phytochemical cluster No. 34 (40 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 123 |
| asterids | 90 |
| Magnoliophyta | 34 |
| Liliopsida | 22 |
| Spermatophyta | 14 |
| eudicotyledons | 12 |
| Embryophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Rutaceae
|
78 |
|
Lamiaceae
|
26 |
|
Asteraceae
|
26 |
|
Myrtaceae
|
16 |
|
Solanaceae
|
13 |
|
Piperaceae
|
11 |
|
Poaceae
|
11 |
|
Lauraceae
|
11 |
|
Pinaceae
|
11 |
|
Saururaceae
|
10 |
|
Verbenaceae
|
9 |
|
Zingiberaceae
|
8 |
|
Brassicaceae
|
8 |
|
Apiaceae
|
7 |
|
Crassulaceae
|
6 |
|
Geraniaceae
|
5 |
|
Cistaceae
|
4 |
|
Saxifragaceae
|
4 |
|
Rosaceae
|
4 |
|
Enterobacteriaceae
|
3 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Linear monoterpenes | 16 |
metabolites link (20)
Metabolite list (40)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
figure |
|---|---|---|---|---|---|---|---|
|
C00035042
|
cis-Myrcenol 8
/ (Z)-2-Methyl-6-methylene-2,7-octadien-1-ol |
No. 958 |
|
||||
|
C00034888
|
Myrcene
|
CHEMBL455491
|
C008574
|
3 / 3 / 3 | No. 958 |
|
|
|
C00034358
|
(Z)-3,7-Dimethyl-1,3,7-octatriene
|
No. 958 |
|
||||
|
C00010301
|
(-)-S-Citronellal
/ (S)-3,7-Dimethyl-6-octenal |
CHEMBL1081721
|
2 / 0 / 3 | No. 958 |
|
||
|
C00010294
|
Neo-allo-ocimene
|
No. 958 |
|
||||
|
C00010291
|
Allo-Ocimene
|
C015659
|
No. 958 |
|
|||
|
C00003047
|
trans-beta-Ocimene
|
No. 958 |
|
||||
|
C00010290
|
Z-beta-Ocimene
/ cis-beta-Ocimene / (Z)-beta-Ocimene |
No. 958 |
|
||||
|
C00003035
|
Nerol
/ cis-Geraniol |
CHEMBL25719
CHEMBL452683 |
96 / 41 / 41 | No. 1575 |
|
||
|
C00000845
|
alpha-Linalool
|
No. 1575 |
|
||||
|
C00003036
|
Geranial
/ (E)-alpha-Citral |
CHEMBL1080997
|
6 / 7 / 9 | No. 1575 |
|
||
|
C00035822
|
(3S)-Linalyl diphosphate
|
No. 1575 |
|
||||
|
C00000855
|
(S)-8-Oxolinalool
|
No. 1575 |
|
||||
|
C00029335
|
Methyl geranate
/ Methyl trans-geranate |
No. 1698 |
|
||||
|
C00029351
|
Farnesyl acetate
|
No. 1698 |
|
||||
|
C00000843
|
-(-)-Linalool
/ (-)-R-Linalool |
CHEMBL25306
CHEMBL235672 |
6 / 8 / 2 | No. 1698 |
|
||
|
C00000862
|
Geraniol
|
CHEMBL25719
CHEMBL452683 |
96 / 41 / 41 | No. 1698 |
|
||
|
C00048310
|
6-Hydroxy-7(9)-dehydro-6,7-dihydroneryl acetate
|
No. 1698 |
|
||||
|
C00048486
|
Linalyl acetate
/ Linaloyl acetate |
CHEMBL502773
|
C074463
|
1 / 0 / 1 | No. 1698 |
|
|
|
C00000844
|
(2E,6S)-Dimethyl-2,7-octadiene-1,6-diol
|
No. 1948 |
|
||||
|
C00003037
|
Neral
/ Citral Z |
CHEMBL1080997
|
6 / 7 / 9 | No. 1948 |
|
||
|
C00003038
|
Citral (E/Z)
|
CHEMBL1080997
|
C007076
|
6 / 7 / 9 | 7 / 1 | No. 1948 |
|
|
C00010309
|
Citronellol
|
CHEMBL395827
CHEMBL1907993 CHEMBL1907995 |
C007078
|
7 / 5 / 4 | 1 / 1 | No. 1948 |
|
|
C00035823
|
Geranyl diphosphate
/ Geranyl pyrophosphate |
CHEMBL41342
|
C015234
|
1 / 0 / 0 | 2 / 0 | No. 1948 |
|
|
C00003046
|
cis-beta-Ocimene
|
No. 2157 |
|
||||
|
C00035138
|
(3R)-Linalyl diphosphate
|
No. 2157 |
|
||||
|
C00035130
|
alpha-Myrcene
|
No. 2157 |
|
||||
|
C00030247
|
(E,E)-Farnesyl acetate
|
No. 2157 |
|
||||
|
C00031471
|
(E)-3,7-Dimethyl-1,3,7-octatriene
|
No. 2157 |
|
||||
|
C00010307
|
(R)-Citronellal
/ (R)-3,7-Dimethyl-6-octenal |
CHEMBL1081721
|
2 / 0 / 3 | No. 2285 |
|
||
|
C00000853
|
2,6-Dimethyl-1,7-octadiene-3,6-diol
|
No. 2285 |
|
||||
|
C00048315
|
6-Peroxy-7(9)-dehydro-6,7-dihydroneryl acetate
|
No. 2285 |
|
||||
|
C00010337
|
(+)-R-Citronellol
/ (R)-beta-Citronellol / (R)-3,7-Dimethyl-6-octen-1-ol |
CHEMBL395827
CHEMBL1907993 CHEMBL1907995 |
7 / 5 / 4 | No. 2285 |
|
||
|
C00010306
|
Citronellal
|
CHEMBL1081721
|
C108217
|
2 / 0 / 3 | 0 / 2 | No. 2285 |
|
|
C00000832
|
Coriandrol
/ (S)-Linalool / S-(+)-Linalool / (+)-S-Linalool / (S)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
6 / 8 / 2 | No. 3475 |
|
||
|
C00000833
|
Linalool
/ (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
C018584
|
6 / 8 / 2 | 35 / 4 | No. 3475 |
|
|
C00000846
|
3,7-Dimethyl-1,6-octadiene-3,4-diol
|
No. 3475 |
|
||||
|
C00003048
|
beta-Ocimene
/ E-beta-Ocimene / (E)-beta-Ocimene |
C443996
|
No. 4126 |
|
|||
|
C00022689
|
Neryl acetate
|
CHEMBL1369384
|
5 / 3 / 4 | No. 4126 |
|
||
|
C00022690
|
Geranyl acetate
/ trans-Geranyl acetate / Acetic acid geraniol ester |
CHEMBL1369384
|
5 / 3 / 4 | No. 4126 |
|
Human Protein / Gene in interactions
109 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000844 C00000845 C00000855 C00003038 C00003046 C00003047 C00010301 C00034888 C00035138 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000844 C00003035 C00003036 C00003038 C00003046 C00035138 C00035822 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000844 C00000845 C00000855 C00003037 C00003038 C00010309 C00035823 | 0 / 3 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00000844 C00000845 C00000855 C00003038 C00003047 C00010301 C00034888 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00003035 C00003036 C00003037 C00010309 C00035822 C00035823 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003035 C00003036 C00003047 C00010301 C00034888 C00035822 | 3 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000844 C00003038 C00003047 C00010301 C00034888 | 5 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000845 C00000853 C00000855 C00003046 C00035138 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003035 C00003036 C00003046 C00035138 C00035822 | 3 / 4 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000844 C00003038 C00003046 C00035138 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000845 C00000853 C00000855 C00003048 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003047 C00010301 C00034888 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003035 C00003036 C00035822 | 0 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003047 C00010301 C00034888 | 3 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003035 C00003036 C00035822 | 1 / 4 |
| P03372 | Estrogen receptor | NR3A1 | C00000845 C00000855 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000845 C00000855 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000845 C00000855 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000845 C00000855 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000845 C00000855 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000845 C00000855 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000845 C00000855 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000845 C00000855 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000845 C00000855 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000845 C00000855 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000845 C00000855 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000845 C00000855 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000845 C00000855 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000845 C00000855 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000845 C00000855 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000845 C00000855 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000845 C00000855 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000845 C00000855 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000845 C00000855 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000845 C00000855 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000845 C00000855 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000845 C00000855 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000845 C00000855 | 1 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000845 C00000855 | 2 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000845 C00000855 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000844 C00003038 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000845 C00000855 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000845 C00000855 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000845 C00000855 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000845 C00000855 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000845 C00000855 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000845 C00000855 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000845 C00000855 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000845 C00000855 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000845 C00000855 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000845 C00000855 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000845 C00000855 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000845 C00000855 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000845 C00000855 | 1 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000845 C00000855 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000845 C00000855 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000845 C00000855 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000845 C00000855 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000845 C00000855 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000845 C00000855 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000845 C00000855 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000845 C00000855 | 1 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000845 C00000855 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000845 C00000855 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000845 C00000855 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000845 C00000855 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000845 C00000855 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000845 C00000855 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000845 C00000855 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000845 C00000855 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000845 C00000855 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000845 C00000855 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000845 C00000855 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000845 C00000855 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000845 C00000855 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000845 C00000855 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000845 C00000855 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000845 C00000855 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000845 C00000855 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000845 C00000855 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000845 C00000855 | 1 / 2 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000845 C00000855 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000845 C00000855 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000845 C00000855 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000845 C00000855 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000845 C00000855 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000845 C00000855 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000845 C00000855 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000845 C00000855 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000845 C00000855 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000845 C00000855 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000845 C00000855 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000845 C00000855 | 2 / 2 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000845 C00000855 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000845 C00000855 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000845 C00000855 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000845 C00000855 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000845 C00000855 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000845 C00000855 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000845 C00000855 | 2 / 5 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000845 C00000855 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000853 | 3 / 2 |
| P14324 | Farnesyl pyrophosphate synthase | Transferase | C00000846 | 0 / 0 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00003047
C00035822
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00000846
C00003047
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003047
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00035822
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00035822
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00035822
|
| 23764 | MAFF, U-MAF, hMafF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
C00035822
|
| 7442 | TRPV1, VR1 | transient receptor potential cation channel, subfamily V, member 1 |
C00000844
|
| 1555 | CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 | cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) |
C00035822
|
| 5906 | RAP1A, KREV-1, KREV1, RAP1, SMGP21 | RAP1A, member of RAS oncogene family |
C00000846
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003047
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003047
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003047
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003047
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003047
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00003047
|
| 1028 | CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
C00003047
|
| 1030 | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
C00003047
|
| 1447 | CSN2, CASB | casein beta |
C00003047
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00003047
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003047
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00035822
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003047
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00003047
|
| 1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00003047
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00003047
|
| 3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00003047
|
| 3320 | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
C00003047
|
| 3308 | HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY | heat shock 70kDa protein 4 |
C00003047
|
| 3316 | HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP | heat shock 27kDa protein 2 |
C00003047
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00003047
|
| 3638 | INSIG1, CL-6, CL6 | insulin induced gene 1 |
C00003047
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003047
|
| 8850 | KAT2B, CAF, P, P/CAF, PCAF | K(lysine) acetyltransferase 2B (EC:2.3.1.48) |
C00003047
|
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00003047
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003047
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003047
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00003047
|
| 100124292 |
C00003047
|
||
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003047
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00003047
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00003047
|
| 26118 | WSB1, SWIP1, WSB-1 | WD repeat and SOCS box containing 1 |
C00003047
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (56)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (52)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012640 | Seizures |
C00000844
C00035823 |
| D006937 | Hypercholesterolemia |
C00003047
|
| D017453 | Dermatitis, Irritant |
C00003047
|
| D017449 | Dermatitis, Allergic Contact |
C00035822
|
| D007938 | Leukemia |
C00003047
|
| D009369 | Neoplasms |
C00003047
|
| D005157 | Facial Pain |
C00035823
|