KCF-S cluster No. 13 (190 metabolites)

Corresponding Phytochemical cluster No. 51

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (190)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
rosids	304
asterids	278
eudicotyledons	48
Liliopsida	4
Embryophyta	4
Magnoliophyta	2
Euphyllophyta	1
Spermatophyta	1

---

Cumulative family count (Top 20)

class name	count
Lamiaceae	76
Fabaceae	53
Ebenaceae	44
Rosaceae	33
Asteraceae	30
Celastraceae	28
Myrtaceae	27
Euphorbiaceae	26
Rubiaceae	21
Saxifragaceae	14
Meliaceae	14
Oleaceae	12
Combretaceae	12
Apocynaceae	10
Malvaceae	10
Primulaceae	9
Ericaceae	8
Urticaceae	8
Myricaceae	7
Rutaceae	7

KEGG BRITE br08003

---

Categories (4)

br08003 Category	# of metabolite
Dammarenes	4
Oleananes	5
Ursanes	5
Others	1

---

metabolites link (15)

br08003 Category	KEGG ID	KNApSAcK ID
Dammarenes	C08980	C00000256
Oleananes	C08931	C00003505
Dammarenes	C08942	C00003516
Oleananes	C02283	C00003521
Ursanes	C08950	C00003525
Others	C08965	C00003539
Oleananes	C08971	C00003545
Oleananes	C08972	C00003546
Ursanes	C08988	C00003558
Ursanes	C08617	C00003739
Dammarenes	C08637	C00003758
Oleananes	C17148	C00019064
Ursanes	C17890	C00019491
Ursanes	C16939	C00030742
Dammarenes	C19833	C00037176

Metabolite list (190)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000256	Soyasapogenol B	CHEMBL153969 CHEMBL1762007	C407096	1 / 0 / 0
C00003505	Barringtogenol C	CHEMBL487606
C00003516	Echinocystic acid	CHEMBL230128 CHEMBL464557 CHEMBL1395408 CHEMBL1559201	C022999	5 / 0 / 1	8 / 2
C00003521	Glycyrrhitinic acid	CHEMBL109757 CHEMBL208873 CHEMBL378653 CHEMBL230006 CHEMBL393824 CHEMBL590534 CHEMBL1483862 CHEMBL1601198 CHEMBL1863561	D006034	27 / 37 / 35	8 / 5
C00003525	Gypsogenin
C00003539	Pfaffic acid
C00003545	Propapyriogenin A2
C00003546	Quillaic acid	CHEMBL260060	C005564
C00003558	Ursolic acid	CHEMBL297810 CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720	C005466	47 / 26 / 33	15 / 12
C00003739	Asiatic acid	CHEMBL278622 CHEMBL404313 CHEMBL1395292 CHEMBL1488520 CHEMBL1564373 CHEMBL1773214	C017032	11 / 14 / 43	1 / 0
C00003758	Alnulin / Tiliadin / Skimmiol / Taraxerol	CHEMBL511822 CHEMBL470462	C005802
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15
C00019065	Erythrodiol / 3beta-Erythrodiol	CHEMBL298604 CHEMBL60687 CHEMBL400074	C077953	4 / 0 / 1
C00019226	3-Epitaraxerol	CHEMBL511822 CHEMBL470462
C00019490	Tormentic acid / 2alpha,3beta,19alpha-Trihydroxyurs-12-en-28-oic acid	CHEMBL223484 CHEMBL239077 CHEMBL1270647		2 / 2 / 2
C00019491	Euscophic acid / Jacarandic acid / 2alpha,3alpha,19alpha-Trihydroxyurs-12-en-28-oic acid	CHEMBL223484 CHEMBL239077 CHEMBL1270647	C007695	2 / 2 / 2
C00019525	Maniladiol / 3beta,16beta-Dihydroxyolean-12-ene	CHEMBL1977415	C068534
C00019526	Cornulactic acid	CHEMBL210970 CHEMBL559587		1 / 0 / 0
C00023791	Alnusenone / Friedoolean-5-en-3-one	CHEMBL517609		1 / 0 / 0
C00024110	3beta,24-Dihydroxyurs-12-en-28-oic acid	CHEMBL19968 CHEMBL523622 CHEMBL493907 CHEMBL522373		1 / 0 / 0
C00024118	2alpha,3beta,24-Trihydroxyurs-12-en-28-oic acid	CHEMBL278622 CHEMBL404313 CHEMBL1395292 CHEMBL1488520 CHEMBL1564373 CHEMBL1773214		11 / 14 / 43
C00029412	19alpha-Hydroxyasiatic acid	CHEMBL515920
C00029441	20-Epibryonolic acid	CHEMBL482596 CHEMBL1982562
C00029451	Glucosol / Corsolic acid / 2alpha-Hydroxyursolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993	C113861	17 / 7 / 6
C00029486	3alpha-Hydroxyolean-12-en-27-oic acid	CHEMBL210970 CHEMBL559587		1 / 0 / 0
C00029491	Pygenic acid A / 3-Epicorosolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993		17 / 7 / 6
C00029493	3-Epimaslinic acid	CHEMBL201515 CHEMBL383749 CHEMBL482673 CHEMBL577380		8 / 5 / 4
C00029494	epi-Oleanolic acid / 3-Epioleanolic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454		30 / 8 / 12
C00029495	3-Epipomolic acid	CHEMBL486986 CHEMBL464567		2 / 0 / 0
C00029496	3-Epiursolic acid / Morinoursolic acid A	CHEMBL297810 CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720		47 / 26 / 33
C00029513	3-Oxoolean-12-en-27-oic acid	CHEMBL1081157		1 / 0 / 0
C00029618	Aceriphyllic acid A	CHEMBL207657 CHEMBL552055 CHEMBL1080070		1 / 0 / 0
C00029665	alpha-Amyrone / alpha-Amirenone / Urs-12-en-3-one	CHEMBL518475	C073947
C00029724	Arjunolic acid	CHEMBL464466 CHEMBL1774425 CHEMBL1797308	C061640	2 / 0 / 0	0 / 2
C00029762	Augustic acid / 2beta-Hydroxyoleanolic acid	CHEMBL201515 CHEMBL383749 CHEMBL482673 CHEMBL577380		8 / 5 / 4
C00029789	Barbinervic acid	CHEMBL523209 CHEMBL493908 CHEMBL1271052	C052363	2 / 0 / 0
C00029820	beta-Peltoboykinolic acid / 3beta-Hydroxyolean-12-en-27-oic acid	CHEMBL210970 CHEMBL559587		1 / 0 / 0
C00029859	Bryonolic acid	CHEMBL482596 CHEMBL1982562	C074984
C00029860	Bryonolol	CHEMBL484238
C00029883	Camaldulenic acid
C00029885	Camaranoic acid
C00029938	Cheiranthic acid
C00029993	Clethric acid
C00030297	Foliasalacin C / (-)-Foliasalacin C
C00030437	Gummosogenin
C00030448	Gypsogenic acid / Astrantiagenin J	CHEMBL2336296
C00030459	Hederagenin	CHEMBL486400 CHEMBL492472 CHEMBL1436053	C025763	7 / 11 / 11
C00030585	Kalidiunin / (+)-Kalidiunin
C00030635	Lantanoic acid / 12-Oxolantanolic acid
C00030636	Lantic acid	CHEMBL69937 CHEMBL1595269		11 / 5 / 2
C00030702	Machaerogenin	CHEMBL1710708		1 / 0 / 0
C00030742	Maslinic acid / Crategolic acid / 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid	CHEMBL201515 CHEMBL383749 CHEMBL482673 CHEMBL577380	C412811	8 / 5 / 4
C00030794	Morolic acid	CHEMBL463665		3 / 0 / 0
C00030797	Myricadiol		C008576
C00030994	Phlomishexaol A / (+)-Phlomishexaol A
C00030995	Phlomishexaol B
C00030996	Phlomisin / (+)-Phlomisin
C00030997	Phlomisone
C00030998	Phlomistetraol A
C00030999	Phlomistetraol B
C00031000	Phlomistetraol C / (+)-Phlomistetraol C
C00031074	Pomolic acid	CHEMBL486986 CHEMBL464567		2 / 0 / 0
C00031116	Queretaroic acid	CHEMBL1733823 CHEMBL1886861		4 / 0 / 0
C00031160	Rhoiptelenol		C480303
C00031198	Rotundic acid	CHEMBL523209 CHEMBL493908 CHEMBL1271052		2 / 0 / 0
C00031228	Rotungenic acid / (+)-Rotungenic acid	CHEMBL523209 CHEMBL493908 CHEMBL1271052		2 / 0 / 0
C00031336	Scutellaric acid / (+)-Scutellaric acid	CHEMBL486400 CHEMBL492472 CHEMBL1436053		7 / 11 / 11
C00031545	2alpha,3alpha,19alpha-Trihydroxy-28-norurs-12-ene
C00031648	Canthic acid
C00031690	Corosolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993	C113861	17 / 7 / 6
C00031734	Dianic acid
C00031826	Glutinol / D:B-Friedoolean-5-en-3beta-ol / (+)-D:B-Friedoolean-5-en-3beta-ol	CHEMBL452242
C00032037	Myrianthic acid	CHEMBL515920
C00032041	Myricerol	CHEMBL498636
C00032287	Taraxerone	CHEMBL519077 CHEMBL1990874	C009379
C00032378	Treleasegenic acid	CHEMBL1904698		3 / 2 / 3
C00032465	Ursonic acid / (+)-Ursonic acid	CHEMBL51426 CHEMBL417927 CHEMBL487887		1 / 2 / 2
C00032467	Uvaol / Uvalol / Urs-12-ene-3beta,28-diol / 3beta,28-Dihydroxyurs-12-ene	CHEMBL58872 CHEMBL399873	C013330	5 / 2 / 2
C00033231	Myrica acid / (-)-Myrica acid
C00033265	Olean 18-en-3-one	CHEMBL2023104
C00033322	Pomonic acid
C00034063	Moronic acid	CHEMBL472646	C023607	8 / 16 / 11
C00034622	Papyriogenin A		C038914
C00034652	R1-Barrigenol	CHEMBL520888 CHEMBL2144007		2 / 0 / 0
C00034832	Crotalic acid
C00034839	Emarginellic acid / (-)-Emarginellic acid
C00035051	Arjungenin / (+)-Arjungenin	CHEMBL499598 CHEMBL1078651 CHEMBL1078652
C00035159	Schimperinone / (-)-Schimperinone
C00035162	Sericic acid	CHEMBL499598 CHEMBL1078651 CHEMBL1078652	C097138
C00035251	Bauer-7-ene-3beta,16alpha-diol
C00035252	Baurenol / Bauerenol		C061436
C00035257	Chichipegenin	CHEMBL1707764		7 / 4 / 1
C00035267	Cladocalol / (+)-Cladocalol
C00035357	Oleanonic acid	CHEMBL470029 CHEMBL574496		3 / 1 / 2
C00035383	Rofficerone
C00035942	3-oxo-Olean-12-en-28-oic acid / (+)-3-oxo-Olean-12-en-28-oic acid	CHEMBL470029 CHEMBL574496		3 / 1 / 2
C00035998	Gamboukokoensein A / 1alpha,2alpha,3beta,19alpha,23-Pentahydroxyurs-12-en-28-oic acid
C00036107	Coussaric acid	CHEMBL492458		1 / 0 / 0
C00036473	24-Hydroxy-3-oxo-olean-12-en-28-oic acid / (+)-24-Hydroxy-3-oxoolean-12-en-28-oic acid	CHEMBL1797141
C00036480	Colosic acid / 2alpha-Hydroxyursolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993	C113861	17 / 7 / 6
C00036544	3-Epikatonic acid	CHEMBL490528 CHEMBL463266 CHEMBL482798 CHEMBL487933
C00036675	Abruslactone A	CHEMBL468457 CHEMBL484855 CHEMBL484424	C052981
C00036795	beta-Boswellic acid	CHEMBL267225 CHEMBL391836	C054625	7 / 0 / 1	2 / 0
C00036897	Chiratenol / (+)-Chiratenol
C00037075	Dulcioic acid
C00037176	Germanicol	CHEMBL2023103		1 / 0 / 0
C00037231	Gymnemagenin	CHEMBL1902552 CHEMBL2361872		2 / 0 / 0
C00037290	Hypodiol / (-)-Hypodiol
C00037489	Maytenfolic acid	CHEMBL513961 CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586
C00037683	Presenegenin	CHEMBL1520610	C487713	3 / 0 / 0
C00037685	Primulagenin A / Schiwalligenin B1	CHEMBL496854 CHEMBL1706157
C00037725	Regelindiol A		C061355
C00037953	Triptocallic acid D	CHEMBL513961 CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586
C00037990	Virgatic acid
C00038236	3,11-Dioxoolean-12-en-28-oic acid
C00038247	3beta,22alpha-Dihydroxyolean-12-en-30-oic acid / (+)-3beta,22alpha-Dihydroxyolean-12-en-30-oic acid	CHEMBL513961 CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586
C00038249	3beta-Hydroxymultiflor-8-en-7-one
C00038271	3-Oxo-11,13(18)-oleandien-28-oic acid / (-)-3-Oxo-11,13(18)-oleandien-28-oic acid	CHEMBL55516
C00038406	Aleuritolic acid	CHEMBL258249
C00039370	Hercinolactone
C00040339	Spathodic acid	CHEMBL493893		1 / 0 / 0
C00040605	Ursolaldehyde / 3beta-Hydroxyurs-12-en-28-aldehyde	CHEMBL465571
C00040937	delta-Amyrin
C00041056	Methyl 2alpha-hydroxyoleanolate / (+)-Methyl 2alpha-hydroxyoleanolate	CHEMBL202346	C077960	2 / 2 / 2
C00041059	Methyl euscaphate	CHEMBL600614 CHEMBL2089024 CHEMBL2089025		2 / 2 / 2
C00041062	Methyl tormentate	CHEMBL600614 CHEMBL2089024 CHEMBL2089025		2 / 2 / 2
C00041113	Sarmentolin / (+)-Sarmentolin
C00041212	Triptocallic acid A / (+)-Triptocallic acid A	CHEMBL461696 CHEMBL485459
C00041213	Triptocallic acid B
C00042045	11-Keto-beta-boswellic acid	CHEMBL437964 CHEMBL236501		6 / 2 / 3
C00042084	28-Norurs-12-en-3beta-ol	CHEMBL498255
C00042120	3beta,27-Dihydroxy-12-ursen-28-oic acid	CHEMBL524080
C00042724	Melilotigenin
C00042725	Melilotigenin B
C00042726	Melilotigenin C / (+)-Melilotigenin C
C00042727	Melilotigenin D / (-)-Melilotigenin D
C00043018	Soyasapogenol E	CHEMBL490989
C00043183	3alpha-Hydroxyolean-12-ene	CHEMBL455098 CHEMBL468040 CHEMBL1334750		1 / 0 / 0
C00043184	3beta,22beta-Dihydroxyolean-12-en-29-oic acid	CHEMBL513961 CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586	C064305
C00043188	3-Epiabruslactone A	CHEMBL468457 CHEMBL484855 CHEMBL484424
C00043239	Acridocarpusic acid A / (+)-Acridocarpusic acid A
C00043240	Acridocarpusic acid B / (+)-Acridocarpusic acid B
C00043241	Acridocarpusic acid C / (+)-Acridocarpusic acid C
C00043242	Acridocarpusic acid D / (+)-Acridocarpusic acid D	CHEMBL463665		3 / 0 / 0
C00043697	Maytefolin B / (-)-Maytefolin B
C00043738	Moradiol / (-)-Moradiol
C00043884	Salvinemorol	CHEMBL518457
C00043885	Salvistamineol / (+)-Salvistamineol	CHEMBL476713
C00044053	28-Hydroxy-beta-Amyrone	CHEMBL1631831		1 / 0 / 0
C00044494	Acinospesigenin B	CHEMBL509928
C00044495	Acinospesigenin C	CHEMBL455058
C00044565	Bartogenic acid	CHEMBL551967
C00044566	beta-Amyrenone	CHEMBL461060
C00045045	Robustanic acid / 3beta-Hydroxy-11alpha-methoxyurs-12-en-28-oic acid
C00045565	Katononic acid / 3-Oxoolean-12-en-29-oic acid	CHEMBL491702
C00045579	6beta-Hydroxyarjunic acid	CHEMBL475889
C00045663	Arjunic acid	CHEMBL515705
C00045930	Eucalyptanoic acid	CHEMBL490537 CHEMBL1823027
C00046057	Katonic acid	CHEMBL490528 CHEMBL463266 CHEMBL482798 CHEMBL487933
C00046375	Sandorinic acid A / (+)-Sandorinic acid A	CHEMBL464226
C00046376	Sandorinic acid B / (+)-Sandorinic acid B	CHEMBL465066
C00046377	Sandorinic acid C / (+)-Sandorinic acid C	CHEMBL465067
C00047401	Bartogenic acid	CHEMBL551967
C00047660	alpha-Peltoboykinolic acid / (+)-alpha-Peltoboykinolic acid / 3beta-Hydroxyurs-12-en-27-oic acid	CHEMBL380467 CHEMBL509107		1 / 0 / 0
C00047665	3-Oxo-azukisapogenol
C00047693	Aceriphyllic acid C / (+)-Aceriphyllic acid C	CHEMBL1078928 CHEMBL1079153
C00047694	Aceriphyllic acid D / (+)-Aceriphyllic acid D	CHEMBL1078928 CHEMBL1079153
C00047695	Aceriphyllic acid E / (+)-Aceriphyllic acid E	CHEMBL1079259
C00047699	Aceriphyllic acid I / (+)-Aceriphyllic acid I	CHEMBL1078536
C00047770	Buergericic acid	CHEMBL499598 CHEMBL1078651 CHEMBL1078652
C00047874	Falcatin A
C00047875	Falcatin B
C00048285	3beta-Hydroxy-5-glutinen-28-oic acid / (+)-3beta-Hydroxy-5-glutinen-28-oic acid
C00048317	Alstonic acid B
C00048395	Gymnorhizol / (-)-Gymnorhizol
C00048533	Serjanic acid
C00049070	1alpha,2alpha,3beta,30-Tetrahydroxyurs-12-ene
C00049086	3beta,24,30-Trihydroxyurs-12-ene
C00049120	beta-Amyrone	CHEMBL461060
C00049133	Castanopsol
C00049134	Chamaedrydiol
C00049149	Epigermanidiol
C00049228	Methyl pomolate
C00049606	3alpha-Hydroxy-13(18)-oleanene-27,28-dioic acid
C00049821	Mudanpinoic acid A / (+)-Mudanpinoic acid A
C00049978	alpha-Boswellic acid	CHEMBL395428
C00050029	Camaldulensic acid / (+)-Camaldulensic acid
C00050150	Machaeric acid
C00050372	Krukovine A / (+)-Krukovine A
C00050373	Krukovine B / (+)-Krukovine B

Human Protein / Gene in interactions

89 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003521 C00003558 C00003739 C00019064 C00019065 C00019526 C00024110 C00024118 C00029451 C00029486 C00029491 C00029493 C00029494 C00029495 C00029496 C00029513 C00029618 C00029762 C00029789 C00029820 C00030459 C00030742 C00030794 C00031074 C00031198 C00031228 C00031336 C00031690 C00032467 C00034063 C00035357 C00035942 C00036107 C00036480 C00036795 C00040339 C00042045 C00043242 C00044053 C00047660	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00003521 C00003558 C00003739 C00019064 C00019065 C00024118 C00029451 C00029491 C00029493 C00029494 C00029496 C00029762 C00030742 C00031690 C00035357 C00035942 C00036480 C00036795 C00042045	0 / 1
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003521 C00003558 C00019490 C00019491 C00029451 C00029491 C00029496 C00031690 C00032467 C00036480 C00041056 C00041059 C00041062 C00042045	1 / 1
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00003521 C00003558 C00019490 C00019491 C00029451 C00029491 C00029496 C00031690 C00032467 C00036480 C00041056 C00041059 C00041062 C00042045	1 / 1
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451 C00029491 C00029493 C00029494 C00029496 C00029762 C00030742 C00030794 C00031690 C00034063 C00036480 C00043242	0 / 0
O75496	Geminin	Unclassified protein	C00000256 C00003521 C00019064 C00029451 C00029491 C00029494 C00030636 C00031690 C00032378 C00034652 C00035257 C00036480 C00037231	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00003521 C00003558 C00019064 C00029451 C00029491 C00029493 C00029494 C00029496 C00029762 C00030742 C00031690 C00036480	0 / 0
P15121	Aldose reductase	Enzyme	C00003521 C00003558 C00003739 C00019064 C00019065 C00024118 C00029493 C00029494 C00029496 C00029762 C00030742	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00003521 C00003558 C00003739 C00019064 C00019065 C00024118 C00029493 C00029494 C00029496 C00029762 C00030742	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00003558 C00019064 C00029451 C00029491 C00029494 C00029496 C00031116 C00031690 C00036480 C00037231	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064 C00029451 C00029491 C00029494 C00031690 C00034063 C00035257 C00036480 C00037683	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003558 C00003739 C00019064 C00024118 C00029494 C00029496 C00029724 C00032467	0 / 0
P06746	DNA polymerase beta	Enzyme	C00003558 C00019064 C00029451 C00029491 C00029494 C00029496 C00031690 C00036480	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003558 C00019064 C00029494 C00029496 C00030459 C00030636 C00031336 C00043183	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003516 C00003521 C00003558 C00003739 C00024118 C00029496 C00030459 C00031336	0 / 1
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451 C00029491 C00029494 C00029496 C00031690 C00036480	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00003558 C00003739 C00019064 C00024118 C00029494 C00029496 C00029724 C00032467	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451 C00029491 C00029494 C00029496 C00031690 C00036480	0 / 0
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00003558 C00019064 C00029494 C00029496 C00030794 C00034063 C00043242	0 / 0
P11217	Glycogen phosphorylase, muscle form	Enzyme	C00029451 C00029491 C00029493 C00029762 C00030742 C00031690 C00036480	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003558 C00003739 C00019064 C00024118 C00029494 C00029496 C00036795	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003521 C00003558 C00029496 C00030459 C00031336 C00034063	11 / 10
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00029451 C00029491 C00030636 C00031690 C00035257 C00036480	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00029451 C00029491 C00030636 C00031690 C00035257 C00036480	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00029451 C00029491 C00030636 C00031690 C00035257 C00036480	2 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00003521 C00019064 C00029493 C00029494 C00029762 C00030742	4 / 2
P08047	Transcription factor Sp1	Unclassified protein	C00003558 C00029495 C00029496 C00030459 C00031074 C00031336	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003558 C00019064 C00023791 C00029494 C00029496	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003558 C00019064 C00029494 C00029496 C00036795	0 / 0
P15559	NAD(P)H dehydrogenase [quinone] 1	Enzyme	C00029789 C00030459 C00031198 C00031228 C00031336	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00003558 C00019064 C00029494 C00029496 C00032465	2 / 2
P42858	Huntingtin	Unclassified protein	C00029451 C00029491 C00031690 C00036480	1 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003516 C00003521 C00003558 C00029496	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003558 C00029496 C00030636 C00035257	1 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064 C00029494 C00035357 C00035942	1 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003558 C00019064 C00029494 C00029496	0 / 3
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003558 C00019064 C00029494 C00029496	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003558 C00019064 C00029494 C00029496	1 / 4
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003558 C00019064 C00029494 C00029496	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00030636 C00031116 C00032378 C00034652	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00019064 C00029494 C00031116 C00037683	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00003521 C00003739 C00024118	3 / 2
P10636	Microtubule-associated protein tau	Unclassified protein	C00003521 C00003739 C00024118	4 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003521 C00003558 C00029496	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003521 C00003558 C00029496	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00003521 C00030459 C00031336	0 / 0
O00255	Menin	Unclassified protein	C00003521 C00003558 C00029496	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003521 C00003558 C00029496	1 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003521 C00003558 C00029496	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003521 C00003558 C00029496	0 / 1
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00003521 C00019064 C00029494	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00003739 C00024118	7 / 37
O15379	Histone deacetylase 3	Hydrolase	C00003558 C00029496	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064 C00029494	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00003558 C00029496	3 / 1
P11473	Vitamin D3 receptor	NR1I1	C00003521 C00032378	2 / 3
P56524	Histone deacetylase 4	Hydrolase	C00003558 C00029496	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003558 C00029496	0 / 0
P30305	M-phase inducer phosphatase 2	Ser_Thr_Tyr	C00003558 C00029496	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00003558 C00029496	0 / 0
Q9UQL6	Histone deacetylase 5	Hydrolase	C00003558 C00029496	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064 C00029494	0 / 0
P48147	Prolyl endopeptidase	S9A	C00036795 C00042045	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00003558 C00029496	0 / 0
Q9UBN7	Histone deacetylase 6	Hydrolase	C00003558 C00029496	0 / 0
Q13547	Histone deacetylase 1	Hydrolase	C00003558 C00029496	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00034063 C00036795	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003558 C00029496	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00003558 C00029496	0 / 0
P51684	C-C chemokine receptor type 6	CC chemokine receptor	C00030702	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00031116	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00034063	1 / 0
P30559	Oxytocin receptor	Vasopressin and oxytocin receptor	C00003516	0 / 0
P24723	Protein kinase C eta type	Eta	C00003521	1 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00030636	1 / 1
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00003521	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00003521	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00037683	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00003516	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00035257	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00042045	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00037176	0 / 0
O14684	Prostaglandin E synthase	Enzyme	C00036795	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003521	5 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00003516	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00030636	0 / 0
P19784	Casein kinase II subunit alpha'	Ck2	C00030636	0 / 0
P67870	Casein kinase II subunit beta	REG serine/threonine protein kinase family	C00030636	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00034063	4 / 1

44 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00003558 C00019064 C00036795
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003516 C00003558 C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00003558 C00019064 C00036795
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003516 C00003558 C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003558 C00019064
581	BAX, BCL2L4	BCL2-associated X protein	C00003516 C00003558
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003516 C00003558
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00003521
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003558
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00003558
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003558
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003558
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00003558
9131	AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	C00003558
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00003558
7416	VDAC1, PORIN, VDAC-1	voltage-dependent anion channel 1	C00003739
637	BID, FP497	BH3 interacting domain death agonist	C00003516
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003516
56616	DIABLO, DFNA64, SMAC	diablo, IAP-binding mitochondrial protein	C00003516
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00003516
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00003521
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00003521
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00003558
1109	AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA	aldo-keto reductase family 1, member C4 (EC:1.1.1.225 1.1.1.357)	C00003521
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00003521
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00003521
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00003521
5972	REN, HNFJ2	renin (EC:3.4.23.15)	C00003521
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
847	CAT	catalase (EC:1.11.1.6)	C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions