Metabolite

KNApSAcK Entry

id C00000919
Name beta-Carotene
CAS RN 7235-40-7
Standard InChI InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+
Standard InChI (Main Layer) InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3

Cluster

Phytochemical cluster No. 59
KCF-S cluster No. 26

Link

ChEMBL

By standard InChI CHEMBL1293
By standard InChI Main Layer CHEMBL1293 CHEMBL1966639

KEGG

By LinkDB C02094

CTD

By CAS RN D019207

Species

Summary


List (74)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia dealbata 205042 Fabaceae rosids Viridiplantae
Agrobacterium aurantiacum 44155 Rhizobiaceae Bacteria
Aloe arborescens 45385 Xanthorrhoeaceae Liliopsida Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Asparagus officinalis L. 4686 Asparagaceae Liliopsida Viridiplantae
Bangia fuscopurpurea 101920 Bangiaceae Eukaryota
Bonnemaisonia hamifera 31369 Bonnemaisoniaceae Eukaryota
Caesalpinia decapetala 191885 Fabaceae rosids Viridiplantae
Capsicum annuum 4072 Solanaceae asterids Viridiplantae
Caragana arborescens 20484 Fabaceae rosids Viridiplantae
Ceramium rubrum 35157 Ceramiaceae Eukaryota
Clarias fuscus 33541 Clariidae Metazoa
Corbicula japonica 141464 Corbiculidae Metazoa
Corbicula sandai 141465 Corbiculidae Metazoa
Corydoras melanistius 927907 Callichthyidae Metazoa
Cytisus scoparius 3835 Fabaceae rosids Viridiplantae
Daucus carota 4039 Apiaceae asterids Viridiplantae
Dioscorea spp. 4672 Dioscoreaceae Liliopsida Viridiplantae
Diospyros kaki 35925 Ebenaceae asterids Viridiplantae
Erwinia herbicola strain Eho10 551 Enterobacteriaceae Bacteria
Erwinia herbicola strain Eho13 551 Enterobacteriaceae Bacteria
Erwinia uredovora 553 Enterobacteriaceae Bacteria
Euglena gracilis 3039 Euglenaceae Eukaryota
Feijoa sellowiana 260130 Myrtaceae rosids Viridiplantae
Flavobacterium sp. Strain R1534 237 Flavobacteriaceae Bacteria
Gigartina stellata
Hofmeisteria schaffneri 176606 Asteraceae asterids Viridiplantae
Ipomoea batatas 4120 Convolvulaceae asterids Viridiplantae
Laburnum anagyroides 49828 Fabaceae rosids Viridiplantae
Liobagrus reinii 78875 Amblycipitidae Metazoa
Malapterurus electricus 337630 Malapteruridae Metazoa
Medicago arabica 70936 Fabaceae rosids Viridiplantae
Medicago cancellata 66809 Fabaceae rosids Viridiplantae
Medicago carstiensis 66810 Fabaceae rosids Viridiplantae
Medicago cretacea 66812 Fabaceae rosids Viridiplantae
Medicago daghestanica 70942 Fabaceae rosids Viridiplantae
Medicago falcata 3878 Fabaceae rosids Viridiplantae
Medicago glomerata 66813 Fabaceae rosids Viridiplantae
Medicago hybrida 66814 Fabaceae rosids Viridiplantae
Medicago marina 66815 Fabaceae rosids Viridiplantae
Medicago papillosa 70964 Fabaceae rosids Viridiplantae
Medicago pironae 66816 Fabaceae rosids Viridiplantae
Medicago prostrata 70967 Fabaceae rosids Viridiplantae
Medicago rupestris 3877 Fabaceae rosids Viridiplantae
Medicago ruthenica 70973 Fabaceae rosids Viridiplantae
Medicago sativa 3879 Fabaceae rosids Viridiplantae
Medicago saxatilis 119392 Fabaceae rosids Viridiplantae
Medicago suffruticosa 66818 Fabaceae rosids Viridiplantae
Nemalion helminthoides 35200 Liagoraceae Eukaryota
Neurospora crassa YLO 5140 Sordariaceae Fungi
Ononis spinosa 58890 Fabaceae rosids Viridiplantae
Passiflora edulis 78168 Passifloraceae rosids Viridiplantae
Pelteobagrus nudiceps 175790 Bagridae Metazoa
Phaseolus vulgaris 3885 Fabaceae rosids Viridiplantae
Phodymenia palmata
Pithecellobium dulce 404691 Fabaceae rosids Viridiplantae
Plotosus lineatus 243562 Plotosidae Metazoa
Polysiphonia brodiaei 159751 Rhodomelaceae Eukaryota
Polysiphonia urceolata 65404 Rhodomelaceae Eukaryota
Pseudobagrus aurantiacus 78878 Bagridae Metazoa
Psidium guajava 120290 Myrtaceae rosids Viridiplantae
Pteleopsis hylodendron 507434 Combretaceae rosids Viridiplantae
Rosa foetida 74629 Rosaceae rosids Viridiplantae
Rosa spp. 3764 Rosaceae rosids Viridiplantae
Silurus asotus 30991 Siluridae Metazoa
Silurus biwaensis 94992 Siluridae Metazoa
Silurus lithophilus 94992 Siluridae Metazoa
Silurus microdorsalis 329966 Siluridae Metazoa
Spartium junceum 49843 Fabaceae rosids Viridiplantae
Streptomyces griseus 1911 Streptomycetaceae Bacteria
Thermopsis alterniflora 49852 Fabaceae rosids Viridiplantae
Ulex europaeus 3902 Fabaceae rosids Viridiplantae
Ulex gallii 183290 Fabaceae rosids Viridiplantae
Ulex spp. 3901 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL1293 CHEMBL1614544 (1)
11 / 10
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1293 CHEMBL1614458 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1293 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1293 CHEMBL2114780 (1)
0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1293 CHEMBL650217 (1)
0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1293 CHEMBL650217 (1)
1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1293 CHEMBL650217 (1)
0 / 0

CTD interaction (118)

compound gene gene name gene description interaction interaction type form reference
pmid
D019207 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) beta Carotene results in increased expression of ADH1A mRNA increases expression
mRNA 17034753
D019207 128 ADH5
ADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) beta Carotene results in increased expression of ADH5 mRNA increases expression
mRNA 17034753
D019207 221 ALDH3B1
ALDH4
ALDH7
aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) beta Carotene results in decreased expression of ALDH3B1 mRNA decreases expression
mRNA 17034753
D019207 8659 ALDH4A1
ALDH4
P5CD
P5CDh
aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) beta Carotene results in decreased expression of ALDH4A1 mRNA decreases expression
mRNA 17034753
D019207 287 ANK2
ANK-2
LQT4
brank-2
ankyrin 2, neuronal beta Carotene results in increased expression of ANK2 mRNA increases expression
mRNA 17034753
D019207 288 ANK3
ANKYRIN-G
MRT37
ankyrin 3, node of Ranvier (ankyrin G) beta Carotene results in increased expression of ANK3 mRNA increases expression
mRNA 17034753
D019207 427 ASAH1
AC
ACDase
ASAH
PHP
PHP32
SMAPME
N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) beta Carotene results in increased expression of ASAH1 mRNA increases expression
mRNA 17034753
D019207 51665 ASB1
ASB-1
ankyrin repeat and SOCS box containing 1 beta Carotene results in increased expression of ASB1 mRNA increases expression
mRNA 17034753
D019207 140462 ASB9
ankyrin repeat and SOCS box containing 9 beta Carotene results in increased expression of ASB9 mRNA increases expression
mRNA 17034753
D019207 9531 BAG3
BAG-3
BIS
CAIR-1
MFM6
BCL2-associated athanogene 3 beta Carotene results in decreased expression of BAG3 mRNA decreases expression
mRNA 17034753
D019207 9530 BAG4
BAG-4
SODD
BCL2-associated athanogene 4 beta Carotene results in decreased expression of BAG4 mRNA decreases expression
mRNA 17034753
D019207 9529 BAG5
BAG-5
BCL2-associated athanogene 5 beta Carotene results in decreased expression of BAG5 mRNA decreases expression
mRNA 17034753
D019207 581 BAX
BCL2L4
BCL2-associated X protein beta Carotene results in decreased expression of BAX mRNA decreases expression
mRNA 17034753
D019207 581 BAX
BCL2L4
BCL2-associated X protein beta Carotene results in increased expression of BAX mRNA increases expression
mRNA 15949688
D019207 581 BAX
BCL2L4
BCL2-associated X protein beta Carotene results in increased expression of BAX protein increases expression
protein 15949688
D019207 53630 BCMO1
BCDO
BCDO1
BCMO
BCO
BCO1
beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) beta Carotene results in increased expression of and results in increased activity of BCMO1 protein increases activity
/ increases expression
protein 16186334
D019207 53630 BCMO1
BCDO
BCDO1
BCMO
BCO
BCO1
beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) beta Carotene results in increased expression of BCMO1 mRNA increases expression
mRNA 16186334
D019207 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein] decreases activity
/ increases reaction
protein 17618090
D019207 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) beta Carotene metabolite results in increased activity of CASP3 protein increases activity
protein 17618090
D019207 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) beta Carotene results in increased expression of CDH1 mRNA increases expression
mRNA 17034753
D019207 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator beta Carotene results in increased expression of CFLAR mRNA increases expression
mRNA 17034753
D019207 9071 CLDN10
CPETRL3
OSP-L
claudin 10 beta Carotene results in increased expression of CLDN10 mRNA increases expression
mRNA 17034753
D019207 51208 CLDN18
SFTA5
SFTPJ
claudin 18 beta Carotene results in increased expression of CLDN18 mRNA increases expression
mRNA 17034753
D019207 1277 COL1A1
OI4
collagen, type I, alpha 1 beta Carotene results in decreased expression of COL1A1 mRNA decreases expression
mRNA 17034753
D019207 1282 COL4A1
HANAC
ICH
POREN1
arresten
collagen, type IV, alpha 1 beta Carotene results in decreased expression of COL4A1 mRNA decreases expression
mRNA 17034753
D019207 1284 COL4A2
ICH
POREN2
collagen, type IV, alpha 2 beta Carotene results in decreased expression of COL4A2 mRNA decreases expression
mRNA 17034753
D019207 8738 CRADD
MRT34
RAIDD
CASP2 and RIPK1 domain containing adaptor with death domain beta Carotene results in increased expression of CRADD mRNA increases expression
mRNA 17034753
D019207 1508 CTSB
APPS
CPSB
cathepsin B (EC:3.4.22.1) beta Carotene results in decreased expression of CTSB mRNA decreases expression
mRNA 17034753
D019207 6387 CXCL12
IRH
PBSF
SCYB12
SDF1
TLSF
TPAR1
SDF1A
SDF1B
chemokine (C-X-C motif) ligand 12 beta Carotene results in increased expression of CXCL12 mRNA increases expression
mRNA 17034753
D019207 6372 CXCL6
CKA-3
GCP-2
GCP2
SCYB6
chemokine (C-X-C motif) ligand 6 beta Carotene results in increased expression of CXCL6 mRNA increases expression
mRNA 17034753
D019207 4283 CXCL9
CMK
Humig
MIG
SCYB9
crg-10
chemokine (C-X-C motif) ligand 9 beta Carotene results in increased expression of CXCL9 mRNA increases expression
mRNA 17034753
D019207 7852 CXCR4
CD184
D2S201E
FB22
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
chemokine (C-X-C motif) receptor 4 beta Carotene results in increased expression of CXCR4 mRNA increases expression
mRNA 17034753
D019207 1592 CYP26A1
CP26
CYP26
P450RAI
P450RAI1
cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) beta Carotene results in increased expression of CYP26A1 mRNA increases expression
mRNA 16186334
22542753
D019207 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) beta Carotene results in increased expression of CYP2C9 mRNA increases expression
mRNA 17034753
D019207 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] affects binding
/ increases expression
/ increases reaction
mRNA 16632523
D019207 64816 CYP3A43
cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1) beta Carotene results in increased expression of CYP3A43 mRNA increases expression
mRNA 17034753
D019207 1746 DLX2
TES-1
TES1
distal-less homeobox 2 beta Carotene results in increased expression of DLX2 mRNA increases expression
mRNA 17034753
D019207 1748 DLX4
BP1
DLX7
DLX8
DLX9
distal-less homeobox 4 beta Carotene results in increased expression of DLX4 mRNA increases expression
mRNA 17034753
D019207 2068 ERCC2
COFS2
EM9
TTD
XPD
excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) beta Carotene results in decreased expression of ERCC2 mRNA decreases expression
mRNA 17034753
D019207 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] decreases reaction
/ increases activity
protein 17051425
D019207 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein] decreases reaction
/ increases activity
protein 17051425
D019207 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] decreases reaction
/ increases expression
mRNA 19340624
D019207 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein] decreases reaction
/ increases activity
protein 17051425
D019207 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] decreases reaction
/ increases activity
protein 17051425
D019207 23017 FAIM2
LFG
LFG2
NGP35
NMP35
TMBIM2
Fas apoptotic inhibitory molecule 2 beta Carotene results in increased expression of FAIM2 mRNA increases expression
mRNA 17034753
D019207 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor beta Carotene results in increased expression of FAS mRNA increases expression
mRNA 17034753
D019207 3169 FOXA1
HNF3A
TCF3A
forkhead box A1 beta Carotene results in increased expression of FOXA1 mRNA increases expression
mRNA 17034753
D019207 2627 GATA6
GATA binding protein 6 beta Carotene results in increased expression of GATA6 mRNA increases expression
mRNA 17034753
D019207 2633 GBP1
guanylate binding protein 1, interferon-inducible beta Carotene results in increased expression of GBP1 mRNA increases expression
mRNA 17034753
D019207 81025 GJA9
CX58
CX59
GJA10
gap junction protein, alpha 9, 59kDa beta Carotene results in increased expression of GJA9 mRNA increases expression
mRNA 17034753
D019207 373156 GSTK1
GST
GST_13-13
GST13
GST13-13
GSTK1-1
hGSTK1
glutathione S-transferase kappa 1 (EC:2.5.1.18) beta Carotene results in decreased expression of GSTK1 mRNA decreases expression
mRNA 17034753
D019207 2946 GSTM2
GST4
GSTM
GSTM2-2
GTHMUS
glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) beta Carotene results in increased expression of GSTM2 mRNA increases expression
mRNA 17034753
D019207 2948 GSTM4
GSTM4-4
GTM4
glutathione S-transferase mu 4 (EC:2.5.1.18) beta Carotene results in decreased expression of GSTM4 mRNA decreases expression
mRNA 17034753
D019207 2949 GSTM5
GSTM5-5
GTM5
glutathione S-transferase mu 5 (EC:2.5.1.18) beta Carotene results in increased expression of GSTM5 mRNA increases expression
mRNA 17034753
D019207 2954 GSTZ1
GSTZ1-1
MAAI
MAI
glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) beta Carotene results in decreased expression of GSTZ1 mRNA decreases expression
mRNA 17034753
D019207 3204 HOXA7
ANTP
HOX1
HOX1.1
HOX1A
homeobox A7 beta Carotene results in increased expression of HOXA7 mRNA increases expression
mRNA 17034753
D019207 3216 HOXB6
HOX2
HOX2B
HU-2
Hox-2.2
homeobox B6 beta Carotene results in increased expression of HOXB6 mRNA increases expression
mRNA 17034753
D019207 3226 HOXC10
HOX3I
homeobox C10 beta Carotene results in increased expression of HOXC10 mRNA increases expression
mRNA 17034753
D019207 3448 IFNA14
IFN-alphaH
LEIF2H
interferon, alpha 14 beta Carotene results in increased expression of IFNA14 mRNA increases expression
mRNA 17034753
D019207 3449 IFNA16
IFN-alphaO
interferon, alpha 16 beta Carotene results in increased expression of IFNA16 mRNA increases expression
mRNA 17034753
D019207 3451 IFNA17
IFN-alphaI
IFNA
INFA
LEIF2C1
interferon, alpha 17 beta Carotene results in increased expression of IFNA17 mRNA increases expression
mRNA 17034753
D019207 3442 IFNA5
IFN-alpha-5
IFN-alphaG
INA5
INFA5
leIF_G
interferon, alpha 5 beta Carotene results in increased expression of IFNA5 mRNA increases expression
mRNA 17034753
D019207 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21447443
D019207 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein] increases reaction
/ increases secretion
protein 21447443
D019207 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21447443
D019207 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 beta Carotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 19135038
D019207 3394 IRF8
H-ICSBP
ICSBP
ICSBP1
IRF-8
interferon regulatory factor 8 beta Carotene results in increased expression of IRF8 mRNA increases expression
mRNA 17034753
D019207 50805 IRX4
IRXA3
iroquois homeobox 4 beta Carotene results in decreased expression of IRX4 mRNA decreases expression
mRNA 17034753
D019207 3688 ITGB1
CD29
FNRB
GPIIA
MDF2
MSK12
VLA-BETA
VLAB
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) beta Carotene results in decreased expression of ITGB1 mRNA decreases expression
mRNA 17034753
D019207 3691 ITGB4
CD104
integrin, beta 4 beta Carotene results in decreased expression of ITGB4 mRNA decreases expression
mRNA 17034753
D019207 3713 IVL
involucrin beta Carotene results in increased expression of IVL mRNA increases expression
mRNA 17034753
D019207 3875 KRT18
CYK18
K18
keratin 18 beta Carotene results in increased expression of KRT18 mRNA increases expression
mRNA 17034753
D019207 3880 KRT19
CK19
K19
K1CS
keratin 19 beta Carotene results in increased expression of KRT19 mRNA increases expression
mRNA 17034753
D019207 3849 KRT2
CK-2e
K2e
KRT2A
KRT2E
KRTE
keratin 2 beta Carotene results in increased expression of KRT2 mRNA increases expression
mRNA 17034753
D019207 3855 KRT7
CK7
K2C7
K7
SCL
keratin 7 beta Carotene affects the expression of KRT7 mRNA affects expression
mRNA 17034753
D019207 3856 KRT8
CARD2
CK-8
CK8
CYK8
K2C8
K8
KO
keratin 8 beta Carotene results in decreased expression of KRT8 mRNA decreases expression
mRNA 17034753
D019207 8022 LHX3
CPHD3
LIM3
M2-LHX3
LIM homeobox 3 beta Carotene results in increased expression of LHX3 mRNA increases expression
mRNA 17034753
D019207 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) beta Carotene results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 16206275
D019207 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) beta Carotene results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 16206275
D019207 4153 MBL2
COLEC1
HSMBPC
MBL
MBL2D
MBP
MBP-C
MBP1
MBPD
mannose-binding lectin (protein C) 2, soluble MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] affects cotreatment
/ affects response to substance
gene 16960176
D019207 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) beta Carotene affects the expression of MCL1 mRNA affects expression
mRNA 17034753
D019207 4212 MEIS2
HsT18361
MRG1
Meis homeobox 2 beta Carotene results in increased expression of MEIS2 mRNA increases expression
mRNA 17034753
D019207 4222 MEOX1
KFS2
MOX1
mesenchyme homeobox 1 beta Carotene results in increased expression of MEOX1 mRNA increases expression
mRNA 17034753
D019207 4255 MGMT
O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) MGMT gene SNP affects the susceptibility to beta Carotene affects response to substance
gene 16014702
D019207 3110 MNX1
HB9
HLXB9
HOXHB9
SCRA1
motor neuron and pancreas homeobox 1 beta Carotene results in increased expression of MNX1 mRNA increases expression
mRNA 17034753
D019207 4439 MSH5
G7
MUTSH5
NG23
mutS homolog 5 beta Carotene results in increased expression of MSH5 mRNA increases expression
mRNA 17034753
D019207 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming beta Carotene results in increased expression of MUC5AC mRNA increases expression
mRNA 17034753
D019207 4842 NOS1
IHPS1
N-NOS
NC-NOS
NOS
bNOS
nNOS
nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) beta Carotene results in increased expression of NOS1 mRNA increases expression
mRNA 17034753
D019207 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] affects binding
/ increases expression
/ increases reaction
protein 16632523
D019207 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 beta Carotene results in increased activity of NR1I2 protein increases activity
protein 15949683
D019207 4973 OLR1
CLEC8A
LOX1
LOXIN
SCARE1
SLOX1
oxidized low density lipoprotein (lectin-like) receptor 1 beta Carotene results in increased expression of OLR1 mRNA increases expression
mRNA 17034753
D019207 5098 PCDHGC3
PC43
PCDH-GAMMA-C3
PCDH2
protocadherin gamma subfamily C, 3 beta Carotene results in increased expression of PCDHGC3 mRNA increases expression
mRNA 17034753
D019207 5359 PLSCR1
MMTRA1B
phospholipid scramblase 1 beta Carotene results in increased expression of PLSCR1 mRNA increases expression
mRNA 17034753
D019207 57048 PLSCR3
phospholipid scramblase 3 beta Carotene results in increased expression of PLSCR3 mRNA increases expression
mRNA 17034753
D019207 57088 PLSCR4
TRA1
phospholipid scramblase 4 beta Carotene results in increased expression of PLSCR4 mRNA increases expression
mRNA 17034753
D019207 10635 RAD51AP1
PIR51
RAD51 associated protein 1 beta Carotene results in decreased expression of RAD51AP1 mRNA decreases expression
mRNA 17034753
D019207 5892 RAD51D
BROVCA4
R51H3
RAD51L3
TRAD
RAD51 paralog D beta Carotene results in increased expression of RAD51D mRNA increases expression
mRNA 17034753
D019207 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha beta Carotene results in decreased expression of RARA mRNA decreases expression
mRNA 17034753
D019207 5915 RARB
HAP
NR1B2
RRB2
retinoic acid receptor, beta beta Carotene results in increased expression of RARB mRNA increases expression
mRNA 17034753
D019207 5918 RARRES1
LXNL
TIG1
retinoic acid receptor responder (tazarotene induced) 1 beta Carotene results in increased expression of RARRES1 mRNA increases expression
mRNA 17034753
D019207 5950 RBP4
RDCCAS
retinol binding protein 4, plasma beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein decreases expression
/ decreases secretion
protein 22542753
D019207 6256 RXRA
NR2B1
retinoid X receptor, alpha beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] affects binding
/ increases expression
/ increases reaction
protein 16632523
D019207 949 SCARB1
CD36L1
CLA-1
CLA1
HDLQTL6
SR-BI
SRB1
scavenger receptor class B, member 1 SCARB1 protein results in increased transport of beta Carotene increases transport
protein 16177187
D019207 4990 SIX6
MCOPCT2
OPTX2
Six9
SIX homeobox 6 beta Carotene results in increased expression of SIX6 mRNA increases expression
mRNA 17034753
D019207 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) beta Carotene results in decreased expression of SOD1 mRNA decreases expression
mRNA 17034753
D019207 9517 SPTLC2
HSN1C
LCB2
LCB2A
NSAN1C
SPT2
hLCB2a
serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) beta Carotene affects the expression of SPTLC2 mRNA affects expression
mRNA 17034753
D019207 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 beta Carotene results in increased expression of SREBF1 mRNA increases expression
mRNA 17034753
D019207 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) beta Carotene results in increased expression of TGM2 mRNA increases expression
mRNA 17034753
D019207 7047 TGM4
TGP
hTGP
transglutaminase 4 (EC:2.3.2.13) beta Carotene results in increased expression of TGM4 mRNA increases expression
mRNA 17034753
D019207 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21447443
D019207 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein] affects reaction
/ increases secretion
protein 19135038
D019207 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein] increases reaction
/ increases secretion
protein 21447443
D019207 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]] affects reaction
/ increases secretion
protein 19135038
D019207 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21447443
D019207 3604 TNFRSF9
4-1BB
CD137
CDw137
ILA
tumor necrosis factor receptor superfamily, member 9 beta Carotene results in increased expression of TNFRSF9 mRNA increases expression
mRNA 17034753
D019207 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 beta Carotene results in increased expression of TNFSF10 mRNA increases expression
mRNA 17034753
D019207 10190 TXNDC9
APACD
PHLP3
thioredoxin domain containing 9 beta Carotene results in increased expression of TXNDC9 mRNA increases expression
mRNA 17034753
D019207 7517 XRCC3
CMM6
X-ray repair complementing defective repair in Chinese hamster cells 3 beta Carotene results in increased expression of XRCC3 mRNA increases expression
mRNA 17034753

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (11)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00079 Asthma P07550 (related)

Diseases related to CTD interactions

19 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000435 D019207 Alcoholic Intoxication therapeutic
8723618
D001145 D019207 Arrhythmias, Cardiac therapeutic
8723618
D053627 D019207 Asthenozoospermia therapeutic
15304303
D002545 D019207 Brain Ischemia marker/mechanism
therapeutic
16157235
18044087
D006528 D019207 Carcinoma, Hepatocellular therapeutic
7728963
D002318 D019207 Cardiovascular Diseases marker/mechanism
16015255
D003930 D019207 Diabetic Retinopathy therapeutic
18779489
D056486 D019207 Drug-Induced Liver Injury therapeutic
20448084
D006526 D019207 Hepatitis C therapeutic
17420205
D015658 D019207 HIV Infections therapeutic
16960176
D006986 D019207 Hypervitaminosis A marker/mechanism
10424294
D008107 D019207 Liver Diseases marker/mechanism
10424294
D008113 D019207 Liver Neoplasms therapeutic
7852184
8603484
D008114 D019207 Liver Neoplasms, Experimental therapeutic
10965525
17113696
D008175 D019207 Lung Neoplasms marker/mechanism
therapeutic
10636903
16401635
D009369 D019207 Neoplasms therapeutic
17051425
D009845 D019207 Oligospermia therapeutic
15304303
D013272 D019207 Stomach Diseases therapeutic
17638125
D013276 D019207 Stomach Ulcer therapeutic
10674923
12500499