Paeonia albiflora

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Paeonia albiflora
Genus	Paeonia
Family	Paeoniaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Paeonia lactiflora
Linked NCBI taxonomy ID	35924
Linked level	species

Family

Family in NCBI taxonomy	Paeoniaceae
ID	24943

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005182	Kaempferol 3,7-diglucoside / Kaempferol 3,7-O-beta-D-diglucopyranoside	CHEMBL2206209				No. 1	No. 15
C00004565	Kaempferol / Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL150	C006552	76 / 69 / 87	86 / 8	No. 71	No. 15
C00048039	Paeonidanin C / (-)-Paeonidanin C	CHEMBL1078414				No. 1069
C00048037	Paeonidanin A / (-)-Paeonidanin A	CHEMBL1078412				No. 1069
C00048038	Paeonidanin B / (-)-Paeonidanin B	CHEMBL1078413				No. 1069
C00003011	Paeoniflorin	CHEMBL1078549 CHEMBL1397567 CHEMBL1972762	C015423	4 / 4 / 8	3 / 2	No. 1566
C00033623	Albiflorin	CHEMBL1939883	C014959	1 / 1 / 1		No. 1566
C00000207	Benzoic acid	CHEMBL541	D019817	97 / 39 / 33	24 / 1	No. 2192
C00048040	Paeonidanin D / (-)-Paeonidanin D	CHEMBL1078415				No. 5019
C00048041	Paeonidanin E / (-)-Paeonidanin E	CHEMBL1078416				No. 5019
C00010954	Paeoniflorigenone / (+)-Paeoniflorigenone	CHEMBL1077668	C042713			No. 5422
C00048036	Paeonidangenin / (-)-Paeonidangenin	CHEMBL1081704				No. 5422
C00002664	Phenol	CHEMBL14060	D019800	111 / 52 / 47	101 / 30	No. 6006
C00048042	Paeoniflorone / (-)-Paeoniflorone	CHEMBL1081882				No. 6538

Human Protein / Gene in interactions

177 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P03372	Estrogen receptor	NR3A1	C00000207 C00002664 C00003011 C00004565 C00033623	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000207 C00002664 C00004565	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000207 C00002664 C00004565	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000207 C00002664 C00004565	1 / 8
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000207 C00002664 C00004565	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000207 C00002664 C00004565	1 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000207 C00002664 C00004565	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000207 C00002664 C00004565	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000207 C00002664 C00004565	1 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000207 C00002664 C00004565	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000207 C00002664 C00004565	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000207 C00002664 C00004565	0 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000207 C00002664	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000207 C00002664	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000207 C00002664	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000207 C00002664	0 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000207 C00002664	1 / 1
P10275	Androgen receptor	NR3C4	C00002664 C00004565	3 / 4
P29466	Caspase-1	C14	C00000207 C00002664	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000207 C00002664	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000207 C00002664	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002664 C00004565	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000207 C00002664	2 / 2
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000207 C00002664	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000207 C00002664	0 / 0
P08246	Neutrophil elastase	S1A	C00000207 C00002664	2 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000207 C00002664	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000207 C00002664	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002664 C00004565	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000207 C00002664	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000207 C00002664	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000207 C00002664	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000207 C00002664	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000207 C00002664	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000207 C00002664	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000207 C00002664	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000207 C00002664	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000207 C00002664	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000207 C00002664	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000207 C00002664	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000207 C00002664	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000207 C00002664	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000207 C00002664	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000207 C00002664	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000207 C00002664	0 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000207 C00002664	1 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000207 C00002664	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000207 C00002664	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002664 C00004565	1 / 1
O00255	Menin	Unclassified protein	C00003011 C00004565	2 / 5
P14416	D(2) dopamine receptor	Dopamine receptor	C00000207 C00002664	2 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003011 C00004565	1 / 2
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000207 C00002664	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000207 C00002664	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000207 C00002664	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000207 C00002664	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000207 C00002664	2 / 1
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000207 C00002664	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000207 C00002664	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000207 C00002664	1 / 1
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000207 C00002664	1 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000207 C00002664	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000207 C00002664	1 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000207 C00002664	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00003011 C00004565	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000207 C00002664	3 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000207 C00002664	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000207 C00002664	0 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000207 C00002664	0 / 0
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000207 C00002664	1 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000207 C00002664	5 / 9
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000207 C00002664	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000207 C00002664	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000207 C00002664	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000207 C00002664	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000207 C00002664	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000207 C00002664	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000207 C00002664	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000207 C00002664	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002664 C00004565	5 / 3
P25101	Endothelin-1 receptor	Endothelin receptor	C00000207 C00002664	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000207 C00002664	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000207 C00002664	1 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000207 C00002664	2 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000207 C00002664	0 / 0
P08311	Cathepsin G	S1A	C00000207 C00002664	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000207 C00002664	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000207 C00002664	1 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000207 C00002664	0 / 0
P03956	Interstitial collagenase	M10A	C00000207 C00002664	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000207 C00002664	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000207 C00002664	2 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000207 C00002664	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00004565	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00004565	1 / 1
Q9GZT4	Serine racemase	Enzyme	C00000207	0 / 0
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00004565	1 / 1
P14679	Tyrosinase	Oxidoreductase	C00004565	4 / 2
P27487	Dipeptidyl peptidase 4	S9B	C00004565	0 / 1
P00915	Carbonic anhydrase 1	Lyase	C00002664	0 / 0
P15121	Aldose reductase	Enzyme	C00004565	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000207	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00004565	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00004565	4 / 4
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00004565	0 / 0
P06276	Cholinesterase	Hydrolase	C00004565	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00004565	1 / 1
O43570	Carbonic anhydrase 12	Lyase	C00002664	1 / 2
Q9ULX7	Carbonic anhydrase 14	Lyase	C00002664	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00002664	1 / 1
P04745	Alpha-amylase 1	Enzyme	C00004565	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00004565	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00004565	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00004565	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00002664	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00004565	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00002664	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00004565	3 / 3
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00004565	2 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00004565	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00004565	0 / 0
Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Enzyme	C00004565	0 / 0
P14920	D-amino-acid oxidase	Enzyme	C00000207	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00004565	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00004565	0 / 0
Q9UQ49	Sialidase-3	Enzyme	C00000207	0 / 0
P08183	Multidrug resistance protein 1	drug	C00004565	1 / 0
P04066	Tissue alpha-L-fucosidase	Enzyme	C00002664	1 / 2
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00004565	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00004565	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00004565	1 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00004565	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00004565	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000207	3 / 2
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00004565	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00004565	11 / 10
Q99489	D-aspartate oxidase	Enzyme	C00000207	0 / 0
P98170	E3 ubiquitin-protein ligase XIAP	Other cytosolic protein	C00004565	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00004565	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00004565	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00004565	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00004565	4 / 3
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00002664	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00004565	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00002664	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00002664	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00002664	0 / 0
P04062	Glucosylceramidase	Enzyme	C00004565	6 / 4
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00004565	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00004565	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00004565	1 / 1
P07451	Carbonic anhydrase 3	Lyase	C00002664	0 / 0
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00000207	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00004565	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00004565	0 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00004565	0 / 0
P48147	Prolyl endopeptidase	S9A	C00004565	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00002664	1 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00004565	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00004565	7 / 37
P33527	Multidrug resistance-associated protein 1	drugs	C00004565	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00004565	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00004565	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00004565	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00004565	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00004565	0 / 0
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00002664	4 / 2
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00002664	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00002664	1 / 1
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00004565	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00004565	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00004565	0 / 0

200 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002664 C00004565
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000207 C00002664
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000207 C00002664
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000207 C00002664
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003011 C00004565
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002664 C00004565
4502	MT2A, MT2	metallothionein 2A	C00000207 C00004565
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00002664 C00004565
3043	HBB, CD113t-C, beta-globin	hemoglobin, beta	C00002664 C00004565
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00002664 C00004565
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00000207 C00004565
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00000207 C00004565
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00002664 C00004565
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002664 C00004565
10140	TOB1, APRO6, PIG49, TOB, TROB, TROB1	transducer of ERBB2, 1	C00002664
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00004565
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00004565
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00004565
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00004565
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00004565
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00004565
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00004565
37618			C00004565
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00004565
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00004565
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00004565
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00004565
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00004565
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00004565
1734	DIO2, 5DII, D2, DIOII, SelY, TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	C00004565
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00004565
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00004565
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00004565
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00004565
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00004565
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00004565
9687	GREB1	growth regulation by estrogen in breast cancer 1	C00004565
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00004565
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00004565
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00004565
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00004565
3082	HGF, DFNB39, F-TCF, HGFB, HPTA, SF	hepatocyte growth factor (hepapoietin A; scatter factor)	C00004565
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00004565
581	BAX, BCL2L4	BCL2-associated X protein	C00004565
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00004565
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00004565
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00004565
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00004565
4297	KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	C00004565
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00004565
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00004565
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00004565
110357			C00004565
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00004565
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00004565
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00004565
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00004565
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00004565
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00004565
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00004565
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00004565
5241	PGR, NR3C3, PR	progesterone receptor	C00004565
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00004565
8000	PSCA, PRO232	prostate stem cell antigen	C00004565
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00004565
6119	RPA3, REPA3	replication protein A3, 14kDa	C00004565
2810	SFN, YWHAS	stratifin	C00004565
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00004565
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00004565
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00004565
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00004565
7039	TGFA, TFGA	transforming growth factor, alpha	C00004565
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00004565
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00004565
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00004565
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00004565
7161	TP73, P73	tumor protein p73	C00004565
7352	UCP3, SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	C00004565
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00004565
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00004565
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00004565
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00004565
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00004565
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00004565
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00004565
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00004565
664	BNIP3, NIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	C00003011
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00003011
10965	ACOT2, CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128	acyl-CoA thioesterase 2 (EC:3.1.2.2)	C00002664
174	AFP, FETA, HPAFP	alpha-fetoprotein	C00002664
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00002664
249	ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP	alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1)	C00002664
25805	BAMBI, NMA	BMP and activin membrane-bound inhibitor	C00002664
8553	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14	basic helix-loop-helix family, member e40	C00002664
10904	BLCAP, BC10	bladder cancer associated protein	C00002664
813	CALU	calumenin	C00002664
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002664
890	CCNA2, CCN1, CCNA	cyclin A2	C00002664
9469	CHST3, C6ST, C6ST1, HSD	carbohydrate (chondroitin 6) sulfotransferase 3 (EC:2.8.2.17)	C00002664
9076	CLDN1, CLD1, ILVASC, SEMP1	claudin 1	C00002664
1277	COL1A1, OI4	collagen, type I, alpha 1	C00002664
1385	CREB1, CREB	cAMP responsive element binding protein 1	C00002664
100160140			C00002664
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00002664
4051	CYP4F3, CPF3, CYP4F, LTB4H	cytochrome P450, family 4, subfamily F, polypeptide 3 (EC:1.14.13.30)	C00002664
26528	DAZAP1	DAZ associated protein 1	C00002664
55802	DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF	decapping mRNA 1A	C00002664
1654	DDX3X, DBX, DDX14, DDX3, HLP2	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (EC:3.6.4.13)	C00002664
1843	DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	C00002664
22936	ELL2	elongation factor, RNA polymerase II, 2	C00002664
2114	ETS2, ETS2IT1	v-ets avian erythroblastosis virus E26 oncogene homolog 2	C00002664
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00002664
26190	FBXW2, FBW2, Fwd2, Md6	F-box and WD repeat domain containing 2	C00002664
8061	FOSL1, FRA, FRA1, fra-1	FOS-like antigen 1	C00002664
2623	GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT	GATA binding protein 1 (globin transcription factor 1)	C00002664
2624	GATA2, DCML, MONOMAC, NFE1B	GATA binding protein 2	C00002664
9329	GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA	general transcription factor IIIC, polypeptide 4, 90kDa (EC:2.3.1.48)	C00002664
26762	HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1	hepatitis A virus cellular receptor 1	C00002664
3280	HES1, HES-1, HHL, HRY, bHLHb39	hes family bHLH transcription factor 1	C00002664
3145	HMBS, PBG-D, PBGD, PORC, UPS	hydroxymethylbilane synthase (EC:2.5.1.61)	C00002664
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00004565
3188	HNRNPH2, FTP3, HNRPH', HNRPH2, hnRNPH'	heterogeneous nuclear ribonucleoprotein H2 (H')	C00002664
3399	ID3, HEIR-1, bHLHb25	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	C00002664
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00002664
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002664
54556	ING3, Eaf4, ING2, MEAF4, p47ING3	inhibitor of growth family, member 3	C00002664
7071	KLF10, EGR-alpha, EGRA, TIEG, TIEG1	Kruppel-like factor 10	C00002664
1316	KLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9	Kruppel-like factor 6	C00002664
3840	KPNA4, IPOA3, QIP1, SRP3	karyopherin alpha 4 (importin alpha 3)	C00002664
4041	LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2	low density lipoprotein receptor-related protein 5	C00002664
10905	MAN1A2, MAN1B	mannosidase, alpha, class 1A, member 2 (EC:3.2.1.113)	C00002664
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00002664
4247	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143)	C00002664
4353	MPO	myeloperoxidase (EC:1.11.2.2)	C00002664
740	MRPL49, C11orf4, L49mt, MRP-L49, NOF, NOF1	mitochondrial ribosomal protein L49	C00002664
4496	MT1H, MT-0, MT-1H, MT-IH, MT1	metallothionein 1H	C00002664
4501	MT1X, MT-1l, MT1	metallothionein 1X	C00002664
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002664
4778	NFE2, NF-E2, p45	nuclear factor, erythroid 2	C00002664
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002664
4800	NFYA, CBF-A, CBF-B, HAP2, NF-YA	nuclear transcription factor Y, alpha	C00002664
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00004565
8431	NR0B2, SHP, SHP1	nuclear receptor subfamily 0, group B, member 2	C00002664
57162	PELI1	pellino E3 ubiquitin protein ligase 1	C00002664
8864	PER2, FASPS, FASPS1	period circadian clock 2	C00002664
5293	PIK3CD, P110DELTA, PI3K, p110D	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153)	C00002664
5292	PIM1, PIM	pim-1 oncogene (EC:2.7.11.1)	C00002664
9240	PNMA1, MA1	paraneoplastic Ma antigen 1	C00002664
5411	PNN, DRS, DRSP, SDK3, memA	pinin, desmosome associated protein	C00002664
10908	PNPLA6, NTE, NTEMND, SPG39, iPLA2delta, sws	patatin-like phospholipase domain containing 6 (EC:3.1.1.5)	C00002664
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00002664
8493	PPM1D, PP2C-DELTA, WIP1	protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16)	C00002664
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002664
38175			C00002664
9367	RAB9A, RAB9	RAB9A, member RAS oncogene family	C00002664
29803	REPIN1, AP4, RIP60, ZNF464, Zfp464	replication initiator 1	C00002664
10670	RRAGA, FIP-1, FIP1, RAGA	Ras-related GTP binding A	C00002664
51282	SCAND1, RAZ1, SDP1	SCAN domain containing 1	C00002664
22928	SEPHS2, SPS2, SPS2b	selenophosphate synthetase 2 (EC:2.7.9.3)	C00002664
150094	SIK1, MSK, SIK, SNF1LK	salt-inducible kinase 1 (EC:2.7.11.1)	C00002664
23411	SIRT1, SIR2L1	sirtuin 1	C00002664
9990	SLC12A6, ACCPN, KCC3, KCC3A, KCC3B	solute carrier family 12 (potassium/chloride transporter), member 6	C00002664
6426	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a	serine/arginine-rich splicing factor 1	C00002664
6430	SRSF5, HRS, SFRS5, SRP40	serine/arginine-rich splicing factor 5	C00002664
51188	SS18L2, KIAA-iso	synovial sarcoma translocation gene on chromosome 18-like 2	C00002664
6879	TAF7, TAF2F, TAFII55	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	C00002664
23435	TARDBP, ALS10, TDP-43	TAR DNA binding protein	C00002664
10732	TCFL5, CHA, E2BP-1, Figlb, bHLHe82	transcription factor-like 5 (basic helix-loop-helix)	C00002664
7014	TERF2, TRBF2, TRF2	telomeric repeat binding factor 2	C00002664
7037	TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90	transferrin receptor	C00002664
7050	TGIF1, HPE4, TGIF	TGFB-induced factor homeobox 1	C00002664
10440	TIMM17A, TIM17, TIM17A	translocase of inner mitochondrial membrane 17 homolog A (yeast)	C00002664
7082	TJP1, ZO-1	tight junction protein 1	C00002664
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00002664
27242	TNFRSF21, BM-018, CD358, DR6	tumor necrosis factor receptor superfamily, member 21	C00002664
891	CCNB1, CCNB	cyclin B1	C00004565
10221	TRIB1, C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1	tribbles pseudokinase 1	C00002664
7286	TUFT1	tuftelin 1	C00002664
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00004565
7357	UGCG, GCS, GLCT1	UDP-glucose ceramide glucosyltransferase (EC:2.4.1.80)	C00002664
8876	VNN1, HDLCQ8, Tiff66	vanin 1 (EC:3.5.1.92)	C00002664
7444	VRK2	vaccinia related kinase 2 (EC:2.7.11.1)	C00002664
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000207
57016	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI	aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2)	C00000207
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00000207
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00000207
2235	FECH, EPP, FCE	ferrochelatase (EC:4.99.1.1)	C00000207
2512	FTL, NBIA3	ferritin, light polypeptide	C00000207
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00000207
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00000207
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00000207
4097	MAFG, hMAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	C00000207
4199	ME1, HUMNDME, MES	malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40)	C00000207
4489	MT1A, MT1, MT1S, MTC	metallothionein 1A	C00000207
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00000207
5226	PGD, 6PGD	phosphogluconate dehydrogenase (EC:1.1.1.44)	C00000207
22949	PTGR1, LTB4DH, PGR1, ZADH3	prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74)	C00000207
6566	SLC16A1, HHF7, MCT, MCT1	solute carrier family 16 (monocarboxylate transporter), member 1	C00000207
140809	SRXN1, C20orf139, Npn3, SRX, SRX1	sulfiredoxin 1 (EC:1.8.98.2)	C00000207
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00000207

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