Species

KNApSAcK Entry

Organism name Thymus vulgaris
Genus Thymus
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Thymus vulgaris
Linked NCBI taxonomy ID 49992
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (63)

Species Activity
Thymus vulgaris L. Abortifacient
Thymus vulgaris L. Allergic
Thymus vulgaris L. Analgesic
Thymus vulgaris L. Antiallergic
Thymus vulgaris L. Antialzheimeran
Thymus vulgaris L. Antianaphylactic
Thymus vulgaris L. Antiarthritic
Thymus vulgaris L. Antibacterial
Thymus vulgaris L. Anticancer
Thymus vulgaris L. Anticariogenic
Thymus vulgaris L. Anticellulitis
Thymus vulgaris L. Anticomplementary
Thymus vulgaris L. Antiedemic
Thymus vulgaris L. Antienuretic
Thymus vulgaris L. Antiinflammatory
Thymus vulgaris L. Antimutagenic
Thymus vulgaris L. Antioxidant
Thymus vulgaris L. Antipyretic
Thymus vulgaris L. Antiseptic
Thymus vulgaris L. Antispasmodic
Thymus vulgaris L. Antithyroid
Thymus vulgaris L. Antitussive
Thymus vulgaris L. Antiulcer
Thymus vulgaris L. Aperitif
Thymus vulgaris L. Ascaricide
Thymus vulgaris L. Astringent
Thymus vulgaris L. Bronchospasmolytic
Thymus vulgaris L. Calcium Antagonist
Thymus vulgaris L. Carminative
Thymus vulgaris L. Choleretic
Thymus vulgaris L. Cicatrizant
Thymus vulgaris L. CNS Depressant
Thymus vulgaris L. COX-2 Inhibitor
Thymus vulgaris L. Decongestant
Thymus vulgaris L. Deodorant
Thymus vulgaris L. Dermatitigenic
Thymus vulgaris L. Diaphoretic
Thymus vulgaris L. Digestive
Thymus vulgaris L. Diuretic
Thymus vulgaris L. Emmenagogue
Thymus vulgaris L. Eupeptic
Thymus vulgaris L. Expectorant
Thymus vulgaris L. Fungicide
Thymus vulgaris L. Hyperemic
Thymus vulgaris L. Hypolipidemic
Thymus vulgaris L. Hypotensive
Thymus vulgaris L. Immunostimulant
Thymus vulgaris L. Insecticide
Thymus vulgaris L. Mucogenic
Thymus vulgaris L. Myorelaxant
Thymus vulgaris L. Nervine
Thymus vulgaris L. Pectoral
Thymus vulgaris L. Phagocytotic
Thymus vulgaris L. Respirosis
Thymus vulgaris L. Rubefacient
Thymus vulgaris L. Secretolytic
Thymus vulgaris L. Secretomotor
Thymus vulgaris L. Sedative
Thymus vulgaris L. Stimulant
Thymus vulgaris L. Tonic
Thymus vulgaris L. Tracheorelaxant
Thymus vulgaris L. Urinary Antiseptic
Thymus vulgaris L. Vermifuge

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004268 External link 512 Luteolin 7-glucuronide
/ Luteolin 7-O-glucuronide
/ Luteolin 7-O-beta-D-glucuronide
CHEMBL464224
C075406
No. 2 No. 15
C00013595 External link 512 Eupatrin
/ Anisomelin
/ Fastigenin
/ Cirsilineol
/ 5,4'-Dihydroxy-6,7,3'-trimethoxyflavone
CHEMBL487213
C057618
No. 3 No. 15
C00003931 External link 512 Thymonin
/ Majoranin
/ Mucroflavone B
/ 5,6,4'-Trihydroxy-7,8,3'-trimethoxyflavone
/ 5,6-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one
CHEMBL478416
No. 3 No. 15
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00000960 External link 512 Eriodictyol
CHEMBL8996
CHEMBL307893
CHEMBL1975989
C007619
32 / 29 / 55 5 / 0 No. 25 No. 14
C00000677 External link 512 Distylin
/ Dihydroquercetin
/ (2R,3R)-Taxifolin
CHEMBL66
CHEMBL9249
CHEMBL337309
CHEMBL1492383
C003377
65 / 41 / 37 29 / 1 No. 42 No. 14
C00002770 External link 512 Rosmarinic acid
CHEMBL66966
CHEMBL324842
CHEMBL1315100
CHEMBL2111558
48 / 35 / 38 No. 749
C00000156 External link 512 Carvacrol
CHEMBL281202
C073316
10 / 6 / 1 4 / 2 No. 969 No. 35
C00000155 External link 512 Thymol
CHEMBL29411
D013943
9 / 17 / 14 12 / 0 No. 969 No. 35
C00000184 External link 512 alpha-Thujene
No. 1343 No. 35
C00003040 External link 512 p-Cymene
CHEMBL442915
C007210
No. 2172 No. 35
C00010337 External link 512 cis-Myrcenol 8
/ (Z)-2-Methyl-6-methylene-2,7-octadien-1-ol
No. 2285 No. 34
C00003065 External link 512 Thymyl acetate
No. 3288 No. 35
C00000842 External link 512 Bornyl acetate
CHEMBL1439452
4 / 1 / 4 No. 4140 No. 35

Human Protein / Gene in interactions

138 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q01196 Runt-related transcription factor 1 Unclassified protein C00000677 C00000842 C00002770 C00003558 C00019064 1 / 4
P06746 DNA polymerase beta Enzyme C00000677 C00000960 C00002770 C00003558 C00019064 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000677 C00000960 C00002770 C00003558 C00019064 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00000677 C00000842 C00002770 C00003558 C00019064 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000156 C00002770 C00003558 C00019064 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000677 C00000960 C00002770 C00003558 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000677 C00000842 C00000960 C00002770 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000677 C00000960 C00002770 C00003558 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000677 C00000960 C00002770 C00019064 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000842 C00002770 C00003558 C00019064 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000677 C00002770 C00003558 C00019064 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000155 C00002770 C00003558 C00019064 0 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000677 C00000960 C00002770 C00003558 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000677 C00002770 C00003558 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000677 C00000960 C00002770 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000677 C00000960 C00002770 1 / 1
P15121 Aldose reductase Enzyme C00002770 C00003558 C00019064 0 / 0
O75496 Geminin Unclassified protein C00000677 C00000960 C00019064 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000677 C00000960 C00002770 1 / 1
P39748 Flap endonuclease 1 Enzyme C00000677 C00000960 C00002770 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000960 C00002770 C00003558 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000677 C00000960 C00002770 3 / 3
P10636 Microtubule-associated protein tau Unclassified protein C00000677 C00000960 C00002770 4 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000677 C00000960 C00002770 2 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000677 C00002770 C00003558 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000677 C00002770 C00003558 1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002770 C00003558 C00019064 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000677 C00003558 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000155 C00003558 11 / 10
O75164 Lysine-specific demethylase 4A Enzyme C00000960 C00002770 0 / 0
O00255 Menin Unclassified protein C00000677 C00003558 2 / 5
P10828 Thyroid hormone receptor beta NR1A2 C00002770 C00003558 3 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000677 C00003558 1 / 2
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 C00019064 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000677 C00000960 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003558 C00019064 0 / 0
P54132 Bloom syndrome protein Enzyme C00000677 C00002770 1 / 2
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 C00019064 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000677 C00002770 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000155 C00000156 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002770 C00019064 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000155 C00000156 5 / 1
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00000155 C00000156 1 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000155 C00000156 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000677 C00000960 1 / 1
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 C00019064 0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 C00019064 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003558 C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000155 C00000156 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000155 C00000156 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000677 C00000960 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00000960 C00002770 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P03956 Interstitial collagenase M10A C00000677 C00002770 0 / 1
Q96RI1 Bile acid receptor NR1H4 C00003558 C00019064 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000677 C00002770 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 C00019064 2 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002770 C00003558 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000155 C00000156 3 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000677 C00000960 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002770 0 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00000960 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000960 4 / 4
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002770 0 / 0
P45452 Collagenase 3 M10A C00000677 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000677 2 / 0
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002770 1 / 2
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000677 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000960 0 / 1
P56817 Beta-secretase 1 A1A C00000677 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000677 0 / 0
P08253 72 kDa type IV collagenase M10A C00000677 1 / 3
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000677 1 / 1
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002770 1 / 1
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00000960 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000677 5 / 2
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000960 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000156 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000677 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000960 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000677 0 / 0
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002770 1 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002770 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000960 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000677 1 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003558 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000677 0 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000677 0 / 0
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000677 2 / 2
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000960 3 / 1
P39900 Macrophage metalloelastase M10A C00000677 0 / 0
P08254 Stromelysin-1 M10A C00000677 1 / 0
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002770 1 / 2
P04062 Glucosylceramidase Enzyme C00002770 6 / 4
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002770 3 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000677 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000677 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000677 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002770 3 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000677 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002770 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000677 2 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000156 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000677 4 / 1
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002770 0 / 0
Q05513 Protein kinase C zeta type Iota C00000677 0 / 0
Q04759 Protein kinase C theta type Delta C00000677 0 / 1
Q02156 Protein kinase C epsilon type Eta C00000677 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000677 0 / 0
P17252 Protein kinase C alpha type Alpha C00000677 0 / 0
Q05655 Protein kinase C delta type Delta C00000677 0 / 0
P05129 Protein kinase C gamma type Alpha C00000677 1 / 1
P05771 Protein kinase C beta type Alpha C00000677 0 / 0
P24723 Protein kinase C eta type Eta C00000677 1 / 0
P41743 Protein kinase C iota type Iota C00000677 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000677 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000960 7 / 37
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00002770 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000960 2 / 1

69 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000155 C00000156 C00003558 C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000677 C00000960 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000677 C00003558 C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000155 C00003558 C00019064
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000155 C00003558
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003558 C00019064
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000677 C00000960
581 BAX, BCL2L4 BCL2-associated X protein C00000155 C00003558
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00000155 C00003558
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003558 C00019064
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000155 C00000156
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000677 C00000960
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00000677
2621 GAS6, AXLLG, AXSF growth arrest-specific 6 C00000677
3458 IFNG, IFG, IFI interferon, gamma C00000677
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000677
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000677
4547 MTTP, ABL, MTP microsomal triglyceride transfer protein C00000677
2248 FGF3, HBGF-3, INT2 fibroblast growth factor 3 C00000677
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000677
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00000677
5921 RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP RAS p21 protein activator (GTPase activating protein) 1 C00000677
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000677
7187 TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 TNF receptor-associated factor 3 C00000677
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000677
7498 XDH, XO, XOR xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) C00000677
7507 XPA, XP1, XPAC xeroderma pigmentosum, complementation group A C00000677
7518 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 C00000677
8817 FGF18, FGF-18, ZFGF5 fibroblast growth factor 18 C00000677
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
1950 EGF, HOMG4, URG epidermal growth factor C00000677
1630 DCC, CRC18, CRCR1, IGDCC1, MRMV1 deleted in colorectal carcinoma C00000677
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000677
993 CDC25A, CDC25A2 cell division cycle 25A (EC:3.1.3.48) C00000677
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003558
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
8900 CCNA1 cyclin A1 C00000677
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00000677
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000960
29110 TBK1, NAK, T2K TANK-binding kinase 1 (EC:2.7.11.1) C00000960
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00000156
335 APOA1 apolipoprotein A-I C00000677
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000156
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00000677
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000155
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000155
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000155
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000155
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000155
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000155

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (104)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#163950 Noonan syndrome 1; ns1 Q06124
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (103)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
P04637 (related)
P08253 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35228 (related)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

25 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006949 Hyperlipidemias C00003558
C00019064
D009369 Neoplasms C00003558
C00019064
D017202 Myocardial Ischemia C00003558
C00019064
D008103 Liver Cirrhosis C00003558
C00019064
D007249 Inflammation C00003558
C00019064
D012878 Skin Neoplasms C00003558
D006461 Hemolysis C00000677
D006965 Hyperplasia C00003558
D003921 Diabetes Mellitus, Experimental C00003558
D002471 Cell Transformation, Neoplastic C00003558
D006528 Carcinoma, Hepatocellular C00003558
D001284 Atrophy C00003558
D006943 Hyperglycemia C00003558
D003866 Depressive Disorder C00000156
D010146 Pain C00000156
D002252 Carbon Tetrachloride Poisoning C00019064
D056486 Drug-Induced Liver Injury C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D007674 Kidney Diseases C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064