phytochemical cluster No. 59 (112 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (8)
• Metabolite list (112)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	201
asterids	101
Liliopsida	37
Viridiplantae	23
eudicotyledons	20
Spermatophyta	3
Euphyllophyta	3
Magnoliophyta	1

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Cumulative family count (Top 20)

class name	count
Fabaceae	88
Solanaceae	44
Rosaceae	31
Asteraceae	24
Enterobacteriaceae	22
Brassicaceae	20
Siluridae	16
Myrtaceae	16
Corbiculidae	16
Ranunculaceae	13
Passifloraceae	12
Rhodomelaceae	12
Rhizobiaceae	11
Asparagaceae	11
Flavobacteriaceae	10
Liliaceae	10
Rutaceae	10
Rhodobacteraceae	8
Bagridae	8
Convolvulaceae	7

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Carotenoids	30

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metabolites link (31)

br08003 Category	KEGG ID	KNApSAcK ID
Carotenoids	C05421	C00000905
Carotenoids	C05432	C00000911
Carotenoids	C05414	C00000913
Carotenoids	C08580	C00000918
Carotenoids	C02094	C00000919
Carotenoids	C08591	C00000920
Carotenoids	C08583	C00000922
Carotenoids	C05435	C00000926
Carotenoids	C06098	C00000931
Carotenoids	C05430	C00000934
Carotenoids	C08579	C00003760
Carotenoids	C08584	C00003763
Carotenoids	C08585	C00003764
Carotenoids	C05433	C00003765
Carotenoids	C08586	C00003766
Carotenoids	C08587	C00003767
Carotenoids	C15981	C00003770
Carotenoids	C08593	C00003771
Carotenoids	C08594	C00003772
Carotenoids	C08599	C00003775
Carotenoids	C08601	C00003776
Carotenoids	C08602	C00003777
Carotenoids	C08603	C00003778
Carotenoids	C08605	C00003779
Carotenoids	C08606	C00003780
Carotenoids	C08610	C00003784
Carotenoids	C08611	C00003785
Carotenoids	C08614	C00003787
Carotenoids	C16276	C00022813
Carotenoids	C16276	C00022814
Carotenoids	C13433	C00045500

KCF-S cluster (8)

KCF-S ID	# of metabolite
No. 26	36
No. 114	29
No. 97	15
No. 131	9
No. 262	9
No. 664	7
No. 1206	5
No. 2614	2

Metabolite list (112)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00023248	(9Z)-Capsanthin / 9-cis-Capsanthin	CHEMBL1480032 CHEMBL1519371		2 / 0 / 0		No. 26
C00023050	1',2'-Epoxy-1',2'-dihydro-beta,psi-carotene					No. 26
C00023043	delta-Carotene					No. 26
C00023249	Capsanthin	CHEMBL1480032 CHEMBL1519371	C006889	2 / 0 / 0		No. 26
C00023250	(13Z)-Capsanthin / Neocapsanthin A'	CHEMBL1480032 CHEMBL1519371		2 / 0 / 0		No. 26
C00000918	(15Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 26
C00000919	beta-Cryptoxanthin		C010564			No. 26
C00000920	(2R)-beta,beta-Caroten-2-ol					No. 26
C00000922	3-Hydroxyechinenone / 3-Hydroxy-beta,beta-caroten-4-one					No. 26
C00023022	Capsorubin		C035624			No. 26
C00000929	Eschscholtzxanthin					No. 26
C00000931	Rhodoxanthin		C038054			No. 26
C00023006	5,6-Diepicapsokarpoxanthin / (3S,3'S,5S,5'R,6S)-5,6-Dihydro-3,3',5,6-tetrahydroxy-beta,kappa-caroten-6'-one					No. 26
C00022983	Capsanthin 5,6-epoxide / (3S,5R,6S,3'S,5'R)-5,6-Epoxy-5,6-dihydro-3,3'-dihydroxy-beta,kappa-caroten-6'-one					No. 26
C00022977	Ipomoeaxanthin B					No. 26
C00022975	5,6-Diepilatoxanthin / (3S,3'S,5S,5'R,6S,6'S)-5',6'-Epoxy-5,5',6,6'-tetrahydro-3,3',5,5'-tetrahydroxy-beta,beta-carotene					No. 26
C00003765	Phoeniconone / 2,3-Didehydro-3-hydroxy-beta,beta-carotene-4,4'-dione					No. 26
C00022919	1,2-Epoxy-1,2,7,7',8,8'-hexahydro-psi,psi-carotene					No. 26
C00022916	Lycopene 1,2-epoxide / 1,2-Epoxy-1,2-dihydro-psi,psi-carotene					No. 26
C00003770	(9'Z)-Lutein	CHEMBL173929 CHEMBL172477 CHEMBL1559643 CHEMBL1979448		4 / 2 / 3		No. 26
C00003771	(9Z)-Lutein	CHEMBL173929 CHEMBL172477 CHEMBL1559643 CHEMBL1979448		4 / 2 / 3		No. 26
C00043845	Mimulaxanthin / (3S,3'S,5R,5'R,6R,6'R)-6,6',7,7'-Tetradehydro-5,5',6,6'-tetrahydro-3,3',5,5'-tetrahydroxy-beta,beta-carotene					No. 26
C00022814	Siphonaxanthin / (3R,3'R,6'R)-7,8-Dihydro-8-oxo-beta,epsilon-carotene-3,3',19-triol		C003314			No. 26
C00003776	4-Ketolutein / 3,3'-dihydroxy-beta,epsilon-carotene-4-one					No. 26
C00035776	(8'R)-Neochrome					No. 26
C00022872	Lycophyll / psi,psi-Carotene-16,16'-diol					No. 26
C00035777	Deepoxyneoxanthin / (3R,3'R)-6,7-Didehydro-5,6-dihydro-3,3',5-trihydroxy-beta,beta-carotene					No. 26
C00022869	Lycoxanthin					No. 26
C00003784	(3'R,6'S)-beta,epsilon-Caroten-3'-ol					No. 26
C00022861	(15Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 26
C00022837	Lycopene / all-trans-Lycopene	CHEMBL501174 CHEMBL1984187	C015329	6 / 13 / 13	84 / 13	No. 26
C00007425	Lactucaxanthin					No. 26
C00022835	(13Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 26
C00022831	Prolycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 26
C00022813	Prenigroxanthin					No. 26
C00003775	Fritschiellaxanthin / (3S,3'R,6'R)-3,3'-Dihydroxy-beta,epsilon-caroten-4-one					No. 26
C00022807	(6S,6'S)-epsilon,epsilon-Carotene					No. 97
C00007592	epsilon-Carotene					No. 97
C00000909	(2R,2'R)-beta,beta-Carotene-2,2'-diol					No. 97
C00022844	(9Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 97
C00000911	beta-Carotene	CHEMBL1293 CHEMBL1966639	D019207	7 / 12 / 11	104 / 19	No. 97
C00000912	(9Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 97
C00003778	Nigroxanthin / (3R,6'S)-3',18'-Didehydro-beta,epsilon-carotene-3,6'-diol					No. 97
C00022905	Neurosporene		C008604			No. 97
C00000913	(13Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 97
C00000934	Astaxanthin / (3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione	CHEMBL445751 CHEMBL1358053	C005948	1 / 4 / 3	0 / 7	No. 97
C00023251	(9'Z)-Capsanthin / 9'-cis-Capsanthin	CHEMBL1480032 CHEMBL1519371		2 / 0 / 0		No. 97
C00023252	Cryptocapsin / (3'S,5'R)-3'-Hydroxy-beta,kappa-caroten-6'-one					No. 97
C00023253	Capsanthone					No. 97
C00022937	Antheraxanthin / (3R,5R,6S,3'R)-zeaxanthin 5,6-epoxide		C031140			No. 97
C00022938	Cucurbitaxanthin A / (3S,3'R,5R,6R)-3,6-Epoxy-5,6-dihydro-3',5-dihydroxy-beta,beta-carotene					No. 97
C00022932	Karpoxanthin / Carpoxanthin / (3S,3'R,5R,6R)-5,6-Dihydro-3,3',5,6-tetrahydroxy-beta,beta-carotene					No. 114
C00022933	(3S,3'R,5S,6S)-5,6-Dihydro-3,3',5,6-tetrahydroxy-beta,beta-carotene					No. 114
C00034544	(3S,5R,8S)-5,8-Epoxy-5,8-dihydro-beta,beta-caroten-3-ol					No. 114
C00003787	Micromonol / (3R,3'R,6'R)-7',8'-Dihydro-beta,epsilon-carotene-3,3',19'-triol					No. 114
C00034547	Cryptochrome / 5,8:5',8'-diepoxy-5,5',8,8'-tetrahydro-beta,beta-caroten-3-ol					No. 114
C00023042	gamma-Carotene					No. 114
C00034546	Flavoxanthin					No. 114
C00034545	Mutatoxanthin / (3S,3'R,5R)-5,8-Epoxy-5,8-dihydro-beta,beta-carotene-3,3'-diol					No. 114
C00022945	Neoflor / (3S,3'S,5R,5'R,6R,6'R)-6,7-Didehydro-5,5',6,6'-tetrahydro-3,3',5,5',6'-pentahydroxy-beta,beta-carotene					No. 114
C00022946	Neoxanthin / Folioxanthin		C011947		4 / 0	No. 114
C00022948	Latochrome / (3S,3'S,5R,5'R,6R)-5',8'-Epoxy-5,5',6,8'-tetrahydro-3,3',5,6-tetrahydroxy-beta,beta-carotene					No. 114
C00022928	beta-Zeacarotene / 7',8'-Dihydro-beta,psi-carotene					No. 114
C00022927	Phytofluene					No. 114
C00022951	Ipomoeaxanthin C2					No. 114
C00022952	(5R,5'R,6S,6'S)-5,6:5',6'-Diepoxy-5,5',6,6'-tetrahydro-beta,beta-carotene					No. 114
C00022953	Cryptoxanthin diepoxide / 5,6:5',6'-Diepoxy-5,5',6,6'-tetrahydro-beta-caroten-3-ol					No. 114
C00022954	(9Z)-Violaxanthin					No. 114
C00022955	Violaxanthin		C005613			No. 114
C00003780	alpha-Cryptoxanthin					No. 114
C00022926	zeta-Carotene					No. 114
C00023036	(3'Z,5'Z)-Torulene					No. 114
C00003764	2,3-Didehydro-3-hydroxy-beta,beta-caroten-4-one					No. 114
C00023035	(3'Z,5'Z)-Celaxanthin					No. 114
C00003760	Phenicoxanthin / all-trans-Adonirubin					No. 114
C00023034	Rubixanthin					No. 114
C00045500	5',6'-Epoxy-3'-hydroxy-3-methoxy-4,6-didehydro-5',6'-dihydro-4,6-cyclo-5,6-seco-beta,beta-caroten-5-one					No. 114
C00023029	Ternstroemiaxanthin / 3-Hydroxy-beta,psi-caroten-18'-al					No. 114
C00003777	3'-Dehydrolutein / (3R,6'R)-3-Hydroxy-beta,epsilon-caroten-3'-one	CHEMBL1999562	C051820			No. 114
C00022956	Cucurbitaxanthin B / (3S,3'S,5R,5'R,6R,6'S)-3,6:4',5'-Diepoxy-5,5',6,6'-tetrahydro-3',5-dihydroxy-beta,beta-carotene					No. 114
C00000926	Eschscholtzxanthone / (3'S)-4',5'-Didehydro-3'-hydroxy-4,5'-retro-beta,beta-caroten-3-one					No. 131
C00003766	Lutein B / 3'-Epilutein / Calthaxanthin / (3R,3'S,6'R)-beta,epsilon-Carotene-3,3'-diol	CHEMBL173929 CHEMBL172477 CHEMBL1559643 CHEMBL1979448		4 / 2 / 3		No. 131
C00048243	Phytoene 1,2-epoxide / 1,2-Epoxy-1,2,7,7',8,8',11,11',12,12'-decahydro-psi,psi-carotene					No. 131
C00022960	Latoxanthin / (3S,3'S,5R,5'R,6R,6'S)-5,6-Epoxy-5,5',6,6'-tetrahydro-3,3',5',6'-tetrahydroxy-beta,beta-carotene					No. 131
C00023115	Methyl 8'-apo-beta-carotenoate					No. 131
C00003785	alpha-Carotene					No. 131
C00022936	Ipomoeaxanthin A					No. 131
C00022935	6-Epiheteroxanthin / (3S,3'R,5R,6S)-5,6-Dihydro-3,3',5,6-tetrahydroxy-beta,beta-carotene					No. 131
C00048244	Phytoene / 15-cis-Phytoene / 15,15'-cis-Phytoene	CHEMBL1988265				No. 131
C00023053	1',2'-Epoxy-1',2'-dihydro-epsilon,psi-carotene					No. 262
C00045499	5',8'-Epoxy-3'-hydroxy-3-methoxy-4,6-didehydro-5',8'-dihydro-4,6-cyclo-5,6-seco-beta,beta-caroten-5-one					No. 262
C00045498	5,6-epoxy-beta-Carotene / beta-Carotene 5,6-epoxide		C073147			No. 262
C00023025	Dihydroprasinoxanthin epoxide / (3S,3'R,4'S,5'R,6R,6'R)-5,18-Didehydro-4',5'-epoxy-5,5',6,6',7,7',8,8'-octahydro-3,3',6-trihydroxy-8-oxo-beta,beta-carotene					No. 262
C00023024	Preprasinoxanthin / (3S,3'R,5R,6S,6'R)-5,6-Epoxy-5,6,7,8-tetrahydro-8-oxo-beta,epsilon-carotene-3,3'-diol					No. 262
C00022984	Capsanthin 3,6-epoxide / (3S,3'S,5R,5'R,6R)-3,6-Epoxy-5,6-dihydro-3',5-dihydroxy-beta,kappa-caroten-6'-one					No. 262
C00045482	Mutatochrome / beta-carotene 5,8-epoxide		C001792			No. 262
C00003763	Canthaxanthin / beta-Carotene-4,4'-dione	CHEMBL1329004	D016644	4 / 4 / 3	0 / 1	No. 262
C00045483	(2R,5S,6R)-5,6-Epoxy-5,6-dihydro-beta,beta-caroten-2-ol					No. 262
C00023254	Lilixanthin / (3S,3'S,4S,5'R)-3,3',4-Trihydroxy-beta,kappa-caroten-6'-one					No. 664
C00022949	Curcurbitachrome 1 / (3S,3'S,5R,5'R,6R,8'R)-3,6:5',8'-Diepoxy-5,5',6,8'-tetrahydro-3',5-dihydroxy-beta,beta-carotene					No. 664
C00022950	Ipomoeaxanthin C1					No. 664
C00022929	3-Hydroxy-beta-zeacarotene / 7',8'-Dihydro-beta,psi-caroten-3-ol					No. 664
C00022912	7,9,9'-tri-cis-Neurosporene					No. 664
C00022957	Cycloviolaxanthin / (3S,3'S,5R,5'R,6R,6'R)-3,6:3',6'-Diepoxy-5,5',6,6'-tetrahydro-5,5'-dihydroxy-beta,beta-carotene					No. 664
C00003772	Loroxanthin / (3R,3'R,6'R)-beta,epsilon-Carotene-3,3',19-triol					No. 664
C00022940	(3S,3'S,5R,5'R,6S,6'R)-6,7-Didehydro-5,5',6,6'-tetrahydro-3,3',5,5',6'-pentahydroxy-beta,beta-carotene					No. 1206
C00003779	(2R,6'R)-beta,epsilon-Caroten-2-ol					No. 1206
C00023171	Capsoneoxanthin / (3S,3'S,5R,5'R,6R)-6,7-Didehydro-5,6-dihydro-3,3',5-trihydroxy-beta,kappa-caroten-6'-one					No. 1206
C00023172	(13'Z)-Capsanthin	CHEMBL1480032 CHEMBL1519371		2 / 0 / 0		No. 1206
C00003767	Lutein / (all-E)-Lutein / all-trans-(+)-Xanthophyll / (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol	CHEMBL173929 CHEMBL172477 CHEMBL1559643 CHEMBL1979448	D014975	4 / 2 / 3	7 / 2	No. 1206
C00022939	taraxanthin / Lutein 5,6-epoxide					No. 2614
C00000905	Zeaxanthin / all-trans-Zeaxanthin	CHEMBL1357855 CHEMBL2359248	C005881	4 / 2 / 3	1 / 0	No. 2614

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000909 C00000911 C00000922 C00000931 C00003763 C00003776 C00022872 C00023251 C00023252 C00023253 C00035776 C00035777 C00045482 C00045483 C00045498 C00045499	0 / 0
O75496	Geminin	Unclassified protein	C00000909 C00000911 C00000919 C00000931 C00003776 C00022872 C00023248 C00023249 C00023250 C00023251 C00023252 C00023253 C00035776 C00035777	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000909 C00000911 C00000931 C00003776 C00022872 C00023251 C00023252 C00023253 C00035776 C00035777	2 / 3
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000909 C00000911 C00000931 C00003776 C00022872 C00023251 C00023252 C00023253 C00035776 C00035777	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000909 C00000911 C00000919 C00023248 C00023249 C00023250 C00023251 C00023252 C00023253	11 / 10
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000922 C00003763 C00045482 C00045483 C00045498 C00045499	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000919 C00000922 C00023248 C00023249 C00023250	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000909 C00000911 C00023251 C00023252 C00023253	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000919 C00023248 C00023249 C00023250	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	0 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000918 C00000922	4 / 3

188 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000919 C00003780
581	BAX, BCL2L4	BCL2-associated X protein	C00000919 C00003776
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000911 C00000919
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000911 C00003780
4842	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	C00000911 C00000919
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000911 C00000919
3713	IVL	involucrin	C00000911 C00000919
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000911 C00000919
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000911 C00000919
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000911 C00000919
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00000911 C00003776
847	CAT	catalase (EC:1.11.1.6)	C00000911 C00003776
3451	IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1	interferon, alpha 17	C00000919
8314	BAP1, HUCEP-13, UCHL2	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC:3.4.19.12)	C00000911
571	BACH1, BACH-1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	C00000911
898	CCNE1, CCNE	cyclin E1	C00000911
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000911
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000911
1020	CDK5, PSSALRE	cyclin-dependent kinase 5 (EC:2.7.11.22)	C00000911
1022	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15	cyclin-dependent kinase 7 (EC:2.7.11.23 2.7.11.22)	C00000911
1025	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK	cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22)	C00000911
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000911
1113	CHGA, CGA	chromogranin A (parathyroid secretory protein 1)	C00000911
1114	CHGB, SCG1	chromogranin B (secretogranin 1)	C00000911
23418	CRB1, LCA8, RP12	crumbs homolog 1 (Drosophila)	C00000911
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00000911
1643	DDB2, DDBB, UV-DDB2	damage-specific DNA binding protein 2, 48kDa	C00000911
1981	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18	eukaryotic translation initiation factor 4 gamma, 1	C00000911
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000911
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000911
2176	FANCC, FA3, FAC, FACC	Fanconi anemia, complementation group C	C00000911
2188	FANCF, FAF	Fanconi anemia, complementation group F	C00000911
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00000911
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000911
2701	GJA4, CX37	gap junction protein, alpha 4, 37kDa	C00000911
2702	GJA5, ATFB11, CX40	gap junction protein, alpha 5, 40kDa	C00000911
2879	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx	glutathione peroxidase 4 (EC:1.11.1.12)	C00000911
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00000911
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000911
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00000911
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00000911
3485	IGFBP2, IBP2, IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	C00000911
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000911
3716	JAK1, JAK1A, JAK1B, JTK3	Janus kinase 1 (EC:2.7.10.2)	C00000911
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000911
3796	KIF2A, CDCBM3, HK2, KIF2	kinesin heavy chain member 2A	C00000911
3838	KPNA2, IPOA1, QIP2, RCH1, SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	C00000911
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00000911
3988	LIPA, CESD, LAL	lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)	C00000911
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00000911
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00000911
6416	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1	mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)	C00000911
5608	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	C00000911
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000911
118	ADD1, ADDA	adducin 1 (alpha)	C00000911
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000911
4247	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143)	C00000911
100507436	MICA, MIC-A, PERB11.1	MHC class I polypeptide-related sequence A	C00000911
4292	MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1	mutL homolog 1	C00000911
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00000911
2956	MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160	mutS homolog 6	C00000911
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003780
8021	NUP214, CAIN, CAN, D9S46E, N214, p250	nucleoporin 214kDa	C00000911
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00000911
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00000911
10111	RAD50, NBSLD, RAD502, hRad50	RAD50 homolog (S. cerevisiae)	C00000911
8045	RASSF7, C11orf13, HRAS1, HRC1	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	C00000911
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000911
5962	RDX, DFNB24	radixin	C00000911
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00000911
6197	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)	C00000911
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00000911
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000911
6414	SEPP1, SELP, SeP	selenoprotein P, plasma, 1	C00000911
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00000911
8243	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB	structural maintenance of chromosomes 1A	C00000911
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00000911
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00000911
7980	TFPI2, PP5, REF1, TFPI-2	tissue factor pathway inhibitor 2	C00000911
7039	TGFA, TFGA	transforming growth factor, alpha	C00000911
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00000911
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00000911
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000931
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000911
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000911
7415	VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97	valosin containing protein (EC:3.6.4.6)	C00000911
7485	WRB, CHD5	tryptophan rich basic protein	C00000911
7697	ZNF138, pHZ-32	zinc finger protein 138	C00000911
9131	AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	C00003780
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003776
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00003776
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00003776
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00003776
124	ADH1A, ADH1	alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1)	C00000919
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00000919
221	ALDH3B1, ALDH4, ALDH7	aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5)	C00000919
8659	ALDH4A1, ALDH4, P5CD, P5CDh	aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88)	C00000919
287	ANK2, ANK-2, LQT4, brank-2	ankyrin 2, neuronal	C00000919
288	ANK3, ANKYRIN-G, MRT37	ankyrin 3, node of Ranvier (ankyrin G)	C00000919
427	ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME	N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23)	C00000919
51665	ASB1, ASB-1	ankyrin repeat and SOCS box containing 1	C00000919
140462	ASB9	ankyrin repeat and SOCS box containing 9	C00000919
9531	BAG3, BAG-3, BIS, CAIR-1, MFM6	BCL2-associated athanogene 3	C00000919
9530	BAG4, BAG-4, SODD	BCL2-associated athanogene 4	C00000919
9529	BAG5, BAG-5	BCL2-associated athanogene 5	C00000919
53630	BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1	beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36)	C00000919
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00000919
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00000919
9071	CLDN10, CPETRL3, OSP-L	claudin 10	C00000919
51208	CLDN18, SFTA5, SFTPJ	claudin 18	C00000919
1277	COL1A1, OI4	collagen, type I, alpha 1	C00000919
1282	COL4A1, HANAC, ICH, POREN1, arresten	collagen, type IV, alpha 1	C00000919
1284	COL4A2, ICH, POREN2	collagen, type IV, alpha 2	C00000919
8738	CRADD, MRT34, RAIDD	CASP2 and RIPK1 domain containing adaptor with death domain	C00000919
1508	CTSB, APPS, CPSB	cathepsin B (EC:3.4.22.1)	C00000919
6387	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B	chemokine (C-X-C motif) ligand 12	C00000919
6372	CXCL6, CKA-3, GCP-2, GCP2, SCYB6	chemokine (C-X-C motif) ligand 6	C00000919
4283	CXCL9, CMK, Humig, MIG, SCYB9, crg-10	chemokine (C-X-C motif) ligand 9	C00000919
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00000919
1592	CYP26A1, CP26, CYP26, P450RAI, P450RAI1	cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-)	C00000919
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00000919
64816	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1)	C00000919
1746	DLX2, TES-1, TES1	distal-less homeobox 2	C00000919
1748	DLX4, BP1, DLX7, DLX8, DLX9	distal-less homeobox 4	C00000919
2068	ERCC2, COFS2, EM9, TTD, XPD	excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12)	C00000919
23017	FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2	Fas apoptotic inhibitory molecule 2	C00000919
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00000919
3169	FOXA1, HNF3A, TCF3A	forkhead box A1	C00000919
2627	GATA6	GATA binding protein 6	C00000919
2633	GBP1	guanylate binding protein 1, interferon-inducible	C00000919
81025	GJA9, CX58, CX59, GJA10	gap junction protein, alpha 9, 59kDa	C00000919
373156	GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1	glutathione S-transferase kappa 1 (EC:2.5.1.18)	C00000919
2946	GSTM2, GST4, GSTM, GSTM2-2, GTHMUS	glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18)	C00000919
2948	GSTM4, GSTM4-4, GTM4	glutathione S-transferase mu 4 (EC:2.5.1.18)	C00000919
2949	GSTM5, GSTM5-5, GTM5	glutathione S-transferase mu 5 (EC:2.5.1.18)	C00000919
2954	GSTZ1, GSTZ1-1, MAAI, MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	C00000919
3204	HOXA7, ANTP, HOX1, HOX1.1, HOX1A	homeobox A7	C00000919
3216	HOXB6, HOX2, HOX2B, HU-2, Hox-2.2	homeobox B6	C00000919
3226	HOXC10, HOX3I	homeobox C10	C00000919
3448	IFNA14, IFN-alphaH, LEIF2H	interferon, alpha 14	C00000919
3449	IFNA16, IFN-alphaO	interferon, alpha 16	C00000919
673	BRAF, B-RAF1, BRAF1, NS7, RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	C00000911
3442	IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G	interferon, alpha 5	C00000919
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000919
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000919
3394	IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8	interferon regulatory factor 8	C00000919
50805	IRX4, IRXA3	iroquois homeobox 4	C00000919
3688	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	C00000919
3691	ITGB4, CD104	integrin, beta 4	C00000919
3875	KRT18, CYK18, K18	keratin 18	C00000919
3880	KRT19, CK19, K19, K1CS	keratin 19	C00000919
3849	KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE	keratin 2	C00000919
3855	KRT7, CK7, K2C7, K7, SCL	keratin 7	C00000919
3856	KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO	keratin 8	C00000919
8022	LHX3, CPHD3, LIM3, M2-LHX3	LIM homeobox 3	C00000919
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000919
4153	MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD	mannose-binding lectin (protein C) 2, soluble	C00000919
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00000919
4212	MEIS2, HsT18361, MRG1	Meis homeobox 2	C00000919
4222	MEOX1, KFS2, MOX1	mesenchyme homeobox 1	C00000919
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00000919
3110	MNX1, HB9, HLXB9, HOXHB9, SCRA1	motor neuron and pancreas homeobox 1	C00000919
4439	MSH5, G7, MUTSH5, NG23	mutS homolog 5	C00000919
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00000919
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000919
4973	OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1	oxidized low density lipoprotein (lectin-like) receptor 1	C00000919
5098	PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2	protocadherin gamma subfamily C, 3	C00000919
5359	PLSCR1, MMTRA1B	phospholipid scramblase 1	C00000919
57048	PLSCR3	phospholipid scramblase 3	C00000919
57088	PLSCR4, TRA1	phospholipid scramblase 4	C00000919
10635	RAD51AP1, PIR51	RAD51 associated protein 1	C00000919
5892	RAD51D, BROVCA4, R51H3, RAD51L3, TRAD	RAD51 paralog D	C00000919
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00000919
5915	RARB, HAP, NR1B2, RRB2	retinoic acid receptor, beta	C00000919
5918	RARRES1, LXNL, TIG1	retinoic acid receptor responder (tazarotene induced) 1	C00000919
5950	RBP4, RDCCAS	retinol binding protein 4, plasma	C00000919
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00000919
949	SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1	scavenger receptor class B, member 1	C00000919
4990	SIX6, MCOPCT2, OPTX2, Six9	SIX homeobox 6	C00000919
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000919
9517	SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a	serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50)	C00000919
6720	SREBF1, SREBP-1c, SREBP1, bHLHd1	sterol regulatory element binding transcription factor 1	C00000919
7052	TGM2, G-ALPHA-h, GNAH, TG2, TGC	transglutaminase 2 (EC:2.3.2.13)	C00000919
7047	TGM4, TGP, hTGP	transglutaminase 4 (EC:2.3.2.13)	C00000919
3604	TNFRSF9, 4-1BB, CD137, CDw137, ILA	tumor necrosis factor receptor superfamily, member 9	C00000919
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00000919
10190	TXNDC9, APACD, PHLP3	thioredoxin domain containing 9	C00000919
7517	XRCC3, CMM6	X-ray repair complementing defective repair in Chinese hamster cells 3	C00000919

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