KCF-S cluster No. 969 (9 metabolites)
Corresponding Phytochemical cluster No. 35
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 31 |
| Magnoliophyta | 4 |
| rosids | 2 |
| eudicotyledons | 2 |
| Spermatophyta | 2 |
Cumulative family count
| class name | count |
|---|---|
| Lamiaceae | 15 |
| Asteraceae | 11 |
| Saururaceae | 3 |
| Verbenaceae | 3 |
| Crassulaceae | 2 |
| Cupressaceae | 2 |
| Lauraceae | 1 |
| Apiaceae | 1 |
| Gentianaceae | 1 |
| Rutaceae | 1 |
| Myrtaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Cyclic monoterpenes | 2 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Cyclic monoterpenes | C09908 | C00000155 |
| Cyclic monoterpenes | C09840 | C00000156 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000155
|
Thymol
|
CHEMBL29411
|
D013943
|
9 / 17 / 14 | 12 / 0 |
|
|
C00000156
|
Carvacrol
|
CHEMBL281202
|
C073316
|
10 / 6 / 1 | 4 / 2 |
|
|
C00010857
|
9,10-Dihydroxythymol
/ 2-(2Hydroxy-4-methylphenyl)-1,3-propanediol |
|
||||
|
C00010862
|
Hydrothymoquinone
/ 2,5-Dihydroxy-p-cymene |
C003465
|
|
|||
|
C00010864
|
Cymorcin
|
|
||||
|
C00010968
|
2-Isopropyl-p-cresol
/ 4-Methyl-2-isopropylphenol |
|
||||
|
C00029535
|
Isocarvacrol
/ 4-Isopropyl-2-methylphenol |
|
||||
|
C00030934
|
p-Cymene-2,3-diol
|
|
||||
|
C00037524
|
Multiflotriol
|
|
Human Protein / Gene in interactions
12 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000155 C00000156 | 3 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000155 C00000156 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000155 C00000156 | 5 / 1 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00000155 C00000156 | 0 / 0 |
| O75762 | Transient receptor potential cation channel subfamily A member 1 | Unclassified protein | C00000155 C00000156 | 1 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000155 C00000156 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000155 C00000156 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000156 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000156 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000155 | 11 / 10 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000155 | 0 / 3 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000156 | 0 / 0 |
14 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000155
C00000156
|
| 162514 | TRPV3, OLMS, VRL3 | transient receptor potential cation channel, subfamily V, member 3 |
C00000155
C00000156
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000155
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000156
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00000155
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000155
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000155
|
| 8989 | TRPA1, ANKTM1, FEPS | transient receptor potential cation channel, subfamily A, member 1 |
C00000156
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000155
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000155
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000155
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000155
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000155
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000155
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615040 | Episodic pain syndrome, familial, 1; feps1 |
O75762
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (14)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|