Nerium oleander

• Index
• Plant Species
• Metabolite list (22)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Nerium oleander
Genus	Nerium
Family	Apocynaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Nerium oleander
Linked NCBI taxonomy ID	63479
Linked level	species

Family

Family in NCBI taxonomy	Apocynaceae
ID	4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (22)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00042120	3beta,27-Dihydroxy-12-ursen-28-oic acid	CHEMBL524080				No. 13	No. 51
C00040605	Ursolaldehyde / 3beta-Hydroxyurs-12-en-28-aldehyde	CHEMBL465571				No. 13	No. 51
C00003558	Ursolic acid	CHEMBL297810 CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720	C005466	47 / 26 / 33	15 / 12	No. 13	No. 51
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00032467	Uvaol / Uvalol / Urs-12-ene-3beta,28-diol / 3beta,28-Dihydroxyurs-12-ene	CHEMBL58872 CHEMBL399873	C013330	5 / 2 / 2		No. 13	No. 51
C00042084	28-Norurs-12-en-3beta-ol	CHEMBL498255				No. 13	No. 51
C00003741	Betulinic acid	CHEMBL269277 CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635	C002070	34 / 17 / 14	10 / 2	No. 23	No. 51
C00042003	Ocotillol / (20S,24R)-Epoxydammarane-3beta,25-diol	CHEMBL375698 CHEMBL523757				No. 23	No. 51
C00041257	20beta,28-Epoxytaraxaster-21-en-3beta-ol / (+)-20beta,28-Epoxytaraxaster-21-en-3beta-ol	CHEMBL500910				No. 23	No. 51
C00004565	Kaempferol / Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL150	C006552	76 / 69 / 87	86 / 8	No. 71	No. 15
C00038705	Cardenolide N-4	CHEMBL229258 CHEMBL413068 CHEMBL1162954				No. 109	No. 56
C00038702	Cardenolide N-1 / (-)-Cardenolide N-1	CHEMBL229533 CHEMBL229259 CHEMBL1993326				No. 109	No. 56
C00003600	Adynerin	CHEMBL375720				No. 109	No. 56
C00038703	Cardenolide N-2 / (+)-Cardenolide N-2	CHEMBL375720				No. 109	No. 56
C00038704	Cardenolide N-3 / (+)-Cardenolide N-3	CHEMBL229203				No. 109	No. 56
C00029633	Ursolic acid / Acetylursolic acid	CHEMBL55086 CHEMBL410525		4 / 2 / 2		No. 177
C00049578	Proceragenin					No. 822	No. 56
C00042119	3beta,13beta-Dihydroxyurs-11-en-28-oic acid	CHEMBL498254				No. 1519
C00039846	Neridienone B	CHEMBL219812				No. 4783
C00039845	Neridienone A	CHEMBL375572	C008600			No. 4783
C00001127	Oleandrose / 2,6-Dideoxy-3-O-methyl-beta-L-arabino-Hexopyranose					No. 5274

Human Protein / Gene in interactions

134 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003558 C00004565 C00005413 C00019064 C00029633	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003558 C00003741 C00004565 C00019064 C00032467	0 / 0
P06746	DNA polymerase beta	Enzyme	C00003558 C00003741 C00005413 C00019064 C00029633	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003558 C00003741 C00004565 C00019064	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003558 C00003741 C00004565 C00005413	0 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003558 C00004565 C00005413 C00019064	0 / 3
P15121	Aldose reductase	Enzyme	C00003558 C00003741 C00004565 C00019064	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00003558 C00003741 C00019064 C00032467	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003558 C00004565 C00005413	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00003558 C00003741 C00019064	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003558 C00003741 C00004565	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003558 C00003741 C00004565	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003558 C00019064 C00032467	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003558 C00003741 C00004565	1 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003558 C00004565 C00019064	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003741 C00004565 C00005413	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003558 C00003741 C00004565	0 / 1
P02545	Prelamin-A/C	Unclassified protein	C00003558 C00003741 C00004565	11 / 10
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003558 C00003741 C00019064	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00003558 C00019064 C00029633	2 / 2
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00003558 C00019064	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003558 C00019064	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003558 C00019064	0 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00004565 C00005413	1 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003558 C00004565	1 / 2
O00255	Menin	Unclassified protein	C00003558 C00004565	2 / 5
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003558 C00003741	1 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00003558 C00029633	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00004565 C00005413	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00003741 C00005413	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00003558 C00019064	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003558 C00032467	1 / 1
P48147	Prolyl endopeptidase	S9A	C00004565 C00005413	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00003558 C00019064	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00003558 C00019064	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00003558 C00019064	0 / 1
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003558 C00004565	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00004565 C00005413	4 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00004565 C00019064	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00004565 C00005413	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003558 C00003741	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00004565 C00005413	1 / 0
P03372	Estrogen receptor	NR3A1	C00004565 C00005413	1 / 1
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00004565 C00005413	2 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00004565 C00005413	3 / 3
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00003558 C00019064	0 / 0
P06276	Cholinesterase	Hydrolase	C00004565 C00005413	0 / 0
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00003558 C00032467	1 / 1
P14679	Tyrosinase	Oxidoreductase	C00004565 C00005413	4 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00003558 C00019064	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003741 C00004565	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00003741 C00004565	1 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003558 C00019064	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00003558 C00003741	0 / 0
O75496	Geminin	Unclassified protein	C00003741 C00019064	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00004565 C00005413	0 / 1
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00004565	2 / 2
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003741	0 / 0
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00004565	1 / 1
P08151	Zinc finger protein GLI1	Unclassified protein	C00003741	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00004565	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00004565	1 / 1
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00003741	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00004565	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00004565	0 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003741	2 / 0
Q9UQL6	Histone deacetylase 5	Hydrolase	C00003558	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00004565	5 / 3
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00004565	4 / 4
P00352	Retinal dehydrogenase 1	Enzyme	C00004565	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00004565	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00004565	1 / 1
O15379	Histone deacetylase 3	Hydrolase	C00003558	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00003741	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00004565	0 / 0
P04062	Glucosylceramidase	Enzyme	C00004565	6 / 4
P28482	Mitogen-activated protein kinase 1	Erk	C00005413	0 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00004565	0 / 0
P55055	Oxysterols receptor LXR-beta	NR1H3	C00003741	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00004565	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005413	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00004565	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00004565	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064	0 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P11387	DNA topoisomerase 1	Isomerase	C00003741	0 / 0
P56524	Histone deacetylase 4	Hydrolase	C00003558	1 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00004565	1 / 8
P30305	M-phase inducer phosphatase 2	Ser_Thr_Tyr	C00003558	0 / 0
P05771	Protein kinase C beta type	Alpha	C00003741	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00004565	0 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00004565	7 / 37
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00004565	0 / 0
Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Enzyme	C00004565	0 / 0
P98170	E3 ubiquitin-protein ligase XIAP	Other cytosolic protein	C00004565	1 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005413	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00004565	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00004565	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00004565	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00004565	0 / 0
P10275	Androgen receptor	NR3C4	C00004565	3 / 4
Q00535	Cyclin-dependent kinase 5	Cdk5	C00004565	0 / 0
P15559	NAD(P)H dehydrogenase [quinone] 1	Enzyme	C00003741	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00004565	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00004565	0 / 0
Q9UBN7	Histone deacetylase 6	Hydrolase	C00003558	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00004565	0 / 0
P08183	Multidrug resistance protein 1	drug	C00004565	1 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00004565	0 / 0
Q02156	Protein kinase C epsilon type	Eta	C00003741	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00004565	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00004565	1 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00005413	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00004565	1 / 1
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00003741	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00004565	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00003558	3 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00003558	0 / 0
Q13547	Histone deacetylase 1	Hydrolase	C00003558	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00004565	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00004565	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00004565	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00004565	0 / 0
Q9UBT2	SUMO-activating enzyme subunit 2	Enzyme	C00003741	0 / 0
Q9UBE0	SUMO-activating enzyme subunit 1	Unclassified protein	C00003741	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00004565	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00003558	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00004565	0 / 0

118 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003558 C00003741 C00004565 C00005413 C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00003741 C00004565 C00005413 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00003741 C00004565 C00005413 C00019064
581	BAX, BCL2L4	BCL2-associated X protein	C00003558 C00003741 C00004565 C00005413
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00004565 C00005413 C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00003558 C00003741 C00019064
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003558 C00004565 C00005413
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003558 C00004565 C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00003558 C00003741 C00019064
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003558 C00004565
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413 C00019064
7039	TGFA, TFGA	transforming growth factor, alpha	C00004565 C00005413
847	CAT	catalase (EC:1.11.1.6)	C00005413 C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003558 C00019064
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00003741 C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00004565 C00005413
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003741 C00004565
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00004565 C00005413
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00004565 C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00004565 C00019064
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00004565 C00005413
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00004565 C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00004565 C00005413
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00004565 C00005413
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00004565 C00019064
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00004565 C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00004565 C00005413
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00004565 C00019064
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00004565 C00005413
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00004565
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00004565
891	CCNB1, CCNB	cyclin B1	C00004565
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00004565
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00004565
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00004565
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00004565
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00004565
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00004565
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00004565
37618			C00004565
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00004565
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00004565
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00004565
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00004565
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00004565
1734	DIO2, 5DII, D2, DIOII, SelY, TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	C00004565
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00004565
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00004565
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00004565
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00004565
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00004565
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00004565
9687	GREB1	growth regulation by estrogen in breast cancer 1	C00004565
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00004565
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00004565
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00004565
3043	HBB, CD113t-C, beta-globin	hemoglobin, beta	C00004565
3082	HGF, DFNB39, F-TCF, HGFB, HPTA, SF	hepatocyte growth factor (hepapoietin A; scatter factor)	C00004565
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00004565
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00004565
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00004565
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00004565
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00003558
4297	KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	C00004565
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003558
110357			C00004565
4502	MT2A, MT2	metallothionein 2A	C00004565
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00004565
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00004565
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003558
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00003558
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00004565
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00004565
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00004565
5241	PGR, NR3C3, PR	progesterone receptor	C00004565
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00004565
8000	PSCA, PRO232	prostate stem cell antigen	C00004565
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00003558
6119	RPA3, REPA3	replication protein A3, 14kDa	C00004565
2810	SFN, YWHAS	stratifin	C00004565
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00004565
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00004565
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00004565
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00004565
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00003558
9131	AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	C00003558
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00004565
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00004565
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00004565
7161	TP73, P73	tumor protein p73	C00004565
7352	UCP3, SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	C00004565
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00004565
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00004565
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00004565
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00004565
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00004565
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00004565
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00004565
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00004565
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003741
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00003741
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413

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