KCF-S cluster No. 958 (9 metabolites)

Corresponding Phytochemical cluster No. 34

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	27
rosids	22
Magnoliophyta	5
Liliopsida	5
Spermatophyta	2
eudicotyledons	2

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Cumulative family count (Top 20)

class name	count
Rutaceae	14
Asteraceae	7
Lamiaceae	5
Lauraceae	4
Solanaceae	3
Apiaceae	3
Verbenaceae	3
Zingiberaceae	3
Actinidiaceae	2
Ganodermataceae	2
Pinaceae	2
Brassicaceae	2
Fagaceae	1
Burseraceae	1
Rubiaceae	1
Saururaceae	1
Meliaceae	1
Rhizophyllidaceae	1
Acoraceae	1
Crassulaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Linear monoterpenes	2

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Linear monoterpenes	C11388	C00003047
Linear monoterpenes	C11389	C00010301
Linear monoterpenes	C11388	C00034888

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003047	Linalool / (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol	CHEMBL25306 CHEMBL235672	C018584	6 / 8 / 2	35 / 4
C00010290	2,6-Dimethyl-1,7-octadiene-3,6-diol
C00010291	(2E,6S)-Dimethyl-2,7-octadiene-1,6-diol
C00010294	3,7-Dimethyl-1,6-octadiene-3,4-diol
C00010301	Coriandrol / (S)-Linalool / S-(+)-Linalool / (+)-S-Linalool / (S)-3,7-Dimethyl-1,6-octadien-3-ol	CHEMBL25306 CHEMBL235672		6 / 8 / 2
C00010345	6-Methyl-2-vinyl-5-heptene-1,2-diol
C00034358	(S)-8-Oxolinalool
C00034888	-(-)-Linalool / (-)-R-Linalool	CHEMBL25306 CHEMBL235672		6 / 8 / 2
C00035042	alpha-Linalool

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00003047 C00010301 C00034888	3 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00003047 C00010301 C00034888	3 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00003047 C00010301 C00034888	0 / 0
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00003047 C00010301 C00034888	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003047 C00010301 C00034888	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00003047 C00010301 C00034888	5 / 1

35 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00003047
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003047
1386	ATF2, CRE-BP1, CREB2, HB16, TREB7	activating transcription factor 2 (EC:2.3.1.48)	C00003047
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00003047
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00003047
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003047
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00003047
1028	CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	C00003047
1030	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	C00003047
1447	CSN2, CASB	casein beta	C00003047
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00003047
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003047
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00003047
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00003047
2335	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF	fibronectin 1	C00003047
1647	GADD45A, DDIT1, GADD45	growth arrest and DNA-damage-inducible, alpha	C00003047
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00003047
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00003047
3297	HSF1, HSTF1	heat shock transcription factor 1	C00003047
3320	HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	C00003047
3308	HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY	heat shock 70kDa protein 4	C00003047
3316	HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP	heat shock 27kDa protein 2	C00003047
3398	ID2, GIG8, ID2A, ID2H, bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	C00003047
3638	INSIG1, CL-6, CL6	insulin induced gene 1	C00003047
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003047
8850	KAT2B, CAF, P, P/CAF, PCAF	K(lysine) acetyltransferase 2B (EC:2.3.1.48)	C00003047
4193	MDM2, ACTFS, HDMX, hdm2	MDM2 oncogene, E3 ubiquitin protein ligase	C00003047
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00003047
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00003047
4852	NPY, PYY4	neuropeptide Y	C00003047
100124292			C00003047
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003047
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00003047
7471	WNT1, BMND16, INT1, OI15	wingless-type MMTV integration site family, member 1	C00003047
26118	WSB1, SWIP1, WSB-1	WD repeat and SOCS box containing 1	C00003047

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions