Species

KNApSAcK Entry

Organism name Adina racemosa
Genus Adina
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Adina
Linked NCBI taxonomy ID 170034
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (29)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005372 External link 512 Hyperin
/ Hyperoside
/ Quercetin 3-O-galactoside
/ Quercetin 3-O-beta-D-galactoside
/ Quercetin 3-beta-galactopyranoside
/ Quercetin 3-O-beta-D-galactopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
C021304
38 / 43 / 34 4 / 0 No. 2 No. 15
C00005137 External link 512 Trifolin
/ Kaempferol 3-O-beta-D-galactopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C066407
10 / 6 / 7 1 / 1 No. 2 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00035981 External link 512 8-Epiloganin
CHEMBL1081584
CHEMBL1081586
CHEMBL1589904
CHEMBL2135791
2 / 1 / 1 No. 56 No. 36
C00003088 External link 512 Loganin
CHEMBL1081584
CHEMBL1081586
CHEMBL1589904
CHEMBL2135791
C059516
2 / 1 / 1 0 / 1 No. 56 No. 36
C00042991 External link 512 Secologanoside dimethyl ester
No. 56 No. 36
C00044503 External link 512 Adinoside A
No. 56 No. 36
C00004565 External link 512 Kaempferol
/ Nimbecetin
/ Rhamnolutein
/ Pelargidenolon
/ 5,7,4'-Trihydroxyflavonol
/ 3,5,7,4'-Tetrahydroxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL150
C006552
76 / 69 / 87 86 / 8 No. 71 No. 15
C00037801 External link 512 Secologanoside 7-methyl ester
No. 100 No. 36
C00037800 External link 512 Secologanoside
No. 100 No. 36
C00034978 External link 512 Secologanic acid
No. 100 No. 36
C00010755 External link 512 Grandifloroside
No. 213
C00031468 External link 512 Corchoinoside C
/ (6R,9S)-Roseoside
CHEMBL444196
CHEMBL482383
CHEMBL520291
CHEMBL465921
No. 225
C00044506 External link 512 Adinoside D
/ (-)-Adinoside D
No. 284
C00044507 External link 512 Adinoside E
/ (-)-Adinoside E
No. 284
C00029948 External link 512 Methyl chlorogenate
/ Methyl 5-O-caffeoylquinate
/ Chlorogenic acid methyl ester
CHEMBL416955
CHEMBL596924
CHEMBL1765881
CHEMBL1765882
CHEMBL2048503
CHEMBL2349427
6 / 5 / 4 No. 314 No. 6
C00044603 External link 512 Butyl chlorogenate
CHEMBL1087756
No. 314 No. 6
C00044753 External link 512 Ethyl chlorogenate
CHEMBL482232
No. 314 No. 6
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00044788 External link 512 Grandifloroside 11-methyl ester
/ (+)-Grandifloroside 11-methyl ester
No. 374
C00032210 External link 512 Strictosamide
CHEMBL480522
No. 577 No. 4
C00045134 External link 512 Vincosamide
CHEMBL480522
No. 577 No. 4
C00010800 External link 512 Vogeloside
No. 806 No. 36
C00031346 External link 512 Secoxyloganin
C059515
No. 806 No. 36
C00031339 External link 512 Secologanin dimethyl acetal
/ (-)-Secologanin dimethyl acetal
CHEMBL464473
No. 806 No. 36
C00044505 External link 512 Adinoside C
/ (-)-Adinoside C
No. 806 No. 36
C00010794 External link 512 Sweroside
CHEMBL456137
C049412
1 / 0 / 0 No. 806 No. 36
C00003098 External link 512 Secologanin
CHEMBL1235867
CHEMBL1971881
C021086
1 / 0 / 0 No. 806 No. 36
C00044504 External link 512 Adinoside B
/ (-)-Adinoside B
No. 806 No. 36

Human Protein / Gene in interactions

123 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002724 C00004565 C00005137 C00005372 C00005374 0 / 0
P15121 Aldose reductase Enzyme C00002724 C00004565 C00005137 C00005372 C00005374 0 / 0
O75496 Geminin Unclassified protein C00002724 C00003088 C00005372 C00035981 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00004565 C00005137 C00005372 C00005374 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002724 C00004565 C00005372 C00005374 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004565 C00005137 C00005372 C00005374 1 / 1
P39748 Flap endonuclease 1 Enzyme C00004565 C00005372 C00005374 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002724 C00004565 C00005374 0 / 0
P14679 Tyrosinase Oxidoreductase C00004565 C00005137 C00005372 4 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004565 C00005372 C00005374 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002724 C00005372 C00005374 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002724 C00004565 C00005372 0 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00002724 C00004565 C00005374 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005137 C00005372 C00005374 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002724 C00004565 0 / 1
P04062 Glucosylceramidase Enzyme C00004565 C00005372 6 / 4
P10636 Microtubule-associated protein tau Unclassified protein C00004565 C00005372 4 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002724 C00004565 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002724 C00004565 1 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004565 C00005372 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002724 C00004565 3 / 3
P02545 Prelamin-A/C Unclassified protein C00004565 C00005372 11 / 10
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002724 C00004565 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002724 C00004565 0 / 0
Q99700 Ataxin-2 Unclassified protein C00004565 C00005137 1 / 1
P60033 CD81 antigen Unclassified protein C00003088 C00035981 1 / 1
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00003098 C00010794 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005372 C00005374 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004565 C00005372 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002724 C00005372 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002724 C00004565 0 / 1
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00004565 C00005372 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002724 C00004565 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002724 C00004565 1 / 0
P04150 Glucocorticoid receptor NR3C1 C00002724 C00004565 0 / 1
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00004565 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005372 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00004565 1 / 8
P11388 DNA topoisomerase 2-alpha Isomerase C00004565 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00004565 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005372 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00004565 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004565 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00004565 0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00004565 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00004565 0 / 0
P08183 Multidrug resistance protein 1 drug C00004565 1 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004565 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002724 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005372 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00004565 0 / 0
P10145 Interleukin-8 Secreted protein C00002724 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00004565 0 / 1
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x C00004565 1 / 1
P03956 Interstitial collagenase M10A C00029948 0 / 1
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00004565 1 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00005372 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005372 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00004565 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005372 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00004565 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00004565 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004565 4 / 4
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
P06276 Cholinesterase Hydrolase C00004565 0 / 0
P06280 Alpha-galactosidase A Enzyme C00005372 1 / 1
P04745 Alpha-amylase 1 Enzyme C00004565 0 / 0
P45452 Collagenase 3 M10A C00029948 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00004565 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005372 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005372 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00002724 3 / 2
P08253 72 kDa type IV collagenase M10A C00029948 1 / 3
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005137 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029948 2 / 2
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00004565 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00004565 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005137 0 / 0
P03372 Estrogen receptor NR3A1 C00004565 1 / 1
P22303 Acetylcholinesterase Hydrolase C00004565 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005372 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00004565 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00004565 0 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00004565 0 / 0
P39900 Macrophage metalloelastase M10A C00029948 0 / 0
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00004565 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00005372 1 / 1
P06746 DNA polymerase beta Enzyme C00005372 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002724 3 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004565 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00002724 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005372 1 / 0
P10275 Androgen receptor NR3C4 C00004565 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00004565 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002724 0 / 1
Q04760 Lactoylglutathione lyase Enzyme C00004565 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00004565 0 / 0
P08254 Stromelysin-1 M10A C00029948 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005372 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005372 1 / 1
P48147 Prolyl endopeptidase S9A C00004565 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005372 4 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
P04637 Cellular tumor antigen p53 Transcription Factor C00004565 7 / 37
P33527 Multidrug resistance-associated protein 1 drugs C00004565 0 / 0
O00255 Menin Unclassified protein C00004565 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004565 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005372 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005372 1 / 4
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00004565 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00004565 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00004565 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00004565 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00004565 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00004565 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00004565 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005137 0 / 3
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00004565 0 / 0

120 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00004565 C00005372
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002724 C00004565
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002724 C00004565
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002724 C00004565
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002724 C00004565
5241 PGR, NR3C3, PR progesterone receptor C00002724 C00004565
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00004565 C00005372
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004565 C00005374
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00004565 C00005374
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00004565 C00005372
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00004565
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00004565
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00004565
891 CCNB1, CCNB cyclin B1 C00004565
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00004565
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00004565
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00004565
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00004565
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00004565
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00004565
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00004565
37618 C00004565
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00004565
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00004565
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00004565
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004565
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00004565
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00004565
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00004565
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00004565
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00004565
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00004565
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00004565
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00004565
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00004565
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00004565
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00004565
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00004565
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00004565
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00004565
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00004565
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00004565
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00004565
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00004565
3567 IL5, EDF, IL-5, TRF interleukin 5 (colony-stimulating factor, eosinophil) C00004565
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00004565
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00004565
4297 KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) C00004565
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00004565
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00004565
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00004565
110357 C00004565
4502 MT2A, MT2 metallothionein 2A C00004565
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00004565
8202 NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP nuclear receptor coactivator 3 (EC:2.3.1.48) C00004565
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00004565
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00004565
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00004565
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00004565
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00004565
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00004565
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00004565
8000 PSCA, PRO232 prostate stem cell antigen C00004565
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00004565
6119 RPA3, REPA3 replication protein A3, 14kDa C00004565
2810 SFN, YWHAS stratifin C00004565
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00004565
6773 STAT2, ISGF-3, P113, STAT113 signal transducer and activator of transcription 2, 113kDa C00004565
7019 TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 transcription factor A, mitochondrial C00004565
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004565
7039 TGFA, TFGA transforming growth factor, alpha C00004565
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00004565
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00004565
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00004565
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00004565
7161 TP73, P73 tumor protein p73 C00004565
7352 UCP3, SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) C00004565
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00004565
239 ALOX12, 12-LOX, 12S-LOX, LOG12 arachidonate 12-lipoxygenase (EC:1.13.11.31) C00004565
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00004565
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004565
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004565
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00004565
7402 UTRN, DMDL, DRP, DRP1 utrophin C00004565
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00004565
23411 SIRT1, SIR2L1 sirtuin 1 C00005372
5320 PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) C00005137
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00004565
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002724
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (99)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#613496 Immunodeficiency, common variable, 6; cvid6 P60033
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04637
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (106)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
P98170 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00088 Common variable immunodeficiency (CVID) P60033 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

20 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D050197 Atherosclerosis C00004565
D001943 Breast Neoplasms C00004565
D009202 Cardiomyopathies C00004565
D002318 Cardiovascular Diseases C00004565
D006943 Hyperglycemia C00004565
D007938 Leukemia C00004565
D010024 Osteoporosis C00004565
D011297 Prenatal Exposure Delayed Effects C00004565
D010146 Pain C00005374
D008569 Memory Disorders C00003088
D004487 Edema C00005137
D000647 Amnesia C00002724
D056486 Drug-Induced Liver Injury C00002724
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D008545 Melanoma C00002724
D009336 Necrosis C00002724
D015431 Weight Loss C00002724