Psidium guajava

• Index
• Plant Species
• Natural Activity
• Metabolite list (41)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Psidium guajava
Genus	Psidium
Family	Myrtaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Psidium guajava
Linked NCBI taxonomy ID	120290
Linked level	species

Family

Family in NCBI taxonomy	Myrtaceae
ID	3931

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (68)

Species	Activity
Psidium guajava L.	Abortifacient
Psidium guajava L.	Amebicide
Psidium guajava L.	Analgesic
Psidium guajava L.	Anti-HIV
Psidium guajava L.	Antiadhesive
Psidium guajava L.	Antibacterial
Psidium guajava L.	Anticolitic
Psidium guajava L.	Anticonvulsant
Psidium guajava L.	Antidiarrheal
Psidium guajava L.	Antidiarrheic
Psidium guajava L.	Antiemetic
Psidium guajava L.	Antiepileptic
Psidium guajava L.	Antigastritic
Psidium guajava L.	AntiHIV
Psidium guajava L.	Antihyperglycemic
Psidium guajava L.	Antiinflammatory
Psidium guajava L.	Antiinsomniac
Psidium guajava L.	Antiischemic
Psidium guajava L.	Antileukemic
Psidium guajava L.	Antimalarial
Psidium guajava L.	Antimutagenic
Psidium guajava L.	Antimutagenic
Psidium guajava L.	Antioxidant
Psidium guajava L.	Antioxidant
Psidium guajava L.	Antiperistaltic
Psidium guajava L.	Antiplasmodial
Psidium guajava L.	Antiproliferant
Psidium guajava L.	Antiradicular
Psidium guajava L.	Antiseptic
Psidium guajava L.	Antiseptic
Psidium guajava L.	Antispasmodic
Psidium guajava L.	Antispasmodic
Psidium guajava L.	Antitumor
Psidium guajava L.	Antitumor
Psidium guajava L.	Antitussive
Psidium guajava L.	Antiviral
Psidium guajava L.	Aperient
Psidium guajava L.	Aphrodisiac
Psidium guajava L.	Astringent
Psidium guajava L.	Astringent
Psidium guajava L.	Bactericide
Psidium guajava L.	Candidicide
Psidium guajava L.	Candidicide
Psidium guajava L.	Cardiodepressant
Psidium guajava L.	Cardioprotective
Psidium guajava L.	Chemopreventive
Psidium guajava L.	CNS-Depressant
Psidium guajava L.	Digestive
Psidium guajava L.	Emmenagogue
Psidium guajava L.	Expectorant
Psidium guajava L.	Expectorant
Psidium guajava L.	Febrifuge
Psidium guajava L.	Gastrotonic
Psidium guajava L.	Hemostat
Psidium guajava L.	Hemostat
Psidium guajava L.	Hypoglycemic
Psidium guajava L.	Hypoglycemic
Psidium guajava L.	Hypotensive
Psidium guajava L.	Myorelaxant
Psidium guajava L.	Proaggregant
Psidium guajava L.	Radioprotective
Psidium guajava L.	Radioprotective
Psidium guajava L.	Sedative
Psidium guajava L.	Sedative
Psidium guajava L.	Tonic
Psidium guajava L.	Vasoconstrictor
Psidium guajava L.	Vasoconstrictor
Psidium guajava L.	Vulnerary

Metabolite list (41)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00013836	Quercetin 4'-glucuronide / 2-Hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl beta-D-glucopyranosiduronic acid					No. 2	No. 15
C00005367	Avicularin / Avicularine / Avicularoside / Quercetin 3-alpha-L-arabinofuranoside / Quercetin 3-O-alpha-L-arabinofuranoside	CHEMBL471282 CHEMBL1590676	C041388	10 / 2 / 3		No. 2	No. 15
C00005368	Guaijaverin / Quercetin 3-O-alpha-L-arabinopyranoside	CHEMBL183031 CHEMBL185461 CHEMBL488198 CHEMBL464507 CHEMBL520637	C088178			No. 2	No. 15
C00036480	Colosic acid / 2alpha-Hydroxyursolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993	C113861	17 / 7 / 6		No. 13	No. 51
C00003739	Asiatic acid	CHEMBL278622 CHEMBL404313 CHEMBL1395292 CHEMBL1488520 CHEMBL1564373 CHEMBL1773214	C017032	11 / 14 / 43	1 / 0	No. 13	No. 51
C00009117	Prodelphinidin B1 / Epigallocatechin-(4beta->8)-gallocatechin	CHEMBL349509 CHEMBL161013				No. 16	No. 19
C00037295	Ilelatifol D					No. 23	No. 51
C00000920	beta-Cryptoxanthin		C010564			No. 26	No. 59
C00000919	beta-Carotene	CHEMBL1293 CHEMBL1966639	D019207	7 / 12 / 11	104 / 19	No. 26	No. 59
C00023249	(13Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 26	No. 59
C00023248	(9Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 26	No. 59
C00023250	(15Z)-beta,beta-Carotene	CHEMBL1293 CHEMBL1966639		7 / 12 / 11		No. 26	No. 59
C00003776	Lutein / (all-E)-Lutein / all-trans-(+)-Xanthophyll / (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol	CHEMBL173929 CHEMBL172477 CHEMBL1559643 CHEMBL1979448	D014975	4 / 2 / 3	7 / 2	No. 26	No. 59
C00037357	Jacoumaric acid	CHEMBL507062 CHEMBL443637				No. 78
C00037334	Isoneriucoumaric acid					No. 78
C00037223	Guavacoumaric acid					No. 78
C00023251	(9Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 97	No. 59
C00023253	(15Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 97	No. 59
C00000913	Phytofluene					No. 97	No. 59
C00023252	(13Z)-Lycopene	CHEMBL501174 CHEMBL1984187		6 / 13 / 13		No. 97	No. 59
C00000911	Lycopene / all-trans-Lycopene	CHEMBL501174 CHEMBL1984187	C015329	6 / 13 / 13	84 / 13	No. 97	No. 59
C00003785	Rubixanthin					No. 131	No. 59
C00000926	gamma-Carotene					No. 131	No. 59
C00009339	Eugenigrandin A	CHEMBL508771				No. 142
C00009366	Guavin D					No. 142
C00009338	Guajavin B	CHEMBL507287				No. 142
C00009365	Guavin C					No. 142
C00009364	Guavin A					No. 142
C00009337	Psiguavin					No. 142
C00009336	Psidinin C					No. 142
C00009335	Psidinin B					No. 142
C00009340	Guajavin A					No. 142
C00009334	Psidinin A					No. 142
C00037224	Guavanoic acid					No. 177
C00002909	Casuarictin	CHEMBL305099 CHEMBL446979	C073064			No. 226	No. 81
C00002910	Casuarinin	CHEMBL79244 CHEMBL507387		11 / 2 / 2		No. 226	No. 81
C00002938	Tellimagrandin I	CHEMBL450376	C087926		7 / 0	No. 302	No. 81
C00019308	Doursterol / Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside	CHEMBL197711 CHEMBL506678 CHEMBL2304043	C011015	5 / 4 / 2	0 / 3	No. 520
C00022949	(3S,5R,8S)-5,8-Epoxy-5,8-dihydro-beta,beta-caroten-3-ol					No. 664	No. 59
C00023254	(8'R)-Neochrome					No. 664	No. 59
C00002647	Gallic acid	CHEMBL288114	D005707	42 / 53 / 68	52 / 16	No. 817	No. 81

Human Protein / Gene in interactions

86 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000911 C00000919 C00003776 C00005367 C00023248 C00023249 C00023250 C00023251 C00023252 C00023253 C00036480	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000911 C00000919 C00002647 C00023248 C00023249 C00023250 C00023251 C00023252 C00023253	11 / 10
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000911 C00002647 C00003776 C00023251 C00023252 C00023253	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000911 C00002647 C00003776 C00023251 C00023252 C00023253	2 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00000911 C00002647 C00005367 C00023251 C00023252 C00023253	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000911 C00003776 C00023251 C00023252 C00023253	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000919 C00002647 C00023248 C00023249 C00023250	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000919 C00002647 C00023248 C00023249 C00023250	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	0 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	1 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000919 C00023248 C00023249 C00023250	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003739 C00019308 C00036480	0 / 0
P15121	Aldose reductase	Enzyme	C00002647 C00003739 C00005367	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002647 C00036480	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002647 C00003739	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002647 C00003739	4 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00005367 C00036480	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00003739 C00036480	0 / 1
P06746	DNA polymerase beta	Enzyme	C00019308 C00036480	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002647 C00003739	7 / 37
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002647 C00005367	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00002647	1 / 1
Q9ULX7	Carbonic anhydrase 14	Lyase	C00002647	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00036480	0 / 0
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00036480	1 / 1
P16581	E-selectin	Adhesion	C00002647	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00002647	1 / 2
P39748	Flap endonuclease 1	Enzyme	C00005367	0 / 0
P78536	Disintegrin and metalloproteinase domain-containing protein 17	M12B	C00002647	1 / 0
P42858	Huntingtin	Unclassified protein	C00036480	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00036480	2 / 0
P00918	Carbonic anhydrase 2	Lyase	C00002647	1 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00003739	3 / 2
P10145	Interleukin-8	Secreted protein	C00002647	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00002647	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019308	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00005367	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00005367	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00005367	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00036480	0 / 0
P08047	Transcription factor Sp1	Unclassified protein	C00019308	0 / 0
P00734	Prothrombin	S1A	C00019308	4 / 2
P04150	Glucocorticoid receptor	NR3C1	C00002647	0 / 1
Q96RI1	Bile acid receptor	NR1H4	C00003739	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00036480	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00002647	2 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00002647	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00002647	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002647	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002647	2 / 2
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00003739	0 / 0
P03372	Estrogen receptor	NR3A1	C00002647	1 / 1
P12821	Angiotensin-converting enzyme	M2	C00002647	4 / 2
P14151	L-selectin	Adhesion	C00002647	0 / 0
P16109	P-selectin	Adhesion	C00002647	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003739	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00005367	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002647	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00002647	5 / 1
P43166	Carbonic anhydrase 7	Lyase	C00002647	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00002647	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00002647	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00002647	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00036480	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00002647	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00036480	1 / 1
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00036480	0 / 0
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00002647	3 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002647	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002647	0 / 3
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002647	1 / 1
Q05513	Protein kinase C zeta type	Iota	C00002910	0 / 0
Q04759	Protein kinase C theta type	Delta	C00002910	0 / 1
Q02156	Protein kinase C epsilon type	Eta	C00002910	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00002910	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002910	0 / 0
Q05655	Protein kinase C delta type	Delta	C00002910	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00002910	1 / 1
P05771	Protein kinase C beta type	Alpha	C00002910	0 / 0
P24723	Protein kinase C eta type	Eta	C00002910	1 / 0
P41743	Protein kinase C iota type	Iota	C00002910	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00002910	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00003739	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00036480	1 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00002647	4 / 1
P11217	Glycogen phosphorylase, muscle form	Enzyme	C00036480	1 / 1

223 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
581	BAX, BCL2L4	BCL2-associated X protein	C00000919 C00002647 C00003776
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000911 C00000919 C00002647
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000911 C00000919 C00002647
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000911 C00002647
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000919 C00002647
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000919 C00002647
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00000919 C00002647
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000919 C00002647
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000911 C00002647
847	CAT	catalase (EC:1.11.1.6)	C00000911 C00003776
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00000911 C00003776
898	CCNE1, CCNE	cyclin E1	C00000911 C00002647
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002647 C00003776
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000911 C00002647
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00000919 C00002647
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002647 C00003776
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00000911 C00002647
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000911 C00002647
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00000911 C00002647
4842	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	C00000911 C00000919
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000911 C00002647
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000911 C00000919
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002647 C00003776
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00000911 C00002647
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000911 C00000919
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000911 C00000919
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00000911 C00002647
3713	IVL	involucrin	C00000911 C00000919
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00000911 C00002647
4153	MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD	mannose-binding lectin (protein C) 2, soluble	C00000919
2701	GJA4, CX37	gap junction protein, alpha 4, 37kDa	C00000911
2702	GJA5, ATFB11, CX40	gap junction protein, alpha 5, 40kDa	C00000911
2879	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx	glutathione peroxidase 4 (EC:1.11.1.12)	C00000911
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00000911
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000911
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00000911
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00000911
3485	IGFBP2, IBP2, IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	C00000911
2188	FANCF, FAF	Fanconi anemia, complementation group F	C00000911
3716	JAK1, JAK1A, JAK1B, JTK3	Janus kinase 1 (EC:2.7.10.2)	C00000911
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000911
3796	KIF2A, CDCBM3, HK2, KIF2	kinesin heavy chain member 2A	C00000911
3838	KPNA2, IPOA1, QIP2, RCH1, SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	C00000911
2176	FANCC, FA3, FAC, FACC	Fanconi anemia, complementation group C	C00000911
3988	LIPA, CESD, LAL	lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)	C00000911
1981	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18	eukaryotic translation initiation factor 4 gamma, 1	C00000911
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00000911
6416	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1	mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)	C00000911
5608	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	C00000911
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000911
1643	DDB2, DDBB, UV-DDB2	damage-specific DNA binding protein 2, 48kDa	C00000911
23418	CRB1, LCA8, RP12	crumbs homolog 1 (Drosophila)	C00000911
4247	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143)	C00000911
100507436	MICA, MIC-A, PERB11.1	MHC class I polypeptide-related sequence A	C00000911
4292	MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1	mutL homolog 1	C00000911
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00000911
2956	MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160	mutS homolog 6	C00000911
1114	CHGB, SCG1	chromogranin B (secretogranin 1)	C00000911
8021	NUP214, CAIN, CAN, D9S46E, N214, p250	nucleoporin 214kDa	C00000911
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00000911
1113	CHGA, CGA	chromogranin A (parathyroid secretory protein 1)	C00000911
10111	RAD50, NBSLD, RAD502, hRad50	RAD50 homolog (S. cerevisiae)	C00000911
8045	RASSF7, C11orf13, HRAS1, HRC1	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	C00000911
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000911
5962	RDX, DFNB24	radixin	C00000911
1025	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK	cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22)	C00000911
6197	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)	C00000911
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00000911
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000911
6414	SEPP1, SELP, SeP	selenoprotein P, plasma, 1	C00000911
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00000911
8243	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB	structural maintenance of chromosomes 1A	C00000911
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00000911
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00000911
7980	TFPI2, PP5, REF1, TFPI-2	tissue factor pathway inhibitor 2	C00000911
7039	TGFA, TFGA	transforming growth factor, alpha	C00000911
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00000911
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00000911
1022	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15	cyclin-dependent kinase 7 (EC:2.7.11.23 2.7.11.22)	C00000911
1020	CDK5, PSSALRE	cyclin-dependent kinase 5 (EC:2.7.11.22)	C00000911
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000911
7415	VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97	valosin containing protein (EC:3.6.4.6)	C00000911
7485	WRB, CHD5	tryptophan rich basic protein	C00000911
7697	ZNF138, pHZ-32	zinc finger protein 138	C00000911
7416	VDAC1, PORIN, VDAC-1	voltage-dependent anion channel 1	C00003739
43	ACHE, ACEE, ARACHE, N-ACHE, YT	acetylcholinesterase (EC:3.1.1.7)	C00002938
2623	GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT	GATA binding protein 1 (globin transcription factor 1)	C00002938
2624	GATA2, DCML, MONOMAC, NFE1B	GATA binding protein 2	C00002938
2993	GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2	glycophorin A (MNS blood group)	C00002938
3145	HMBS, PBG-D, PBGD, PORC, UPS	hydroxymethylbilane synthase (EC:2.5.1.61)	C00002938
3690	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	C00002938
4778	NFE2, NF-E2, p45	nuclear factor, erythroid 2	C00002938
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002647
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00002647
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00002647
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00002647
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00002647
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000911
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000911
613	BCR, ALL, BCR1, CML, D22S11, D22S662, PHL	breakpoint cluster region (EC:2.7.11.1)	C00002647
673	BRAF, B-RAF1, BRAF1, NS7, RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	C00000911
998	CDC42, CDC42Hs, G25K	cell division cycle 42	C00002647
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002647
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00002647
8314	BAP1, HUCEP-13, UCHL2	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC:3.4.19.12)	C00000911
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002647
2551	GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07	GA binding protein transcription factor, alpha subunit 60kDa	C00002647
2885	GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2	growth factor receptor-bound protein 2	C00002647
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002647
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002647
571	BACH1, BACH-1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	C00000911
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00000911
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00002647
118	ADD1, ADDA	adducin 1 (alpha)	C00000911
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002647
4316	MMP7, MMP-7, MPSL1, PUMP-1	matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23)	C00002647
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002647
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00002647
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00002647
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000911
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00002647
19412			C00002647
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000911
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00002647
388	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6	ras homolog family member B	C00002647
9252	RPS6KA5, MSK1, MSPK1, RLPK	ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1)	C00002647
6622	SNCA, NACP, PARK1, PARK4, PD1	synuclein, alpha (non A4 component of amyloid precursor)	C00002647
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00002647
7224	TRPC5, TRP5	transient receptor potential cation channel, subfamily C, member 5	C00002647
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002647
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002647
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00003776
124	ADH1A, ADH1	alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1)	C00000919
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00000919
221	ALDH3B1, ALDH4, ALDH7	aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5)	C00000919
8659	ALDH4A1, ALDH4, P5CD, P5CDh	aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88)	C00000919
287	ANK2, ANK-2, LQT4, brank-2	ankyrin 2, neuronal	C00000919
288	ANK3, ANKYRIN-G, MRT37	ankyrin 3, node of Ranvier (ankyrin G)	C00000919
427	ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME	N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23)	C00000919
51665	ASB1, ASB-1	ankyrin repeat and SOCS box containing 1	C00000919
140462	ASB9	ankyrin repeat and SOCS box containing 9	C00000919
9531	BAG3, BAG-3, BIS, CAIR-1, MFM6	BCL2-associated athanogene 3	C00000919
9530	BAG4, BAG-4, SODD	BCL2-associated athanogene 4	C00000919
9529	BAG5, BAG-5	BCL2-associated athanogene 5	C00000919
53630	BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1	beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36)	C00000919
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00000919
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00000919
9071	CLDN10, CPETRL3, OSP-L	claudin 10	C00000919
51208	CLDN18, SFTA5, SFTPJ	claudin 18	C00000919
1277	COL1A1, OI4	collagen, type I, alpha 1	C00000919
1282	COL4A1, HANAC, ICH, POREN1, arresten	collagen, type IV, alpha 1	C00000919
1284	COL4A2, ICH, POREN2	collagen, type IV, alpha 2	C00000919
8738	CRADD, MRT34, RAIDD	CASP2 and RIPK1 domain containing adaptor with death domain	C00000919
1508	CTSB, APPS, CPSB	cathepsin B (EC:3.4.22.1)	C00000919
6387	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B	chemokine (C-X-C motif) ligand 12	C00000919
6372	CXCL6, CKA-3, GCP-2, GCP2, SCYB6	chemokine (C-X-C motif) ligand 6	C00000919
4283	CXCL9, CMK, Humig, MIG, SCYB9, crg-10	chemokine (C-X-C motif) ligand 9	C00000919
1592	CYP26A1, CP26, CYP26, P450RAI, P450RAI1	cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-)	C00000919
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00000919
64816	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1)	C00000919
1746	DLX2, TES-1, TES1	distal-less homeobox 2	C00000919
1748	DLX4, BP1, DLX7, DLX8, DLX9	distal-less homeobox 4	C00000919
2068	ERCC2, COFS2, EM9, TTD, XPD	excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12)	C00000919
23017	FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2	Fas apoptotic inhibitory molecule 2	C00000919
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00000919
3169	FOXA1, HNF3A, TCF3A	forkhead box A1	C00000919
2627	GATA6	GATA binding protein 6	C00000919
2633	GBP1	guanylate binding protein 1, interferon-inducible	C00000919
81025	GJA9, CX58, CX59, GJA10	gap junction protein, alpha 9, 59kDa	C00000919
373156	GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1	glutathione S-transferase kappa 1 (EC:2.5.1.18)	C00000919
2946	GSTM2, GST4, GSTM, GSTM2-2, GTHMUS	glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18)	C00000919
2948	GSTM4, GSTM4-4, GTM4	glutathione S-transferase mu 4 (EC:2.5.1.18)	C00000919
2949	GSTM5, GSTM5-5, GTM5	glutathione S-transferase mu 5 (EC:2.5.1.18)	C00000919
2954	GSTZ1, GSTZ1-1, MAAI, MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	C00000919
3204	HOXA7, ANTP, HOX1, HOX1.1, HOX1A	homeobox A7	C00000919
3216	HOXB6, HOX2, HOX2B, HU-2, Hox-2.2	homeobox B6	C00000919
3226	HOXC10, HOX3I	homeobox C10	C00000919
3448	IFNA14, IFN-alphaH, LEIF2H	interferon, alpha 14	C00000919
3449	IFNA16, IFN-alphaO	interferon, alpha 16	C00000919
3451	IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1	interferon, alpha 17	C00000919
3442	IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G	interferon, alpha 5	C00000919
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000919
3394	IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8	interferon regulatory factor 8	C00000919
50805	IRX4, IRXA3	iroquois homeobox 4	C00000919
3688	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	C00000919
3691	ITGB4, CD104	integrin, beta 4	C00000919
3875	KRT18, CYK18, K18	keratin 18	C00000919
3880	KRT19, CK19, K19, K1CS	keratin 19	C00000919
3849	KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE	keratin 2	C00000919
3855	KRT7, CK7, K2C7, K7, SCL	keratin 7	C00000919
3856	KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO	keratin 8	C00000919
8022	LHX3, CPHD3, LIM3, M2-LHX3	LIM homeobox 3	C00000919
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000911
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00000919
4212	MEIS2, HsT18361, MRG1	Meis homeobox 2	C00000919
4222	MEOX1, KFS2, MOX1	mesenchyme homeobox 1	C00000919
3110	MNX1, HB9, HLXB9, HOXHB9, SCRA1	motor neuron and pancreas homeobox 1	C00000919
4439	MSH5, G7, MUTSH5, NG23	mutS homolog 5	C00000919
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00000919
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000919
4973	OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1	oxidized low density lipoprotein (lectin-like) receptor 1	C00000919
5098	PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2	protocadherin gamma subfamily C, 3	C00000919
5359	PLSCR1, MMTRA1B	phospholipid scramblase 1	C00000919
57048	PLSCR3	phospholipid scramblase 3	C00000919
57088	PLSCR4, TRA1	phospholipid scramblase 4	C00000919
10635	RAD51AP1, PIR51	RAD51 associated protein 1	C00000919
5892	RAD51D, BROVCA4, R51H3, RAD51L3, TRAD	RAD51 paralog D	C00000919
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00000919
5915	RARB, HAP, NR1B2, RRB2	retinoic acid receptor, beta	C00000919
5918	RARRES1, LXNL, TIG1	retinoic acid receptor responder (tazarotene induced) 1	C00000919
5950	RBP4, RDCCAS	retinol binding protein 4, plasma	C00000919
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00000919
949	SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1	scavenger receptor class B, member 1	C00000919
4990	SIX6, MCOPCT2, OPTX2, Six9	SIX homeobox 6	C00000919
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000919
9517	SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a	serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50)	C00000919
6720	SREBF1, SREBP-1c, SREBP1, bHLHd1	sterol regulatory element binding transcription factor 1	C00000919
7052	TGM2, G-ALPHA-h, GNAH, TG2, TGC	transglutaminase 2 (EC:2.3.2.13)	C00000919
7047	TGM4, TGP, hTGP	transglutaminase 4 (EC:2.3.2.13)	C00000919
3604	TNFRSF9, 4-1BB, CD137, CDw137, ILA	tumor necrosis factor receptor superfamily, member 9	C00000919
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00000919
10190	TXNDC9, APACD, PHLP3	thioredoxin domain containing 9	C00000919
7517	XRCC3, CMM6	X-ray repair complementing defective repair in Chinese hamster cells 3	C00000919

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