KCF-S cluster No. 12 (197 metabolites)

Corresponding Phytochemical cluster No. 14

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (197)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	168
asterids	67
Spermatophyta	36
eudicotyledons	31
Euphyllophyta	20
Liliopsida	10
Magnoliophyta	3
Embryophyta	3

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Cumulative family count (Top 20)

class name	count
Fabaceae	48
Rosaceae	30
Pinaceae	19
Rutaceae	17
Asteraceae	15
Ericaceae	15
Lamiaceae	11
Viscaceae	9
Podocarpaceae	8
Cupressaceae	8
Polypodiaceae	7
Davalliaceae	7
Polygonaceae	7
Smilacaceae	6
Moraceae	6
Fagaceae	6
Solanaceae	5
Hypericaceae	5
Cleomaceae	5
Juglandaceae	5

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Dihyroflavonols	2
Flavanones	2
Flavan 3-ols	1

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Dihyroflavonols	C09808	C00000989
Flavanones	C09099	C00000998
Flavanones	C16422	C00008297
Dihyroflavonols	C09803	C00008706
Flavan 3-ols	C09617	C00008852

Metabolite list (197)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000989	Phellamurin	CHEMBL516116	C016043
C00000998	Prunin / Naringenin 7-O-beta-D-glucoside / 5,7,4'-Trihydroxyflavanone 7-O-beta-D-glucopyranoside	CHEMBL469654 CHEMBL526845		1 / 2 / 0
C00008048	Aureusidin 6-glucuronide
C00008137	Pinocembrin 5-O-glucoside
C00008138	Pinocembrin 7-O-rhamnoside
C00008147	Dihydrobaicalein 7-O-glucuronide	CHEMBL467197		1 / 0 / 0
C00008152	Dihydronorwogonin 7-O-glucuronide
C00008157	Dihydrowogonin 7-O-glucoside
C00008193	Liquiritin	CHEMBL511995		8 / 8 / 38
C00008194	Neoliquiritin
C00008204	Floribundoside	CHEMBL2152489 CHEMBL2152490
C00008205	Naringenin 5-O-rhamnoside
C00008207	Naringerin
C00008208	Naringenin 4'-O-glucoside	CHEMBL453552
C00008209	Naringenin 4'-O-galactoside	CHEMBL453552
C00008219	Sakuranin	CHEMBL489338 CHEMBL495847 CHEMBL1998622
C00008220	Isosakuranetin 5-O-glucoside
C00008221	Isosakuranetin 7-O-xyloside
C00008222	Isosakuranin
C00008231	Carthamidin 5-glucoside
C00008236	Haplanthin
C00008238	Poriolin
C00008240	Cyrtopterin
C00008244	Matteucinol 7-O-glucoside
C00008264	5-Hydroxy-7,4'-dimethoxy-6,8-di-C-prenylflavanone 5-O-galactoside
C00008278	Isomonospermoside
C00008279	Isocoreopsin		C010595
C00008282	Isookaninglucoside	CHEMBL1405715		2 / 0 / 0
C00008283	Isookaninrhamnoside
C00008289	Eriodictyol 5-O-rhamnoside
C00008290	Eriodictyol 5-O-glucoside
C00008291	Miscanthoside / Eriodictyol 7-O-glucoside / (2S)-Eriodictyol 7-O-beta-D-glucopyranoside	CHEMBL509624 CHEMBL1602917		2 / 0 / 0
C00008292	Eriodictin
C00008293	Eriodictyol 3'-O-glucoside
C00008296	Hesperetin 5-O-glucoside	CHEMBL463462	C069231
C00008297	Hesperetin 7-O-glucoside
C00008298	Hesperetin 7-O-rhamnoside
C00008301	Persiconin
C00008302	Eriodictyol 3',4'-dimethyl ether 5-O-glucoside
C00008305	Eriodictyol 5,4'-dimethyl ether 7-O-glucoside
C00008313	7,3',4'-Trihydroxy-5-methoxy-6-C-methylflavanone 7-O-glucoside
C00008343	Plantagoside		C062295
C00008351	5,7,3',4'-Tetrahydroxy-6-C-methylflavanone 7-O-glucosdie
C00008353	2,5,7,3',4'-Pentahydroxyflavanone 5-O-glucoside
C00008368	Stepposide
C00008396	7,8,4'-Trihydroxy-3',5'-dimethoxyflavanone 4'-O-glucoside
C00008402	Puddumin A
C00008414	5,7,2'-Trihydroxyflavanone 7-glucoside
C00008418	Strobopinin 7-galactoside
C00008419	Strobopinin 7-glucoside
C00008434	Isosakuranetin 7-O-rhamnoside
C00008435	Puddumin B
C00008437	Eriodictyol 7-glucuronide
C00008439	7-O-Methyleriodictyol 3'-O-glucoside
C00008441	Viscumside A / (2S)-Homoeriodictyol 7-O-beta-D-glucoside	CHEMBL1086150
C00008442	Viscumneoside VI		C060401
C00008449	Andrographidin A
C00008484	Pinostrobin 5-O-glucoside
C00008485	6,7-Dihydroxy-5-methoxyflavanone 7-O-glucoside
C00008487	Isocarthamidin 7-O-rhamnoside
C00008667	Lecontin
C00008669	Aromadendrin 3-beta-L-arabinopyranoside
C00008670	Aromadendrin 3-galactoside
C00008671	Aromadendrin 3-glucoside
C00008672	Engeletin
C00008673	Isoengeletin
C00008674	Sinensin
C00008676	Aromadendrin 4'-xyloside
C00008677	Aromadendrin 4'-glucoside
C00008682	Aromadendrin 7-methyl ether 5-glucoside
C00008683	Dihydrokaempferide 7-rhamnoside
C00008684	Aurapin
C00008685	Aromadendrin 7,4'-dimethyl ether 5-glucoside
C00008686	Fustin 3-glucoside
C00008687	Fustin 7-rhamnoside
C00008689	Callunin
C00008690	2''-Acetylcallunin
C00008691	Dihydroprudomenin
C00008692	3,5,7,2',5'-Pentahydroxyflavanone 3-rhamnoside
C00008693	Taxifolin 3-apioside
C00008694	(2R,3R)-Taxifolin 3-xyloside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00008695	(2R,3S)-Epitaxifolin 3-xyloside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00008696	(2S,3R)-Epitaxifolin 3-xyloside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00008697	(2S,3S)-Taxifolin 3-xyloside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00008698	Taxifolin 3-galactoside	CHEMBL2332678 CHEMBL2332679
C00008699	(2R,3R)-Taxifolin 3-glucoside	CHEMBL2332678 CHEMBL2332679
C00008700	Isoglucodistylin	CHEMBL2332678 CHEMBL2332679
C00008701	(2S,3S)-Taxifolin 3-glucoside	CHEMBL2332678 CHEMBL2332679	C067156
C00008703	Astilbin	CHEMBL486017 CHEMBL1159406 CHEMBL1159407 CHEMBL1314522	C099069	8 / 1 / 2
C00008704	Isoastibin	CHEMBL486017 CHEMBL1159406 CHEMBL1159407 CHEMBL1314522		8 / 1 / 2
C00008705	Neoisoastilbin	CHEMBL486017 CHEMBL1159406 CHEMBL1159407 CHEMBL1314522		8 / 1 / 2
C00008706	Neoastilbin	CHEMBL486017 CHEMBL1159406 CHEMBL1159407 CHEMBL1314522		8 / 1 / 2
C00008707	Taxifolin 5-galactoside
C00008708	Taxifolin 7-galactoside
C00008709	Taxifolin 7-glucoside / Taxifolin 7-O-beta-D-glucopyranoside / 3,5,7,3',4'-Pentahydroxyflavanone 7-beta-D-glucopyranoside
C00008710	Taxifolin 7-rhamnoside
C00008711	Taxifolin 3'-glucoside
C00008713	Taxifolin 4'-glucoside
C00008719	Padmatin 3-glucoside
C00008720	Padmatin 5-glucoside
C00008722	Ampelopsin 3-rhamnoside
C00008723	Ampelopsin 7-glucoside
C00008724	Ampelopsin 3'-glucoside
C00008725	Ampelopsin 3'-methyl ether 4'-rhamnoside
C00008726	3,5,7,4'-Tetrahydroxy-6-methylflavanone 7-glucoside
C00008727	Cedrinoside
C00008728	Phellavin
C00008730	Phellodendroside
C00008765	Viscutin 3
C00008771	Apigeniflavan 5-O-xyloside
C00008830	Arthromerin A
C00008831	Epiafzelechin 3-O-beta-D-allopyranoside		C081710
C00008832	Arthromerin B
C00008833	Epiafzelechin 3-O-beta-D-glucopyranoside
C00008834	Afzelechin-3-O-alpha-L-rhamnoside / Afzelechin 3-O-alpha-L-rhamnopyranoside	CHEMBL517484 CHEMBL517149		2 / 0 / 3
C00008835	Epiafzelechin 5-O-beta-D-glucopyranoside
C00008836	Afzelechin 7-O-beta-D-apiofuranoside
C00008837	Afzelechin 4'-O-beta-D-glucopyranosdie
C00008838	Epicatechin 3-O-beta-D-allopyranoside
C00008841	Catechin 3-O-beta-D-glucopyranoside
C00008842	Epicatechin 3-O-beta-D-glucopyranoside
C00008843	Catechin 3-O-alpha-L-rhamnoside
C00008845	Catechin 5-O-beta-D-apiofuranoside
C00008846	Catechin-5-O-beta-D-glucopyranoside / (+)-Catechin-5-O-beta-D-glucopyranoside
C00008847	Epicatechin-5-O-beta-D-glucopyranoside / (-)-Epicatechin-5-O-beta-D-glucopyranoside
C00008849	Catechin 7-O-apiofuranoside
C00008850	Polydine	CHEMBL102065
C00008851	Catechin 7-O-beta-D-xylopyranoside / (+)-Catechin-7-O-beta-D-xylopyranoside	CHEMBL102065
C00008852	Catechin 7-O-beta-D-glucopyranoside
C00008853	ent-Catechin 7-O-beta-D-glucopyranoside
C00008854	Catechin 7-O-alpha-L-rhamnopyranoside
C00008855	Catechin 3'-O-beta-D-glucopyranoside
C00008856	Catechin 4'-O-beta-D-glucopyranoside
C00008861	Symplocoside
C00009015	Leucopelargonidin 3-O-glucoside
C00009016	Catechin-4-ol 3-O-beta-D-galactopyranoside
C00009017	Catechin-4-ol 3-O-beta-D-glycopyranoside
C00009018	Catechin-4-ol 3-O-alpha-L-rhamnopyranoside
C00009019	Catechin-4-ol 3'-methyl ether 3-O-alpha-L-rhamnopyranoside
C00009020	Leucodelphinidin 3-glucoside
C00009021	Leucodelphinidin 3-O-alpha-L-rhamnopyranoside
C00009031	3,4,7-Trihydroxy-5-methoxy-8-prenylflavan 7-O-beta-D-glucopyranoside
C00009032	3,7-Dihydroxy-4,5-dimethoxy-8-prenylflavan 7-O-beta-D-glucopyranoside
C00010174	2,3-Dihydro-ononin / Dihydroformononetin 7-O-glucoside
C00011346	Dihydrokaempferide 3-glucuronide
C00013251	Anadanthoside / Fisetinidol 3-beta-D-xylopyranoside
C00013253	Barbatoflavan / (2R,3R)-3-(Acetyloxy)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-7-hydroxy-5-methoxy-2H-1-benzopyran-8-yl beta-D-Glucopyranoside
C00013254	Ent-afzelechin-7-O-beta-D-glucopyranoside
C00013255	Catechin 5-O-beta-D-glucopyranoside-4'-Me
C00014303	7-Hydroxyflavanone beta-D-glucopyranoside
C00014304	Pinocembroside / Pinocembrin 7-O-beta-D-glucoside / (2S)-7-O-beta-D-glucopyranosyl-5-hydroxyflavanone	CHEMBL1083808
C00014315	(2S)-5,6,7-Trihydroxyflavanone 7-glucoside
C00014316	Naringenin 4'-O-alpha-L-rhamnopyranoside / 5,7,4'-Trihydroxyflavanone 4'-rhamnoside
C00014317	Naringenin 7-O-beta-D-glucoside 6''-acetate / 5,7,4'-Trihydroxyflavanone 7-(6-acetylglucoside)
C00014324	Alhagitin / 7,4'-Dihydroxy-5-methoxyflavanone 4'-glucoside
C00014326	5-Hydroxy-7,8-dimethoxyflavanone 5-rhamnoside
C00014328	2,5,7,4'-Tetrahydroxyflavanone 7-glucoside
C00014330	Isocarthamidin 8-glucoside / 5,7,8,4'-Tetrahydroxyflavanone 8-glucoside
C00014331	Steppogenin 4'-O-beta-D-glucoside / 5,7,2',4'-Tetrahydroxyflavanone 4'-glucoside
C00014332	Coccinoside B / 5,7,2',5'-Tetrahydroxyflavanone 7-glucoside / (2S)-5,7,2',5'-Tetrahydroxyflavonone 7-O-beta-D-glucopyranoside
C00014335	(2S)-5,7,3',4'-Tetrahydroxyflavanone 7-glucuronide
C00014336	Coccinoside A / 5,7,3',4'-Tetrahydroxyflavanone 7-(6-acetylglucoside)
C00014347	Persicogenin 3'-glucoside / 5,3'-Dihydroxy-7,4'-dimethoxyflavanone 3'-glucoside
C00014350	Pervianoside I / Peruvianoside I / (2R)-5,7,4'-Trihydroxy-3',5'-methoxyflavanone 5-glucoside
C00014351	Peruvianoside II / (2S)-2,7,4'-Trihydroxy-3',5'-methoxyflavanone 5-glucoside
C00014360	Flavaprin / Phellodensin F / 5,7,4'-Trihydroxy-8-C-prenylflavanone 7-glucoside
C00014361	Phellodensin E / 5,7,4'-Trihydroxy-8-C-(3-hydroxymethyl-2-butenyl)flavanone 7-glucoside
C00014406	(2R,3R)-3,5,7,4'-Tetrahydroxyflavanone 7-(6-[4-Hydroxy-2-methylenebutanoyl]glucoside)
C00014407	(2R,3R)-Taxifolin 3-alpha-arabinopyranoside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00014408	(2R,3S)-Taxifolin 3-alpha-arabinopyranoside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00014409	Taxifolin 3-alpha-L-arabinofuranoside
C00014412	Dihydrorhamnetin 3-O-beta-D-arabinopyranoside
C00014413	(2R,3R)-3,5,7,3',5'-Pentahydroxyflavanone 3-rhamnoside	CHEMBL1257642		1 / 0 / 0
C00014414	Smitilbin / (2R,3S)-3,5,7,3',5'-Pentahydroxyflavanone 3-rhamnoside	CHEMBL1257642		1 / 0 / 0
C00014415	Neosmitilbin / (2S,3S)-3,5,7,3',5'-Pentahydroxyflavanone 3-rhamnoside	CHEMBL1257642		1 / 0 / 0
C00014416	Phellochinin A / 3,5,7,4'-Tetrahydroxy-3'-prenylflavanone 7-glucoside
C00014417	3,5,7,3',4'-Pentahydroxy-6-prenylflavanone 7-glucoside
C00014669	Hovetrichoside C / Maesopsin 4-O-glucoside / 2,4,6,4'-Tetrahydroxy-2-benzylcoumaranone 4-O-glucoside
C00014670	Maesopsin 6-beta-D-glucopyranoside / 2,4,6,4'-Tetrahydroxy-2-benzylcoumaranone 6-beta-D-glucopyranoside
C00018997	Dihydrodaidzin / 7,4'-Dihydroxyisoflavanone 7-O-glucoside	CHEMBL464455
C00018998	Dihydrogenistin / 5,7,4'-Trihydroxyisoflavanone 7-O-glucoside	CHEMBL518255
C00019539	Dalbergioidin 4'-O-beta-D-glucopyranoside / 5,7,2',4'-Tetrahydroxyisoflavanone 4'-O-glucoside		C091401
C00020649	Matteucinol 7-rhamnoside
C00020670	Taxifolin 7-O-alpha-D-glucopyranoside / 3,5,7,3',4'-Pentahydroxyflavanone 7-alpha-D-glucopyranoside
C00020684	Leucocyanidin 4',7-dimethylether 3-O-beta-D-glucopyranoside
C00020686	Leucocyanidin 4'-methylether 3-O-beta-D-galactopyranoside
C00029319	Poncirenin / Isosakuranin / (2S)-Poncirenin
C00032671	6''-O-Acetylliquiritin
C00033501	(+)-Catechin 3-O-beta-D-galactopyranoside
C00035112	Helicioside A / (+)-Helicioside A
C00035113	Helicioside B / (+)-Helicioside B
C00040735	(-)-4'-Methylepigallocatechin 5-O-beta-glucopyranoside
C00040739	Symposide / (-)-Epiafzelechin 7-O-beta-D-glucopyranoside
C00040745	(+)-4'-Methylgallocatechin 3'-O-beta-glucopyranoside
C00043059	Taxifolin 3-O-beta-D-arabinopyranoside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00043060	Taxifolin 3-O-beta-D-xylopyranoside / (-)-Taxifolin 3-O-beta-D-xylopyranoside	CHEMBL2332674 CHEMBL2332675 CHEMBL2332676 CHEMBL2332677
C00049037	(-)-Epicatechin 5-O-beta-D-xylopyranoside / (-)-(-)-Epicatechin 5-O-beta-D-xylopyranoside

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P07237	Protein disulfide-isomerase	Enzyme	C00008193 C00008703 C00008704 C00008705 C00008706	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00008703 C00008704 C00008705 C00008706	0 / 0
P19784	Casein kinase II subunit alpha'	Ck2	C00008703 C00008704 C00008705 C00008706	0 / 0
P67870	Casein kinase II subunit beta	REG serine/threonine protein kinase family	C00008703 C00008704 C00008705 C00008706	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00008703 C00008704 C00008705 C00008706	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00008703 C00008704 C00008705 C00008706	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00008703 C00008704 C00008705 C00008706	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00008703 C00008704 C00008705 C00008706	1 / 2
P49327	Fatty acid synthase	Transferase	C00014413 C00014414 C00014415	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00008282 C00008291	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00008282 C00008291	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00008193	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00008147	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00000998	2 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00008193	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00008193	1 / 0
O75496	Geminin	Unclassified protein	C00008193	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00008834	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00008193	0 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00008834	0 / 3
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00008193	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00008193	7 / 37

Related Diseases

Diseases related to proteins in ChEMBL interactions