| Organism name | Rosa spp. |
|---|---|
| Genus | Rosa |
| Family | Rosaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Rosa |
|---|---|
| Linked NCBI taxonomy ID | 3764 |
| Linked level | genus |
| Family in NCBI taxonomy | Rosaceae |
|---|---|
| ID | 3745 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00006728
|
Petunin
/ Petunidin 3,5-di-O-beta-D-glucoside |
No. 1 | No. 15 |
|
||||
|
C00006658
|
Cyanidin 3-sophoroside
|
No. 1 | No. 15 |
|
||||
|
C00002376
|
Cyanidin 3-rutinoside
|
CHEMBL505251
|
C020386
|
3 / 0 / 1 | No. 1 | No. 15 |
|
|
|
C00002378
|
Cyanin
/ Cyanidin 3,5-diglucoside |
No. 1 | No. 15 |
|
||||
|
C00006686
|
Peonidin 3-rutinoside
|
No. 1 | No. 15 |
|
||||
|
C00002387
|
Pelargonin
/ Pelargonidin 3,5-di-beta-D-glucoside |
No. 1 | No. 15 |
|
||||
|
C00002374
|
Chrysanthemin
/ Cyanidin 3-O-glucoside |
CHEMBL257839
CHEMBL1197952 |
C114438
|
1 / 0 / 1 | No. 2 | No. 15 |
|
|
|
C00005132
|
Juglanin
/ Kaempferol 3-O-arabinoside / (-)-Kaempferol 3-O-arabinoside |
CHEMBL469440
|
No. 2 | No. 15 |
|
|||
|
C00006630
|
Callistephin
/ Pelargonidin 3-O-beta-D-glucopyranoside |
C078485
|
No. 2 | No. 15 |
|
|||
|
C00000919
|
beta-Carotene
|
CHEMBL1293
CHEMBL1966639 |
D019207
|
7 / 12 / 11 | 104 / 19 | No. 26 | No. 59 |
|
|
C00006800
|
Hyacinthin
/ Cyanidin 3-(6-O-p-coumarylglucoside) |
No. 30 | No. 15 |
|
||||
|
C00006861
|
Peonidin 3-(6''-p-coumarylglucoside)
|
No. 30 | No. 15 |
|
||||
|
C00003760
|
Antheraxanthin
/ (3R,5R,6S,3'R)-zeaxanthin 5,6-epoxide |
C031140
|
No. 114 | No. 59 |
|
|||
|
C00002920
|
Eugeniin
|
CHEMBL450745
CHEMBL510512 |
C110634
|
1 / 1 / 0 | No. 302 | No. 81 |
|
|
|
C00002938
|
Tellimagrandin I
|
CHEMBL450376
|
C087926
|
7 / 0 | No. 302 | No. 81 |
|
|
|
C00003772
|
Flavoxanthin
|
No. 664 | No. 59 |
|
||||
|
C00002670
|
Pyrogallol
|
CHEMBL307145
|
D011748
|
115 / 69 / 60 | 8 / 2 | No. 1590 | No. 82 |
|
|
C00011383
|
(E)-4,8-Dimethyl-1,3,7-nonatriene
|
No. 4390 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00000919 C00002670 | 11 / 10 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000919 C00002670 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000919 C00002670 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000919 C00002670 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000919 C00002670 | 0 / 1 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002670 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002670 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002670 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002670 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002670 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002670 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002670 | 2 / 2 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00002374 | 0 / 1 |
| Q07812 | Apoptosis regulator BAX | Unclassified protein | C00002376 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002670 | 1 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002670 | 1 / 2 |
| P08246 | Neutrophil elastase | S1A | C00002670 | 2 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002670 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002670 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002670 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002670 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002670 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002670 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002670 | 2 / 2 |
| P02768 | Serum albumin | Secreted protein | C00002670 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002670 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002670 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002670 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002670 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002670 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002670 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002670 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002670 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002670 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002670 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002670 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002670 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002670 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002670 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002670 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002670 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002670 | 1 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002670 | 0 / 3 |
| P16581 | E-selectin | Adhesion | C00002670 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002670 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000919 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000919 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002670 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002670 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002670 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002670 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002670 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002670 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002670 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002670 | 0 / 1 |
| P00742 | Coagulation factor X | S1A | C00002920 | 1 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002670 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002670 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002670 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002670 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002670 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002670 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002670 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002670 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002670 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002670 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002670 | 0 / 0 |
| Q16611 | Bcl-2 homologous antagonist/killer | Unclassified protein | C00002376 | 0 / 0 |
| O43521 | Bcl-2-like protein 11 | Unclassified protein | C00002376 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002670 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002670 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002670 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002670 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002670 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002670 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002670 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002670 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002670 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002670 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002670 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002670 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002670 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002670 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002670 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002670 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002670 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002670 | 2 / 2 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002670 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002670 | 1 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002670 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002670 | 1 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002670 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002670 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002670 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002670 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002670 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002670 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002670 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002670 | 0 / 0 |
| P14151 | L-selectin | Adhesion | C00002670 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00002670 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002670 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002670 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002670 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002670 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002670 | 5 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002670 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002670 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002670 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002670 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002670 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002670 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002670 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002670 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002670 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002670 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002670 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002670 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002670 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002670 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002670 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002670 | 0 / 0 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000919
C00002670
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00000919
|
| 2624 | GATA2, DCML, MONOMAC, NFE1B | GATA binding protein 2 |
C00002938
|
| 2993 | GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 | glycophorin A (MNS blood group) |
C00002938
|
| 3145 | HMBS, PBG-D, PBGD, PORC, UPS | hydroxymethylbilane synthase (EC:2.5.1.61) |
C00002938
|
| 3690 | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
C00002938
|
| 4778 | NFE2, NF-E2, p45 | nuclear factor, erythroid 2 |
C00002938
|
| 351 | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 | amyloid beta (A4) precursor protein |
C00002670
|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00002938
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002670
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00002670
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002670
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002670
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002670
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002670
|
| 124 | ADH1A, ADH1 | alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) |
C00000919
|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00000919
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00000919
|
| 8659 | ALDH4A1, ALDH4, P5CD, P5CDh | aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) |
C00000919
|
| 287 | ANK2, ANK-2, LQT4, brank-2 | ankyrin 2, neuronal |
C00000919
|
| 288 | ANK3, ANKYRIN-G, MRT37 | ankyrin 3, node of Ranvier (ankyrin G) |
C00000919
|
| 427 | ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME | N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) |
C00000919
|
| 51665 | ASB1, ASB-1 | ankyrin repeat and SOCS box containing 1 |
C00000919
|
| 140462 | ASB9 | ankyrin repeat and SOCS box containing 9 |
C00000919
|
| 9531 | BAG3, BAG-3, BIS, CAIR-1, MFM6 | BCL2-associated athanogene 3 |
C00000919
|
| 9530 | BAG4, BAG-4, SODD | BCL2-associated athanogene 4 |
C00000919
|
| 9529 | BAG5, BAG-5 | BCL2-associated athanogene 5 |
C00000919
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000919
|
| 53630 | BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1 | beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) |
C00000919
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00000919
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00000919
|
| 9071 | CLDN10, CPETRL3, OSP-L | claudin 10 |
C00000919
|
| 51208 | CLDN18, SFTA5, SFTPJ | claudin 18 |
C00000919
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00000919
|
| 1282 | COL4A1, HANAC, ICH, POREN1, arresten | collagen, type IV, alpha 1 |
C00000919
|
| 1284 | COL4A2, ICH, POREN2 | collagen, type IV, alpha 2 |
C00000919
|
| 8738 | CRADD, MRT34, RAIDD | CASP2 and RIPK1 domain containing adaptor with death domain |
C00000919
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00000919
|
| 6387 | CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B | chemokine (C-X-C motif) ligand 12 |
C00000919
|
| 6372 | CXCL6, CKA-3, GCP-2, GCP2, SCYB6 | chemokine (C-X-C motif) ligand 6 |
C00000919
|
| 4283 | CXCL9, CMK, Humig, MIG, SCYB9, crg-10 | chemokine (C-X-C motif) ligand 9 |
C00000919
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00000919
|
| 1592 | CYP26A1, CP26, CYP26, P450RAI, P450RAI1 | cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) |
C00000919
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000919
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000919
|
| 64816 | CYP3A43 | cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1) |
C00000919
|
| 1746 | DLX2, TES-1, TES1 | distal-less homeobox 2 |
C00000919
|
| 1748 | DLX4, BP1, DLX7, DLX8, DLX9 | distal-less homeobox 4 |
C00000919
|
| 2068 | ERCC2, COFS2, EM9, TTD, XPD | excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) |
C00000919
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000919
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000919
|
| 23017 | FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2 | Fas apoptotic inhibitory molecule 2 |
C00000919
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000919
|
| 3169 | FOXA1, HNF3A, TCF3A | forkhead box A1 |
C00000919
|
| 2627 | GATA6 | GATA binding protein 6 |
C00000919
|
| 2633 | GBP1 | guanylate binding protein 1, interferon-inducible |
C00000919
|
| 81025 | GJA9, CX58, CX59, GJA10 | gap junction protein, alpha 9, 59kDa |
C00000919
|
| 373156 | GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 | glutathione S-transferase kappa 1 (EC:2.5.1.18) |
C00000919
|
| 2946 | GSTM2, GST4, GSTM, GSTM2-2, GTHMUS | glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) |
C00000919
|
| 2948 | GSTM4, GSTM4-4, GTM4 | glutathione S-transferase mu 4 (EC:2.5.1.18) |
C00000919
|
| 2949 | GSTM5, GSTM5-5, GTM5 | glutathione S-transferase mu 5 (EC:2.5.1.18) |
C00000919
|
| 2954 | GSTZ1, GSTZ1-1, MAAI, MAI | glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) |
C00000919
|
| 3204 | HOXA7, ANTP, HOX1, HOX1.1, HOX1A | homeobox A7 |
C00000919
|
| 3216 | HOXB6, HOX2, HOX2B, HU-2, Hox-2.2 | homeobox B6 |
C00000919
|
| 3226 | HOXC10, HOX3I | homeobox C10 |
C00000919
|
| 3448 | IFNA14, IFN-alphaH, LEIF2H | interferon, alpha 14 |
C00000919
|
| 3449 | IFNA16, IFN-alphaO | interferon, alpha 16 |
C00000919
|
| 3451 | IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1 | interferon, alpha 17 |
C00000919
|
| 3442 | IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G | interferon, alpha 5 |
C00000919
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000919
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000919
|
| 3394 | IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8 | interferon regulatory factor 8 |
C00000919
|
| 50805 | IRX4, IRXA3 | iroquois homeobox 4 |
C00000919
|
| 3688 | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
C00000919
|
| 3691 | ITGB4, CD104 | integrin, beta 4 |
C00000919
|
| 3713 | IVL | involucrin |
C00000919
|
| 3875 | KRT18, CYK18, K18 | keratin 18 |
C00000919
|
| 3880 | KRT19, CK19, K19, K1CS | keratin 19 |
C00000919
|
| 3849 | KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE | keratin 2 |
C00000919
|
| 3855 | KRT7, CK7, K2C7, K7, SCL | keratin 7 |
C00000919
|
| 3856 | KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO | keratin 8 |
C00000919
|
| 8022 | LHX3, CPHD3, LIM3, M2-LHX3 | LIM homeobox 3 |
C00000919
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000919
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000919
|
| 4153 | MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD | mannose-binding lectin (protein C) 2, soluble |
C00000919
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00000919
|
| 4212 | MEIS2, HsT18361, MRG1 | Meis homeobox 2 |
C00000919
|
| 4222 | MEOX1, KFS2, MOX1 | mesenchyme homeobox 1 |
C00000919
|
| 2623 | GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT | GATA binding protein 1 (globin transcription factor 1) |
C00002938
|
| 3110 | MNX1, HB9, HLXB9, HOXHB9, SCRA1 | motor neuron and pancreas homeobox 1 |
C00000919
|
| 4439 | MSH5, G7, MUTSH5, NG23 | mutS homolog 5 |
C00000919
|
| 4586 | MUC5AC, MUC5, TBM, leB | mucin 5AC, oligomeric mucus/gel-forming |
C00000919
|
| 4842 | NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS | nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) |
C00000919
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000919
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00000919
|
| 5098 | PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 | protocadherin gamma subfamily C, 3 |
C00000919
|
| 5359 | PLSCR1, MMTRA1B | phospholipid scramblase 1 |
C00000919
|
| 57048 | PLSCR3 | phospholipid scramblase 3 |
C00000919
|
| 57088 | PLSCR4, TRA1 | phospholipid scramblase 4 |
C00000919
|
| 10635 | RAD51AP1, PIR51 | RAD51 associated protein 1 |
C00000919
|
| 5892 | RAD51D, BROVCA4, R51H3, RAD51L3, TRAD | RAD51 paralog D |
C00000919
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00000919
|
| 5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00000919
|
| 5918 | RARRES1, LXNL, TIG1 | retinoic acid receptor responder (tazarotene induced) 1 |
C00000919
|
| 5950 | RBP4, RDCCAS | retinol binding protein 4, plasma |
C00000919
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00000919
|
| 949 | SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 | scavenger receptor class B, member 1 |
C00000919
|
| 4990 | SIX6, MCOPCT2, OPTX2, Six9 | SIX homeobox 6 |
C00000919
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00000919
|
| 9517 | SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a | serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) |
C00000919
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00000919
|
| 7052 | TGM2, G-ALPHA-h, GNAH, TG2, TGC | transglutaminase 2 (EC:2.3.2.13) |
C00000919
|
| 7047 | TGM4, TGP, hTGP | transglutaminase 4 (EC:2.3.2.13) |
C00000919
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000919
|
| 3604 | TNFRSF9, 4-1BB, CD137, CDw137, ILA | tumor necrosis factor receptor superfamily, member 9 |
C00000919
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00000919
|
| 10190 | TXNDC9, APACD, PHLP3 | thioredoxin domain containing 9 |
C00000919
|
| 7517 | XRCC3, CMM6 | X-ray repair complementing defective repair in Chinese hamster cells 3 |
C00000919
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #227600 | Factor x deficiency |
P00742
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P16109
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P28907
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00020 | Colorectal cancer |
Q07812
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D056486 | Drug-Induced Liver Injury |
C00002670
C00000919 |
| D015658 | HIV Infections |
C00000919
|
| D000435 | Alcoholic Intoxication |
C00000919
|
| D001145 | Arrhythmias, Cardiac |
C00000919
|
| D053627 | Asthenozoospermia |
C00000919
|
| D002545 | Brain Ischemia |
C00000919
|
| D006528 | Carcinoma, Hepatocellular |
C00000919
|
| D002318 | Cardiovascular Diseases |
C00000919
|
| D003930 | Diabetic Retinopathy |
C00000919
|
| D006526 | Hepatitis C |
C00000919
|
| D048629 | Micronuclei, Chromosome-Defective |
C00002670
|
| D006986 | Hypervitaminosis A |
C00000919
|
| D008107 | Liver Diseases |
C00000919
|
| D008113 | Liver Neoplasms |
C00000919
|
| D008114 | Liver Neoplasms, Experimental |
C00000919
|
| D008175 | Lung Neoplasms |
C00000919
|
| D009369 | Neoplasms |
C00000919
|
| D009845 | Oligospermia |
C00000919
|
| D013272 | Stomach Diseases |
C00000919
|
| D013276 | Stomach Ulcer |
C00000919
|