PCIDB

KNApSAcK Metabolite C00002770

Metabolite

KNApSAcK Entry

id C00002770
Name Rosmarinic acid
CAS RN 20283-92-5
Standard InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
Standard InChI (Main Layer) InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)

Cluster

Phytochemical cluster
KCF-S cluster No. 749

Link

ChEMBL

By standard InChI CHEMBL324842
By standard InChI Main Layer CHEMBL66966 CHEMBL324842 CHEMBL1315100 CHEMBL2111558

KEGG

By LinkDB C01850

CTD

By CAS RN

Species

Summary

Plant class

class name count
asterids 27
Liliopsida 1
rosids 1

Family

family name count
Lamiaceae 20
Apiaceae 5
Boraginaceae 2
Araceae 1
Malvaceae 1

List (30)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Anethum spp. 40921 Apiaceae asterids Viridiplantae
Anthurium versicolor 78377 Araceae Liliopsida Viridiplantae
Astrantia major 52448 Apiaceae asterids Viridiplantae
Clinopodium chinense var. parviflorum 758499 Lamiaceae asterids Viridiplantae
Elsholtzia rugulosa Hemsl. 41225 Lamiaceae asterids Viridiplantae
Helicteres angustifolia 190244 Malvaceae rosids Viridiplantae
Ligusticum spp. 49551 Apiaceae asterids Viridiplantae
Melissa officinalis 39338 Lamiaceae asterids Viridiplantae
Mentha piperita 34256 Lamiaceae asterids Viridiplantae
Nepeta cadmea 39172 Lamiaceae asterids Viridiplantae
Orthosiphon stamineus 260636 Lamiaceae asterids Viridiplantae
Perilla frutescens var.acuta. 4136 Lamiaceae asterids Viridiplantae
Robdosia coetsa
Rosmarinus officinalis 39367 Lamiaceae asterids Viridiplantae
Salvia bowleyana 424416 Lamiaceae asterids Viridiplantae
Salvia cavaleriei 424418 Lamiaceae asterids Viridiplantae
Salvia chinensis 424420 Lamiaceae asterids Viridiplantae
Salvia flava 342063 Lamiaceae asterids Viridiplantae
Salvia lavandulifolia 49214 Lamiaceae asterids Viridiplantae
Salvia miltiorrhiza 226208 Lamiaceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Salvia prionitis 588964 Lamiaceae asterids Viridiplantae
Salvia sonchifolia 21880 Lamiaceae asterids Viridiplantae
Salvia yunnanensis 342062 Lamiaceae asterids Viridiplantae
Sanicula europaea 71982 Apiaceae asterids Viridiplantae
Sanicula spp. 13665 Apiaceae asterids Viridiplantae
Symphytum officinale 278672 Boraginaceae asterids Viridiplantae
Teucrium scorodonia 53178 Lamiaceae asterids Viridiplantae
Thymus vulgaris 49992 Lamiaceae asterids Viridiplantae
Tournefortia sarmentosa 79403 Boraginaceae asterids Viridiplantae

Human Protein / Gene in interaction

48 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1315100 CHEMBL1741321 (1)
1 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL324842 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL66966 CHEMBL324842 CHEMBL1738312 (2)
0 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL324842 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL324842 CHEMBL1008498 (1)
0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL324842 CHEMBL1032505 (1)
3 / 0
P06746 DNA polymerase beta Enzyme CHEMBL66966 CHEMBL324842 CHEMBL1614079 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL324842 CHEMBL1613818 (1)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL66966 CHEMBL324842 CHEMBL1614076 (2)
1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL324842 CHEMBL1614474 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL324842 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P06241 Tyrosine-protein kinase Fyn Src CHEMBL324842 CHEMBL919495 (1) CHEMBL919496 (1)
CHEMBL919497 (1) CHEMBL919498 (1)
CHEMBL919499 (1) CHEMBL919500 (1)
CHEMBL919501 (1) CHEMBL919502 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1315100 CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL324842 CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL66966 CHEMBL1614166 (1)
1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL324842 CHEMBL1008497 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL66966 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL66966 CHEMBL1738606 (2)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL324842 CHEMBL1103716 (1)
0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL324842 CHEMBL1029438 (1)
1 / 2
P03956 Interstitial collagenase M10A CHEMBL324842 CHEMBL2342140 (1) CHEMBL2342141 (1)
0 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL66966 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL66966 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1315100 CHEMBL1794467 (1)
0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL324842 CHEMBL1024395 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1315100 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL66966 CHEMBL1315100 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P51692 Signal transducer and activator of transcription 5B Unclassified protein CHEMBL324842 CHEMBL1029439 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL66966 CHEMBL1315100 CHEMBL1614038 (2)
2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL324842 CHEMBL1738588 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1315100 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1315100 CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL66966 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL66966 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL66966 CHEMBL324842 CHEMBL1315100 CHEMBL1614466 (1) CHEMBL1614211 (4)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL66966 CHEMBL324842 CHEMBL1315100 CHEMBL1614250 (1) CHEMBL1614421 (3)
CHEMBL1614502 (2)
4 / 3
P06239 Tyrosine-protein kinase Lck Src CHEMBL324842 CHEMBL841495 (1) CHEMBL1024394 (1)
0 / 1
Q12794 Hyaluronidase-1 Enzyme CHEMBL324842 CHEMBL1111859 (1)
1 / 2
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL66966 CHEMBL1315100 CHEMBL1794536 (4)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL66966 CHEMBL324842 CHEMBL1315100 CHEMBL1613914 (4)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL66966 CHEMBL324842 CHEMBL1613829 (2)
0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein CHEMBL324842 CHEMBL1024398 (1)
3 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL66966 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL66966 CHEMBL324842 CHEMBL1315100 CHEMBL1614364 (4)
1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL66966 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL66966 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL66966 CHEMBL2114738 (1)
0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL66966 CHEMBL2114881 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#210900 Bloom syndrome; blm P54132
#614162 Candidiasis, familial, 7; candf7 P42224
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147050 Ige responsiveness, atopic; iger Q13093
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (38)

KEGG disease name UniProt
H00028 Choriocarcinoma P03956 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)