PCIDB

KNApSAcK Metabolite C00000156

Metabolite

KNApSAcK Entry

id C00000156
Name Carvacrol
CAS RN 499-75-2
Standard InChI InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
Standard InChI (Main Layer) InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3

Cluster

Phytochemical cluster No. 35
KCF-S cluster No. 969

Link

ChEMBL

By standard InChI CHEMBL281202
By standard InChI Main Layer CHEMBL281202

KEGG

By LinkDB C09840

CTD

By CAS RN C073316

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL281202 CHEMBL816283 (1) CHEMBL1908082 (1)
3 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL281202 CHEMBL1908087 (1)
0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL281202 CHEMBL1008496 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL281202 CHEMBL1908086 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL281202 CHEMBL1908090 (1)
0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein CHEMBL281202 CHEMBL1118243 (1)
1 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL281202 CHEMBL1908085 (1)
0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme CHEMBL281202 CHEMBL1908088 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL281202 CHEMBL1908080 (2)
5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL281202 CHEMBL1908083 (2)
0 / 0

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C073316 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) carvacrol results in increased activity of CASP3 protein increases activity
protein 23146755
C073316 8989 TRPA1
ANKTM1
FEPS
transient receptor potential cation channel, subfamily A, member 1 carvacrol results in increased activity of TRPA1 protein increases activity
protein 22935519
C073316 162514 TRPV3
OLMS
VRL3
transient receptor potential cation channel, subfamily V, member 3 carvacrol results in increased activity of TRPV3 protein increases activity
protein 16617338
C073316 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of carvacrol increases metabolic processing
protein 7835232

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#143500 Gilbert syndrome P22309
P22310
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309

KEGG DISEASE (1)

KEGG disease name UniProt
H00208 Hyperbilirubinemia P22309 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003866 C073316 Depressive Disorder marker/mechanism
21723308
D010146 C073316 Pain therapeutic
20849525