat shock 27kDa protein 2	C00003047
3398	ID2, GIG8, ID2A, ID2H, bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	C00003047
3638	INSIG1, CL-6, CL6	insulin induced gene 1	C00003047
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003047
8850	KAT2B, CAF, P, P/CAF, PCAF	K(lysine) acetyltransferase 2B (EC:2.3.1.48)	C00003047
4193	MDM2, ACTFS, HDMX, hdm2	MDM2 oncogene, E3 ubiquitin protein ligase	C00003047
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00003047
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00003047
4852	NPY, PYY4	neuropeptide Y	C00003047
100124292			C00003047
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003047
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00003047
7471	WNT1, BMND16, INT1, OI15	wingless-type MMTV integration site family, member 1	C00003047
26118	WSB1, SWIP1, WSB-1	WD repeat and SOCS box containing 1	C00003047
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000156
8989	TRPA1, ANKTM1, FEPS	transient receptor potential cation channel, subfamily A, member 1	C00000156
162514	TRPV3, OLMS, VRL3	transient receptor potential cation channel, subfamily V, member 3	C00000156
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00000156
259296	TAS2R50, T2R50, T2R51, TAS2R51	taste receptor, type 2, member 50	C00003070

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions