PCIDB

KNApSAcK Metabolite C00005373

Metabolite

KNApSAcK Entry

id C00005373
Name Hirsutrin / Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside
CAS RN 482-35-9
Standard InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17?,18?,21+/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 2

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336

KEGG

By LinkDB C05623

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 59
asterids 42
Magnoliophyta 16
eudicotyledons 5
Liliopsida 5
Spermatophyta 4
Euphyllophyta 3
Embryophyta 1

Family (Top 10)

family name count
Fabaceae 20
Asteraceae 18
Annonaceae 12
Lamiaceae 8
Euphorbiaceae 6
Malvaceae 5
Hypericaceae 5
Apiaceae 4
Rosaceae 4
Crassulaceae 3

List (139)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Abies amabilis 97174 Pinaceae Spermatophyta Viridiplantae
Acacia caven 72367 Fabaceae rosids Viridiplantae
Aganosma caryophyllata
Ajuga remota 38595 Lamiaceae asterids Viridiplantae
Alkanna orientalis 543563 Boraginaceae asterids Viridiplantae
Angelica furcijuga KITAGAWA 40948 Apiaceae asterids Viridiplantae
Annona crassiflora 508206 Annonaceae Magnoliophyta Viridiplantae
Annona monticola 13336 Annonaceae Magnoliophyta Viridiplantae
Annona tomentosa 13336 Annonaceae Magnoliophyta Viridiplantae
Annona warmingiana 13336 Annonaceae Magnoliophyta Viridiplantae
Anthemis altissima 99027 Asteraceae asterids Viridiplantae
Ardisia colorata 1009002 Primulaceae asterids Viridiplantae
Arnica montana cv.ARBO 4246 Asteraceae asterids Viridiplantae
Artemisia spp. 4219 Asteraceae asterids Viridiplantae
Ascarina lucida 130721 Chloranthaceae Magnoliophyta Viridiplantae
Baptisia spp. 49796 Fabaceae rosids Viridiplantae
Bauhinia vahlii L. 3805 Fabaceae rosids Viridiplantae
Bocagea sp.nov. 22140 Annonaceae Magnoliophyta Viridiplantae
Bupleurum rotundifolium L. 90446 Apiaceae asterids Viridiplantae
Calendula officinalis 41496 Asteraceae asterids Viridiplantae
Campanula glomerata L. 82281 Campanulaceae asterids Viridiplantae
Carum carvi 48032 Apiaceae asterids Viridiplantae
Carya pecan 13402 Juglandaceae rosids Viridiplantae
Centaurea gigantea 41503 Asteraceae asterids Viridiplantae
Centaurea solstitialis 347529 Asteraceae asterids Viridiplantae
Chaerophyllum hirsutum 109101 Apiaceae asterids Viridiplantae
Clibadium spp. 183010 Asteraceae asterids Viridiplantae
Clitoria ternatea 43366 Fabaceae rosids Viridiplantae
Coleogyne ramosissima Torr. 401069 Rosaceae rosids Viridiplantae
Commelina communis L 4743 Commelinaceae Liliopsida Viridiplantae
Conyza filaginoides 41552 Asteraceae asterids Viridiplantae
Costus spicatus 328782 Costaceae Liliopsida Viridiplantae
Curcuma mangga 379528 Zingiberaceae Liliopsida Viridiplantae
Davidsonia pruriens 60422 Cunoniaceae rosids Viridiplantae
Descurainia sophia 89411 Brassicaceae rosids Viridiplantae
Desmanthodium spp. 183021 Asteraceae asterids Viridiplantae
Dicranopteris linearis 37229 Gleicheniaceae Euphyllophyta Viridiplantae
Elsholtzia rugulosa Hemsl. 41225 Lamiaceae asterids Viridiplantae
Eriobotrya japonica 32224 Rosaceae rosids Viridiplantae
Eucalyptus maideni 3932 Myrtaceae rosids Viridiplantae
Eucommia ulmoides Oliv. 4391 Eucommiaceae asterids Viridiplantae
Euphorbia chamaesyce 1046441 Euphorbiaceae rosids Viridiplantae
Euphorbia larica 1031526 Euphorbiaceae rosids Viridiplantae
Euphorbia magalanta 3977 Euphorbiaceae rosids Viridiplantae
Euphorbia virgata 526204 Euphorbiaceae rosids Viridiplantae
Ficus ruficaulis 479338 Moraceae rosids Viridiplantae
Gaillardia aristata Pursh. 55623 Asteraceae asterids Viridiplantae
Gentiana pyrenaica L. 49955 Gentianaceae asterids Viridiplantae
Ginkgo biloba 3311 Ginkgoaceae Spermatophyta Viridiplantae
Gleditsia japonica Miquel. 54873 Fabaceae rosids Viridiplantae
Gleditsia sinensis Lam. 66096 Fabaceae rosids Viridiplantae
Glycyrrhiza glabra L. 49827 Fabaceae rosids Viridiplantae
Gossypium barbadense 3634 Malvaceae rosids Viridiplantae
Gossypium herbaceum 34274 Malvaceae rosids Viridiplantae
Gossypium hirsutum L. 3635 Malvaceae rosids Viridiplantae
Guatteria australis 295152 Annonaceae Magnoliophyta Viridiplantae
Guatteria notabilis 343280 Annonaceae Magnoliophyta Viridiplantae
Guatteria rupestris 295187 Annonaceae Magnoliophyta Viridiplantae
Guatteria villosissima 295194 Annonaceae Magnoliophyta Viridiplantae
Gutierrezia wrightii 71047 Asteraceae asterids Viridiplantae
Haplopappus foliosus 147773 Asteraceae asterids Viridiplantae
Hebe parviflora 163752 Plantaginaceae asterids Viridiplantae
Hedysarum sericeum 47034 Fabaceae rosids Viridiplantae
Heterogaura heterandra 3934 Onagraceae rosids Viridiplantae
Hibiscus mutabilis 455430 Malvaceae rosids Viridiplantae
Hypericum japonicum 282542 Hypericaceae rosids Viridiplantae
Hypericum perforatum 65561 Hypericaceae rosids Viridiplantae
Hypericum perforatum L. 65561 Hypericaceae rosids Viridiplantae
Hypericum sampsonii 282553 Hypericaceae rosids Viridiplantae
Hypericum thasium 1321357 Hypericaceae rosids Viridiplantae
Indigofera tetrantha 20685 Fabaceae rosids Viridiplantae
Kalanchoe blossfeldiana 45339 Crassulaceae eudicotyledons Viridiplantae
Lactuca indica 75953 Asteraceae asterids Viridiplantae
Larix decidua 71402 Pinaceae Spermatophyta Viridiplantae
Leptarrhena pyrolifolia 23253 Saxifragaceae eudicotyledons Viridiplantae
Lotus japonicus 34305 Fabaceae rosids Viridiplantae
Lysimachia nummularia 175113 Primulaceae asterids Viridiplantae
Marah oreganus 252534 Cucurbitaceae rosids Viridiplantae
Marrubium velutinum 41229 Lamiaceae asterids Viridiplantae
Melicope micrococca 1226092 Rutaceae rosids Viridiplantae
Millettia zechiana 53625 Fabaceae rosids Viridiplantae
Monochaetun multiflorum
Morus alba 3498 Moraceae rosids Viridiplantae
Morus insignis 1031565 Moraceae rosids Viridiplantae
Nymphaea caerulea 49506 Nymphaeaceae Magnoliophyta Viridiplantae
Ochna obtusata 56628 Ochnaceae rosids Viridiplantae
Onobrychis amoena 1233737 Fabaceae rosids Viridiplantae
Onobrychis chlorassanica 3881 Fabaceae rosids Viridiplantae
Onobrychis echidna 3881 Fabaceae rosids Viridiplantae
Onobrychis ferganica 3881 Fabaceae rosids Viridiplantae
Onobrychis grandis 3881 Fabaceae rosids Viridiplantae
Onobrychis seravschanica 3881 Fabaceae rosids Viridiplantae
Onopordum acanthium 92915 Asteraceae asterids Viridiplantae
Pedilanthus tithymaloides 212310 Euphorbiaceae rosids Viridiplantae
Pelargonium reniforme 59871 Geraniaceae rosids Viridiplantae
Peltiphyllum peltatum
Peltophorum africanum 321567 Fabaceae rosids Viridiplantae
Phellodendron amurense 68554 Rutaceae rosids Viridiplantae
Phlomis spinidens 316257 Lamiaceae asterids Viridiplantae
Phoenix hanceana var. formosana 4719 Arecaceae Liliopsida Viridiplantae
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Phyllanthus niruri 296034 Phyllanthaceae rosids Viridiplantae
Physalis alkekengi var. franchetii 221454 Solanaceae asterids Viridiplantae
Piper umbellatum 130418 Piperaceae Magnoliophyta Viridiplantae
Pitcairnia rubiflora 49526 Bromeliaceae Liliopsida Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Porcelia macrocarpa 306974 Annonaceae Magnoliophyta Viridiplantae
Psidium guaijava 120289 Myrtaceae rosids Viridiplantae
Pteridium aquilinum 32101 Dennstaedtiaceae Euphyllophyta Viridiplantae
Pyrola elliptica 93825 Ericaceae asterids Viridiplantae
Pyrola spp. 13650 Ericaceae asterids Viridiplantae
Rodgersia podophylla 262050 Saxifragaceae eudicotyledons Viridiplantae
Rollinia dolabripetala 301698 Annonaceae Magnoliophyta Viridiplantae
Salix viminalis 40686 Salicaceae rosids Viridiplantae
Salvia blepharophylla 933122 Lamiaceae asterids Viridiplantae
Salvia cavaleriei 424418 Lamiaceae asterids Viridiplantae
Salvia lavandulifolia 49214 Lamiaceae asterids Viridiplantae
Salvia pinnata 21880 Lamiaceae asterids Viridiplantae
Sapium haematospermum 316852 Euphorbiaceae rosids Viridiplantae
Saussurea medusa 137893 Asteraceae asterids Viridiplantae
Sedum acre 23028 Crassulaceae eudicotyledons Viridiplantae
Silphium perfoliatum L. 53588 Asteraceae asterids Viridiplantae
Sinocrassula indica 91157 Crassulaceae eudicotyledons Viridiplantae
Solanum tuberosum L. 4113 Solanaceae asterids Viridiplantae
Solidago altissima 59294 Asteraceae asterids Viridiplantae
Sophora japonica 3897 Fabaceae rosids Viridiplantae
Sorbus commixta 186521 Rosaceae rosids Viridiplantae
Spiraea formosana 409510 Rosaceae rosids Viridiplantae
Strychnos spinosa 99302 Loganiaceae asterids Viridiplantae
Tachigalia paniculata
Takakia spp. 37424 Takakiaceae Embryophyta Viridiplantae
Thelypteris nipponica 746521 Thelypteridaceae Euphyllophyta Viridiplantae
Theobroma cacao L. 3640 Malvaceae rosids Viridiplantae
Tribulus alatus Del. 43873 Zygophyllaceae rosids Viridiplantae
Trifolium subterraneum 3900 Fabaceae rosids Viridiplantae
Vitis vinifera var.'Trebbiano'. 3603 Vitaceae rosids Viridiplantae
Warburgia stuhlmannii 549618 Canellaceae Magnoliophyta Viridiplantae
Xylopia aromatica 225838 Annonaceae Magnoliophyta Viridiplantae
Zinnia elegans 34245 Asteraceae asterids Viridiplantae

Human Protein / Gene in interaction

38 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9NPH5 NADPH oxidase 4 Enzyme CHEMBL1098724 CHEMBL1249157 (1) CHEMBL1249158 (1)
CHEMBL1249160 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL33027 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL251254 CHEMBL1738312 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL250450 CHEMBL1008559 (1) CHEMBL1693776 (1)
0 / 3
P06746 DNA polymerase beta Enzyme CHEMBL250450 CHEMBL251254 CHEMBL1614079 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL251254 CHEMBL1613818 (1)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL33027 CHEMBL250450 CHEMBL251254 CHEMBL1614175 (1) CHEMBL1614076 (3)
1 / 1
P02545 Prelamin-A/C Unclassified protein CHEMBL251254 CHEMBL1614544 (1)
11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL250450 CHEMBL1014040 (2)
1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1098724 CHEMBL1120976 (1)
0 / 0
P07237 Protein disulfide-isomerase Enzyme CHEMBL33027 CHEMBL1964080 (1) CHEMBL2114805 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL33027 CHEMBL250450 CHEMBL251254 CHEMBL1614166 (3)
1 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL250450 CHEMBL926465 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL250450 CHEMBL2337335 CHEMBL2337336 CHEMBL2342404 (3)
1 / 1
P39748 Flap endonuclease 1 Enzyme CHEMBL33027 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL33027 CHEMBL2114780 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL250450 CHEMBL926467 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL250450 CHEMBL1942674 (2)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL33027 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL250450 CHEMBL1738679 (1) CHEMBL1738192 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL250450 CHEMBL1738602 (1)
3 / 1
P14679 Tyrosinase Oxidoreductase CHEMBL250450 CHEMBL814345 (1)
4 / 2
P06280 Alpha-galactosidase A Enzyme CHEMBL251254 CHEMBL1614217 (1)
1 / 1
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL251254 CHEMBL1614521 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL250450 CHEMBL1738040 (1)
0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL250450 CHEMBL1687393 (1) CHEMBL1687394 (1)
2 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL250450 CHEMBL926466 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL33027 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL33027 CHEMBL250450 CHEMBL251254 CHEMBL1614211 (3)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL250450 CHEMBL251254 CHEMBL1614421 (2)
4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL250450 CHEMBL993916 (1)
1 / 0
P34949 Mannose-6-phosphate isomerase Enzyme CHEMBL33027 CHEMBL1614255 (1)
1 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL33027 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL33027 CHEMBL250450 CHEMBL251254 CHEMBL1613914 (3)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL250450 CHEMBL251254 CHEMBL1738442 (2)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL33027 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL33027 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL33027 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (34)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)