KCF-S cluster No. 26 (119 metabolites)
Corresponding Phytochemical cluster No. 59
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 106 |
| asterids | 25 |
| Liliopsida | 17 |
| Viridiplantae | 14 |
| eudicotyledons | 12 |
| Spermatophyta | 3 |
| Euphyllophyta | 3 |
| Magnoliophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Fabaceae
|
68 |
|
Siluridae
|
50 |
|
Corbiculidae
|
32 |
|
Phasmatidae
|
17 |
|
Bagridae
|
16 |
|
Rhizobiaceae
|
14 |
|
Rhodomelaceae
|
12 |
|
Cyprinidae
|
11 |
|
Brassicaceae
|
10 |
|
Solanaceae
|
10 |
|
Ranunculaceae
|
9 |
|
Asteraceae
|
8 |
|
Rosaceae
|
8 |
|
Asterinidae
|
8 |
|
Myrtaceae
|
7 |
|
Coryphaenidae
|
7 |
|
Ictaluridae
|
7 |
|
Ceramiaceae
|
7 |
|
Enterobacteriaceae
|
7 |
|
Sinipercidae
|
7 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Carotenoids | 12 |
metabolites link (13)
Metabolite list (119)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000917
|
Adonixanthin
/ Doradexanthin |
|
||||
|
C00000918
|
Astaxanthin
/ (3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione |
CHEMBL445751
CHEMBL1358053 |
C005948
|
1 / 4 / 3 | 0 / 7 |
|
|
C00000919
|
beta-Carotene
|
CHEMBL1293
CHEMBL1966639 |
D019207
|
7 / 12 / 11 | 104 / 19 |
|
|
C00000920
|
beta-Cryptoxanthin
|
C010564
|
|
|||
|
C00000922
|
Canthaxanthin
/ beta-Carotene-4,4'-dione |
CHEMBL1329004
|
D016644
|
4 / 4 / 3 | 0 / 1 |
|
|
C00000925
|
Myxoxanthine
/ beta-Echinenone |
C105515
|
|
|||
|
C00000929
|
Phenicoxanthin
/ all-trans-Adonirubin |
|
||||
|
C00000931
|
Zeaxanthin
/ all-trans-Zeaxanthin |
CHEMBL1357855
CHEMBL2359248 |
C005881
|
4 / 2 / 3 | 1 / 0 |
|
|
C00003765
|
alpha-Carotene
|
|
||||
|
C00003770
|
alpha-Cryptoxanthin
|
|
||||
|
C00003771
|
Eschscholtzxanthin
|
|
||||
|
C00003775
|
Lactucaxanthin
|
|
||||
|
C00003776
|
Lutein
/ (all-E)-Lutein / all-trans-(+)-Xanthophyll / (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol |
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
D014975
|
4 / 2 / 3 | 7 / 2 |
|
|
C00003784
|
Rhodoxanthin
|
C038054
|
|
|||
|
C00007425
|
4-Ketolutein
/ 3,3'-dihydroxy-beta,epsilon-carotene-4-one |
|
||||
|
C00022801
|
3,3',4,4',7,7',8,8'-Octadehydro-beta,beta-carotene
|
|
||||
|
C00022802
|
(6'S)-beta,gamma-Carotene
/ (6S)-5,18-Didehydro-5,6-dihydro-beta,beta-carotene |
|
||||
|
C00022809
|
gamma,gamma-Carotene
|
|
||||
|
C00022813
|
epsilon-Carotene
|
|
||||
|
C00022814
|
(6S,6'S)-epsilon,epsilon-Carotene
|
|
||||
|
C00022831
|
(2R)-beta,beta-Caroten-2-ol
|
|
||||
|
C00022832
|
(3R)-7,8,3',4',7',8'-Hexadehydro-beta,beta-caroten-3-ol
|
|
||||
|
C00022833
|
(3R)-3',4',7',8'-tetradehydro-beta,beta-Caroten-3-ol
|
|
||||
|
C00022834
|
Deoxylutein II
/ Anhydrolutein I |
CHEMBL172328
|
|
|||
|
C00022835
|
(2R,6'R)-beta,epsilon-Caroten-2-ol
|
|
||||
|
C00022836
|
(3R,6'R)-7,8-Didehydro-beta,epsilon-caroten-3-ol
|
|
||||
|
C00022837
|
(3'R,6'S)-beta,epsilon-Caroten-3'-ol
|
|
||||
|
C00022860
|
(2R,3R)-beta,beta-Carotene-2,3-diol
|
|
||||
|
C00022861
|
(2R,2'R)-beta,beta-Carotene-2,2'-diol
|
|
||||
|
C00022862
|
Alloxanthin
/ Cynthiaxanthin / Pectenoxanthin / (3R,3'R)-7,7',8,8'-Tetradehydro-beta,beta-carotene-3,3'-diol |
C006462
|
|
|||
|
C00022863
|
Diatoxanthin
/ (3R,3'R)-7,8-Didehydro-beta,beta-carotene-3,3'-diol |
C103105
|
|
|||
|
C00022866
|
Parasiloxanthin
/ 7,8-Dihydro-beta,beat-carotene-3,3'-diol |
|
||||
|
C00022867
|
7,8-Dihydroparasiloxanthin
/ 7,7',8,8'-Tetrahydro-beta,beat-carotene-3,3'-diol |
|
||||
|
C00022868
|
Isozeaxanthin
/ beta,beta-Carotene-4,4'-diol |
|
||||
|
C00022869
|
Nigroxanthin
/ (3R,6'S)-3',18'-Didehydro-beta,epsilon-carotene-3,6'-diol |
|
||||
|
C00022871
|
(3R,3'R,6'S)-beta,epsilon-Carotene-3,3'-diol
|
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 |
|
||
|
C00022872
|
Lutein B
/ 3'-Epilutein / Calthaxanthin / (3R,3'S,6'R)-beta,epsilon-Carotene-3,3'-diol |
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 |
|
||
|
C00022873
|
Lutein D
/ (3R,3'S,6'S)-beta,epsilon-Carotene-3,3'-diol |
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 |
|
||
|
C00022879
|
Tunaxanthin H
/ (3R,3'R,6R,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022880
|
Tunaxanthin I
/ (3R,6R,3'S,6'R)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022881
|
Tunaxanthin E
/ (3R,3'S,6R,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022882
|
Tunaxanthin C
/ (3R,3'R,6S,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022883
|
Tunaxanthin D
/ (3R,3'S,6S,6'R)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022884
|
Tunaxanthin J
/ Chiriquixanthin / Chiriquixanthin B / (3S,3'S,6R,6'R)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022885
|
Tunaxanthin B
/ (3R,3'S,6S,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022886
|
Tunaxanthin G
/ (3S,3'S,6R,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022887
|
Tunaxanthin A
/ Oxyxanthin 45 / (3S,3'S,6S,6'S)-epsilon,epsilon-Carotene-3,3'-diol |
|
||||
|
C00022906
|
Caloxanthin
/ (2R,3R,3'R)-beta,beta-Carotene-2,3,3'-triol |
|
||||
|
C00022907
|
(3S,4R,3'R)-4-Hydroxyalloxanthin
/ (3S,3'R,4R)-7,7',8,8'-Tetradehydro-beta,beta-carotene-3,3',4-triol |
|
||||
|
C00022908
|
(3S,4S,3'R)-4-Hydroxyalloxanthin
/ (3S,3'R,4S)-7,7',8,8'-Tetradehydro-beta,beta-carotene-3,3',4-triol |
|
||||
|
C00022909
|
Pectenol A
/ (3S,3'R,4R)-7',8'-Didehydro-beta,beta-carotene-3,3',4-triol |
|
||||
|
C00022910
|
(3S,3'R,4R)-beta,beta-Carotene-3,3',4-triol
|
|
||||
|
C00022911
|
(3S,4S,3'R)-beta,beta-Carotene-3,4,3'-triol
|
|
||||
|
C00022914
|
(3S,3'S,4R,6'R)-beta,epsilon-Carotene-3,3',4-triol
|
|
||||
|
C00022915
|
(3S,3'R,4R,6'R)-beta,epsilon-Carotene-3,3',4-triol
|
|
||||
|
C00022916
|
Loroxanthin
/ (3R,3'R,6'R)-beta,epsilon-Carotene-3,3',19-triol |
|
||||
|
C00022917
|
Gobiusxanthin
/ 7,8-Didehydrodeepoxysalmoxanthin / (3R,3'S,6'R)-7,8-Didehydro-beta,epsilon-carotene-3,3',6'-triol |
|
||||
|
C00022918
|
Deepoxysalmoxanthin
/ (3R,3'S,6'R)-beta,epsilon-Carotene-3,3',6'-triol |
|
||||
|
C00022919
|
Micromonol
/ (3R,3'R,6'R)-7',8'-Dihydro-beta,epsilon-carotene-3,3',19'-triol |
|
||||
|
C00022921
|
Nostoxanthin
/ (2R,3R,2'R,3'R)-beta,beta-Carotene-2,3,2',3'-tetrol |
|
||||
|
C00022922
|
4,4'-Dihydroxyalloxanthin
/ (3S,3'S,4S,4'S)-7,7',8,8'-Tetradehydro-beta,beta-carotene-3,3',4,4'-tetrol |
|
||||
|
C00022923
|
4,4'-Dihydroxydiatoxanthin
/ (3S,3'S,4S,4'S)-7,8-Didehydro-beta,beta-carotene-3,3',4,4'-tetrol |
|
||||
|
C00022924
|
Crustaxanthin
/ beta,beta-Carotene-3,3',4,4'-tetrol |
|
||||
|
C00022966
|
3,4-Didehydro-beta,beta-caroten-2-one
|
|
||||
|
C00022967
|
beta,beta-Caroten-2-one
|
|
||||
|
C00022969
|
beta,epsilon-Caroten-2-one
|
|
||||
|
C00022973
|
3,4-Didehydro-2'-hydroxy-beta,beta-caroten-2-one
|
|
||||
|
C00022974
|
2'-Hydroxy-beta,beta-caroten-2-one
|
|
||||
|
C00022975
|
2,3-Didehydro-3-hydroxy-beta,beta-caroten-4-one
|
|
||||
|
C00022976
|
(2R)-2-Hydroxy-beta,beta-caroten-4-one
|
|
||||
|
C00022977
|
3-Hydroxyechinenone
/ 3-Hydroxy-beta,beta-caroten-4-one |
|
||||
|
C00022980
|
3'-Hydroxyechinenone
/ 3'-Hydroxy-beta,beta-caroten-4-one |
|
||||
|
C00022981
|
4'-Hydroxy-beta,beta-caroten-4-one
|
|
||||
|
C00022983
|
3'-Dehydrolutein
/ (3R,6'R)-3-Hydroxy-beta,epsilon-caroten-3'-one |
CHEMBL1999562
|
C051820
|
|
||
|
C00022997
|
(3'R,6S,6'S)-3'-Hydroxy-epsilon,epsilon-Caroten-3-one
|
|
||||
|
C00023002
|
2,3-Dihydroxyechinenone
/ (2,3-trans)-2,3-Dihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023003
|
Pectenolone
/ 7',8'-Didehydro-3,3'-dihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023005
|
alpha-Doradecin
/ 3'-Hydroxy-beta,epsilon-carotene-3,4-dione |
|
||||
|
C00023006
|
Fritschiellaxanthin
/ (3S,3'R,6'R)-3,3'-Dihydroxy-beta,epsilon-caroten-4-one |
|
||||
|
C00023007
|
alpha-Doradexanthin
/ (3S,3'S,6'R)-3,3'-Dihydroxy-beta,epsilon-caroten-4-one |
C037439
|
|
|||
|
C00023017
|
(3S,3'S,4'R)-4-keto-4'-Hydroxyalloxanthin
/ (3S,3'S,4'R)-7,7',8,8'-Tetradehydro-3,3',4'-trihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023018
|
4-Keto-4'-hydroxyalloxanthin
/ (3S,3'S,4'S)-7,7',8,8'-Tetradehydro-3,3',4'-trihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023019
|
(3S,3'S,4'R)-4-Keto-4'-hydroxydiatoxanthin
/ (3S,3'S,4'R)-7',8'-Didehydro-3,3',4'-trihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023020
|
4-Keto-4'-hydroxydiatoxanthin
/ (3S,3'S,4'S)-7',8'-Didehydro-3,3',4'-trihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023021
|
Idoxanthin
/ 3,3',4'-Trihydroxy-beta,beta-caroten-4-one |
|
||||
|
C00023022
|
Siphonaxanthin
/ (3R,3'R,6'R)-7,8-Dihydro-8-oxo-beta,epsilon-carotene-3,3',19-triol |
C003314
|
|
|||
|
C00023027
|
(2R,2'R,3S,3'R)-2,2',3,3'-Tetrahydroxy-beta,beta-caroten-4-one
|
|
||||
|
C00023043
|
Eschscholtzxanthone
/ (3'S)-4',5'-Didehydro-3'-hydroxy-4,5'-retro-beta,beta-caroten-3-one |
|
||||
|
C00023044
|
3,4,3',4'-Tetradehydro-beta,beta-carotene-2,2'-dione
|
|
||||
|
C00023045
|
3,4-Didehydro-b,b-carotene-2,2'-dione
|
|
||||
|
C00023046
|
beta,beta-Carotene-2,2'-dione
|
|
||||
|
C00023049
|
(6S,6'S)-epsilon,epsilon-Carotene-3,3'-dione
|
CHEMBL1969059
|
|
|||
|
C00023050
|
Phoeniconone
/ 2,3-Didehydro-3-hydroxy-beta,beta-carotene-4,4'-dione |
|
||||
|
C00023051
|
2-Hydroxycanthaxanthin
/ (2R)-2-Hydroxy-beta,beta-carotene-4,4'-dione |
|
||||
|
C00023055
|
(2R,3S)-2,3-Dihydroxy-beta,beta-carotene-4,4'-dione
|
|
||||
|
C00023056
|
7,7',8,8'-Tetradehydroastaxanthin
/ (3S,3'S)-7,7',8,8'-Tetradehydro-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione |
|
||||
|
C00023057
|
7,8-Didehydroastaxanthin
/ (3S,3'S)-7,8-Didehydro-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione |
C014344
|
|
|||
|
C00023058
|
(3R,3'R)-Astaxanthin
/ (3R,3'R)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione |
CHEMBL445751
CHEMBL1358053 |
1 / 4 / 3 |
|
||
|
C00023059
|
meso-Astaxanthin
/ (3R,3'S)-Astaxanthin / (3R,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione |
CHEMBL445751
CHEMBL1358053 |
1 / 4 / 3 |
|
||
|
C00023069
|
(2R,2'R,3S,3'S)-2,2',3,3'-Tetrahydroxy-beta,beta-carotene-4,4'-dione
|
|
||||
|
C00023157
|
3,4-Diketo-2',3'-dihydroxy-2-nor-beta-carotene
|
|
||||
|
C00023159
|
Hurghadin
/ (3R,3'R)-Actinioerythrol / (3R,3'R)-3,3'-Dihydroxy-2,2'-dinor-beta,beta-carotene-4,4'-dione |
|
||||
|
C00023160
|
Actinioerythrol
/ 2,2'-Bisnorastaxanthin / (3S,3'S)-3,3'-Dihydroxy-2,2'-dinor-beta,beta-carotene-4,4'-dione |
|
||||
|
C00023214
|
7,8-Dihydro-beta,beta-carotene
|
|
||||
|
C00023215
|
7,7',8,8'-Tetrahydro-beta,beta-carotene
|
|
||||
|
C00023216
|
(3R)-7',8'-Dihydro-beta-cryptoxanthin
|
|
||||
|
C00023217
|
7,8-Dihydrolutein A
|
|
||||
|
C00023218
|
(3R,3'S)-Zeaxanthin
|
CHEMBL1357855
CHEMBL2359248 |
4 / 2 / 3 |
|
||
|
C00023219
|
(3S,3'S)-Zeaxanthin
|
CHEMBL1357855
CHEMBL2359248 |
4 / 2 / 3 |
|
||
|
C00023230
|
(6'R)-alpha-Echinenone
|
|
||||
|
C00023231
|
Isocryptoxanthin
/ beta,beta-Caroten-4-ol |
|
||||
|
C00023232
|
7,8-Didehydro-beta,beta-caroten-3-ol
|
|
||||
|
C00023234
|
(3S,3'S,4R,4'R)-Crustaxanthin
|
|
||||
|
C00023248
|
(9Z)-beta,beta-Carotene
|
CHEMBL1293
CHEMBL1966639 |
7 / 12 / 11 |
|
||
|
C00023249
|
(13Z)-beta,beta-Carotene
|
CHEMBL1293
CHEMBL1966639 |
7 / 12 / 11 |
|
||
|
C00023250
|
(15Z)-beta,beta-Carotene
|
CHEMBL1293
CHEMBL1966639 |
7 / 12 / 11 |
|
||
|
C00035776
|
(9Z)-Lutein
|
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 |
|
||
|
C00035777
|
(9'Z)-Lutein
|
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 |
|
||
|
C00043845
|
Prenigroxanthin
|
|
Human Protein / Gene in interactions
12 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00000919 C00000931 C00003776 C00022871 C00022872 C00022873 C00023218 C00023219 C00023248 C00023249 C00023250 C00035776 C00035777 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000922 C00000931 C00003776 C00022871 C00022872 C00022873 C00023218 C00023219 C00035776 C00035777 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000931 C00003776 C00022871 C00022872 C00022873 C00023218 C00023219 C00035776 C00035777 | 2 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000931 C00003776 C00022871 C00022872 C00022873 C00023218 C00023219 C00035776 C00035777 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000919 C00000922 C00023248 C00023249 C00023250 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000919 C00023248 C00023249 C00023250 | 11 / 10 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000919 C00023248 C00023249 C00023250 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000918 C00000922 C00023058 C00023059 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000919 C00023248 C00023249 C00023250 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000919 C00023248 C00023249 C00023250 | 0 / 1 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000919 C00023248 C00023249 C00023250 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000922 | 0 / 0 |
111 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000919
C00003776
|
| 3110 | MNX1, HB9, HLXB9, HOXHB9, SCRA1 | motor neuron and pancreas homeobox 1 |
C00000919
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003776
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003776
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00003776
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00003776
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003776
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003776
|
| 124 | ADH1A, ADH1 | alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) |
C00000919
|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00000919
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00000919
|
| 8659 | ALDH4A1, ALDH4, P5CD, P5CDh | aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) |
C00000919
|
| 287 | ANK2, ANK-2, LQT4, brank-2 | ankyrin 2, neuronal |
C00000919
|
| 288 | ANK3, ANKYRIN-G, MRT37 | ankyrin 3, node of Ranvier (ankyrin G) |
C00000919
|
| 427 | ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME | N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) |
C00000919
|
| 51665 | ASB1, ASB-1 | ankyrin repeat and SOCS box containing 1 |
C00000919
|
| 140462 | ASB9 | ankyrin repeat and SOCS box containing 9 |
C00000919
|
| 9531 | BAG3, BAG-3, BIS, CAIR-1, MFM6 | BCL2-associated athanogene 3 |
C00000919
|
| 9530 | BAG4, BAG-4, SODD | BCL2-associated athanogene 4 |
C00000919
|
| 9529 | BAG5, BAG-5 | BCL2-associated athanogene 5 |
C00000919
|
| 53630 | BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1 | beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) |
C00000919
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000919
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00000919
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00000919
|
| 9071 | CLDN10, CPETRL3, OSP-L | claudin 10 |
C00000919
|
| 51208 | CLDN18, SFTA5, SFTPJ | claudin 18 |
C00000919
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00000919
|
| 1282 | COL4A1, HANAC, ICH, POREN1, arresten | collagen, type IV, alpha 1 |
C00000919
|
| 1284 | COL4A2, ICH, POREN2 | collagen, type IV, alpha 2 |
C00000919
|
| 8738 | CRADD, MRT34, RAIDD | CASP2 and RIPK1 domain containing adaptor with death domain |
C00000919
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00000919
|
| 6387 | CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B | chemokine (C-X-C motif) ligand 12 |
C00000919
|
| 6372 | CXCL6, CKA-3, GCP-2, GCP2, SCYB6 | chemokine (C-X-C motif) ligand 6 |
C00000919
|
| 4283 | CXCL9, CMK, Humig, MIG, SCYB9, crg-10 | chemokine (C-X-C motif) ligand 9 |
C00000919
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00000919
|
| 1592 | CYP26A1, CP26, CYP26, P450RAI, P450RAI1 | cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) |
C00000919
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000919
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000919
|
| 64816 | CYP3A43 | cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1) |
C00000919
|
| 1746 | DLX2, TES-1, TES1 | distal-less homeobox 2 |
C00000919
|
| 1748 | DLX4, BP1, DLX7, DLX8, DLX9 | distal-less homeobox 4 |
C00000919
|
| 2068 | ERCC2, COFS2, EM9, TTD, XPD | excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) |
C00000919
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000919
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000919
|
| 23017 | FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2 | Fas apoptotic inhibitory molecule 2 |
C00000919
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000919
|
| 3169 | FOXA1, HNF3A, TCF3A | forkhead box A1 |
C00000919
|
| 2627 | GATA6 | GATA binding protein 6 |
C00000919
|
| 2633 | GBP1 | guanylate binding protein 1, interferon-inducible |
C00000919
|
| 81025 | GJA9, CX58, CX59, GJA10 | gap junction protein, alpha 9, 59kDa |
C00000919
|
| 373156 | GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 | glutathione S-transferase kappa 1 (EC:2.5.1.18) |
C00000919
|
| 2946 | GSTM2, GST4, GSTM, GSTM2-2, GTHMUS | glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) |
C00000919
|
| 2948 | GSTM4, GSTM4-4, GTM4 | glutathione S-transferase mu 4 (EC:2.5.1.18) |
C00000919
|
| 2949 | GSTM5, GSTM5-5, GTM5 | glutathione S-transferase mu 5 (EC:2.5.1.18) |
C00000919
|
| 2954 | GSTZ1, GSTZ1-1, MAAI, MAI | glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) |
C00000919
|
| 3204 | HOXA7, ANTP, HOX1, HOX1.1, HOX1A | homeobox A7 |
C00000919
|
| 3216 | HOXB6, HOX2, HOX2B, HU-2, Hox-2.2 | homeobox B6 |
C00000919
|
| 3226 | HOXC10, HOX3I | homeobox C10 |
C00000919
|
| 3448 | IFNA14, IFN-alphaH, LEIF2H | interferon, alpha 14 |
C00000919
|
| 3449 | IFNA16, IFN-alphaO | interferon, alpha 16 |
C00000919
|
| 3451 | IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1 | interferon, alpha 17 |
C00000919
|
| 3442 | IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G | interferon, alpha 5 |
C00000919
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000919
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000919
|
| 3394 | IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8 | interferon regulatory factor 8 |
C00000919
|
| 50805 | IRX4, IRXA3 | iroquois homeobox 4 |
C00000919
|
| 3688 | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
C00000919
|
| 3691 | ITGB4, CD104 | integrin, beta 4 |
C00000919
|
| 3713 | IVL | involucrin |
C00000919
|
| 3875 | KRT18, CYK18, K18 | keratin 18 |
C00000919
|
| 3880 | KRT19, CK19, K19, K1CS | keratin 19 |
C00000919
|
| 3849 | KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE | keratin 2 |
C00000919
|
| 3855 | KRT7, CK7, K2C7, K7, SCL | keratin 7 |
C00000919
|
| 3856 | KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO | keratin 8 |
C00000919
|
| 8022 | LHX3, CPHD3, LIM3, M2-LHX3 | LIM homeobox 3 |
C00000919
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000919
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000919
|
| 4153 | MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD | mannose-binding lectin (protein C) 2, soluble |
C00000919
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00000919
|
| 4212 | MEIS2, HsT18361, MRG1 | Meis homeobox 2 |
C00000919
|
| 4222 | MEOX1, KFS2, MOX1 | mesenchyme homeobox 1 |
C00000919
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00000919
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00000931
|
| 4439 | MSH5, G7, MUTSH5, NG23 | mutS homolog 5 |
C00000919
|
| 4586 | MUC5AC, MUC5, TBM, leB | mucin 5AC, oligomeric mucus/gel-forming |
C00000919
|
| 4842 | NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS | nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) |
C00000919
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000919
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00000919
|
| 5098 | PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 | protocadherin gamma subfamily C, 3 |
C00000919
|
| 5359 | PLSCR1, MMTRA1B | phospholipid scramblase 1 |
C00000919
|
| 57048 | PLSCR3 | phospholipid scramblase 3 |
C00000919
|
| 57088 | PLSCR4, TRA1 | phospholipid scramblase 4 |
C00000919
|
| 10635 | RAD51AP1, PIR51 | RAD51 associated protein 1 |
C00000919
|
| 5892 | RAD51D, BROVCA4, R51H3, RAD51L3, TRAD | RAD51 paralog D |
C00000919
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00000919
|
| 5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00000919
|
| 5918 | RARRES1, LXNL, TIG1 | retinoic acid receptor responder (tazarotene induced) 1 |
C00000919
|
| 5950 | RBP4, RDCCAS | retinol binding protein 4, plasma |
C00000919
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00000919
|
| 949 | SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 | scavenger receptor class B, member 1 |
C00000919
|
| 4990 | SIX6, MCOPCT2, OPTX2, Six9 | SIX homeobox 6 |
C00000919
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00000919
|
| 9517 | SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a | serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) |
C00000919
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00000919
|
| 7052 | TGM2, G-ALPHA-h, GNAH, TG2, TGC | transglutaminase 2 (EC:2.3.2.13) |
C00000919
|
| 7047 | TGM4, TGP, hTGP | transglutaminase 4 (EC:2.3.2.13) |
C00000919
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000919
|
| 3604 | TNFRSF9, 4-1BB, CD137, CDw137, ILA | tumor necrosis factor receptor superfamily, member 9 |
C00000919
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00000919
|
| 10190 | TXNDC9, APACD, PHLP3 | thioredoxin domain containing 9 |
C00000919
|
| 7517 | XRCC3, CMM6 | X-ray repair complementing defective repair in Chinese hamster cells 3 |
C00000919
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
Diseases related to CTD interactions
28 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008114 | Liver Neoplasms, Experimental |
C00000918
C00000919 |
| D006528 | Carcinoma, Hepatocellular |
C00000919
|
| D003110 | Colonic Neoplasms |
C00000918
|
| D003921 | Diabetes Mellitus, Experimental |
C00000918
|
| D003924 | Diabetes Mellitus, Type 2 |
C00000918
|
| D000230 | Adenocarcinoma |
C00000918
|
| D015427 | Reperfusion Injury |
C00000918
|
| D007939 | Leukemia L1210 |
C00003776
|
| D014605 | Uveitis |
C00003776
|
| D005128 | Eye Diseases |
C00000922
|
| D000435 | Alcoholic Intoxication |
C00000919
|
| D001145 | Arrhythmias, Cardiac |
C00000919
|
| D053627 | Asthenozoospermia |
C00000919
|
| D002545 | Brain Ischemia |
C00000919
|
| D003092 | Colitis |
C00000918
|
| D002318 | Cardiovascular Diseases |
C00000919
|
| D003930 | Diabetic Retinopathy |
C00000919
|
| D056486 | Drug-Induced Liver Injury |
C00000919
|
| D006526 | Hepatitis C |
C00000919
|
| D015658 | HIV Infections |
C00000919
|
| D006986 | Hypervitaminosis A |
C00000919
|
| D008107 | Liver Diseases |
C00000919
|
| D008113 | Liver Neoplasms |
C00000919
|
| D008175 | Lung Neoplasms |
C00000919
|
| D009369 | Neoplasms |
C00000919
|
| D009845 | Oligospermia |
C00000919
|
| D013272 | Stomach Diseases |
C00000919
|
| D013276 | Stomach Ulcer |
C00000919
|