Peltophorum africanum

• Index
• Plant Species
• Metabolite list (16)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Peltophorum africanum
Genus	Peltophorum
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Peltophorum africanum
Linked NCBI taxonomy ID	321567
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (16)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00005737	Myricetin 3-rutinoside / Myricetin-3-O-rutinoside					No. 1	No. 15
C00005374	Quercetin	CHEMBL82242 CHEMBL479232 CHEMBL1437696	C012526	14 / 2 / 2	2 / 1	No. 2	No. 15
C00005373	Hirsutrin / Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside	CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336		38 / 43 / 34		No. 2	No. 15
C00001071	Myricetin	CHEMBL164	C040015	78 / 70 / 56	39 / 2	No. 3	No. 15
C00009143	Fisetinidol-(4alpha->6)-fisetinidol					No. 16	No. 19
C00009036	7,3',4'-Trihydroxyflavan-(3->O->4,4->O->3)-7,3',4'-trihydroxyflavan					No. 16	No. 19
C00009002	6,12-Mehthano-6H,12H-dibenzo[b,f][1,5]dioxocin-2,3,9,13-tetrol					No. 52	No. 14
C00008822	Fisetinidol	CHEMBL1367159		10 / 7 / 7		No. 52	No. 14
C00004565	Kaempferol / Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL150	C006552	76 / 69 / 87	86 / 8	No. 71	No. 15
C00006040	Myricetin 3-(6''-galloylglucoside)					No. 98
C00002724	Heriguard / Chlorogenic acid / 3-O-Caffeoylquinic acid	CHEMBL284616 CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319	D002726	30 / 19 / 22	37 / 9	No. 314	No. 6
C00009322	6-(3,4-Dihydroxyphenyl)-6a,12b-dihydro-3,10,11,12-tetrahydroxy-[2]benzopyrano[3,4-c]benzopyran-8(6H)-one					No. 444
C00020679	4alpha-(2,4-Dihydroxy-3-methoxyphenyl)fisetinidol					No. 444
C00009324	4beta-(2,4-Dihydroxy-3-methoxyphenyl)fisetinidol					No. 444
C00002647	Gallic acid	CHEMBL288114	D005707	42 / 53 / 68	52 / 16	No. 817	No. 81

Human Protein / Gene in interactions

161 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001071 C00002647 C00002724 C00004565 C00005373 C00005374 C00005413 C00008822	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001071 C00002647 C00002724 C00004565 C00005373 C00005374 C00005413 C00008822	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001071 C00002647 C00002724 C00004565 C00005413 C00008822	3 / 3
P10636	Microtubule-associated protein tau	Unclassified protein	C00001071 C00002647 C00004565 C00005373 C00005413 C00008822	4 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00001071 C00002647 C00005373 C00005374 C00005413 C00008822	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001071 C00002647 C00002724 C00004565 C00005373 C00005413	0 / 3
P15121	Aldose reductase	Enzyme	C00001071 C00002647 C00002724 C00004565 C00005373 C00005374	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001071 C00002647 C00002724 C00004565 C00005374 C00008822	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001071 C00002724 C00004565 C00005413 C00008822	0 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00001071 C00004565 C00005373 C00005374 C00005413	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001071 C00002647 C00002724 C00005373 C00005374	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001071 C00002647 C00002724 C00005373 C00005413	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001071 C00002724 C00004565 C00005374	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001071 C00002647 C00002724 C00004565	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001071 C00004565 C00005373 C00005374	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001071 C00004565 C00005373 C00005374	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00001071 C00004565 C00005373 C00005374	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002647 C00005373 C00005413 C00008822	0 / 0
P04062	Glucosylceramidase	Enzyme	C00001071 C00004565 C00005373	6 / 4
P06746	DNA polymerase beta	Enzyme	C00001071 C00005373 C00005413	0 / 0
P06276	Cholinesterase	Hydrolase	C00001071 C00004565 C00005413	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001071 C00005373 C00005413	1 / 0
P14679	Tyrosinase	Oxidoreductase	C00004565 C00005373 C00005413	4 / 2
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002647 C00002724 C00004565	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00004565 C00005373 C00005413	2 / 0
P04150	Glucocorticoid receptor	NR3C1	C00002647 C00002724 C00004565	0 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001071 C00004565 C00005413	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001071 C00004565 C00008822	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00001071 C00004565 C00005373	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001071 C00002724 C00004565	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00002647 C00004565 C00005373	11 / 10
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001071 C00004565 C00008822	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00001071 C00004565 C00005413	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001071 C00004565 C00005413	1 / 0
P03372	Estrogen receptor	NR3A1	C00002647 C00004565 C00005413	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001071 C00002724 C00004565	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001071 C00002647 C00004565	2 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001071 C00002724 C00004565	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001071 C00002724 C00004565	1 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00001071 C00004565 C00005413	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00001071 C00004565	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00001071 C00004565	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005373 C00005413	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00001071 C00005373	0 / 1
P07237	Protein disulfide-isomerase	Enzyme	C00005373 C00005374	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00001071 C00004565	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00001071 C00004565	0 / 0
P48147	Prolyl endopeptidase	S9A	C00004565 C00005413	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005373 C00005413	1 / 1
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00001071 C00004565	4 / 4
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00002647 C00002724	3 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002724 C00004565	2 / 2
P11473	Vitamin D3 receptor	NR1I1	C00001071 C00002647	2 / 3
Q99700	Ataxin-2	Unclassified protein	C00001071 C00004565	1 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001071 C00005373	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001071 C00004565	1 / 2
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001071 C00005374	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00001071 C00004565	0 / 0
O00255	Menin	Unclassified protein	C00001071 C00004565	2 / 5
Q16637	Survival motor neuron protein	Unclassified protein	C00002647 C00005373	4 / 1
Q9NPH5	NADPH oxidase 4	Enzyme	C00004565 C00005373	0 / 0
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00001071 C00005373	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001071 C00005373	0 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00002647 C00004565	7 / 37
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001071 C00004565	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001071 C00005373	1 / 4
P27487	Dipeptidyl peptidase 4	S9B	C00004565 C00005413	0 / 1
O75496	Geminin	Unclassified protein	C00002724 C00005373	0 / 0
P10145	Interleukin-8	Secreted protein	C00002647 C00002724	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00001071 C00005373	3 / 1
P41143	Delta-type opioid receptor	Opioid receptor	C00005373	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00002724	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00002647	0 / 0
Q14790	Caspase-8	C14	C00001071	2 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002647	0 / 0
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002724	1 / 2
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00004565	1 / 1
O43570	Carbonic anhydrase 12	Lyase	C00002647	1 / 2
P16581	E-selectin	Adhesion	C00002647	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00002647	0 / 0
Q15746	Myosin light chain kinase, smooth muscle	Mlck	C00001071	1 / 1
P23280	Carbonic anhydrase 6	Lyase	C00002647	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001071	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00001071	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00005373	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00004565	0 / 0
P06213	Insulin receptor	TK tyrosine-protein kinase INSR subfamily	C00001071	5 / 4
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00001071	2 / 2
P11387	DNA topoisomerase 1	Isomerase	C00001071	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00004565	5 / 3
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00004565	1 / 8
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00002724	0 / 0
Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Enzyme	C00004565	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00005373	1 / 1
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00001071	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001071	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00004565	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00002647	2 / 3
P54132	Bloom syndrome protein	Enzyme	C00001071	1 / 2
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00004565	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00004565	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00002647	0 / 1
P78536	Disintegrin and metalloproteinase domain-containing protein 17	M12B	C00002647	1 / 0
P08183	Multidrug resistance protein 1	drug	C00004565	1 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00001071	1 / 1
P51692	Signal transducer and activator of transcription 5B	Unclassified protein	C00002724	1 / 1
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00004565	1 / 0
Q01453	Peripheral myelin protein 22	Unclassified protein	C00001071	5 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00004565	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00002647	1 / 2
P12821	Angiotensin-converting enzyme	M2	C00002647	4 / 2
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00004565	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00005373	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00001071	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002724	3 / 2
P14151	L-selectin	Adhesion	C00002647	0 / 0
P16109	P-selectin	Adhesion	C00002647	1 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001071	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00004565	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00001071	0 / 1
P98170	E3 ubiquitin-protein ligase XIAP	Other cytosolic protein	C00004565	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001071	0 / 0
Q15046	Lysine--tRNA ligase	Enzyme	C00001071	2 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00004565	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002647	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00002647	5 / 1
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Enzyme	C00001071	9 / 1
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00001071	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00002724	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00002647	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00005373	1 / 0
P10275	Androgen receptor	NR3C4	C00004565	3 / 4
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00004565	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00002647	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00002724	0 / 1
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00002647	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00004565	0 / 0
P34949	Mannose-6-phosphate isomerase	Enzyme	C00005373	1 / 1
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00002647	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00002647	1 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001071	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00004565	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001071	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00001071	1 / 1
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002724	3 / 3
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00002724	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001071	2 / 0
P31941	DNA dC->dU-editing enzyme APOBEC-3A	Enzyme	C00001071	0 / 0
Q9P1W9	Serine/threonine-protein kinase pim-2	Pim	C00005374	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00004565	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00004565	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00004565	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00004565	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00004565	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00004565	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00004565	0 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001071	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00004565	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001071	2 / 1
Q9HCT0	Fibroblast growth factor 22	Unclassified protein	C00001071	0 / 0

178 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001071 C00002647 C00004565 C00005413
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001071 C00002647 C00004565 C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001071 C00002647 C00004565 C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001071 C00002647 C00004565 C00005413
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001071 C00002647 C00004565 C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001071 C00004565 C00005374 C00005413
581	BAX, BCL2L4	BCL2-associated X protein	C00001071 C00002647 C00004565 C00005413
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001071 C00004565 C00005374 C00005413
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00001071 C00002647 C00004565
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002647 C00004565 C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001071 C00002647 C00005413
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002647 C00004565 C00005413
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00001071 C00002647 C00004565
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00001071 C00002647
891	CCNB1, CCNB	cyclin B1	C00001071 C00004565
847	CAT	catalase (EC:1.11.1.6)	C00001071 C00005413
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00001071 C00004565
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00001071 C00004565
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002724 C00004565
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00002647 C00004565
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002724 C00004565
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00002724 C00004565
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002724 C00004565
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002647 C00005413
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00002647 C00004565
7161	TP73, P73	tumor protein p73	C00001071 C00004565
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00004565 C00005413
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00001071 C00004565
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00001071 C00004565
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002647 C00004565
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002647 C00005413
7039	TGFA, TFGA	transforming growth factor, alpha	C00004565 C00005413
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00001071 C00004565
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00001071 C00004565
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002647 C00004565
8000	PSCA, PRO232	prostate stem cell antigen	C00001071 C00004565
5241	PGR, NR3C3, PR	progesterone receptor	C00002724 C00004565
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00004565 C00005413
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00001071 C00004565
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00001071 C00004565
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00004565 C00005413
3082	HGF, DFNB39, F-TCF, HGFB, HPTA, SF	hepatocyte growth factor (hepapoietin A; scatter factor)	C00001071 C00004565
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001071 C00004565
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00004565 C00005413
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00004565 C00005413
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002647 C00004565
7306	TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN	tyrosinase-related protein 1 (EC:1.14.18.-)	C00002724
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00004565
4297	KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	C00004565
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00004565
3043	HBB, CD113t-C, beta-globin	hemoglobin, beta	C00004565
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00004565
110357			C00004565
4502	MT2A, MT2	metallothionein 2A	C00004565
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00004565
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00004565
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00004565
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00004565
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00004565
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00004565
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00004565
9687	GREB1	growth regulation by estrogen in breast cancer 1	C00004565
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00004565
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00004565
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00004565
6119	RPA3, REPA3	replication protein A3, 14kDa	C00004565
2810	SFN, YWHAS	stratifin	C00004565
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00004565
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00004565
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00004565
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00004565
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00004565
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00004565
1734	DIO2, 5DII, D2, DIOII, SelY, TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	C00004565
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00004565
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00004565
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00004565
7352	UCP3, SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	C00004565
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00004565
37618			C00004565
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00004565
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00004565
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00004565
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00004565
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00004565
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00004565
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00001071
397	ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2	Rho GDP dissociation inhibitor (GDI) beta	C00001071
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00004565
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00001071
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00001071
1786	DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	C00001071
54583	EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6	egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29)	C00001071
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00001071
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00001071
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00004565
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00001071
8505	PARG, PARG99	poly (ADP-ribose) glycohydrolase (EC:3.2.1.143)	C00001071
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001071
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00004565
23411	SIRT1, SIR2L1	sirtuin 1	C00001071
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00001071
47	ACLY, ACL, ATPCL, CLATP	ATP citrate lyase (EC:2.3.3.8)	C00002724
358	AQP1, AQP-CHIP, CHIP28, CO	aquaporin 1	C00002724
360	AQP3, AQP-3, GIL	aquaporin 3 (Gill blood group)	C00002724
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00002724
960	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1	CD44 molecule (Indian blood group)	C00002724
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00002724
1277	COL1A1, OI4	collagen, type I, alpha 1	C00002724
4512	COX1, COI, MTCO1, MT-CO1	cytochrome c oxidase subunit I	C00002724
114757	CYGB, HGB, STAP	cytoglobin	C00002724
1830	DSG3, CDHF6, PVA	desmoglein 3	C00002724
1950	EGF, HOMG4, URG	epidermal growth factor	C00002724
2200	FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2	fibrillin 1	C00002724
2201	FBN2, CCA, DA9	fibrillin 2	C00002724
2246	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1	fibroblast growth factor 1 (acidic)	C00002724
2896	GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN	granulin	C00002724
3036	HAS1, HAS	hyaluronan synthase 1 (EC:2.4.1.212)	C00002724
3315	HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27	heat shock 27kDa protein 1	C00002724
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00002724
3852	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A	keratin 5	C00002724
4157	MC1R, CMM5, MSH-R, SHEP2	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	C00002724
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00002724
8985	PLOD3, LH3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4)	C00002724
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00002724
5886	RAD23A, HHR23A, HR23A	RAD23 homolog A (S. cerevisiae)	C00002724
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00002724
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00002724
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00002724
6716	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22)	C00002724
7178	TPT1, HRF, TCTP, p02, p23	tumor protein, translationally-controlled 1	C00002724
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00002724
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00002724
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00004565
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00002647
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00002647
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00002647
613	BCR, ALL, BCR1, CML, D22S11, D22S662, PHL	breakpoint cluster region (EC:2.7.11.1)	C00002647
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00002647
898	CCNE1, CCNE	cyclin E1	C00002647
998	CDC42, CDC42Hs, G25K	cell division cycle 42	C00002647
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002647
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002647
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00002647
2551	GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07	GA binding protein transcription factor, alpha subunit 60kDa	C00002647
2885	GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2	growth factor receptor-bound protein 2	C00002647
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002647
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00004565
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00002647
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00002647
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00002647
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00002647
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00002647
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002647
4316	MMP7, MMP-7, MPSL1, PUMP-1	matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23)	C00002647
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00002647
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00002647
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002647
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00002647
19412			C00002647
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00002647
388	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6	ras homolog family member B	C00002647
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00002647
9252	RPS6KA5, MSK1, MSPK1, RLPK	ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1)	C00002647
6622	SNCA, NACP, PARK1, PARK4, PD1	synuclein, alpha (non A4 component of amyloid precursor)	C00002647
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00002647
7224	TRPC5, TRP5	transient receptor potential cation channel, subfamily C, member 5	C00002647
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00004565
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002647
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413

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