Theobroma grandiflorum
Species
KNApSAcK Entry
| Organism name | Theobroma grandiflorum |
|---|---|
| Genus | Theobroma |
| Family | Malvaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Theobroma grandiflorum |
|---|---|
| Linked NCBI taxonomy ID | 108881 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Malvaceae |
|---|---|
| ID | 3629 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00045108
|
Theograndin II
/ (+)-Theograndin II |
CHEMBL466583
|
No. 2 | No. 15 |
|
|||
|
C00045107
|
Theograndin I
/ (+)-Theograndin I |
CHEMBL460972
|
No. 2 | No. 15 |
|
|||
|
C00044825
|
Isoscutellarein 8-O-beta-D-glucuronide 6''-methyl ester
|
CHEMBL467412
|
No. 2 | No. 15 |
|
|||
|
C00005374
|
Quercetin
|
CHEMBL82242
CHEMBL479232 CHEMBL1437696 |
C012526
|
14 / 2 / 2 | 2 / 1 | No. 2 | No. 15 |
|
|
C00005376
|
Miquelianin
/ Quercetin 3-O-beta-D-glucuronide |
CHEMBL520546
CHEMBL1506682 |
23 / 30 / 21 | No. 2 | No. 15 |
|
||
|
C00000947
|
D-Catechol
/ D-Catechin / Teafuran 30A / (+)-Catechin / Dexcyanidanol / (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol |
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
D002392
|
85 / 58 / 54 | 91 / 13 | No. 52 | No. 14 |
|
|
C00000956
|
(-)-Epicatechin
|
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
85 / 58 / 54 | No. 52 | No. 14 |
|
||
|
C00004565
|
Kaempferol
/ Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL150
|
C006552
|
76 / 69 / 87 | 86 / 8 | No. 71 | No. 15 |
|
|
C00034312
|
Theacrine
|
CHEMBL143715
|
C077059
|
No. 6185 |
|
Human Protein / Gene in interactions
144 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000947 C00000956 C00004565 C00005374 C00005376 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000947 C00000956 C00004565 C00005376 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000947 C00000956 C00005374 C00005376 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000947 C00000956 C00004565 C00005374 | 1 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000947 C00000956 C00005376 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000947 C00000956 C00004565 | 1 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000947 C00000956 C00005376 | 3 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000947 C00000956 C00004565 | 0 / 3 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000947 C00000956 C00005376 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000947 C00000956 C00004565 | 0 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00000947 C00000956 C00005376 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000947 C00000956 C00004565 | 2 / 5 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000947 C00000956 C00005376 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00004565 C00005374 C00005376 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000947 C00000956 C00004565 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000947 C00000956 C00004565 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000947 C00000956 C00004565 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000947 C00000956 C00004565 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000947 C00000956 C00004565 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000947 C00000956 C00004565 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000947 C00000956 C00004565 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000947 C00000956 C00005376 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000947 C00000956 C00004565 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000947 C00000956 C00004565 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000947 C00000956 C00005376 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000947 C00000956 C00004565 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000947 C00000956 C00004565 | 2 / 2 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000947 C00000956 C00004565 | 1 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000947 C00000956 C00004565 | 1 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000947 C00000956 C00004565 | 3 / 3 |
| P02768 | Serum albumin | Secreted protein | C00000947 C00000956 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00000947 C00000956 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000947 C00000956 | 1 / 2 |
| Q04759 | Protein kinase C theta type | Delta | C00000947 C00000956 | 0 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000947 C00000956 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000947 C00000956 | 3 / 2 |
| P54132 | Bloom syndrome protein | Enzyme | C00000947 C00000956 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00004565 C00005376 | 11 / 10 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000947 C00000956 | 0 / 7 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000947 C00000956 | 1 / 1 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000947 C00000956 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000947 C00000956 | 2 / 3 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000947 C00000956 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000947 C00000956 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000947 C00000956 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00000947 C00000956 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000947 C00000956 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000947 C00000956 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000947 C00000956 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000947 C00000956 | 1 / 2 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000947 C00000956 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000947 C00000956 | 5 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000947 C00000956 | 0 / 0 |
| P07998 | Ribonuclease pancreatic | Enzyme | C00000947 C00000956 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000947 C00000956 | 2 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000947 C00000956 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00004565 C00005374 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000947 C00000956 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00000947 C00000956 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000947 C00000956 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000947 C00000956 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000947 C00000956 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000947 C00000956 | 3 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00000947 C00000956 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00000947 C00000956 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00000947 C00000956 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000947 C00000956 | 4 / 1 |
| P24723 | Protein kinase C eta type | Eta | C00000947 C00000956 | 1 / 0 |
| P00734 | Prothrombin | S1A | C00000947 C00000956 | 4 / 2 |
| P41743 | Protein kinase C iota type | Iota | C00000947 C00000956 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000947 C00000956 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000947 C00000956 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000947 C00000956 | 0 / 0 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00000947 C00000956 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000947 C00000956 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000947 C00000956 | 5 / 2 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000947 C00000956 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000947 C00000956 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000947 C00000956 | 3 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000947 C00000956 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005374 C00005376 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000947 C00000956 | 0 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000947 C00000956 | 1 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00000947 C00000956 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00004565 | 2 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00004565 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00004565 | 0 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00004565 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00004565 | 1 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | C00004565 | 1 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00004565 | 4 / 4 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00004565 | 5 / 3 |
| P14679 | Tyrosinase | Oxidoreductase | C00004565 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00004565 | 0 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00004565 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00005376 | 0 / 0 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00004565 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005374 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00005376 | 7 / 3 |
| Q12791 | Calcium-activated potassium channel subunit alpha-1 | KCNM, KCa1.x | C00004565 | 1 / 1 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00004565 | 0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00004565 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00004565 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00004565 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00004565 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00004565 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00004565 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00004565 | 0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00004565 | 0 / 0 |
| P48147 | Prolyl endopeptidase | S9A | C00004565 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00004565 | 1 / 8 |
| Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Enzyme | C00004565 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005376 | 1 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005374 | 0 / 0 |
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | C00004565 | 0 / 0 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00004565 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00004565 | 1 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00004565 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00004565 | 0 / 0 |
| Q00534 | Cyclin-dependent kinase 6 | CMGC serine/threonine protein kinase family | C00004565 | 1 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00004565 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005376 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00004565 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00004565 | 6 / 4 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00004565 | 2 / 2 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00004565 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00004565 | 1 / 1 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00004565 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005374 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00004565 | 7 / 37 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00004565 | 0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00004565 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00004565 | 0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00004565 | 0 / 0 |
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | C00004565 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00004565 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00004565 | 0 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00004565 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005376 | 2 / 1 |
160 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000947
C00004565
C00005374
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000947
C00004565
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00000947
C00004565
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000947
C00004565
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000947
C00004565
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000947
C00004565
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00000947
C00004565
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000947
C00004565
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000947
C00004565
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000947
C00004565
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000947
C00004565
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000947
C00004565
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000947
C00004565
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000947
C00004565
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00000947
C00004565
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00004565
C00005374
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000947
C00004565
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00000947
C00004565
|
| 9235 | IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd | interleukin 32 |
C00000947
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00004565
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00004565
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00004565
|
| 37618 |
C00004565
|
||
| 1031 | CDKN2C, INK4C, p18, p18-INK4C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
C00004565
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00004565
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00004565
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00004565
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00004565
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00004565
|
| 1734 | DIO2, 5DII, D2, DIOII, SelY, TXDI2 | deiodinase, iodothyronine, type II (EC:1.97.1.10) |
C00004565
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00004565
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00004565
|
| 2203 | FBP1, FBP | fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) |
C00004565
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00004565
|
| 4616 | GADD45B, GADD45BETA, MYD118 | growth arrest and DNA-damage-inducible, beta |
C00004565
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00004565
|
| 9687 | GREB1 | growth regulation by estrogen in breast cancer 1 |
C00004565
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00004565
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00004565
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00004565
|
| 3043 | HBB, CD113t-C, beta-globin | hemoglobin, beta |
C00004565
|
| 3082 | HGF, DFNB39, F-TCF, HGFB, HPTA, SF | hepatocyte growth factor (hepapoietin A; scatter factor) |
C00004565
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00004565
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00004565
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00004565
|
| 3567 | IL5, EDF, IL-5, TRF | interleukin 5 (colony-stimulating factor, eosinophil) |
C00004565
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00004565
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00004565
|
| 4297 | KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS | lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) |
C00004565
|
| 27113 | BBC3, JFY-1, JFY1, PUMA | BCL2 binding component 3 |
C00004565
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00004565
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00004565
|
| 110357 |
C00004565
|
||
| 4502 | MT2A, MT2 | metallothionein 2A |
C00004565
|
| 4586 | MUC5AC, MUC5, TBM, leB | mucin 5AC, oligomeric mucus/gel-forming |
C00004565
|
| 8202 | NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP | nuclear receptor coactivator 3 (EC:2.3.1.48) |
C00004565
|
| 239 | ALOX12, 12-LOX, 12S-LOX, LOG12 | arachidonate 12-lipoxygenase (EC:1.13.11.31) |
C00004565
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00004565
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00004565
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00004565
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00004565
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00004565
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00004565
|
| 8000 | PSCA, PRO232 | prostate stem cell antigen |
C00004565
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00004565
|
| 6119 | RPA3, REPA3 | replication protein A3, 14kDa |
C00004565
|
| 2810 | SFN, YWHAS | stratifin |
C00004565
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00004565
|
| 6773 | STAT2, ISGF-3, P113, STAT113 | signal transducer and activator of transcription 2, 113kDa |
C00004565
|
| 7019 | TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 | transcription factor A, mitochondrial |
C00004565
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00004565
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00004565
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00004565
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00004565
|
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 |
C00004565
|
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 |
C00004565
|
| 7161 | TP73, P73 | tumor protein p73 |
C00004565
|
| 7352 | UCP3, SLC25A9 | uncoupling protein 3 (mitochondrial, proton carrier) |
C00004565
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00004565
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00004565
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00004565
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00004565
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00004565
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00004565
|
| 7402 | UTRN, DMDL, DRP, DRP1 | utrophin |
C00004565
|
| 8839 | WISP2, CCN5, CT58, CTGF-L | WNT1 inducible signaling pathway protein 2 |
C00004565
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00000947
|
| 302 | ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV | annexin A2 |
C00000947
|
| 393 | ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 | Rho GTPase activating protein 4 |
C00000947
|
| 468 | ATF4, CREB-2, CREB2, TAXREB67, TXREB | activating transcription factor 4 |
C00000947
|
| 2683 | B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) |
C00000947
|
| 56751 | BARHL1 | BarH-like homeobox 1 |
C00000947
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00000947
|
| 388962 | BOLA3, MMDS2 | bolA family member 3 |
C00000947
|
| 79184 | BRCC3, BRCC36, C6.1A, CXorf53 | BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) |
C00000947
|
| 694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000947
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00000947
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000947
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00000947
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00000947
|
| 930 | CD19, B4, CVID3 | CD19 molecule |
C00000947
|
| 975 | CD81, CVID6, S5.7, TAPA1, TSPAN28 | CD81 molecule |
C00000947
|
| 928 | CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 | CD9 molecule |
C00000947
|
| 1054 | CEBPG, GPE1BP, IG/EBP-1 | CCAAT/enhancer binding protein (C/EBP), gamma |
C00000947
|
| 10978 | CLP1, HEAB, hClp1 | cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) |
C00000947
|
| 10063 | COX17 | COX17 cytochrome c oxidase copper chaperone |
C00000947
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00000947
|
| 7913 | DEK, D6S231E | DEK oncogene |
C00000947
|
| 1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00000947
|
| 2130 | EWSR1, EWS, bK984G1.4 | EWS RNA-binding protein 1 |
C00000947
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000947
|
| 2323 | FLT3LG, FL, FLT3L | fms-related tyrosine kinase 3 ligand |
C00000947
|
| 2495 | FTH1, FHC, FTH, FTHL6, PIG15, PLIF | ferritin, heavy polypeptide 1 (EC:1.16.3.1) |
C00000947
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00000947
|
| 3054 | HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF | host cell factor C1 (VP16-accessory protein) |
C00000947
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000947
|
| 3232 | HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 | homeobox D3 |
C00000947
|
| 3329 | HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 | heat shock 60kDa protein 1 (chaperonin) |
C00000947
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00000947
|
| 3559 | IL2RA, CD25, IDDM10, IL2R, TCGFR | interleukin 2 receptor, alpha |
C00000947
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00004565
|
| 3662 | IRF4, LSIRF, MUM1, NF-EM5 | interferon regulatory factor 4 |
C00000947
|
| 3683 | ITGAL, CD11A, LFA-1, LFA1A | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
C00000947
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00000947
|
| 4067 | LYN, JTK8, p53Lyn, p56Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) |
C00000947
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00000947
|
| 5605 | MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 | mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) |
C00000947
|
| 4282 | MIF, GIF, GLIF, MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) |
C00000947
|
| 64975 | MRPL41, BMRP, MRP-L27, MRPL27, RPML27 | mitochondrial ribosomal protein L41 |
C00000947
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00000947
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00000947
|
| 4851 | NOTCH1, TAN1, hN1 | notch 1 |
C00000947
|
| 4869 | NPM1, B23, NPM | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
C00000947
|
| 5175 | PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM | platelet/endothelial cell adhesion molecule 1 |
C00000947
|
| 5187 | PER1, PER, RIGUI, hPER | period circadian clock 1 |
C00000947
|
| 5327 | PLAT, T-PA, TPA | plasminogen activator, tissue (EC:3.4.21.68) |
C00000947
|
| 5328 | PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA | plasminogen activator, urokinase (EC:3.4.21.73) |
C00000947
|
| 7916 | PRRC2A, BAT2, D6S51, D6S51E, G2 | proline-rich coiled-coil 2A |
C00000947
|
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) |
C00000947
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00000947
|
| 5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00000947
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00000947
|
| 6128 | RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 | ribosomal protein L6 |
C00000947
|
| 6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00000947
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000947
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00000947
|
| 7536 | SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 | splicing factor 1 |
C00000947
|
| 6574 | SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 | solute carrier family 20 (phosphate transporter), member 1 |
C00000947
|
| 6699 | SPRR1B, CORNIFIN, GADD33, SPRR1 | small proline-rich protein 1B |
C00000947
|
| 6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00000947
|
| 6777 | STAT5B, STAT5 | signal transducer and activator of transcription 5B |
C00000947
|
| 6778 | STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C | signal transducer and activator of transcription 6, interleukin-4 induced |
C00000947
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000947
|
| 6932 | TCF7, TCF-1 | transcription factor 7 (T-cell specific, HMG-box) |
C00000947
|
| 7083 | TK1, TK2 | thymidine kinase 1, soluble (EC:2.7.1.21) |
C00000947
|
| 943 | TNFRSF8, CD30, D1S166E, Ki-1 | tumor necrosis factor receptor superfamily, member 8 |
C00000947
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00000947
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00000947
|
| 2829 | XCR1, CCXCR1, GPR5 | chemokine (C motif) receptor 1 |
C00000947
|
| 51042 | ZNF593, ZT86 | zinc finger protein 593 |
C00000947
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (119)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #609446 | Generalized epilepsy and paroxysmal dyskinesia; gepd |
Q12791
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04637 |
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| %612223 | Stature quantitative trait locus 11; stqtl11 |
Q00534
|
| #601367 | Stroke, ischemic |
P00734
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (112)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) P08581 (related) P10415 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) P10415 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P10415 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) P28907 (marker) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P27487 (marker) P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) Q9NUW8 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H01258 | Generalized epilepsy and paroxysmal dyskinesia (GEPD) |
Q12791
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
20 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D050197 | Atherosclerosis |
C00004565
C00000947 |
| D001943 | Breast Neoplasms |
C00004565
C00000947 |
| D003556 | Cystitis |
C00000947
|
| D002318 | Cardiovascular Diseases |
C00004565
|
| D006943 | Hyperglycemia |
C00004565
|
| D007938 | Leukemia |
C00004565
|
| D010024 | Osteoporosis |
C00004565
|
| D011297 | Prenatal Exposure Delayed Effects |
C00004565
|
| D010146 | Pain |
C00005374
|
| D002471 | Cell Transformation, Neoplastic |
C00000947
|
| D009202 | Cardiomyopathies |
C00004565
|
| D056486 | Drug-Induced Liver Injury |
C00000947
|
| D034381 | Hearing Loss |
C00000947
|
| D006331 | Heart Diseases |
C00000947
|
| D020138 | HYPERHOMOCYSTEINEMIA |
C00000947
|
| D008107 | Liver Diseases |
C00000947
|
| D017114 | Liver Failure, Acute |
C00000947
|
| D008113 | Liver Neoplasms |
C00000947
|
| D008325 | Mammary Neoplasms, Experimental |
C00000947
|
| D009362 | Neoplasm Metastasis |
C00000947
|