PCIDB

KNApSAcK Metabolite C00003521

Metabolite

KNApSAcK Entry

id C00003521
Name Glycyrrhitinic acid
CAS RN 471-53-4
Standard InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
Standard InChI (Main Layer) InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)

Cluster

Phytochemical cluster No. 51
KCF-S cluster No. 13

Link

ChEMBL

By standard InChI CHEMBL230006
By standard InChI Main Layer CHEMBL109757 CHEMBL208873 CHEMBL378653 CHEMBL230006 CHEMBL393824 CHEMBL590534 CHEMBL1483862 CHEMBL1601198 CHEMBL1863561

KEGG

By LinkDB C02283

CTD

By CAS RN D006034

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Fabaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Glycyrrhiza glabra 49827 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL230006 CHEMBL2071965 (1)
1 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL230006 CHEMBL957998 (1) CHEMBL957999 (1)
0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL208873 CHEMBL378653 CHEMBL230006 CHEMBL854300 (2) CHEMBL963010 (1)
CHEMBL1646369 (1)
0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme CHEMBL230006 CHEMBL2168780 (1) CHEMBL2169008 (1)
0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr CHEMBL230006 CHEMBL1646367 (1)
4 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL230006 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1601198 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL230006 CHEMBL2071963 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL1483862 CHEMBL1794311 (1)
2 / 3
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme CHEMBL230006 CHEMBL590534 CHEMBL949067 (1) CHEMBL973434 (1)
CHEMBL1064825 (3) CHEMBL1272433 (1)
CHEMBL1272437 (1) CHEMBL1693353 (1)
CHEMBL1693468 (1) CHEMBL1693477 (1)
CHEMBL1837224 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL230006 CHEMBL1863561 CHEMBL2114843 (3)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL230006 CHEMBL2168781 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1483862 CHEMBL1863561 CHEMBL1794467 (2)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL230006 CHEMBL1837273 (1)
5 / 3
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr CHEMBL230006 CHEMBL1646370 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL230006 CHEMBL2071962 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL230006 CHEMBL2071964 (1)
1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL230006 CHEMBL958788 (1) CHEMBL958789 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL230006 CHEMBL1483862 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL2071966 (1) CHEMBL2071967 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL230006 CHEMBL1483862 CHEMBL1614250 (2) CHEMBL1614421 (2)
4 / 3
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr CHEMBL230006 CHEMBL963011 (1)
0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr CHEMBL230006 CHEMBL1646368 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL230006 CHEMBL1804506 (1)
1 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme CHEMBL230006 CHEMBL590534 CHEMBL1064826 (1) CHEMBL1064827 (3)
CHEMBL1272432 (1) CHEMBL1272436 (1)
CHEMBL1693469 (1) CHEMBL1693471 (1)
CHEMBL1693478 (1)
1 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL230006 CHEMBL1794536 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL230006 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL230006 CHEMBL1614531 (1)
1 / 3

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
D006034 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein decreases activity
protein 12604236
D006034 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) Glycyrrhetinic Acid results in decreased activity of AKR1C2 protein decreases activity
protein 12604236
D006034 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein decreases activity
protein 12604236
D006034 1109 AKR1C4
3-alpha-HSD
C11
CDR
CHDR
DD-4
DD4
HAKRA
aldo-keto reductase family 1, member C4 (EC:1.1.1.225 1.1.1.357) Glycyrrhetinic Acid results in decreased activity of AKR1C4 protein decreases activity
protein 12604236
D006034 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 10460758
D006034 3265 HRAS
C-BAS/HAS
C-H-RAS
C-HA-RAS1
CTLO
H-RASIDX
HAMSV
HRAS1
K-RAS
N-RAS
RASH1
Harvey rat sarcoma viral oncogene homolog Glycyrrhetinic Acid results in decreased expression of HRAS protein decreases expression
protein 19958823
D006034 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 10460758
D006034 5972 REN
HNFJ2
renin (EC:3.4.23.15) Glycyrrhetinic Acid results in decreased activity of REN protein decreases activity
protein 20460744

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#218030 Apparent mineralocorticoid excess; ame P80365
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (35)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001145 D006034 Arrhythmias, Cardiac marker/mechanism
1418542
D006816 D006034 Huntington Disease therapeutic
21909362
D006973 D006034 Hypertension marker/mechanism
8291900
9683905
D008106 D006034 Liver Cirrhosis, Experimental therapeutic
23341968
D009120 D006034 Muscle Cramp therapeutic
23164761