PCIDB

Salvia cavaleriei

Species

KNApSAcK Entry

Organism name Salvia cavaleriei
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia cavaleriei
Linked NCBI taxonomy ID 424418
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00002400 External link 512 Lithospermic acid
/ Lithosperminc acid
CHEMBL518243
C046833
0 / 2 No. 494
C00002772 External link 512 Salvianolic acid A
CHEMBL457077
C066201
5 / 5 / 7 0 / 3 No. 494
C00037778 External link 512 Salvianolic acid H
/ (+)-Salvianolic acid H
CHEMBL463829
No. 494
C00037773 External link 512 Salvianolic acid C
No. 494
C00037345 External link 512 Isosalvianolic acid C
CHEMBL464633
No. 494
C00037781 External link 512 Salvianolic acid I
No. 494
C00002770 External link 512 Rosmarinic acid
CHEMBL66966
CHEMBL324842
CHEMBL1315100
CHEMBL2111558
48 / 35 / 38 No. 749
C00031982 External link 512 Salvianolic acid B
/ Lithospermic acid B
CHEMBL1615434
C111702
No. 1276

Human Protein / Gene in interactions

71 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002770 C00005138 C00005373 0 / 0
P15121 Aldose reductase Enzyme C00002770 C00005138 C00005373 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002770 C00005138 C00005373 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002770 C00005138 C00005373 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002770 C00005373 4 / 3
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002770 C00002772 3 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002770 C00005373 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002770 C00005373 0 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00002770 C00005373 0 / 0
P06746 DNA polymerase beta Enzyme C00002770 C00005373 0 / 0
P04062 Glucosylceramidase Enzyme C00002770 C00005373 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00002770 C00005373 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002770 C00002772 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002770 C00005373 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002770 C00005373 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002770 C00005373 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002770 C00005138 0 / 0
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002770 C00002772 1 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002770 C00002772 0 / 0
P14679 Tyrosinase Oxidoreductase C00005138 C00005373 4 / 2
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005373 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00002770 C00005373 1 / 4
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002770 C00005373 1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002770 C00002772 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002770 C00005373 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002770 C00005373 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00002770 0 / 0
O75496 Geminin Unclassified protein C00005373 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002770 0 / 0
P03956 Interstitial collagenase M10A C00002770 0 / 1
P54132 Bloom syndrome protein Enzyme C00002770 1 / 2
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002770 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002770 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002770 0 / 1
P06241 Tyrosine-protein kinase Fyn Src C00002770 0 / 0
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005373 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002770 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002770 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002770 2 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00002770 3 / 1
P35372 Mu-type opioid receptor Opioid receptor C00005373 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002770 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002770 0 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002770 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005373 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002770 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002770 1 / 2
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002770 3 / 0
P14618 Pyruvate kinase PKM Enzyme C00002770 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002770 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002770 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002770 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002770 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00002770 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (65)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#147050 Ige responsiveness, atopic; iger Q13093
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (59)

KEGG name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138
D015210 Arthritis, Gouty C00002400
D007249 Inflammation C00002400
D020324 Amnesia, Anterograde C00002772
D008107 Liver Diseases C00002772
D009203 Myocardial Infarction C00002772