Species

KNApSAcK Entry

Organism name Artabotrys uncinatus
Genus Artabotrys
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Artabotrys
Linked NCBI taxonomy ID 225832
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (47)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00013738 External link 512 Artabotryside B
/ Kaempferol 3-rhamnosyl-(1->2)-alpha-L-arabinofuranoside
/ 3-[[2-O-(6-Deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinofuranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-Bbenzopyran-4-one
C470038
No. 1 No. 15
C00013837 External link 512 Artabotryside A
/ Quercetin 3-rhamnosyl-(1->2)-alpha-L-arabinofuranoside
/ 3-[[2-O-(6-Deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinofuranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
C470037
No. 1 No. 15
C00001016 External link 512 7-O-Methylacacetin
/ Acacetin 7-methyl ether
/ Genkwanin 4'-methyl ether
/ Apigenin 7,4'-dimethyl ether
/ 5-Hydroxy-4',7-dimethoxyflavone
/ 5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL350958
C044998
1 / 0 / 0 No. 3 No. 15
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00001807 External link 512 Anonaine
/ (-)-Anonaine
/ (R)-Annonaine
CHEMBL401798
C098138
1 / 0 / 0 No. 20 No. 4
C00045468 External link 512 (-)-Cissaglaberrimine
No. 20 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00027391 External link 512 Isopiline
/ (-)-Isopiline
CHEMBL508011
No. 20 No. 4
C00027441 External link 512 Nornuciferine
/ Sanjoinine Ia
/ Daechualkaloid E
CHEMBL36496
CHEMBL325416
CHEMBL1164391
1 / 0 / 0 No. 20 No. 4
C00025991 External link 512 O-Nornuciferine
/ (-)-Nornuciferine
/ (-)-N-Methylasimilobine
CHEMBL2316499
No. 20 No. 4
C00027438 External link 512 Sanjoinine Ib
/ Norisocorydine
CHEMBL465212
No. 20 No. 4
C00027281 External link 512 Anonaine
CHEMBL401798
C098138
1 / 0 / 0 No. 20 No. 4
C00027428 External link 512 N-Methylisopiline
CHEMBL257747
CHEMBL519236
No. 20 No. 4
C00027246 External link 512 10-O-Demethyldiscretine
/ (-)-O10-Demethyldiscretine
No. 37 No. 4
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00000947 External link 512 D-Catechol
/ D-Catechin
/ Teafuran 30A
/ (+)-Catechin
/ Dexcyanidanol
/ (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
D002392
85 / 58 / 54 91 / 13 No. 52 No. 14
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00029312 External link 512 7alpha-Hydroxystigmasterol
/ Stigmasta-5,22-dien-3beta,7alpha.-diol
/ (22E,24S)-Stigmasta-5,22-dien-3beta,7alpha-diol
CHEMBL455107
No. 53 No. 11
C00000674 External link 512 Luteolin
CHEMBL151
D047311
99 / 91 / 95 76 / 6 No. 71 No. 15
C00003817 External link 512 Apigenin
/ 5,7,4'-Trihydroxyflavone
CHEMBL28
D047310
164 / 119 / 105 68 / 8 No. 71 No. 15
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00027298 External link 512 Artabonatine C
No. 74
C00025890 External link 512 Liridine
/ Homomoschatoline
/ O-Methylmoschatoline
/ O-Methylisomoschatoline
CHEMBL227533
No. 74
C00001813 External link 512 Atherospermidine
C064684
No. 74
C00021776 External link 512 Clovanediol
/ Cloven-2beta,9alpha-diol
/ Clovane-2beta,9alpha-diol
CHEMBL465622
CHEMBL504604
No. 161 No. 38
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00027366 External link 512 Flavinantine
/ (-)-Flavinantine
CHEMBL463084
1 / 4 / 2 No. 426 No. 4
C00001916 External link 512 Salutaridine
/ (+)-Salutaridine
CHEMBL402782
CHEMBL404097
C009270
3 / 4 / 2 No. 426 No. 4
C00045477 External link 512 (+)-Flavinantine
CHEMBL463084
1 / 4 / 2 No. 426 No. 4
C00028801 External link 512 Paprazine
/ N-p-Coumaroyl-tyramine
/ trans-N-(p-Coumaroyl)tyramine
CHEMBL64286
No. 499
C00012483 External link 512 Betula pubescens
/ Caryophyllene oxide
/ trans-Caryophyllene oxide
/ beta-Caryophyllene epoxide
/ (-)-Epoxydihydrocaryophyllene
/ 6,7-Epoxy-3(15)-caryophyllene
/ (-)-beta-Caryophyllene epoxide
/ 4beta,5alpha-Epoxycaryophyllene
/ Caryophyllene 4beta,5alpha-epoxide
CHEMBL399036
CHEMBL508894
CHEMBL479134
CHEMBL1513806
CHEMBL1553274
3 / 1 / 3 No. 500
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00027444 External link 512 Michelalbine
/ Norushinsunine
CHEMBL464657
CHEMBL1618042
No. 553
C00003467 External link 512 Phytol
/ trans-Phytol
CHEMBL390773
CHEMBL1644111
D010836
0 / 5 No. 641 No. 38
C00025272 External link 512 Stepharine
/ (+)-Stepharine
CHEMBL463957
CHEMBL1975436
C009320
No. 688
C00027300 External link 512 Artabonatine F
No. 796
C00000149 External link 512 Spathulenol
CHEMBL518542
CHEMBL1774433
C013258
No. 1603
C00049425 External link 512 Artabonatine A
No. 3108
C00045664 External link 512 Artabonatine E
/ (-)-Artabonatine E
No. 3108
C00036764 External link 512 Artabonatine B
/ (-)-Artabonatine B
CHEMBL458523
1 / 4 / 2 No. 3212
C00046415 External link 512 Squamolone
CHEMBL506960
1 / 4 / 2 No. 4369
C00046491 External link 512 Uncinine
CHEMBL502212
1 / 4 / 2 No. 5800
C00027301 External link 512 Artacinatine
No. 7639
C00027299 External link 512 Artabonatine D
No. 8396

Human Protein / Gene in interactions

238 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00734 Prothrombin S1A C00000947 C00001916 C00003672 C00019308 C00025629 C00027366 C00036764 C00045477 C00046415 C00046491 4 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000674 C00000947 C00001872 C00003672 C00003817 C00012483 0 / 1
P06746 DNA polymerase beta Enzyme C00000674 C00000947 C00003672 C00019308 C00023774 C00025625 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000674 C00000947 C00001872 C00003672 C00003817 C00012483 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000674 C00000947 C00001872 C00003672 C00003817 C00012483 1 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00000674 C00001872 C00001916 C00003817 C00025629 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000947 C00001910 C00001916 C00003817 C00025629 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000674 C00000947 C00001872 C00003672 C00003817 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000674 C00000947 C00003672 C00003817 C00025625 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000674 C00000947 C00001872 C00003672 C00003817 1 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001807 C00001878 C00025625 C00027281 C00027441 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000674 C00000947 C00003817 C00025625 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000674 C00000947 C00001872 C00003817 3 / 3
P39748 Flap endonuclease 1 Enzyme C00000674 C00000947 C00003817 C00025625 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000674 C00001872 C00003817 C00025625 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000674 C00000947 C00003672 C00003817 3 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00000674 C00000947 C00001872 C00003817 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000674 C00000947 C00003817 C00025625 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00000674 C00001872 C00003817 C00025625 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00000674 C00001872 C00003817 C00025625 0 / 1
O75496 Geminin Unclassified protein C00000674 C00001872 C00003817 C00025625 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000674 C00000947 C00003817 C00025625 1 / 2
P49841 Glycogen synthase kinase-3 beta Gsk C00000674 C00003672 C00003817 C00019308 0 / 0
O00255 Menin Unclassified protein C00000674 C00000947 C00003817 C00025625 2 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00000674 C00000947 C00003817 C00025625 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000674 C00000947 C00001872 C00003817 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000674 C00000947 C00003817 C00023774 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000674 C00000947 C00003817 C00025625 0 / 0
P03372 Estrogen receptor NR3A1 C00000674 C00003672 C00003817 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00000674 C00000947 C00003817 4 / 1
Q9Y3R4 Sialidase-2 Enzyme C00000674 C00000947 C00003817 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000674 C00000947 C00025625 1 / 1
P22303 Acetylcholinesterase Hydrolase C00000674 C00003817 C00025231 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000674 C00003817 C00025625 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000674 C00000947 C00025625 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000674 C00000947 C00003817 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000947 C00003672 C00019308 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000674 C00000947 C00003817 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000674 C00000947 C00003817 4 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000674 C00003817 C00025625 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000674 C00000947 C00003817 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000674 C00000947 C00003817 0 / 3
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000674 C00000947 C00003817 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000674 C00000947 C00003817 2 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000674 C00000947 C00003817 0 / 0
P08183 Multidrug resistance protein 1 drug C00000674 C00003672 C00003817 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000674 C00025625 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000674 C00003817 1 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000947 C00003817 1 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00000674 C00003817 1 / 0
Q15046 Lysine--tRNA ligase Enzyme C00000674 C00003817 2 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim C00000674 C00003817 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000674 C00003817 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000947 C00003817 5 / 1
P49327 Fatty acid synthase Transferase C00000674 C00000947 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000674 C00003817 3 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00019308 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000674 C00003817 11 / 10
O95271 Tankyrase-1 Enzyme C00000674 C00003817 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000674 C00000947 0 / 1
Q00535 Cyclin-dependent kinase 5 Cdk5 C00000674 C00003817 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000674 C00003817 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00000674 C00003817 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00003817 C00023774 0 / 0
P54132 Bloom syndrome protein Enzyme C00000674 C00000947 1 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000947 C00003817 0 / 0
P10275 Androgen receptor NR3C4 C00000674 C00003817 3 / 4
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00000674 C00025625 1 / 0
P06239 Tyrosine-protein kinase Lck Src C00000674 C00003817 0 / 1
P11387 DNA topoisomerase 1 Isomerase C00000674 C00002631 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000674 C00000947 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000947 C00003817 2 / 3
P17252 Protein kinase C alpha type Alpha C00000947 C00003817 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000947 C00003817 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000674 C00000947 0 / 0
Q9H2K2 Tankyrase-2 Enzyme C00000674 C00003817 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00003817 1 / 0
P04062 Glucosylceramidase Enzyme C00000674 C00003817 6 / 4
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00000674 C00003817 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000947 C00003817 5 / 2
P33765 Adenosine receptor A3 Adenosine receptor C00001016 C00003817 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003817 C00025625 1 / 1
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00000674 C00003817 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000674 C00003817 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000674 C00003817 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000674 C00003817 2 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00000674 C00003817 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 C00003817 2 / 0
Q99700 Ataxin-2 Unclassified protein C00000674 C00003817 1 / 1
P06493 Cyclin-dependent kinase 1 Cdc2 C00000674 C00003817 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00000674 C00003817 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000674 C00003817 4 / 2
P56817 Beta-secretase 1 A1A C00000947 C00003817 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000947 C00003817 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000947 C00003817 0 / 0
P04745 Alpha-amylase 1 Enzyme C00000674 C00000947 0 / 0
P06276 Cholinesterase Hydrolase C00000674 C00003817 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000674 C00003817 7 / 37
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000674 C00003817 4 / 4
P14679 Tyrosinase Oxidoreductase C00000674 C00003672 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00000674 C00003817 0 / 1
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00000674 C00003817 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000947 C00003817 3 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00000674 C00003817 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00000674 C00003817 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000674 C00003817 0 / 0
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00003817 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00000947 0 / 0
P03956 Interstitial collagenase M10A C00000674 0 / 1
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x C00003817 1 / 1
O15264 Mitogen-activated protein kinase 13 p38 C00003817 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003817 2 / 2
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00003817 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00003817 5 / 3
P07711 Cathepsin L1 C1A C00000947 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000947 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000674 1 / 1
P10145 Interleukin-8 Secreted protein C00003817 0 / 0
P45452 Collagenase 3 M10A C00000674 1 / 1
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00003817 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000674 2 / 0
Q96RI1 Bile acid receptor NR1H4 C00003817 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000947 2 / 3
Q92731 Estrogen receptor beta NR3A2 C00003817 0 / 1
P10696 Alkaline phosphatase, placental-like Enzyme C00000947 0 / 1
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00003817 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000947 0 / 1
P08253 72 kDa type IV collagenase M10A C00000674 1 / 3
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily C00003817 0 / 0
P07998 Ribonuclease pancreatic Enzyme C00000947 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00003817 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00003817 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00000947 1 / 2
P68871 Hemoglobin subunit beta Secreted protein C00003817 4 / 4
Q9ULX7 Carbonic anhydrase 14 Lyase C00000947 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00003817 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000674 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00003817 0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00003817 0 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00000674 1 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00003817 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00000947 1 / 1
P23280 Carbonic anhydrase 6 Lyase C00000947 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00003817 1 / 8
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00000674 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00003817 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00003817 0 / 0
P51570 Galactokinase Enzyme C00000674 1 / 1
P07948 Tyrosine-protein kinase Lyn Src C00003817 0 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P31749 RAC-alpha serine/threonine-protein kinase Akt C00003817 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00003817 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00003817 0 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00003817 0 / 0
P02768 Serum albumin Secreted protein C00000947 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000947 1 / 2
P68400 Casein kinase II subunit alpha Ck2 C00003817 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00003817 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003817 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00003817 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00003817 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000947 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003817 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000947 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000674 2 / 2
Q04760 Lactoylglutathione lyase Enzyme C00000674 0 / 0
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00003817 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00003817 0 / 0
P43405 Tyrosine-protein kinase SYK Syk C00003817 0 / 0
P08254 Stromelysin-1 M10A C00000674 1 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00003817 1 / 0
P22748 Carbonic anhydrase 4 Lyase C00000947 1 / 1
P53778 Mitogen-activated protein kinase 12 p38 C00003817 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000947 0 / 7
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00003817 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000947 0 / 0
P39900 Macrophage metalloelastase M10A C00000674 0 / 0
P40225 Thrombopoietin Unclassified protein C00003817 1 / 1
P43166 Carbonic anhydrase 7 Lyase C00000947 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000947 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000947 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00003817 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00003817 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00003817 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000947 3 / 0
Q05513 Protein kinase C zeta type Iota C00000947 0 / 0
Q04759 Protein kinase C theta type Delta C00000947 0 / 1
Q02156 Protein kinase C epsilon type Eta C00000947 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000947 0 / 0
Q05655 Protein kinase C delta type Delta C00000947 0 / 0
P05129 Protein kinase C gamma type Alpha C00000947 1 / 1
P05771 Protein kinase C beta type Alpha C00000947 0 / 0
P24723 Protein kinase C eta type Eta C00000947 1 / 0
P41743 Protein kinase C iota type Iota C00000947 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000947 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00003817 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00003817 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00003817 1 / 1
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000947 3 / 1
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00003817 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00003817 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00003817 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00003817 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00003817 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00003817 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00003817 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00003817 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00003817 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00003817 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00003817 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00003817 1 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00003817 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00003817 0 / 1
P45984 Mitogen-activated protein kinase 9 Jnk C00003817 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00003817 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00003817 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00003817 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00003817 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00003817 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00003817 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00003817 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00003817 0 / 0
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00003817 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00003817 1 / 0
P49674 Casein kinase I isoform epsilon Ck1 C00003817 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00003817 0 / 0
P48729 Casein kinase I isoform alpha Ck1 C00003817 0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00003817 1 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000947 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000674 2 / 1

175 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000674 C00000947 C00003817
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000674 C00000947 C00003817
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000674 C00000947 C00003817
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000674 C00000947 C00003817
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000674 C00000947 C00003817
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000674 C00000947 C00003817
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000674 C00000947 C00003817
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000674 C00000947 C00003817
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000674 C00000947 C00003817
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000674 C00000947 C00003817
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000674 C00000947 C00003817
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000674 C00000947 C00003817
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000674 C00000947 C00003817
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000674 C00003817
8000 PSCA, PRO232 prostate stem cell antigen C00000674 C00003817
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00000674 C00003817
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00000674 C00003817
581 BAX, BCL2L4 BCL2-associated X protein C00000674 C00000947
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000674 C00003817
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00000674 C00003817
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000674 C00003817
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000674 C00003817
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00000674 C00003817
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00000674 C00003817
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00000674 C00003817
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000674 C00003817
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000674 C00003817
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000947 C00003817
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00000674 C00003817
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000674 C00003817
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00000674 C00003817
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000674 C00003817
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00000674 C00003817
958 CD40, Bp50, CDW40, TNFRSF5, p50 CD40 molecule, TNF receptor superfamily member 5 C00000674 C00003817
891 CCNB1, CCNB cyclin B1 C00000674 C00003817
847 CAT catalase (EC:1.11.1.6) C00000674 C00003817
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000674 C00003817
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000674 C00003817
7161 TP73, P73 tumor protein p73 C00000674 C00003817
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000947 C00003817
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000674 C00003817
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000674 C00003817
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000674 C00000947
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000674 C00000947
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000674 C00000947
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00000674 C00003817
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00000674 C00003817
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000674 C00000947
6783 SULT1E1, EST, EST-1, ST1E1, STE sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) C00003817
4067 LYN, JTK8, p53Lyn, p56Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) C00000947
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000947
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00000947
3683 ITGAL, CD11A, LFA-1, LFA1A integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) C00000947
3662 IRF4, LSIRF, MUM1, NF-EM5 interferon regulatory factor 4 C00000947
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00000947
64975 MRPL41, BMRP, MRP-L27, MRPL27, RPML27 mitochondrial ribosomal protein L41 C00000947
4493 MT1E, MT1, MTD metallothionein 1E C00000947
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000947
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000947
9235 IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd interleukin 32 C00000947
4851 NOTCH1, TAN1, hN1 notch 1 C00000947
4869 NPM1, B23, NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) C00000947
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00000947
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00000947
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000947
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00000947
7916 PRRC2A, BAT2, D6S51, D6S51E, G2 proline-rich coiled-coil 2A C00000947
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000947
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00000947
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000947
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000947
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00000947
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00000947
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00000947
6286 S100P, MIG9 S100 calcium binding protein P C00000947
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000947
7536 SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 splicing factor 1 C00000947
6574 SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 solute carrier family 20 (phosphate transporter), member 1 C00000947
6699 SPRR1B, CORNIFIN, GADD33, SPRR1 small proline-rich protein 1B C00000947
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000947
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000947
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00000947
3232 HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 homeobox D3 C00000947
6932 TCF7, TCF-1 transcription factor 7 (T-cell specific, HMG-box) C00000947
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00000947
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000947
943 TNFRSF8, CD30, D1S166E, Ki-1 tumor necrosis factor receptor superfamily, member 8 C00000947
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00000947
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000947
2829 XCR1, CCXCR1, GPR5 chemokine (C motif) receptor 1 C00000947
51042 ZNF593, ZT86 zinc finger protein 593 C00000947
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774
3054 HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF host cell factor C1 (VP16-accessory protein) C00000947
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000947
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00003817
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003817
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00000947
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00000947
2323 FLT3LG, FL, FLT3L fms-related tyrosine kinase 3 ligand C00000947
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000947
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00000947
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00000947
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00003817
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00003817
1584 CYP11B1, CPN1, CYP11B, FHI, P450C11 cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4) C00003817
1586 CYP17A1, CPT7, CYP17, P450C17, S17AH cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) C00003817
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003817
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00003817
7913 DEK, D6S231E DEK oncogene C00000947
1589 CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) C00003817
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003817
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00000947
2064 ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) C00003817
10063 COX17 COX17 cytochrome c oxidase copper chaperone C00000947
10978 CLP1, HEAB, hClp1 cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) C00000947
1054 CEBPG, GPE1BP, IG/EBP-1 CCAAT/enhancer binding protein (C/EBP), gamma C00000947
928 CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 CD9 molecule C00000947
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003817
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00003817
3284 HSD3B2, HSD3B, HSDB, SDR11E2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) C00003817
975 CD81, CVID6, S5.7, TAPA1, TSPAN28 CD81 molecule C00000947
930 CD19, B4, CVID3 CD19 molecule C00000947
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000947
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000947
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000947
5241 PGR, NR3C3, PR progesterone receptor C00003817
5562 PRKAA1, AMPK, AMPKa1 protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) C00003817
79184 BRCC3, BRCC36, C6.1A, CXorf53 BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) C00000947
6198 RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) C00003817
388962 BOLA3, MMDS2 bolA family member 3 C00000947
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00000947
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003817
637 BID, FP497 BH3 interacting domain death agonist C00000947
56751 BARHL1 BarH-like homeobox 1 C00000947
2683 B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) C00000947
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000947
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00003817
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00003817
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00003817
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00003817
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00003817
7402 UTRN, DMDL, DRP, DRP1 utrophin C00003817
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00000947
393 ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 Rho GTPase activating protein 4 C00000947
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00000947
177 AGER, RAGE advanced glycosylation end product-specific receptor C00000674
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000674
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00000674
890 CCNA2, CCN1, CCNA cyclin A2 C00000674
972 CD74, DHLAG, HLADG, II, Ia-GAMMA CD74 molecule, major histocompatibility complex, class II invariant chain C00000674
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000674
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000674
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00000674
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00000674
1950 EGF, HOMG4, URG epidermal growth factor C00000674
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00000674
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00000674
2354 FOSB, AP-1, G0S3, GOS3, GOSB FBJ murine osteosarcoma viral oncogene homolog B C00000674
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00000674
3726 JUNB, AP-1 jun B proto-oncogene C00000674
3727 JUND, AP-1 jun D proto-oncogene C00000674
5602 MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK mitogen-activated protein kinase 10 (EC:2.7.11.24) C00000674
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000674
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00000674
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00000674
9572 NR1D1, EAR1, THRA1, THRAL, ear-1, hRev nuclear receptor subfamily 1, group D, member 1 C00000674
5347 PLK1, PLK, STPK13 polo-like kinase 1 (EC:2.7.11.21) C00000674
2810 SFN, YWHAS stratifin C00000674
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000674
29110 TBK1, NAK, T2K TANK-binding kinase 1 (EC:2.7.11.1) C00000674
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00000674
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000674
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000674
10451 VAV3 vav 3 guanine nucleotide exchange factor C00000674
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00000674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (155)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P47869
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P31749
P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#230200 Galactokinase deficiency P51570
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#176920 Proteus syndrome P31749
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#603903 Sickle cell anemia P68871
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (126)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
P08581 (related)
P10415 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04637 (related)
P08253 (related)
P10415 (related)
H00030 Cervical cancer P00533 (related)
P10415 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00070 Galactosemia P51570 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

31 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00000947
C00003467
C00003817
D009362 Neoplasm Metastasis C00000947
C00003817
D001943 Breast Neoplasms C00000947
C00003817
D002493 Central Nervous System Diseases C00019308
D013118 Spinal Cord Diseases C00019308
D002471 Cell Transformation, Neoplastic C00000947
D003556 Cystitis C00000947
D003072 Cognition Disorders C00019308
D034381 Hearing Loss C00000947
D006331 Heart Diseases C00000947
D020138 HYPERHOMOCYSTEINEMIA C00000947
D008107 Liver Diseases C00000947
D017114 Liver Failure, Acute C00000947
D008113 Liver Neoplasms C00000947
D008325 Mammary Neoplasms, Experimental C00000947
D050197 Atherosclerosis C00000947
D006965 Hyperplasia C00003467
D006984 Hypertrophy C00003467
D009336 Necrosis C00003467
D015431 Weight Loss C00003467
D000257 Adenoviridae Infections C00003817
D003110 Colonic Neoplasms C00003817
D009361 Neoplasm Invasiveness C00003817
D011041 Poisoning C00003817
D011471 Prostatic Neoplasms C00003817
D009202 Cardiomyopathies C00000674
D002386 Cataract C00000674
D005483 Flushing C00000674
D006529 Hepatomegaly C00000674
D008103 Liver Cirrhosis C00000674
D010051 Ovarian Neoplasms C00000674