Species

KNApSAcK Entry

Organism name Rosa spp.
Genus Rosa
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rosa
Linked NCBI taxonomy ID 3764
Linked level genus

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006728 External link 512 Petunin
/ Petunidin 3,5-di-O-beta-D-glucoside
No. 1 No. 15
C00006658 External link 512 Cyanidin 3-sophoroside
No. 1 No. 15
C00002376 External link 512 Cyanidin 3-rutinoside
CHEMBL505251
C020386
3 / 0 / 1 No. 1 No. 15
C00002378 External link 512 Cyanin
/ Cyanidin 3,5-diglucoside
No. 1 No. 15
C00006686 External link 512 Peonidin 3-rutinoside
No. 1 No. 15
C00002387 External link 512 Pelargonin
/ Pelargonidin 3,5-di-beta-D-glucoside
No. 1 No. 15
C00002374 External link 512 Chrysanthemin
/ Cyanidin 3-O-glucoside
CHEMBL257839
CHEMBL1197952
C114438
1 / 0 / 1 No. 2 No. 15
C00005132 External link 512 Juglanin
/ Kaempferol 3-O-arabinoside
/ (-)-Kaempferol 3-O-arabinoside
CHEMBL469440
No. 2 No. 15
C00006630 External link 512 Callistephin
/ Pelargonidin 3-O-beta-D-glucopyranoside
C078485
No. 2 No. 15
C00000919 External link 512 beta-Carotene
CHEMBL1293
CHEMBL1966639
D019207
7 / 12 / 11 104 / 19 No. 26 No. 59
C00006800 External link 512 Hyacinthin
/ Cyanidin 3-(6-O-p-coumarylglucoside)
No. 30 No. 15
C00006861 External link 512 Peonidin 3-(6''-p-coumarylglucoside)
No. 30 No. 15
C00003760 External link 512 Antheraxanthin
/ (3R,5R,6S,3'R)-zeaxanthin 5,6-epoxide
C031140
No. 114 No. 59
C00002920 External link 512 Eugeniin
CHEMBL450745
CHEMBL510512
C110634
1 / 1 / 0 No. 302 No. 81
C00002938 External link 512 Tellimagrandin I
CHEMBL450376
C087926
7 / 0 No. 302 No. 81
C00003772 External link 512 Flavoxanthin
No. 664 No. 59
C00002670 External link 512 Pyrogallol
CHEMBL307145
D011748
115 / 69 / 60 8 / 2 No. 1590 No. 82
C00011383 External link 512 (E)-4,8-Dimethyl-1,3,7-nonatriene
No. 4390

Human Protein / Gene in interactions

122 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00000919 C00002670 11 / 10
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000919 C00002670 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000919 C00002670 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000919 C00002670 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000919 C00002670 0 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002670 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002670 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002670 0 / 0
P29466 Caspase-1 C14 C00002670 0 / 0
P17252 Protein kinase C alpha type Alpha C00002670 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002670 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002670 2 / 2
P28907 ADP-ribosyl cyclase 1 Enzyme C00002374 0 / 1
Q07812 Apoptosis regulator BAX Unclassified protein C00002376 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002670 1 / 0
P00918 Carbonic anhydrase 2 Lyase C00002670 1 / 2
P08246 Neutrophil elastase S1A C00002670 2 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002670 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002670 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002670 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002670 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002670 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002670 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002670 2 / 2
P02768 Serum albumin Secreted protein C00002670 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002670 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002670 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002670 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002670 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002670 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00002670 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00002670 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002670 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002670 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002670 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002670 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002670 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002670 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002670 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002670 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002670 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002670 1 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002670 0 / 3
P16581 E-selectin Adhesion C00002670 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002670 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000919 0 / 0
O75496 Geminin Unclassified protein C00000919 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002670 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002670 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002670 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002670 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002670 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002670 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002670 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002670 0 / 1
P00742 Coagulation factor X S1A C00002920 1 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002670 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002670 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002670 0 / 0
P10145 Interleukin-8 Secreted protein C00002670 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002670 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00002670 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002670 0 / 0
P08311 Cathepsin G S1A C00002670 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002670 1 / 0
P03956 Interstitial collagenase M10A C00002670 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002670 0 / 0
Q16611 Bcl-2 homologous antagonist/killer Unclassified protein C00002376 0 / 0
O43521 Bcl-2-like protein 11 Unclassified protein C00002376 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002670 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002670 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002670 0 / 0
P14679 Tyrosinase Oxidoreductase C00002670 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002670 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002670 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002670 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002670 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002670 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002670 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002670 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002670 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002670 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002670 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002670 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002670 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002670 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002670 2 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002670 0 / 0
P03372 Estrogen receptor NR3A1 C00002670 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00002670 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002670 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002670 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002670 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002670 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002670 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002670 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002670 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002670 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002670 0 / 0
P14151 L-selectin Adhesion C00002670 0 / 0
P16109 P-selectin Adhesion C00002670 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002670 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002670 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002670 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002670 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002670 5 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002670 0 / 0
P10275 Androgen receptor NR3C4 C00002670 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002670 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002670 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002670 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002670 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002670 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002670 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002670 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002670 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002670 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002670 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002670 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002670 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002670 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002670 0 / 0

118 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000919 C00002670
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00000919
2624 GATA2, DCML, MONOMAC, NFE1B GATA binding protein 2 C00002938
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00002938
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002938
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00002938
4778 NFE2, NF-E2, p45 nuclear factor, erythroid 2 C00002938
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00002670
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00002938
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002670
847 CAT catalase (EC:1.11.1.6) C00002670
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002670
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002670
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002670
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002670
124 ADH1A, ADH1 alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) C00000919
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00000919
221 ALDH3B1, ALDH4, ALDH7 aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) C00000919
8659 ALDH4A1, ALDH4, P5CD, P5CDh aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) C00000919
287 ANK2, ANK-2, LQT4, brank-2 ankyrin 2, neuronal C00000919
288 ANK3, ANKYRIN-G, MRT37 ankyrin 3, node of Ranvier (ankyrin G) C00000919
427 ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) C00000919
51665 ASB1, ASB-1 ankyrin repeat and SOCS box containing 1 C00000919
140462 ASB9 ankyrin repeat and SOCS box containing 9 C00000919
9531 BAG3, BAG-3, BIS, CAIR-1, MFM6 BCL2-associated athanogene 3 C00000919
9530 BAG4, BAG-4, SODD BCL2-associated athanogene 4 C00000919
9529 BAG5, BAG-5 BCL2-associated athanogene 5 C00000919
581 BAX, BCL2L4 BCL2-associated X protein C00000919
53630 BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1 beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) C00000919
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00000919
8837 CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS CASP8 and FADD-like apoptosis regulator C00000919
9071 CLDN10, CPETRL3, OSP-L claudin 10 C00000919
51208 CLDN18, SFTA5, SFTPJ claudin 18 C00000919
1277 COL1A1, OI4 collagen, type I, alpha 1 C00000919
1282 COL4A1, HANAC, ICH, POREN1, arresten collagen, type IV, alpha 1 C00000919
1284 COL4A2, ICH, POREN2 collagen, type IV, alpha 2 C00000919
8738 CRADD, MRT34, RAIDD CASP2 and RIPK1 domain containing adaptor with death domain C00000919
1508 CTSB, APPS, CPSB cathepsin B (EC:3.4.22.1) C00000919
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00000919
6372 CXCL6, CKA-3, GCP-2, GCP2, SCYB6 chemokine (C-X-C motif) ligand 6 C00000919
4283 CXCL9, CMK, Humig, MIG, SCYB9, crg-10 chemokine (C-X-C motif) ligand 9 C00000919
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00000919
1592 CYP26A1, CP26, CYP26, P450RAI, P450RAI1 cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) C00000919
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000919
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000919
64816 CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1) C00000919
1746 DLX2, TES-1, TES1 distal-less homeobox 2 C00000919
1748 DLX4, BP1, DLX7, DLX8, DLX9 distal-less homeobox 4 C00000919
2068 ERCC2, COFS2, EM9, TTD, XPD excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) C00000919
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000919
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000919
23017 FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2 Fas apoptotic inhibitory molecule 2 C00000919
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000919
3169 FOXA1, HNF3A, TCF3A forkhead box A1 C00000919
2627 GATA6 GATA binding protein 6 C00000919
2633 GBP1 guanylate binding protein 1, interferon-inducible C00000919
81025 GJA9, CX58, CX59, GJA10 gap junction protein, alpha 9, 59kDa C00000919
373156 GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 glutathione S-transferase kappa 1 (EC:2.5.1.18) C00000919
2946 GSTM2, GST4, GSTM, GSTM2-2, GTHMUS glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) C00000919
2948 GSTM4, GSTM4-4, GTM4 glutathione S-transferase mu 4 (EC:2.5.1.18) C00000919
2949 GSTM5, GSTM5-5, GTM5 glutathione S-transferase mu 5 (EC:2.5.1.18) C00000919
2954 GSTZ1, GSTZ1-1, MAAI, MAI glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) C00000919
3204 HOXA7, ANTP, HOX1, HOX1.1, HOX1A homeobox A7 C00000919
3216 HOXB6, HOX2, HOX2B, HU-2, Hox-2.2 homeobox B6 C00000919
3226 HOXC10, HOX3I homeobox C10 C00000919
3448 IFNA14, IFN-alphaH, LEIF2H interferon, alpha 14 C00000919
3449 IFNA16, IFN-alphaO interferon, alpha 16 C00000919
3451 IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1 interferon, alpha 17 C00000919
3442 IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G interferon, alpha 5 C00000919
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000919
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000919
3394 IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8 interferon regulatory factor 8 C00000919
50805 IRX4, IRXA3 iroquois homeobox 4 C00000919
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00000919
3691 ITGB4, CD104 integrin, beta 4 C00000919
3713 IVL involucrin C00000919
3875 KRT18, CYK18, K18 keratin 18 C00000919
3880 KRT19, CK19, K19, K1CS keratin 19 C00000919
3849 KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE keratin 2 C00000919
3855 KRT7, CK7, K2C7, K7, SCL keratin 7 C00000919
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00000919
8022 LHX3, CPHD3, LIM3, M2-LHX3 LIM homeobox 3 C00000919
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000919
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000919
4153 MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD mannose-binding lectin (protein C) 2, soluble C00000919
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00000919
4212 MEIS2, HsT18361, MRG1 Meis homeobox 2 C00000919
4222 MEOX1, KFS2, MOX1 mesenchyme homeobox 1 C00000919
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002938
3110 MNX1, HB9, HLXB9, HOXHB9, SCRA1 motor neuron and pancreas homeobox 1 C00000919
4439 MSH5, G7, MUTSH5, NG23 mutS homolog 5 C00000919
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00000919
4842 NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) C00000919
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000919
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00000919
5098 PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 protocadherin gamma subfamily C, 3 C00000919
5359 PLSCR1, MMTRA1B phospholipid scramblase 1 C00000919
57048 PLSCR3 phospholipid scramblase 3 C00000919
57088 PLSCR4, TRA1 phospholipid scramblase 4 C00000919
10635 RAD51AP1, PIR51 RAD51 associated protein 1 C00000919
5892 RAD51D, BROVCA4, R51H3, RAD51L3, TRAD RAD51 paralog D C00000919
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00000919
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000919
5918 RARRES1, LXNL, TIG1 retinoic acid receptor responder (tazarotene induced) 1 C00000919
5950 RBP4, RDCCAS retinol binding protein 4, plasma C00000919
6256 RXRA, NR2B1 retinoid X receptor, alpha C00000919
949 SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 scavenger receptor class B, member 1 C00000919
4990 SIX6, MCOPCT2, OPTX2, Six9 SIX homeobox 6 C00000919
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000919
9517 SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) C00000919
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00000919
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC:2.3.2.13) C00000919
7047 TGM4, TGP, hTGP transglutaminase 4 (EC:2.3.2.13) C00000919
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000919
3604 TNFRSF9, 4-1BB, CD137, CDw137, ILA tumor necrosis factor receptor superfamily, member 9 C00000919
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000919
10190 TXNDC9, APACD, PHLP3 thioredoxin domain containing 9 C00000919
7517 XRCC3, CMM6 X-ray repair complementing defective repair in Chinese hamster cells 3 C00000919

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (70)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#227600 Factor x deficiency P00742
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P16109
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (62)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00020 Colorectal cancer Q07812 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

20 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002670
C00000919
D015658 HIV Infections C00000919
D000435 Alcoholic Intoxication C00000919
D001145 Arrhythmias, Cardiac C00000919
D053627 Asthenozoospermia C00000919
D002545 Brain Ischemia C00000919
D006528 Carcinoma, Hepatocellular C00000919
D002318 Cardiovascular Diseases C00000919
D003930 Diabetic Retinopathy C00000919
D006526 Hepatitis C C00000919
D048629 Micronuclei, Chromosome-Defective C00002670
D006986 Hypervitaminosis A C00000919
D008107 Liver Diseases C00000919
D008113 Liver Neoplasms C00000919
D008114 Liver Neoplasms, Experimental C00000919
D008175 Lung Neoplasms C00000919
D009369 Neoplasms C00000919
D009845 Oligospermia C00000919
D013272 Stomach Diseases C00000919
D013276 Stomach Ulcer C00000919