Species

KNApSAcK Entry

Organism name Prunus persica
Genus Prunus
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Prunus persica
Linked NCBI taxonomy ID 3760
Linked level species

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (33)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005886 External link 512 Multiflorin A
C087918
No. 1 No. 15
C00005172 External link 512 Multifloein B
/ Multiflorin B
CHEMBL503913
No. 1 No. 15
C00000998 External link 512 Prunin
/ Naringenin 7-O-beta-D-glucoside
/ 5,7,4'-Trihydroxyflavanone 7-O-beta-D-glucopyranoside
CHEMBL469654
CHEMBL526845
1 / 2 / 0 No. 12 No. 14
C00008301 External link 512 Persiconin
No. 12 No. 14
C00008296 External link 512 Hesperetin 5-O-glucoside
CHEMBL463462
C069231
No. 12 No. 14
C00009261 External link 512 ent-Epiafzelechin-(2alpha->7,4alpha->8)-catechin
CHEMBL1288727
No. 16 No. 19
C00009258 External link 512 ent-Epiafzelechin-(2alpha->7,4alpha->8)-afzelechin
CHEMBL447152
No. 16 No. 19
C00008300 External link 512 Persicogenin
No. 25 No. 14
C00000982 External link 512 Naringenin
/ (-)-Naringenin
CHEMBL9352
CHEMBL32571
C005273
57 / 46 / 40 35 / 10 No. 25 No. 14
C00000968 External link 512 Hesperetin
CHEMBL88169
CHEMBL399121
CHEMBL1589200
C013015
42 / 50 / 65 18 / 3 No. 25 No. 14
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000295 External link 512 GA95
/ Gibberellin A95
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000086 External link 512 GA86
/ Gibberellin A86
No. 40 No. 41
C00000068 External link 512 GA68
/ Gibberellin A68
No. 40 No. 41
C00000087 External link 512 GA87
/ Gibberellin A87
No. 40 No. 41
C00000030 External link 512 GA30
/ Gibberellin A30
No. 40 No. 41
C00000032 External link 512 GA32
/ Gibberellin A32
No. 40 No. 41
C00007876 External link 512 GA119
/ Gibberellin A119
No. 40 No. 41
C00000063 External link 512 GA63
/ Gibberellin A63
No. 40 No. 41
C00000044 External link 512 GA44
/ Gibberellin A44
No. 40 No. 41
C00007868 External link 512 GA126
/ Gibberellin A126
No. 40 No. 41
C00007866 External link 512 GA121
/ Gibberellin A121
No. 40 No. 41
C00007867 External link 512 GA122
/ Gibberellin A122
No. 40 No. 41
C00006244 External link 512 GA118
/ Gibberellin A118
No. 40 No. 41
C00000937 External link 512 Afzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00004565 External link 512 Kaempferol
/ Nimbecetin
/ Rhamnolutein
/ Pelargidenolon
/ 5,7,4'-Trihydroxyflavonol
/ 3,5,7,4'-Tetrahydroxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL150
C006552
76 / 69 / 87 86 / 8 No. 71 No. 15
C00003780 External link 512 Neoxanthin
/ Folioxanthin
C011947
4 / 0 No. 114 No. 59
C00000298 External link 512 GA97
/ Gibberellin A97
No. 187 No. 41
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00022957 External link 512 Cryptochrome
/ 5,8:5',8'-diepoxy-5,5',8,8'-tetrahydro-beta,beta-caroten-3-ol
No. 664 No. 59
C00001329 External link 512 gamma-Undecalactone
CHEMBL195827
1 / 0 / 0 No. 1374

Human Protein / Gene in interactions

119 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 C00000968 C00000982 C00001329 C00004565 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 C00000937 C00000968 C00000982 C00004565 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 C00000968 C00000982 C00004565 1 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000968 C00000982 C00000998 C00004565 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 C00000968 C00000982 C00004565 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 C00000968 C00000982 C00004565 0 / 1
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000968 C00000982 C00004565 4 / 4
P04745 Alpha-amylase 1 Enzyme C00000968 C00000982 C00004565 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00000968 C00000982 C00004565 0 / 0
P10275 Androgen receptor NR3C4 C00000003 C00000982 C00004565 3 / 4
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000968 C00000982 C00004565 5 / 3
O00255 Menin Unclassified protein C00000937 C00000982 C00004565 2 / 5
Q9UNA4 DNA polymerase iota Enzyme C00000968 C00000982 C00004565 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000937 C00000982 C00004565 1 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000937 C00000982 C00004565 0 / 3
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00000968 C00000982 C00004565 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000968 C00000982 C00004565 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000968 C00000982 C00004565 0 / 0
O75496 Geminin Unclassified protein C00000003 C00000968 C00000982 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000968 C00000982 C00004565 3 / 3
P22303 Acetylcholinesterase Hydrolase C00000968 C00000982 C00004565 1 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00000968 C00000982 C00004565 0 / 0
P03372 Estrogen receptor NR3A1 C00000982 C00004565 1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000982 C00004565 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000968 C00004565 2 / 2
P02545 Prelamin-A/C Unclassified protein C00000003 C00004565 11 / 10
P35372 Mu-type opioid receptor Opioid receptor C00000968 C00000982 0 / 0
P04062 Glucosylceramidase Enzyme C00000982 C00004565 6 / 4
P08183 Multidrug resistance protein 1 drug C00000982 C00004565 1 / 0
Q99700 Ataxin-2 Unclassified protein C00000968 C00004565 1 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00000968 C00004565 4 / 3
Q04760 Lactoylglutathione lyase Enzyme C00000982 C00004565 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000982 C00004565 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000968 C00004565 7 / 37
P04150 Glucocorticoid receptor NR3C1 C00000982 C00004565 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000982 C00004565 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 C00000968 0 / 0
P15121 Aldose reductase Enzyme C00000982 C00004565 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000937 C00004565 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000968 C00000982 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000968 C00000982 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00000982 C00004565 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000968 C00004565 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000968 C00004565 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000982 C00004565 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00004565 0 / 0
P39748 Flap endonuclease 1 Enzyme C00004565 0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00000982 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004565 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000968 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000968 4 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000982 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00004565 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000982 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00004565 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00004565 0 / 1
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x C00004565 1 / 1
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00000937 1 / 1
Q9Y253 DNA polymerase eta Enzyme C00004565 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00004565 1 / 8
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000982 1 / 0
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00004565 0 / 0
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00000982 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000982 2 / 2
P14679 Tyrosinase Oxidoreductase C00004565 4 / 2
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00000982 0 / 2
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00004565 0 / 0
P06276 Cholinesterase Hydrolase C00004565 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00000982 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000982 2 / 0
Q96RI1 Bile acid receptor NR1H4 C00004565 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00000968 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000968 0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00004565 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00004565 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00004565 1 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000982 1 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00004565 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00000968 1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00004565 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000968 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000982 0 / 0
P02647 Apolipoprotein A-I Unclassified protein C00000968 3 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000982 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000968 3 / 2
P62158 Calmodulin Unclassified protein C00000982 1 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00000968 1 / 4
P04278 Sex hormone-binding globulin Secreted protein C00000982 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000968 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00004565 2 / 2
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004565 0 / 0
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00004565 1 / 1
P14618 Pyruvate kinase PKM Enzyme C00000968 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00004565 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004565 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000982 5 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000982 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00004565 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000982 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000982 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000968 4 / 1
P35869 Aryl hydrocarbon receptor Transcription Factor C00004565 0 / 0
P48147 Prolyl endopeptidase S9A C00004565 0 / 0
P49888 Estrogen sulfotransferase Enzyme C00000982 0 / 0
P37173 TGF-beta receptor type-2 TKL dual-specificity kinase STKR type 2 subfamily C00000968 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00000937 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004565 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004565 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000968 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000982 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000982 3 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00004565 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00004565 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00004565 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00004565 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00004565 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00004565 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00004565 0 / 0

106 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000968 C00000982 C00003780 C00004565
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000968 C00000982 C00004565
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000968 C00000982 C00004565
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000968 C00000982 C00004565
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000982 C00003780 C00004565
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000968 C00000982 C00004565
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000968 C00000982 C00004565
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000968 C00004565
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000982 C00004565
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000982 C00004565
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000968 C00004565
7402 UTRN, DMDL, DRP, DRP1 utrophin C00000968 C00004565
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000968 C00000982
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00000968 C00000982
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00000968 C00000982
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000982 C00004565
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000982 C00004565
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000982 C00004565
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000982 C00004565
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000982 C00004565
581 BAX, BCL2L4 BCL2-associated X protein C00000968 C00004565
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000982 C00004565
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000982 C00004565
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000982 C00004565
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00000982 C00004565
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000982 C00004565
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000982 C00004565
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000982 C00004565
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000982 C00004565
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00004565
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000982
6566 SLC16A1, HHF7, MCT, MCT1 solute carrier family 16 (monocarboxylate transporter), member 1 C00000982
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000982
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00000982
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000982
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004565
239 ALOX12, 12-LOX, 12S-LOX, LOG12 arachidonate 12-lipoxygenase (EC:1.13.11.31) C00004565
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00004565
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000982
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00004565
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00004565
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00004565
891 CCNB1, CCNB cyclin B1 C00004565
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00004565
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00000982
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00004565
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00004565
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00004565
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00004565
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00004565
37618 C00004565
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000982
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00004565
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00004565
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00004565
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00004565
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00004565
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00004565
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00004565
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00004565
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00004565
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00004565
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00004565
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00004565
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00004565
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00004565
3567 IL5, EDF, IL-5, TRF interleukin 5 (colony-stimulating factor, eosinophil) C00004565
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00004565
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00004565
4297 KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) C00004565
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00004565
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00004565
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00004565
110357 C00004565
4502 MT2A, MT2 metallothionein 2A C00004565
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00004565
8202 NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP nuclear receptor coactivator 3 (EC:2.3.1.48) C00004565
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00004565
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00004565
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00000982
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00004565
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00004565
5241 PGR, NR3C3, PR progesterone receptor C00004565
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00004565
8000 PSCA, PRO232 prostate stem cell antigen C00004565
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00004565
6119 RPA3, REPA3 replication protein A3, 14kDa C00004565
2810 SFN, YWHAS stratifin C00004565
6773 STAT2, ISGF-3, P113, STAT113 signal transducer and activator of transcription 2, 113kDa C00004565
7019 TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 transcription factor A, mitochondrial C00004565
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004565
7039 TGFA, TFGA transforming growth factor, alpha C00004565
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00004565
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00004565
7161 TP73, P73 tumor protein p73 C00004565
7352 UCP3, SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) C00004565
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00004565
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000982
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00004565
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003780
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003780
847 CAT catalase (EC:1.11.1.6) C00000968
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000968
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000968
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00000968
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (101)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#105200 Amyloidosis, familial visceral P02647
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614331 Colorectal cancer, hereditary nonpolyposis, type 6; hnpcc6 P37173
#114500 Colorectal cancer; crc P18054
P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
P37173
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#604091 Hypoalphalipoproteinemia, primary P02647
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#610168 Loeys-dietz syndrome, type 1b; lds1b P37173
#610380 Loeys-dietz syndrome, type 2b; lds2b P37173
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04637
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#205400 Tangier disease; tgd P02647
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (100)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
P24864 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P24864 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00845 Familial amyloidosis P02647 (related)
H00930 Hypoalphalipoproteinemia P02647 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
Q9UM73 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P37173 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00800 Loeys-Dietz syndrome (LDS) P37173 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) P37173 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

19 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009202 Cardiomyopathies C00000982
C00004565
D056486 Drug-Induced Liver Injury C00000982
C00000968
D009374 Neoplasms, Experimental C00000982
D001932 Brain Neoplasms C00000982
D064420 Drug-Related Side Effects and Adverse Reactions C00000982
D007674 Kidney Diseases C00000982
D008106 Liver Cirrhosis, Experimental C00000982
D008107 Liver Diseases C00000982
D009369 Neoplasms C00000982
D000647 Amnesia C00000982
D050197 Atherosclerosis C00004565
D001943 Breast Neoplasms C00004565
D002318 Cardiovascular Diseases C00004565
D006943 Hyperglycemia C00004565
D007938 Leukemia C00004565
D010024 Osteoporosis C00004565
D011297 Prenatal Exposure Delayed Effects C00004565
D000230 Adenocarcinoma C00000968
D003110 Colonic Neoplasms C00000968