PCIDB

KNApSAcK Metabolite C00000947

Metabolite

KNApSAcK Entry

id C00000947
Name D-Catechol / D-Catechin / Teafuran 30A / (+)-Catechin / Dexcyanidanol / (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CAS RN 154-23-4
Standard InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 52

Link

ChEMBL

By standard InChI CHEMBL311498
By standard InChI Main Layer CHEMBL80941 CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912

KEGG

By LinkDB C06562

CTD

By CAS RN D002392

Species

Summary

Plant class

class name count
rosids 86
asterids 7
eudicotyledons 5
Magnoliophyta 5
Spermatophyta 5
Liliopsida 4

Family (Top 10)

family name count
Fabaceae 59
Rosaceae 6
Pinaceae 4
Arecaceae 3
Malvaceae 3
Lauraceae 3
Ericaceae 2
Annonaceae 2
Polygonaceae 2
Betulaceae 2

List (114)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia adunca 204988 Fabaceae rosids Viridiplantae
Acacia calamifolia 139006 Fabaceae rosids Viridiplantae
Acacia cardiophylla 383638 Fabaceae rosids Viridiplantae
Acacia catechu 138017 Fabaceae rosids Viridiplantae
Acacia chrysotricha 1174753 Fabaceae rosids Viridiplantae
Acacia clunies-rossiae 1174755 Fabaceae rosids Viridiplantae
Acacia concurrens 3808 Fabaceae rosids Viridiplantae
Acacia constablei 383640 Fabaceae rosids Viridiplantae
Acacia cultriformis 138515 Fabaceae rosids Viridiplantae
Acacia dealbata 205042 Fabaceae rosids Viridiplantae
Acacia deanei 205356 Fabaceae rosids Viridiplantae
Acacia decurrens 205044 Fabaceae rosids Viridiplantae
Acacia elata 138021 Fabaceae rosids Viridiplantae
Acacia erioloba 205069 Fabaceae rosids Viridiplantae
Acacia falciformis 139008 Fabaceae rosids Viridiplantae
Acacia filicifolia 383643 Fabaceae rosids Viridiplantae
Acacia fimbriata 21010 Fabaceae rosids Viridiplantae
Acacia holosericea 1120455 Fabaceae rosids Viridiplantae
Acacia irrorata 383645 Fabaceae rosids Viridiplantae
Acacia ixiophylla 1120458 Fabaceae rosids Viridiplantae
Acacia kettlewelliae 3808 Fabaceae rosids Viridiplantae
Acacia lanigera 3808 Fabaceae rosids Viridiplantae
Acacia leucoclada 138518 Fabaceae rosids Viridiplantae
Acacia longifolia 139010 Fabaceae rosids Viridiplantae
Acacia mabellae 383647 Fabaceae rosids Viridiplantae
Acacia mearnsii 139012 Fabaceae rosids Viridiplantae
Acacia melanoxylon 138028 Fabaceae rosids Viridiplantae
Acacia mollifolia 383648 Fabaceae rosids Viridiplantae
Acacia neriifolia 205053 Fabaceae rosids Viridiplantae
Acacia obtusifolia 866003 Fabaceae rosids Viridiplantae
Acacia omalophylla 1173659 Fabaceae rosids Viridiplantae
Acacia oshanesii 383653 Fabaceae rosids Viridiplantae
Acacia oswaldii 139013 Fabaceae rosids Viridiplantae
Acacia parramattensis 138037 Fabaceae rosids Viridiplantae
Acacia pendula 1173660 Fabaceae rosids Viridiplantae
Acacia planifrons 1226580 Fabaceae rosids Viridiplantae
Acacia retinodes 1050817 Fabaceae rosids Viridiplantae
Acacia rigens 694556 Fabaceae rosids Viridiplantae
Acacia silvestris 205063 Fabaceae rosids Viridiplantae
Acacia terminalis 383657 Fabaceae rosids Viridiplantae
Acacia trachyphloia 383658 Fabaceae rosids Viridiplantae
Acacia verniciflua 1120475 Fabaceae rosids Viridiplantae
Acacia vestita 1120476 Fabaceae rosids Viridiplantae
Acer nikoense 171213 Aceraceae rosids Viridiplantae
Alhagi kirghisorum 47036 Fabaceae rosids Viridiplantae
Alhagi maurorum 47037 Fabaceae rosids Viridiplantae
Ampelopsis japonica 714442 Vitaceae rosids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Arachis hypogaea 3818 Fabaceae rosids Viridiplantae
Artabotrys uncinatus 225832 Annonaceae Magnoliophyta Viridiplantae
Artocarpus dadah 709041 Moraceae rosids Viridiplantae
Astragalus floccosifolius 20400 Fabaceae rosids Viridiplantae
Astragalus kabadianus 20400 Fabaceae rosids Viridiplantae
Betula papyrifera 3507 Betulaceae rosids Viridiplantae
Camellia sinensis 4442 Theaceae asterids Viridiplantae
Carpinus cordata 88034 Betulaceae rosids Viridiplantae
Cassia fistula 53852 Fabaceae rosids Viridiplantae
Cassia roxburghii 948717 Fabaceae rosids Viridiplantae
Casuarina equisetifolia L. 3523 Casuarinaceae rosids Viridiplantae
Ceiba pentandra 193163 Malvaceae rosids Viridiplantae
Chamaerops humilis 54446 Arecaceae Liliopsida Viridiplantae
Cinnamomum sieboldii 119266 Lauraceae Magnoliophyta Viridiplantae
Cinnamomum subavenium 977953 Lauraceae Magnoliophyta Viridiplantae
Cistus salviifolius 335170 Cistaceae rosids Viridiplantae
Coleogyne ramosissima Torr. 401069 Rosaceae rosids Viridiplantae
Colophospermum mopane 162715 Fabaceae rosids Viridiplantae
Combretum quadrangulare 99434 Combretaceae rosids Viridiplantae
Crataegus monogyna calli 23159 Rosaceae rosids Viridiplantae
Croton urucurana 518879 Euphorbiaceae rosids Viridiplantae
Desmoncus polyacanthos 996938 Arecaceae Liliopsida Viridiplantae
Embelia ribes Burm. 459628 Primulaceae asterids Viridiplantae
Eucalyptus camaldulensis 34316 Myrtaceae rosids Viridiplantae
Eucommia ulmoides Oliver 4391 Eucommiaceae asterids Viridiplantae
Euodia meliaefolia 354493 Rutaceae rosids Viridiplantae
Eysenhardtia subcoriacea Pennell 104319 Fabaceae rosids Viridiplantae
Fugopyrum esculentum calli
Ginkgo biloba 3311 Ginkgoaceae Spermatophyta Viridiplantae
Gleditsia triacanthos 54874 Fabaceae rosids Viridiplantae
Gymnosporia trigyna 123423 Celastraceae rosids Viridiplantae
Larix decidua Miller. 3325 Pinaceae Spermatophyta Viridiplantae
Larix sibirica 62751 Pinaceae Spermatophyta Viridiplantae
Laurus nobilis 85223 Lauraceae Magnoliophyta Viridiplantae
Liquidambar styraciflua 4400 Altingiaceae eudicotyledons Viridiplantae
Manilkara zapota cv.Tikal 3740 Sapotaceae asterids Viridiplantae
Mitrella kentii 306987 Annonaceae Magnoliophyta Viridiplantae
Okoubaka aubrevillei 364749 Cervantesiaceae eudicotyledons Viridiplantae
Parkia biglobosa 889930 Fabaceae rosids Viridiplantae
Phoenix hanceana var. formosana 4719 Arecaceae Liliopsida Viridiplantae
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Pinus sibirica L. 3318 Pinaceae Spermatophyta Viridiplantae
Pinus sylvestris L. 3349 Pinaceae Spermatophyta Viridiplantae
Polygonum cuspidatum 83819 Polygonaceae eudicotyledons Viridiplantae
Polygonum hydropiper 46901 Polygonaceae eudicotyledons Viridiplantae
Prosopis nigra 207716 Fabaceae rosids Viridiplantae
Prosopis torquata 433937 Fabaceae rosids Viridiplantae
Prunus avium 42229 Rosaceae rosids Viridiplantae
Quercus robur 38942 Fagaceae rosids Viridiplantae
Rhei rhizoma
Rhododendron mucronatum 401655 Ericaceae asterids Viridiplantae
Rosa amblyotis 1165904 Rosaceae rosids Viridiplantae
Rosa cymosa 117261 Rosaceae rosids Viridiplantae
Rosa maximowicziana 117265 Rosaceae rosids Viridiplantae
Salix caprea 172267 Salicaceae rosids Viridiplantae
Schotia brachypetala 20342 Fabaceae rosids Viridiplantae
Scurrula atropurpurea 1146880 Loranthaceae eudicotyledons Viridiplantae
Theobroma cacao L. 3640 Malvaceae rosids Viridiplantae
Theobroma grandiflorum 108881 Malvaceae rosids Viridiplantae
Typha capensis (Rohrb.) N. E. Br 4732 Typhaceae Liliopsida Viridiplantae
Uncaria gambir 43574 Rubiaceae asterids Viridiplantae
Vaccinium vitis-idaea 180772 Ericaceae asterids Viridiplantae
Vigna angularis 3914 Fabaceae rosids Viridiplantae
Vitis vinifera 29760 Vitaceae rosids Viridiplantae
Wisteria sinensis 20997 Fabaceae rosids Viridiplantae
Xylocarpus granatum 241841 Meliaceae rosids Viridiplantae

Human Protein / Gene in interaction

85 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL583912 CHEMBL1741321 (3)
1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL311498 CHEMBL1908082 (1)
3 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL311498 CHEMBL980220 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL311498 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL583912 CHEMBL1738312 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL583912 CHEMBL1020816 (1) CHEMBL995707 (4)
CHEMBL1008495 (1)
0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1032505 (2)
3 / 0
P06746 DNA polymerase beta Enzyme CHEMBL311498 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL583912 CHEMBL1614076 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL206452 CHEMBL1227478 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL206452 CHEMBL1227477 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL206452 CHEMBL1227480 (1)
0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme CHEMBL200715 CHEMBL583912 CHEMBL921930 (2)
0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase CHEMBL206452 CHEMBL1227626 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL206452 CHEMBL1799589 (1)
0 / 1
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL583912 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL311498 CHEMBL583912 CHEMBL822904 (1) CHEMBL1023248 (2)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL206452 CHEMBL1227474 (1)
1 / 2
P02768 Serum albumin Secreted protein CHEMBL583912 CHEMBL1177441 (1)
0 / 0
P49327 Fatty acid synthase Transferase CHEMBL129482 CHEMBL583912 CHEMBL862461 (1) CHEMBL862462 (1)
CHEMBL1260143 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL583912 CHEMBL1741325 (3)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL311498 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL311498 CHEMBL1014691 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL206452 CHEMBL1794311 (1)
2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL311498 CHEMBL1020815 (1) CHEMBL1008496 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926465 (3)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL206452 CHEMBL1227479 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL200715 CHEMBL1100507 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL206452 CHEMBL1227627 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL311498 CHEMBL206452 CHEMBL1614458 (2)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL206452 CHEMBL1227625 (1)
1 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL311498 CHEMBL1613922 (1) CHEMBL1794486 (1)
0 / 0
P07998 Ribonuclease pancreatic Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1225513 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL583912 CHEMBL1794584 (1)
2 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926467 (3)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL206452 CHEMBL1227473 (1)
0 / 0
P07711 Cathepsin L1 C1A CHEMBL583912 CHEMBL1614088 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL311498 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL583912 CHEMBL1738315 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL583912 CHEMBL1738602 (1)
3 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL206452 CHEMBL1794467 (1)
0 / 0
P00734 Prothrombin S1A CHEMBL311498 CHEMBL976587 (1)
4 / 2
P04745 Alpha-amylase 1 Enzyme CHEMBL206452 CHEMBL583912 CHEMBL964479 (4)
0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL200715 CHEMBL583912 CHEMBL1056839 (2)
2 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL206452 CHEMBL1614521 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL583912 CHEMBL1738514 (1)
0 / 1
P56817 Beta-secretase 1 A1A CHEMBL129482 CHEMBL653507 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL583912 CHEMBL1741322 (3)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL206452 CHEMBL1228226 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1614227 (3)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL206452 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL311498 CHEMBL1614171 (1)
5 / 2
P00374 Dihydrofolate reductase Oxidoreductase CHEMBL583912 CHEMBL930269 (1)
1 / 1
P35372 Mu-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926466 (3)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL583912 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL206452 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL583912 CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL583912 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (3)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1794483 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL311498 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (5)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL206452 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL311498 CHEMBL206452 CHEMBL1614250 (2) CHEMBL1614421 (2)
CHEMBL1614502 (2)
4 / 3
P07451 Carbonic anhydrase 3 Lyase CHEMBL206452 CHEMBL1227475 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL206452 CHEMBL1227476 (1)
1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein CHEMBL206452 CHEMBL583912 CHEMBL937576 (2)
0 / 7
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1794536 (5)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1613914 (5)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL311498 CHEMBL206452 CHEMBL1613829 (2) CHEMBL1613928 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL206452 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL206452 CHEMBL583912 CHEMBL1614257 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1614257 (2)
1 / 3
Q05513 Protein kinase C zeta type Iota CHEMBL80941 CHEMBL769344 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL80941 CHEMBL769344 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL583912 CHEMBL2114881 (1)
0 / 0

CTD interaction (127)

compound gene gene name gene description interaction interaction type form reference
pmid
D002392 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Catechin results in decreased expression of ABCG2 protein decreases expression
protein 17077187
D002392 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Catechin analog results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 16413414
D002392 302 ANXA2
ANX2
ANX2L4
CAL1H
LIP2
LPC2
LPC2D
P36
PAP-IV
annexin A2 Catechin results in increased expression of ANXA2 mRNA increases expression
mRNA 15465739
D002392 393 ARHGAP4
C1
RGC1
RhoGAP4
SrGAP4
p115
Rho GTPase activating protein 4 Catechin results in decreased expression of ARHGAP4 mRNA decreases expression
mRNA 15465739
D002392 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Catechin results in increased expression of ATF4 mRNA increases expression
mRNA 15465739
D002392 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 2683 B4GALT1
B4GAL-T1
CDG2D
GGTB2
GT1
GTB
beta4Gal-T1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of B4GALT1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 56751 BARHL1
BarH-like homeobox 1 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BARHL1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 581 BAX
BCL2L4
BCL2-associated X protein Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Catechin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D002392 637 BID
FP497
BH3 interacting domain death agonist Catechin results in increased cleavage of and results in increased activity of BID protein increases activity
/ increases cleavage
protein 20206613
D002392 388962 BOLA3
MMDS2
bolA family member 3 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BOLA3 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 79184 BRCC3
BRCC36
C6.1A
CXorf53
BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) Catechin results in decreased expression of BRCC3 mRNA decreases expression
mRNA 15465739
D002392 694 BTG1
B-cell translocation gene 1, anti-proliferative Catechin results in increased expression of BTG1 mRNA increases expression
mRNA 15465739
D002392 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Catechin analog results in increased activity of CASP3 protein increases activity
protein 16413414
D002392 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Catechin inhibits the reaction [catechol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 20347921
D002392 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Catechin results in increased activity of CASP3 protein increases activity
protein 20206613
D002392 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Catechin inhibits the reaction [catechol results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 20347921
D002392 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Catechin results in increased activity of CASP8 protein increases activity
protein 20206613
D002392 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Catechin results in increased activity of CASP9 protein increases activity
protein 20206613
D002392 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Catechin inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Catechin analog results in decreased expression of CCND1 protein decreases expression
protein 16413414
D002392 930 CD19
B4
CVID3
CD19 molecule Catechin results in increased expression of CD19 mRNA increases expression
mRNA 15465739
D002392 975 CD81
CVID6
S5.7
TAPA1
TSPAN28
CD81 molecule Catechin results in increased expression of CD81 mRNA increases expression
mRNA 15465739
D002392 928 CD9
BTCC-1
DRAP-27
MIC3
MRP-1
TSPAN-29
TSPAN29
CD9 molecule Catechin results in increased expression of CD9 mRNA increases expression
mRNA 15465739
D002392 1054 CEBPG
GPE1BP
IG/EBP-1
CCAAT/enhancer binding protein (C/EBP), gamma Catechin results in increased expression of CEBPG mRNA increases expression
mRNA 15465739
D002392 10978 CLP1
HEAB
hClp1
cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) Catechin results in decreased expression of CLP1 mRNA decreases expression
mRNA 15465739
D002392 10063 COX17
COX17 cytochrome c oxidase copper chaperone Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of COX17 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Catechin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Catechin affects the localization of CYCS protein affects localization
protein 20206613
D002392 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Catechin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 14558788
D002392 7913 DEK
D6S231E
DEK oncogene Catechin results in decreased expression of DEK mRNA decreases expression
mRNA 15465739
D002392 1786 DNMT1
ADCADN
AIM
CXXC9
DNMT
HSN1E
MCMT
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) Catechin results in decreased activity of DNMT1 protein decreases activity
protein 16037419
D002392 2130 EWSR1
EWS
bK984G1.4
EWS RNA-binding protein 1 Catechin results in increased expression of EWSR1 mRNA increases expression
mRNA 15465739
D002392 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Catechin results in increased expression of FAS protein increases expression
protein 20206613
D002392 2323 FLT3LG
FL
FLT3L
fms-related tyrosine kinase 3 ligand Catechin results in decreased expression of FLT3LG mRNA decreases expression
mRNA 15465739
D002392 2495 FTH1
FHC
FTH
FTHL6
PIG15
PLIF
ferritin, heavy polypeptide 1 (EC:1.16.3.1) Catechin results in increased expression of FTH1 mRNA increases expression
mRNA 15465739
D002392 2896 GRN
CLN11
GEP
GP88
PCDGF
PEPI
PGRN
granulin Catechin results in increased expression of GRN mRNA increases expression
mRNA 15465739
D002392 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21882252
D002392 3054 HCFC1
CFF
HCF-1
HCF1
HFC1
MRX3
VCAF
host cell factor C1 (VP16-accessory protein) Catechin results in increased expression of HCFC1 mRNA increases expression
mRNA 15465739
D002392 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Catechin results in increased expression of HMOX1 protein increases expression
protein 16799064
D002392 3232 HOXD3
HOX1D
HOX4
HOX4A
Hox-4.1
homeobox D3 Catechin results in increased expression of HOXD3 mRNA increases expression
mRNA 15465739
D002392 3329 HSPD1
CPN60
GROEL
HLD4
HSP-60
HSP60
HSP65
HuCHA60
SPG13
heat shock 60kDa protein 1 (chaperonin) Catechin results in decreased expression of HSPD1 mRNA decreases expression
mRNA 15465739
D002392 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Catechin results in increased expression of ICAM1 mRNA increases expression
mRNA 15465739
D002392 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Catechin results in increased expression of IL10 mRNA increases expression
mRNA 15465739
D002392 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Catechin inhibits the reaction [Glucose results in increased expression of IL1B mRNA] decreases reaction
/ increases expression
mRNA 19557821
D002392 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Catechin inhibits the reaction [Glucose results in increased expression of IL1B protein] decreases reaction
/ increases expression
protein 19557821
D002392 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Catechin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 3559 IL2RA
CD25
IDDM10
IL2R
TCGFR
interleukin 2 receptor, alpha Catechin results in decreased expression of IL2RA mRNA decreases expression
mRNA 15465739
D002392 9235 IL32
IL-32alpha
IL-32beta
IL-32delta
IL-32gamma
NK4
TAIF
TAIFa
TAIFb
TAIFc
TAIFd
interleukin 32 Catechin results in decreased expression of IL32 mRNA decreases expression
mRNA 15465739
D002392 3662 IRF4
LSIRF
MUM1
NF-EM5
interferon regulatory factor 4 Catechin results in decreased expression of IRF4 mRNA decreases expression
mRNA 15465739
D002392 3683 ITGAL
CD11A
LFA-1
LFA1A
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Catechin results in increased expression of ITGAL mRNA increases expression
mRNA 15465739
D002392 3689 ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) Catechin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) Catechin results in decreased expression of LYN mRNA decreases expression
mRNA 15465739
D002392 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21882252
D002392 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) Catechin results in decreased expression of MAP2K1 mRNA decreases expression
mRNA 15465739
D002392 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) Catechin results in decreased expression of MAP2K1 protein decreases expression
protein 15465739
D002392 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) Catechin results in increased expression of MAP2K1 mRNA increases expression
mRNA 15465739
D002392 5605 MAP2K2
CFC4
MAPKK2
MEK2
MKK2
PRKMK2
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21882252
D002392 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Catechin analog results in decreased phosphorylation of MAPK1 protein decreases phosphorylation
protein 16413414
D002392 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21882252
D002392 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D002392 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Catechin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 17379280
D002392 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Catechin analog results in decreased phosphorylation of MAPK3 protein decreases phosphorylation
protein 16413414
D002392 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21882252
D002392 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D002392 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Catechin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 17379280
D002392 4282 MIF
GIF
GLIF
MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) Catechin results in decreased expression of MIF mRNA decreases expression
mRNA 15465739
D002392 64975 MRPL41
BMRP
MRP-L27
MRPL27
RPML27
mitochondrial ribosomal protein L41 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of MRPL41 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 4493 MT1E
MT1
MTD
metallothionein 1E Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of MT1E mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Catechin inhibits the reaction [S100B protein results in increased expression of NCF1 protein] decreases reaction
/ increases expression
protein 17103373
D002392 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Catechin results in decreased expression of NCF1 mRNA decreases expression
mRNA 19450372
D002392 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Catechin results in increased expression of NFE2L2 protein increases expression
protein 16799064
D002392 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Catechin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D002392 4851 NOTCH1
TAN1
hN1
notch 1 Catechin results in increased expression of NOTCH1 mRNA increases expression
mRNA 15465739
D002392 4869 NPM1
B23
NPM
nucleophosmin (nucleolar phosphoprotein B23, numatrin) Catechin results in decreased expression of NPM1 mRNA decreases expression
mRNA 15465739
D002392 5175 PECAM1
CD31
CD31/EndoCAM
GPIIA'
PECA1
PECAM-1
endoCAM
platelet/endothelial cell adhesion molecule 1 Catechin inhibits the reaction [S100B protein results in increased expression of PECAM1 mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 5187 PER1
PER
RIGUI
hPER
period circadian clock 1 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Catechin results in increased expression of PLAT mRNA increases expression
mRNA 11236827
D002392 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Catechin results in increased expression of PLAT protein increases expression
protein 11236827
D002392 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA] decreases reaction
/ increases expression
mRNA 11236827
D002392 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) Catechin results in increased expression of PLAU mRNA increases expression
mRNA 11236827
D002392 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) Catechin results in increased expression of PLAU protein increases expression
protein 11236827
D002392 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA] decreases reaction
/ increases expression
mRNA 11236827
D002392 7916 PRRC2A
BAT2
D6S51
D6S51E
G2
proline-rich coiled-coil 2A Catechin results in increased expression of PRRC2A mRNA increases expression
mRNA 15465739
D002392 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 19557821
D002392 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19557821
D002392 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Catechin inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Catechin results in decreased expression of PTGS2 mRNA decreases expression
mRNA 10920275
D002392 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Catechin results in increased phosphorylation of PTK2 protein increases phosphorylation
protein 16038899
D002392 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Catechin results in decreased expression of RAC1 mRNA decreases expression
mRNA 15465739
D002392 5915 RARB
HAP
NR1B2
RRB2
retinoic acid receptor, beta Catechin results in decreased metabolism of RARB promoter decreases metabolic processing
promoter 16037419
D002392 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Catechin inhibits the reaction [Glucose affects the localization of RELA protein] affects localization
/ decreases reaction
protein 19557821
D002392 6128 RPL6
L6
SHUJUN-2
TAXREB107
TXREB1
ribosomal protein L6 Catechin results in increased expression of RPL6 mRNA increases expression
mRNA 15465739
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of NCF1 protein] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of PECAM1 mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B Catechin inhibits the reaction [S100B protein results in increased expression of TNF mRNA] decreases reaction
/ increases expression
protein 17103373
D002392 6286 S100P
MIG9
S100 calcium binding protein P Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA] decreases expression
/ decreases reaction
mRNA 17379280
D002392 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Catechin results in decreased expression of SERPINE1 mRNA decreases expression
mRNA 17379280
D002392 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 U 0126 inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA] decreases expression
/ decreases reaction
mRNA 17379280
D002392 7536 SF1
BBP
D11S636
MBBP
ZCCHC25
ZFM1
ZNF162
splicing factor 1 Catechin results in decreased expression of SF1 mRNA decreases expression
mRNA 15465739
D002392 6574 SLC20A1
GLVR1
Glvr-1
PIT1
PiT-1
solute carrier family 20 (phosphate transporter), member 1 Catechin results in increased expression of SLC20A1 mRNA increases expression
mRNA 15465739
D002392 6699 SPRR1B
CORNIFIN
GADD33
SPRR1
small proline-rich protein 1B Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of SPRR1B mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21882252
D002392 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Catechin results in decreased expression of STAT1 mRNA decreases expression
mRNA 15465739
D002392 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Catechin results in decreased expression of STAT1 protein decreases expression
protein 15465739
D002392 6777 STAT5B
STAT5
signal transducer and activator of transcription 5B Catechin results in increased expression of STAT5B mRNA increases expression
mRNA 15465739
D002392 6778 STAT6
D12S1644
IL-4-STAT
STAT6B
STAT6C
signal transducer and activator of transcription 6, interleukin-4 induced Catechin results in increased expression of STAT6 mRNA increases expression
mRNA 15465739
D002392 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein SNP results in increased sulfation of Catechin increases sulfation
protein 17293380
D002392 6932 TCF7
TCF-1
transcription factor 7 (T-cell specific, HMG-box) Catechin results in increased expression of TCF7 mRNA increases expression
mRNA 15465739
D002392 7083 TK1
TK2
thymidine kinase 1, soluble (EC:2.7.1.21) Catechin results in decreased expression of TK1 mRNA decreases expression
mRNA 15465739
D002392 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Catechin inhibits the reaction [Glucose results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 19557821
D002392 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Catechin inhibits the reaction [Glucose results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 19557821
D002392 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Catechin inhibits the reaction [S100B protein results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 17103373
D002392 943 TNFRSF8
CD30
D1S166E
Ki-1
tumor necrosis factor receptor superfamily, member 8 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA] affects cotreatment
/ decreases expression
/ decreases reaction
mRNA 21882252
D002392 943 TNFRSF8
CD30
D1S166E
Ki-1
tumor necrosis factor receptor superfamily, member 8 Catechin results in decreased expression of TNFRSF8 mRNA decreases expression
mRNA 15465739
D002392 7150 TOP1
TOPI
topoisomerase (DNA) I (EC:5.99.1.2) Catechin results in decreased expression of TOP1 mRNA decreases expression
mRNA 15465739
D002392 7150 TOP1
TOPI
topoisomerase (DNA) I (EC:5.99.1.2) Catechin results in decreased expression of TOP1 protein decreases expression
protein 15465739
D002392 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) Catechin results in decreased expression of TOP2A mRNA decreases expression
mRNA 15465739
D002392 2829 XCR1
CCXCR1
GPR5
chemokine (C motif) receptor 1 Catechin results in decreased expression of XCR1 mRNA decreases expression
mRNA 15465739
D002392 51042 ZNF593
ZT86
zinc finger protein 593 Catechin results in increased expression of ZNF593 mRNA increases expression
mRNA 15465739

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#600852 Retinitis pigmentosa 17; rp17 P22748
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (54)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

13 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D050197 D002392 Atherosclerosis therapeutic
16806235
D001943 D002392 Breast Neoplasms therapeutic
23061908
D002471 D002392 Cell Transformation, Neoplastic therapeutic
21882252
D003556 D002392 Cystitis therapeutic
15800758
D056486 D002392 Drug-Induced Liver Injury therapeutic
20211157
D034381 D002392 Hearing Loss therapeutic
20883750
D006331 D002392 Heart Diseases therapeutic
8564920
D020138 D002392 HYPERHOMOCYSTEINEMIA therapeutic
17292331
D008107 D002392 Liver Diseases therapeutic
19428341
D017114 D002392 Liver Failure, Acute therapeutic
1874459
D008113 D002392 Liver Neoplasms therapeutic
8603484
D008325 D002392 Mammary Neoplasms, Experimental therapeutic
11962253
D009362 D002392 Neoplasm Metastasis therapeutic
23061908