Species

KNApSAcK Entry

Organism name Medicago glomerata
Genus Medicago
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Medicago glomerata
Linked NCBI taxonomy ID 66813
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001071 External link 512 Myricetin
CHEMBL164
C040015
78 / 70 / 56 39 / 2 No. 3 No. 15
C00000919 External link 512 beta-Carotene
CHEMBL1293
CHEMBL1966639
D019207
7 / 12 / 11 104 / 19 No. 26 No. 59
C00000931 External link 512 Zeaxanthin
/ all-trans-Zeaxanthin
CHEMBL1357855
CHEMBL2359248
C005881
4 / 2 / 3 1 / 0 No. 26 No. 59
C00002547 External link 512 (-)-Medicarpin
/ 3-Hydroxy-9-methoxypterocarpan
CHEMBL238845
CHEMBL413297
C047353
3 / 1 / 1 No. 66 No. 15
C00000913 External link 512 Phytofluene
No. 97 No. 59

Human Protein / Gene in interactions

86 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000919 C00000931 C00002547 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000931 C00001071 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000931 C00001071 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000931 C00001071 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00000919 C00001071 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001071 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001071 2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001071 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001071 0 / 3
P06746 DNA polymerase beta Enzyme C00001071 0 / 0
P04062 Glucosylceramidase Enzyme C00001071 6 / 4
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00001071 9 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001071 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00001071 0 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001071 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000919 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001071 1 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim C00001071 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001071 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001071 0 / 1
P54132 Bloom syndrome protein Enzyme C00001071 1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00001071 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001071 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00001071 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00001071 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001071 1 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00001071 1 / 1
Q9Y3R4 Sialidase-2 Enzyme C00001071 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001071 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001071 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00001071 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001071 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001071 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000919 0 / 0
P31941 DNA dC->dU-editing enzyme APOBEC-3A Enzyme C00001071 0 / 0
P15121 Aldose reductase Enzyme C00001071 0 / 0
Q14790 Caspase-8 C14 C00001071 2 / 1
Q9Y253 DNA polymerase eta Enzyme C00001071 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00001071 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00001071 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001071 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001071 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001071 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001071 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00001071 0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00001071 5 / 4
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001071 2 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001071 4 / 4
P06276 Cholinesterase Hydrolase C00001071 0 / 0
P04745 Alpha-amylase 1 Enzyme C00001071 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001071 2 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00001071 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001071 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001071 3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001071 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001071 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00001071 5 / 2
P22303 Acetylcholinesterase Hydrolase C00001071 1 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00001071 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001071 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001071 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001071 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001071 0 / 0
Q15046 Lysine--tRNA ligase Enzyme C00001071 2 / 1
Q99700 Ataxin-2 Unclassified protein C00001071 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001071 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001071 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001071 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002547 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00001071 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001071 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001071 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001071 0 / 0
P40225 Thrombopoietin Unclassified protein C00001071 1 / 1
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001071 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001071 1 / 1
O00255 Menin Unclassified protein C00001071 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001071 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001071 1 / 4
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000919 0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000919 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000919 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001071 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001071 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002547 1 / 1
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00001071 0 / 0

141 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000919 C00001071
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000919 C00001071
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000919 C00001071
8022 LHX3, CPHD3, LIM3, M2-LHX3 LIM homeobox 3 C00000919
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000931
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001071
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00001071
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001071
847 CAT catalase (EC:1.11.1.6) C00001071
891 CCNB1, CCNB cyclin B1 C00001071
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001071
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00001071
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001071
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00001071
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001071
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001071
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001071
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00001071
54583 EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) C00001071
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00001071
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00001071
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00001071
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00001071
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001071
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00001071
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001071
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00001071
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00001071
8505 PARG, PARG99 poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) C00001071
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001071
8000 PSCA, PRO232 prostate stem cell antigen C00001071
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001071
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001071
23411 SIRT1, SIR2L1 sirtuin 1 C00001071
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00001071
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001071
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00001071
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00001071
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00001071
7161 TP73, P73 tumor protein p73 C00001071
124 ADH1A, ADH1 alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) C00000919
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00000919
221 ALDH3B1, ALDH4, ALDH7 aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) C00000919
8659 ALDH4A1, ALDH4, P5CD, P5CDh aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) C00000919
287 ANK2, ANK-2, LQT4, brank-2 ankyrin 2, neuronal C00000919
288 ANK3, ANKYRIN-G, MRT37 ankyrin 3, node of Ranvier (ankyrin G) C00000919
427 ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) C00000919
51665 ASB1, ASB-1 ankyrin repeat and SOCS box containing 1 C00000919
140462 ASB9 ankyrin repeat and SOCS box containing 9 C00000919
9531 BAG3, BAG-3, BIS, CAIR-1, MFM6 BCL2-associated athanogene 3 C00000919
9530 BAG4, BAG-4, SODD BCL2-associated athanogene 4 C00000919
9529 BAG5, BAG-5 BCL2-associated athanogene 5 C00000919
53630 BCMO1, BCDO, BCDO1, BCMO, BCO, BCO1 beta-carotene 15,15'-monooxygenase 1 (EC:1.14.99.36) C00000919
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00000919
8837 CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS CASP8 and FADD-like apoptosis regulator C00000919
9071 CLDN10, CPETRL3, OSP-L claudin 10 C00000919
51208 CLDN18, SFTA5, SFTPJ claudin 18 C00000919
1277 COL1A1, OI4 collagen, type I, alpha 1 C00000919
1282 COL4A1, HANAC, ICH, POREN1, arresten collagen, type IV, alpha 1 C00000919
1284 COL4A2, ICH, POREN2 collagen, type IV, alpha 2 C00000919
8738 CRADD, MRT34, RAIDD CASP2 and RIPK1 domain containing adaptor with death domain C00000919
1508 CTSB, APPS, CPSB cathepsin B (EC:3.4.22.1) C00000919
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00000919
6372 CXCL6, CKA-3, GCP-2, GCP2, SCYB6 chemokine (C-X-C motif) ligand 6 C00000919
4283 CXCL9, CMK, Humig, MIG, SCYB9, crg-10 chemokine (C-X-C motif) ligand 9 C00000919
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00000919
1592 CYP26A1, CP26, CYP26, P450RAI, P450RAI1 cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) C00000919
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000919
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000919
64816 CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 (EC:1.14.14.1) C00000919
1746 DLX2, TES-1, TES1 distal-less homeobox 2 C00000919
1748 DLX4, BP1, DLX7, DLX8, DLX9 distal-less homeobox 4 C00000919
2068 ERCC2, COFS2, EM9, TTD, XPD excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) C00000919
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000919
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000919
23017 FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2 Fas apoptotic inhibitory molecule 2 C00000919
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000919
3169 FOXA1, HNF3A, TCF3A forkhead box A1 C00000919
2627 GATA6 GATA binding protein 6 C00000919
2633 GBP1 guanylate binding protein 1, interferon-inducible C00000919
81025 GJA9, CX58, CX59, GJA10 gap junction protein, alpha 9, 59kDa C00000919
373156 GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 glutathione S-transferase kappa 1 (EC:2.5.1.18) C00000919
2946 GSTM2, GST4, GSTM, GSTM2-2, GTHMUS glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) C00000919
2948 GSTM4, GSTM4-4, GTM4 glutathione S-transferase mu 4 (EC:2.5.1.18) C00000919
2949 GSTM5, GSTM5-5, GTM5 glutathione S-transferase mu 5 (EC:2.5.1.18) C00000919
2954 GSTZ1, GSTZ1-1, MAAI, MAI glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) C00000919
3204 HOXA7, ANTP, HOX1, HOX1.1, HOX1A homeobox A7 C00000919
3216 HOXB6, HOX2, HOX2B, HU-2, Hox-2.2 homeobox B6 C00000919
3226 HOXC10, HOX3I homeobox C10 C00000919
3448 IFNA14, IFN-alphaH, LEIF2H interferon, alpha 14 C00000919
3449 IFNA16, IFN-alphaO interferon, alpha 16 C00000919
3451 IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1 interferon, alpha 17 C00000919
3442 IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G interferon, alpha 5 C00000919
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000919
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000919
3394 IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8 interferon regulatory factor 8 C00000919
50805 IRX4, IRXA3 iroquois homeobox 4 C00000919
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00000919
3691 ITGB4, CD104 integrin, beta 4 C00000919
3713 IVL involucrin C00000919
3875 KRT18, CYK18, K18 keratin 18 C00000919
3880 KRT19, CK19, K19, K1CS keratin 19 C00000919
3849 KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE keratin 2 C00000919
3855 KRT7, CK7, K2C7, K7, SCL keratin 7 C00000919
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00000919
397 ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2 Rho GDP dissociation inhibitor (GDI) beta C00001071
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000919
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000919
4153 MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD mannose-binding lectin (protein C) 2, soluble C00000919
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00000919
4212 MEIS2, HsT18361, MRG1 Meis homeobox 2 C00000919
4222 MEOX1, KFS2, MOX1 mesenchyme homeobox 1 C00000919
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00000919
3110 MNX1, HB9, HLXB9, HOXHB9, SCRA1 motor neuron and pancreas homeobox 1 C00000919
4439 MSH5, G7, MUTSH5, NG23 mutS homolog 5 C00000919
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00000919
4842 NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) C00000919
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000919
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00000919
5098 PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 protocadherin gamma subfamily C, 3 C00000919
5359 PLSCR1, MMTRA1B phospholipid scramblase 1 C00000919
57048 PLSCR3 phospholipid scramblase 3 C00000919
57088 PLSCR4, TRA1 phospholipid scramblase 4 C00000919
10635 RAD51AP1, PIR51 RAD51 associated protein 1 C00000919
5892 RAD51D, BROVCA4, R51H3, RAD51L3, TRAD RAD51 paralog D C00000919
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00000919
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000919
5918 RARRES1, LXNL, TIG1 retinoic acid receptor responder (tazarotene induced) 1 C00000919
5950 RBP4, RDCCAS retinol binding protein 4, plasma C00000919
6256 RXRA, NR2B1 retinoid X receptor, alpha C00000919
949 SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 scavenger receptor class B, member 1 C00000919
4990 SIX6, MCOPCT2, OPTX2, Six9 SIX homeobox 6 C00000919
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000919
9517 SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) C00000919
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00000919
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC:2.3.2.13) C00000919
7047 TGM4, TGP, hTGP transglutaminase 4 (EC:2.3.2.13) C00000919
3604 TNFRSF9, 4-1BB, CD137, CDw137, ILA tumor necrosis factor receptor superfamily, member 9 C00000919
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000919
10190 TXNDC9, APACD, PHLP3 thioredoxin domain containing 9 C00000919
7517 XRCC3, CMM6 X-ray repair complementing defective repair in Chinese hamster cells 3 C00000919

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (83)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P42336
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#607271 Caspase 8 deficiency Q14790
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P42336
Q14191
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer Q14790
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#167000 Ovarian cancer P42336
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (66)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00027 Ovarian cancer P42336 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00108 Autoimmune lymphoproliferative syndromes (ALPS) Q14790 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005909 Glioblastoma C00001071
D009203 Myocardial Infarction C00001071
D000435 Alcoholic Intoxication C00000919
D001145 Arrhythmias, Cardiac C00000919
D053627 Asthenozoospermia C00000919
D002545 Brain Ischemia C00000919
D006528 Carcinoma, Hepatocellular C00000919
D002318 Cardiovascular Diseases C00000919
D003930 Diabetic Retinopathy C00000919
D056486 Drug-Induced Liver Injury C00000919
D006526 Hepatitis C C00000919
D015658 HIV Infections C00000919
D006986 Hypervitaminosis A C00000919
D008107 Liver Diseases C00000919
D008113 Liver Neoplasms C00000919
D008114 Liver Neoplasms, Experimental C00000919
D008175 Lung Neoplasms C00000919
D009369 Neoplasms C00000919
D009845 Oligospermia C00000919
D013272 Stomach Diseases C00000919
D013276 Stomach Ulcer C00000919