KNApSAcK Metabolite C00004565
Metabolite
KNApSAcK Entry
| id | C00004565 |
|---|---|
| Name | Kaempferol / Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| CAS RN | 520-18-3 |
| Standard InChI | InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H |
| Standard InChI (Main Layer) | InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 71 |
Link
ChEMBL
| By standard InChI | CHEMBL150 |
|---|---|
| By standard InChI Main Layer | CHEMBL150 |
KEGG
| By LinkDB | C05903 |
|---|
CTD
| By CAS RN | C006552 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 52 |
| eudicotyledons | 28 |
| asterids | 25 |
| Magnoliophyta | 5 |
| Spermatophyta | 5 |
| Euphyllophyta | 4 |
| Liliopsida | 3 |
Family (Top 10)
| family name | count |
|---|---|
| Berberidaceae | 17 |
| Fabaceae | 13 |
| Euphorbiaceae | 5 |
| Asteraceae | 5 |
| Crassulaceae | 4 |
| Casuarinaceae | 4 |
| Lamiaceae | 4 |
| Hypericaceae | 3 |
| Anacardiaceae | 3 |
| Rhamnaceae | 3 |
List (125)
* NCBI
Human Protein / Gene in interaction
76 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL150 |
CHEMBL1614110
(2)
CHEMBL1741321
(1)
|
1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | CHEMBL150 |
CHEMBL957998
(1)
CHEMBL957999
(1)
|
0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | CHEMBL150 |
CHEMBL1062294
(1)
CHEMBL2077005
(1)
CHEMBL2076024 (1) CHEMBL2076034 (1) |
0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL150 |
CHEMBL1613992
(2)
CHEMBL1613995
(2)
|
7 / 44 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | CHEMBL150 |
CHEMBL1249157
(1)
CHEMBL1249158
(1)
CHEMBL1249160 (1) |
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL150 |
CHEMBL2114784
(1)
|
1 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | CHEMBL150 |
CHEMBL916998
(1)
|
0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL150 |
CHEMBL917000
(1)
|
0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL150 |
CHEMBL1794573
(1)
|
2 / 2 |
| P04062 | Glucosylceramidase | Enzyme | CHEMBL150 |
CHEMBL1613818
(3)
|
6 / 4 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL150 |
CHEMBL1794552
(2)
CHEMBL2341203
(1)
CHEMBL2341207 (1) |
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL150 |
CHEMBL1614544
(1)
|
11 / 10 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | CHEMBL150 |
CHEMBL1023248
(1)
|
1 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL150 |
CHEMBL1794371
(1)
|
0 / 0 |
| Q00534 | Cyclin-dependent kinase 6 | CMGC serine/threonine protein kinase family | CHEMBL150 |
CHEMBL832923
(1)
|
1 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL150 |
CHEMBL862675
(1)
CHEMBL862676
(1)
CHEMBL926333 (1) |
0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | CHEMBL150 |
CHEMBL1225717
(1)
CHEMBL1780345
(1)
|
0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | CHEMBL150 |
CHEMBL1827948
(1)
|
1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL150 |
CHEMBL661229
(1)
CHEMBL1614027
(2)
CHEMBL1741325 (1) |
0 / 1 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | CHEMBL150 |
CHEMBL876996
(1)
|
0 / 0 |
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | CHEMBL150 |
CHEMBL876996
(1)
|
0 / 0 |
| Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Enzyme | CHEMBL150 |
CHEMBL1794574
(1)
|
0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL150 |
CHEMBL941404
(1)
|
1 / 11 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | CHEMBL150 |
CHEMBL1014685
(1)
CHEMBL1014691
(1)
CHEMBL1014692 (1) CHEMBL1014693 (1) |
0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL150 |
CHEMBL917001
(1)
|
0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | CHEMBL150 |
CHEMBL1100507
(1)
|
0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | CHEMBL150 |
CHEMBL1613800
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL150 |
CHEMBL1614458
(2)
|
0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | CHEMBL150 |
CHEMBL2342404
(1)
|
1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL150 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL150 |
CHEMBL1794486
(1)
|
0 / 0 |
| P15121 | Aldose reductase | Enzyme | CHEMBL150 |
CHEMBL1942674
(1)
|
0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | CHEMBL150 |
CHEMBL974554
(1)
|
0 / 1 |
| Q12791 | Calcium-activated potassium channel subunit alpha-1 | KCNM, KCa1.x | CHEMBL150 |
CHEMBL767233
(1)
|
1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL150 |
CHEMBL1794569
(1)
|
1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL150 |
CHEMBL1794467
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL150 |
CHEMBL1052488
(1)
CHEMBL1052489
(1)
CHEMBL1794382 (2) |
0 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | CHEMBL150 |
CHEMBL814344
(1)
|
4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL150 |
CHEMBL1059360
(1)
CHEMBL1059361
(1)
CHEMBL1062054 (1) CHEMBL1794293 (2) |
5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | CHEMBL150 |
CHEMBL1225718
(1)
CHEMBL1780346
(1)
|
4 / 4 |
| P06276 | Cholinesterase | Hydrolase | CHEMBL150 |
CHEMBL1045780
(1)
CHEMBL1045783
(1)
|
0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | CHEMBL150 |
CHEMBL964479
(2)
|
0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL150 |
CHEMBL1794437
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL150 |
CHEMBL1225716
(1)
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL150 |
CHEMBL1614227
(2)
|
3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | CHEMBL150 |
CHEMBL1687393
(1)
CHEMBL1687394
(1)
CHEMBL2076243 (1) CHEMBL2076822 (1) CHEMBL2076836 (1) CHEMBL2078552 (1) |
2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL150 |
CHEMBL1614038
(1)
|
2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL150 |
CHEMBL2114842
(1)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL150 |
CHEMBL1794364
(2)
CHEMBL1941568
(1)
CHEMBL1941569 (1) |
1 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL150 |
CHEMBL1045781
(1)
|
1 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL150 |
CHEMBL1614240
(2)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL150 |
CHEMBL1613777
(2)
CHEMBL1741323
(1)
|
1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | CHEMBL150 |
CHEMBL958788
(1)
CHEMBL958789
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL150 |
CHEMBL1614108
(2)
CHEMBL1613886
(2)
CHEMBL1741324 (1) |
0 / 1 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | CHEMBL150 |
CHEMBL1646332
(1)
|
1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL150 |
CHEMBL1794483
(1)
|
0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL150 |
CHEMBL1737991
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL150 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL150 |
CHEMBL1614421
(1)
CHEMBL1614502
(1)
|
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL150 |
CHEMBL2114890
(2)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL150 |
CHEMBL1052486
(1)
CHEMBL1052490
(1)
CHEMBL1794321 (2) CHEMBL1794560 (1) |
3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | CHEMBL150 |
CHEMBL1059364
(1)
CHEMBL1059365
(1)
|
0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | CHEMBL150 |
CHEMBL967534
(1)
CHEMBL967535
(1)
|
0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | CHEMBL150 |
CHEMBL926264
(1)
CHEMBL2114849
(2)
|
0 / 0 |
| P48147 | Prolyl endopeptidase | S9A | CHEMBL150 |
CHEMBL974553
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL150 |
CHEMBL1613914
(2)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL150 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL150 |
CHEMBL1614257
(2)
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL150 |
CHEMBL1614257
(2)
CHEMBL1614531
(1)
|
1 / 3 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | CHEMBL150 |
CHEMBL832848
(1)
|
0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | CHEMBL150 |
CHEMBL832848
(1)
|
0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | CHEMBL150 |
CHEMBL832848
(1)
|
0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | CHEMBL150 |
CHEMBL832848
(1)
|
0 / 0 |
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | CHEMBL150 |
CHEMBL832706
(1)
|
0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | CHEMBL150 |
CHEMBL832706
(1)
|
0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | CHEMBL150 |
CHEMBL2114881
(1)
|
0 / 0 |
CTD interaction (202)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C006552 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | ABCB1 protein results in increased transport of kaempferol |
increases transport
|
protein |
15969930
|
| C006552 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] |
decreases reaction
/ increases secretion |
protein |
15266218
|
| C006552 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | kaempferol affects the activity of ABCC1 protein |
affects activity
|
protein |
15796199
|
| C006552 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | kaempferol results in decreased activity of ABCC1 protein |
decreases activity
|
protein |
15670588
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol binds to AHR protein |
affects binding
|
protein |
17012224
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] |
decreases reaction
/ increases activity |
protein |
19794518
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] |
affects binding
/ decreases reaction |
protein |
17012224
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
10359656
20846786 |
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
decreases reaction
/ increases activity |
protein |
14644660
20846786 |
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] |
decreases reaction
/ increases phosphorylation |
protein |
20450880
|
| C006552 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | kaempferol results in increased activity of AHR protein |
increases activity
|
protein |
19034627
|
| C006552 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19244381
|
| C006552 | 239 |
ALOX12
12-LOX 12S-LOX LOG12 |
arachidonate 12-lipoxygenase (EC:1.13.11.31) | kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] |
decreases reaction
/ increases chemical synthesis |
protein |
17027136
|
| C006552 | 239 |
ALOX12
12-LOX 12S-LOX LOG12 |
arachidonate 12-lipoxygenase (EC:1.13.11.31) | kaempferol results in decreased activity of ALOX12 protein |
decreases activity
|
protein |
17027136
|
| C006552 | 405 |
ARNT
HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2 |
aryl hydrocarbon receptor nuclear translocator | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 405 |
ARNT
HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2 |
aryl hydrocarbon receptor nuclear translocator | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 405 |
ARNT
HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2 |
aryl hydrocarbon receptor nuclear translocator | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 405 |
ARNT
HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2 |
aryl hydrocarbon receptor nuclear translocator | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 405 |
ARNT
HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2 |
aryl hydrocarbon receptor nuclear translocator | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] |
decreases reaction
/ increases phosphorylation |
protein |
20450880
|
| C006552 | 472 |
ATM
AT1 ATA ATC ATD ATDC ATE TEL1 TELO1 |
ataxia telangiectasia mutated (EC:2.7.11.1) | Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein] |
decreases reaction
/ increases phosphorylation |
protein |
19028473
|
| C006552 | 472 |
ATM
AT1 ATA ATC ATD ATDC ATE TEL1 TELO1 |
ataxia telangiectasia mutated (EC:2.7.11.1) | kaempferol results in increased phosphorylation of ATM protein |
increases phosphorylation
|
protein |
19028473
|
| C006552 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | kaempferol results in increased expression of BAX protein |
increases expression
|
protein |
19028473
|
| C006552 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] |
decreases reaction
/ increases expression |
protein |
19028473
|
| C006552 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein] |
affects binding
/ increases reaction |
protein |
19028473
|
| C006552 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | kaempferol results in increased expression of BBC3 protein |
increases expression
|
protein |
19028473
|
| C006552 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] |
affects binding
/ affects reaction / increases reaction |
protein |
19028473
|
| C006552 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | kaempferol results in decreased expression of BCL2 protein |
decreases expression
|
protein |
19028473
|
| C006552 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein] |
affects binding
/ increases reaction |
protein |
19028473
|
| C006552 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] |
affects binding
/ affects reaction / increases reaction |
protein |
19028473
|
| C006552 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | kaempferol results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
18331776
19028473 19397994 |
| C006552 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | kaempferol results in increased cleavage of CASP9 protein |
increases cleavage
|
protein |
18331776
|
| C006552 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16797527
|
| C006552 | 891 |
CCNB1
CCNB |
cyclin B1 | kaempferol results in decreased expression of CCNB1 mRNA |
decreases expression
|
mRNA |
18331776
19397994 |
| C006552 | 891 |
CCNB1
CCNB |
cyclin B1 | kaempferol results in decreased expression of CCNB1 protein |
decreases expression
|
protein |
18331776
19397994 |
| C006552 | 983 |
CDK1
CDC2 CDC28A P34CDC2 |
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein |
decreases activity
/ increases phosphorylation |
protein |
11322924
|
| C006552 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | kaempferol results in increased expression of CDKN1A mRNA |
increases expression
|
mRNA |
19397994
|
| C006552 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | kaempferol results in increased expression of CDKN1A protein |
increases expression
|
protein |
19397994
|
| C006552 | 1031 |
CDKN2C
INK4C p18 p18-INK4C |
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | kaempferol results in decreased expression of CDKN2C mRNA |
decreases expression
|
mRNA |
18331776
|
| C006552 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | kaempferol affects the localization of CFTR protein mutant form |
affects localization
|
protein |
15191910
|
| C006552 | 1147 |
CHUK
IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16 |
conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) | kaempferol results in decreased phosphorylation of CHUK protein |
decreases phosphorylation
|
protein |
17184768
|
| C006552 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | kaempferol results in decreased expression of CRP mRNA |
decreases expression
|
mRNA |
17184768
|
| C006552 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | kaempferol results in decreased expression of CRP protein |
decreases expression
|
protein |
17184768
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | kaempferol results in increased secretion of CSF2 protein |
increases secretion
|
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] |
decreases reaction
/ increases secretion |
protein |
18346843
|
| C006552 | 37618 | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of CYCB mRNA |
affects cotreatment
/ increases expression |
mRNA |
16797527
|
||
| C006552 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] |
affects localization
/ decreases reaction |
protein |
19028473
|
| C006552 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | kaempferol affects the localization of CYCS protein |
affects localization
|
protein |
19028473
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
decreases reaction
/ increases activity |
protein |
21256954
21329749 |
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
17012224
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein] |
decreases reaction
/ increases expression |
protein |
17012224
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
10359656
20846786 |
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
20846786
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
10359656
17012224 20846786 |
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] |
decreases reaction
/ increases expression |
protein |
17012224
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA] |
increases expression
/ increases reaction |
mRNA |
21256954
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol results in decreased activity of CYP1A1 protein |
decreases activity
|
protein |
16271822
21053930 21482471 |
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol results in increased activity of CYP1A1 protein |
increases activity
|
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | kaempferol results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
11454723
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein |
affects activity
/ affects cotreatment |
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein |
affects activity
/ affects cotreatment |
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C006552 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C006552 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21256954
|
| C006552 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | kaempferol results in decreased activity of CYP1A2 protein |
decreases activity
|
protein |
20806393
21053930 |
| C006552 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | kaempferol results in increased expression of CYP1A2 mRNA |
increases expression
|
mRNA |
19034627
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol binds to and results in decreased activity of CYP1B1 protein |
affects binding
/ decreases activity |
protein |
21053930
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
enhancer |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20846786
|
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol results in decreased activity of CYP1B1 protein |
decreases activity
|
protein |
16271822
21482471 |
| C006552 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | kaempferol results in decreased expression of CYP1B1 mRNA |
decreases expression
|
mRNA |
19794518
|
| C006552 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] |
decreases reaction
/ increases hydroxylation |
protein |
21053930
|
| C006552 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] |
decreases reaction
/ increases degradation |
protein |
15266218
|
| C006552 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | kaempferol results in decreased activity of CYP3A4 protein |
decreases activity
|
protein |
15266218
21053930 |
| C006552 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | kaempferol results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
16442130
|
| C006552 | 1734 |
DIO2
5DII D2 DIOII SelY TXDI2 |
deiodinase, iodothyronine, type II (EC:1.97.1.10) | kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine] |
increases abundance
/ increases activity / increases reaction |
protein |
17327447
|
| C006552 | 1734 |
DIO2
5DII D2 DIOII SelY TXDI2 |
deiodinase, iodothyronine, type II (EC:1.97.1.10) | kaempferol results in increased activity of DIO2 protein |
increases activity
|
protein |
17327447
|
| C006552 | 1734 |
DIO2
5DII D2 DIOII SelY TXDI2 |
deiodinase, iodothyronine, type II (EC:1.97.1.10) | kaempferol results in increased expression of DIO2 mRNA |
increases expression
|
mRNA |
17327447
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [kaempferol results in increased expression of WISP2 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein] |
affects reaction
/ increases activity |
protein |
16118406
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
9751507
15182386 |
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol binds to ESR1 protein |
affects binding
|
protein |
14579009
14706564 19913605 |
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol inhibits the reaction [Estradiol binds to ESR1 protein] |
affects binding
/ decreases reaction |
protein |
14579009
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]] |
affects binding
/ decreases reaction / increases reaction |
protein |
20846786
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer] |
affects binding
/ increases reaction |
protein |
20846786
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol results in increased activity of ESR1 protein |
increases activity
|
protein |
16118406
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol results in increased expression of and results in increased localization of ESR1 protein |
increases expression
/ increases localization |
protein |
20846786
|
| C006552 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | kaempferol results in increased expression of ESR1 mRNA |
increases expression
|
mRNA |
15182386
|
| C006552 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein] |
affects reaction
/ increases activity |
protein |
16118406
|
| C006552 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | kaempferol binds to and results in increased activity of ESR2 protein |
affects binding
/ increases activity |
protein |
9751507
15182386 |
| C006552 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | kaempferol binds to ESR2 protein |
affects binding
|
protein |
12224631
14706564 19913605 |
| C006552 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | kaempferol inhibits the reaction [Estradiol binds to ESR2 protein] |
affects binding
/ decreases reaction |
protein |
9751507
|
| C006552 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | kaempferol results in increased activity of ESR2 protein |
increases activity
|
protein |
16118406
18937077 |
| C006552 | 2203 |
FBP1
FBP |
fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) | kaempferol results in decreased expression of FBP1 mRNA |
decreases expression
|
mRNA |
18331776
|
| C006552 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] |
affects binding
/ decreases reaction / increases activity |
protein |
15322261
|
| C006552 | 4616 |
GADD45B
GADD45BETA MYD118 |
growth arrest and DNA-damage-inducible, beta | kaempferol results in increased expression of GADD45B mRNA |
increases expression
|
mRNA |
18331776
|
| C006552 | 4616 |
GADD45B
GADD45BETA MYD118 |
growth arrest and DNA-damage-inducible, beta | kaempferol results in increased expression of GADD45B protein |
increases expression
|
protein |
18331776
|
| C006552 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | kaempferol results in increased expression of GCLC mRNA |
increases expression
|
mRNA |
11864778
|
| C006552 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20846786
|
| C006552 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer] |
affects binding
/ increases reaction |
enhancer |
20846786
|
| C006552 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] |
affects binding
/ increases reaction |
enhancer |
20846786
|
| C006552 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | kaempferol results in increased expression of GREB1 mRNA |
increases expression
|
mRNA |
20846786
|
| C006552 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | kaempferol results in increased expression of GSTA1 mRNA |
increases expression
|
mRNA |
21256954
|
| C006552 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | kaempferol results in decreased activity of GSTP1 protein |
decreases activity
|
protein |
15041478
|
| C006552 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | kaempferol results in increased phosphorylation of H2AFX protein |
increases phosphorylation
|
protein |
19028473
|
| C006552 | 3043 |
HBB
CD113t-C beta-globin |
hemoglobin, beta | kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] |
decreases reaction
/ increases response to substance |
gene |
14691983
|
| C006552 | 3082 |
HGF
DFNB39 F-TCF HGFB HPTA SF |
hepatocyte growth factor (hepapoietin A; scatter factor) | kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19244381
|
| C006552 | 3082 |
HGF
DFNB39 F-TCF HGFB HPTA SF |
hepatocyte growth factor (hepapoietin A; scatter factor) | kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] |
decreases reaction
/ increases phosphorylation |
protein |
19244381
|
| C006552 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322261
|
| C006552 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
15322261
|
| C006552 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA] |
decreases reaction
/ increases expression |
protein |
19367675
|
| C006552 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19367675
|
| C006552 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19367675
|
| C006552 | 3565 |
IL4
BCGF-1 BCGF1 BSF-1 BSF1 IL-4 |
interleukin 4 | kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12789233
|
| C006552 | 3567 |
IL5
EDF IL-5 TRF |
interleukin 5 (colony-stimulating factor, eosinophil) | kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12789233
|
| C006552 | 3567 |
IL5
EDF IL-5 TRF |
interleukin 5 (colony-stimulating factor, eosinophil) | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16797527
|
| C006552 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16797527
|
| C006552 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] |
affects binding
/ decreases reaction / increases activity |
protein |
15322261
|
| C006552 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322261
|
| C006552 | 4297 |
KMT2A
ALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS |
lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) | kaempferol results in increased mutagenesis of KMT2A gene |
increases mutagenesis
|
gene |
17468513
|
| C006552 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19367675
|
| C006552 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | kaempferol results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
18346843
|
| C006552 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19367675
|
| C006552 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | kaempferol results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
18346843
|
| C006552 | 4233 |
MET
AUTS9 HGFR RCCP2 c-Met |
met proto-oncogene (EC:2.7.10.1) | kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] |
decreases reaction
/ increases phosphorylation |
protein |
19244381
|
| C006552 | 110357 | kaempferol results in increased expression of MOD2 mRNA |
increases expression
|
mRNA |
16442130
|
||
| C006552 | 4502 |
MT2A
MT2 |
metallothionein 2A | kaempferol results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
10656621
|
| C006552 | 4586 |
MUC5AC
MUC5 TBM leB |
mucin 5AC, oligomeric mucus/gel-forming | kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA] |
decreases reaction
/ increases expression |
mRNA |
19367675
|
| C006552 | 8202 |
NCOA3
ACTR AIB-1 AIB1 CAGH16 CTG26 KAT13B RAC3 SRC-3 SRC3 TNRC14 TNRC16 TRAM-1 bHLHe42 pCIP |
nuclear receptor coactivator 3 (EC:2.3.1.48) | kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] |
affects binding
/ increases reaction |
protein |
20846786
|
| C006552 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21256954
|
| C006552 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | kaempferol results in increased expression of NFE2L2 mRNA |
increases expression
|
mRNA |
21256954
|
| C006552 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | kaempferol results in decreased phosphorylation of NFKBIA protein |
decreases phosphorylation
|
protein |
17184768
|
| C006552 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | kaempferol results in decreased expression of NOS2 mRNA |
decreases expression
|
mRNA |
17184768
|
| C006552 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | kaempferol results in decreased expression of NOS2 protein |
decreases expression
|
protein |
17184768
|
| C006552 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | kaempferol results in increased activity of NR1I2 protein |
increases activity
|
protein |
19034627
|
| C006552 | 9970 |
NR1I3
CAR CAR1 MB67 |
nuclear receptor subfamily 1, group I, member 3 | kaempferol results in increased activity of NR1I3 protein |
increases activity
|
protein |
19034627
|
| C006552 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C006552 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | kaempferol binds to PGR protein |
affects binding
|
protein |
14579009
|
| C006552 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | kaempferol inhibits the reaction [Progesterone binds to PGR protein] |
affects binding
/ decreases reaction |
protein |
14579009
|
| C006552 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | kaempferol results in increased expression of PGR mRNA |
increases expression
|
mRNA |
23384675
|
| C006552 | 10891 |
PPARGC1A
LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | kaempferol results in increased expression of PPARGC1A mRNA |
increases expression
|
mRNA |
17327447
|
| C006552 | 8000 |
PSCA
PRO232 |
prostate stem cell antigen | kaempferol results in decreased expression of PSCA mRNA |
decreases expression
|
mRNA |
18331776
|
| C006552 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
10783318
|
| C006552 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | kaempferol results in decreased expression of PTGS2 mRNA |
decreases expression
|
mRNA |
10783318
17184768 |
| C006552 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | kaempferol results in decreased expression of PTGS2 protein |
decreases expression
|
protein |
17184768
|
| C006552 | 6119 |
RPA3
REPA3 |
replication protein A3, 14kDa | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16797527
|
| C006552 | 2810 |
SFN
YWHAS |
stratifin | kaempferol results in increased expression of SFN mRNA |
increases expression
|
mRNA |
18331776
|
| C006552 | 2810 |
SFN
YWHAS |
stratifin | kaempferol results in increased expression of SFN protein |
increases expression
|
protein |
18331776
|
| C006552 | 6513 |
SLC2A1
DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED |
solute carrier family 2 (facilitated glucose transporter), member 1 | kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose] |
affects transport
/ decreases reaction |
protein |
14642735
|
| C006552 | 6513 |
SLC2A1
DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED |
solute carrier family 2 (facilitated glucose transporter), member 1 | kaempferol results in decreased activity of SLC2A1 protein |
decreases activity
|
protein |
14642735
|
| C006552 | 6773 |
STAT2
ISGF-3 P113 STAT113 |
signal transducer and activator of transcription 2, 113kDa | [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16797527
|
| C006552 | 7019 |
TFAM
MTTF1 MTTFA TCF6 TCF6L1 TCF6L2 TCF6L3 |
transcription factor A, mitochondrial | kaempferol results in increased expression of TFAM mRNA |
increases expression
|
mRNA |
17327447
|
| C006552 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C006552 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | kaempferol results in increased expression of TFF1 mRNA |
increases expression
|
mRNA |
14706564
23384675 |
| C006552 | 7039 |
TGFA
TFGA |
transforming growth factor, alpha | kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
protein |
10783318
|
| C006552 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] |
affects binding
/ decreases reaction / increases activity |
protein |
15322261
|
| C006552 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
protein |
15322261
|
| C006552 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
15322261
|
| C006552 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] |
decreases reaction
/ increases expression |
protein |
15322261
|
| C006552 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19028473
|
| C006552 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | kaempferol results in increased expression of TP53 protein |
increases expression
|
protein |
19028473
|
| C006552 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | kaempferol results in increased phosphorylation of TP53 protein |
increases phosphorylation
|
protein |
19028473
|
| C006552 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] |
affects binding
/ affects reaction / increases reaction |
protein |
19028473
|
| C006552 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 protein affects the susceptibility to kaempferol |
affects response to substance
|
protein |
19028473
|
| C006552 | 9540 |
TP53I3
PIG3 |
tumor protein p53 inducible protein 3 | kaempferol results in increased expression of TP53I3 mRNA |
increases expression
|
mRNA |
18331776
19397994 |
| C006552 | 9540 |
TP53I3
PIG3 |
tumor protein p53 inducible protein 3 | kaempferol results in increased expression of TP53I3 protein |
increases expression
|
protein |
18331776
19397994 |
| C006552 | 8626 |
TP63
AIS B(p51A) B(p51B) EEC3 KET LMS NBP OFC8 RHS SHFM4 TP53CP TP53L TP73L p40 p51 p53CP p63 p73H p73L |
tumor protein p63 | kaempferol results in increased expression of TP63 protein |
increases expression
|
protein |
18331776
19397994 |
| C006552 | 7161 |
TP73
P73 |
tumor protein p73 | kaempferol results in increased expression of TP73 protein |
increases expression
|
protein |
18331776
19397994 |
| C006552 | 7352 |
UCP3
SLC25A9 |
uncoupling protein 3 (mitochondrial, proton carrier) | kaempferol results in increased expression of UCP3 mRNA |
increases expression
|
mRNA |
17327447
|
| C006552 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
14557274
|
| C006552 | 54575 |
UGT1A10
UDPGT UGT-1J UGT1-10 UGT1.10 UGT1J |
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | UGT1A10 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
14557274
|
| C006552 | 54659 |
UGT1A3
UDPGT UDPGT_1-3 UGT-1C UGT1-03 UGT1.3 UGT1C |
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | UGT1A3 mutant form affects the glucuronidation of kaempferol |
affects glucuronidation
|
mutant form |
16738032
|
| C006552 | 54659 |
UGT1A3
UDPGT UDPGT_1-3 UGT-1C UGT1-03 UGT1.3 UGT1C |
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | UGT1A3 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
16738032
|
| C006552 | 54577 |
UGT1A7
UDPGT UDPGT_1-7 UGT-1G UGT1-07 UGT1.7 UGT1G |
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) | UGT1A7 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
14557274
|
| C006552 | 54576 |
UGT1A8
UDPGT UDPGT_1-8 UGT-1H UGT1-08 UGT1.8 UGT1A8S UGT1H |
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | UGT1A8 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
14557274
|
| C006552 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased glucuronidation of kaempferol |
increases glucuronidation
|
protein |
14557274
|
| C006552 | 7402 |
UTRN
DMDL DRP DRP1 |
utrophin | kaempferol results in increased expression of UTRN mRNA |
increases expression
|
mRNA |
22028826
|
| C006552 | 8839 |
WISP2
CCN5 CT58 CTGF-L |
WNT1 inducible signaling pathway protein 2 | ESR1 protein inhibits the reaction [kaempferol results in increased expression of WISP2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C006552 | 8839 |
WISP2
CCN5 CT58 CTGF-L |
WNT1 inducible signaling pathway protein 2 | kaempferol results in increased expression of WISP2 mRNA |
increases expression
|
mRNA |
23384675
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (69)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #609446 | Generalized epilepsy and paroxysmal dyskinesia; gepd |
Q12791
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04637 |
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| %612223 | Stature quantitative trait locus 11; stqtl11 |
Q00534
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (87)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P27487 (marker) P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H01258 | Generalized epilepsy and paroxysmal dyskinesia (GEPD) |
Q12791
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
8 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D050197 | C006552 | Atherosclerosis |
therapeutic
|
22005275
|
|
| D001943 | C006552 | Breast Neoplasms |
therapeutic
|
16756079
|
|
| D009202 | C006552 | Cardiomyopathies |
therapeutic
|
22155320
|
|
| D002318 | C006552 | Cardiovascular Diseases |
therapeutic
|
16756079
|
|
| D006943 | C006552 | Hyperglycemia |
therapeutic
|
18262572
|
|
| D007938 | C006552 | Leukemia |
marker/mechanism
|
17468513
|
|
| D010024 | C006552 | Osteoporosis |
therapeutic
|
16756079
|
|
| D011297 | C006552 | Prenatal Exposure Delayed Effects |
marker/mechanism
|
21115944
|