KCF-S cluster No. 20 (140 metabolites)
Corresponding Phytochemical cluster No. 4
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| Magnoliophyta | 394 |
| eudicotyledons | 311 |
| rosids | 16 |
| Liliopsida | 13 |
| asterids | 2 |
| Spermatophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Annonaceae
|
187 |
|
Lauraceae
|
156 |
|
Papaveraceae
|
138 |
|
Menispermaceae
|
124 |
|
Ranunculaceae
|
28 |
|
Berberidaceae
|
19 |
|
Hernandiaceae
|
16 |
|
Colchicaceae
|
13 |
|
Siparunaceae
|
13 |
|
Magnoliaceae
|
12 |
|
Euphorbiaceae
|
9 |
|
Atherospermataceae
|
5 |
|
Monimiaceae
|
3 |
|
Rhamnaceae
|
3 |
|
Fabaceae
|
2 |
|
Aristolochiaceae
|
2 |
|
Rutaceae
|
1 |
|
Phyllanthaceae
|
1 |
|
Proteaceae
|
1 |
|
Gentianaceae
|
1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Isoquinoline alkaloids | 23 |
metabolites link (27)
Metabolite list (140)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001790
|
Actinodaphnine
/ (+)-Actinodaphnine / 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine |
CHEMBL518088
CHEMBL1588263 |
C060992
|
30 / 32 / 24 |
|
|
|
C00001806
|
Anolobine
/ (-)-Anolobine |
CHEMBL257746
|
|
|||
|
C00001807
|
Anonaine
/ (-)-Anonaine / (R)-Annonaine |
CHEMBL401798
|
C098138
|
1 / 0 / 0 |
|
|
|
C00001808
|
Apoglaziovine
/ (-)-Apoglaziovine |
|
||||
|
C00001822
|
Boldine
/ d-Boldine |
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
C011686
|
34 / 32 / 35 |
|
|
|
C00001823
|
Bracteoline
|
CHEMBL410604
CHEMBL1316470 |
C002507
|
13 / 18 / 47 |
|
|
|
C00001824
|
Bulbocapnine
/ d-Bulbocapnine |
CHEMBL157912
|
C083807
|
0 / 1 |
|
|
|
C00001825
|
Caaverine
/ (-)-Caaverine |
|
||||
|
C00001833
|
Cassyfiline
|
CHEMBL254549
|
|
|||
|
C00001834
|
Cassythicine
/ (+)-Cassythicine / N-Methylactinodaphnine / (+)-N-Methylactinodaphnine |
CHEMBL464528
|
|
|||
|
C00001861
|
Glaucine
/ S-(+)-Glaucine / O,O-Dimethylisoboldine |
CHEMBL36536
CHEMBL228082 |
14 / 8 / 6 |
|
||
|
C00001869
|
Isoboldine
/ (S)-Isoboldine |
CHEMBL462880
|
19 / 22 / 55 |
|
||
|
C00001872
|
Isocorydine
/ (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine |
CHEMBL489525
CHEMBL1376826 |
14 / 7 / 10 |
|
||
|
C00001873
|
Isothebaine
|
C111588
|
|
|||
|
C00001887
|
(+)-Mecambroline
|
|
||||
|
C00001908
|
Pukateine
|
CHEMBL258370
|
|
|||
|
C00001928
|
Xylopine
/ (-)-Xylopine |
CHEMBL227689
CHEMBL452201 |
C062700
|
|
||
|
C00025109
|
Hernandine
|
|
||||
|
C00025230
|
(-)-Acetylsukhodianine
/ (-)-O-Acetylsukhodianine |
|
||||
|
C00025231
|
Asimilobine
/ (-)-Asimilobine |
CHEMBL389271
CHEMBL469423 |
C054614
|
1 / 1 / 0 |
|
|
|
C00025235
|
Crebanin
/ (-)-Crebanine |
CHEMBL604339
CHEMBL1989287 |
C061009
|
1 / 0 / 0 |
|
|
|
C00025242
|
/ (-)-Mecambroline / (R)-(-)-Mecambroline |
|
||||
|
C00025244
|
(-)-Nuciferoline
/ (R)-(-)-Nuciferoline |
|
||||
|
C00025249
|
Stesakine
/ (-)-Stesakine |
|
||||
|
C00025250
|
Sukhodianine
/ (-)-Sukhodianine |
|
||||
|
C00025257
|
Tuduranine
/ (-)-Tuduranine |
CHEMBL1625175
|
|
|||
|
C00025267
|
N-Formylnornantenine
/ (+)-N-Formylnornantenine |
|
||||
|
C00025269
|
Nornantenine
/ N-Nornantenine / (+)-Nornantenine |
CHEMBL1254951
|
1 / 0 / 0 |
|
||
|
C00025294
|
Ayuthianine
/ (-)-Ayuthianine |
|
||||
|
C00025607
|
NSC 251699
/ L-Dicentrine / (-)-Dicentrine / (R)-(-)-Dicentrine |
CHEMBL464748
CHEMBL478754 |
15 / 20 / 16 |
|
||
|
C00025612
|
(-)-Isolaureline
|
CHEMBL389270
CHEMBL510954 CHEMBL600966 |
|
|||
|
C00025622
|
(-)-Nordicentrine
|
CHEMBL518744
|
|
|||
|
C00025623
|
Phanostenine
/ (-)-Phanostenine |
CHEMBL515639
|
|
|||
|
C00025625
|
Roemerine
/ (-)-Remerine / (-)-Aporheine / (-)-Roemerine |
CHEMBL36654
CHEMBL483825 |
C030169
|
23 / 10 / 13 |
|
|
|
C00025626
|
Remeroline
/ (R)-Roemeroline / (-)-Roemeroline / N-Methylanolobine |
CHEMBL499835
|
|
|||
|
C00025630
|
Stephanine
/ l-Stephanine / (-)-Stephanine / (R)-(-)-Stephanine |
CHEMBL601020
|
C054160
|
1 / 0 / 0 |
|
|
|
C00025655
|
Corytuberine
/ (+)-Corytuberine |
CHEMBL227965
|
C013896
|
1 / 0 / 0 |
|
|
|
C00025658
|
/ Eximine / Dicentrine / d-Dicentrine / (+)-Dicentrine / O,N-Dimethyllitseferine |
CHEMBL464748
CHEMBL478754 |
C067342
|
15 / 20 / 16 |
|
|
|
C00025659
|
Epiglaufidine
/ (+)-Epiglaufidine |
|
||||
|
C00025675
|
Lauroscholtzine
/ 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine |
CHEMBL464099
|
1 / 1 / 0 |
|
||
|
C00025676
|
Norglaucin
/ Norglaucine / (+)-Norglaucine / O,O-Dimethyllaurelliptine |
|
||||
|
C00025699
|
(R)-Roemeroline
|
CHEMBL499835
|
|
|||
|
C00025750
|
4-Hydroxycrebanine
|
|
||||
|
C00025797
|
Cissaglaberrimine
/ (+)-Cissaglaberrimine |
|
||||
|
C00025827
|
Corydine
/ Glaucentrin / (+)-Corydine / Glaucentrine |
CHEMBL489524
CHEMBL2002847 |
C067341
|
1 / 0 / 0 |
|
|
|
C00025905
|
Isocorytuberine
/ (+)-Isocorytuberine / O10-Demethylcorydine |
|
||||
|
C00025931
|
Liriotulipiferine
|
CHEMBL1996399
|
|
|||
|
C00025932
|
Litseferine
/ Litseglutine A / (+)-Litseferine |
|
||||
|
C00025953
|
Nantenine
/ Domestine / (+)-Domestine / (+)-Nantenine / O-Methyldomesticine |
CHEMBL179440
CHEMBL467094 |
38 / 10 / 2 |
|
||
|
C00025962
|
Norisoboldine
/ Laurelliptine / (+)-Norisoboldine / (+)-Laurelliptine / (+)-N-Norisoboldine / (S)-(+)-Laurelliptine |
CHEMBL375902
|
|
|||
|
C00025976
|
Nuciferine
|
CHEMBL464529
|
C008692
|
0 / 1 |
|
|
|
C00025991
|
O-Nornuciferine
/ (-)-Nornuciferine / (-)-N-Methylasimilobine |
CHEMBL2316499
|
|
|||
|
C00026016
|
Predicentrine
/ (+)-Predicentrine |
CHEMBL404136
|
|
|||
|
C00026044
|
Stephalagine
|
|
||||
|
C00026138
|
N-Methyllindcarpine
/ (+)-N-Methyllindcarpine |
|
||||
|
C00027150
|
Nantenine
/ (+)-Domestine / (+)-Nantenine |
CHEMBL179440
CHEMBL467094 |
C041615
|
38 / 10 / 2 |
|
|
|
C00027153
|
Norcorydine
/ (+)-Norcorydine |
CHEMBL494053
|
|
|||
|
C00027157
|
Oliverine
/ O-Methyloliveridine |
CHEMBL494256
CHEMBL2009025 |
|
|||
|
C00027225
|
N-Methyllindcarpine
/ (+)-N-Methyllindcarpine |
|
||||
|
C00027228
|
Nordicentrine
/ (+)-Nordicentrine |
CHEMBL518744
|
C084697
|
|
||
|
C00027238
|
Thalicmidine
/ Thaliporphine / (+)-Thaliporphine / (S)-O-Methylisoboldine |
CHEMBL1394328
CHEMBL1397308 |
C080702
|
20 / 26 / 56 |
|
|
|
C00027239
|
Wilsonirine
/ (+)-Wilsonirine / (+)-1-Hydroxy-2,9,10-trimethoxynoraporphine |
CHEMBL2332233
CHEMBL2332234 |
|
|||
|
C00027281
|
Anonaine
|
CHEMBL401798
|
C098138
|
1 / 0 / 0 |
|
|
|
C00027304
|
Boldine
/ d-Boldine / (+)-Boldine |
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
C011686
|
34 / 32 / 35 |
|
|
|
C00027305
|
Bracteoline
|
CHEMBL410604
CHEMBL1316470 |
C002507
|
13 / 18 / 47 |
|
|
|
C00027307
|
Calycinine
/ (-)-Calycinine |
CHEMBL226824
|
|
|||
|
C00027333
|
Dasymachaline
|
|
||||
|
C00027348
|
Duguetine
|
|
||||
|
C00027349
|
Duguevanine
/ (-)-Duguevanine |
|
||||
|
C00027391
|
Isopiline
/ (-)-Isopiline |
CHEMBL508011
|
|
|||
|
C00027405
|
Laetanine
/ (+)-Laetanine |
|
||||
|
C00027406
|
Laetine
|
|
||||
|
C00027407
|
Launobine
/ (+)-Launobine |
CHEMBL516862
|
|
|||
|
C00027409
|
Laurotetanin
/ Laurotetanine / (+)-Laurotetanine |
CHEMBL464098
|
C008256
|
|
||
|
C00027412
|
Bechuanin
/ Merenderine / (S)-Floramultine |
|
||||
|
C00027428
|
N-Methylisopiline
|
CHEMBL257747
CHEMBL519236 |
|
|||
|
C00027433
|
Laurolitsine
/ (+)-Norboldine / (+)-Laurolitsine |
CHEMBL487388
|
C109133
|
|
||
|
C00027435
|
Nordomesticine
|
|
||||
|
C00027438
|
Sanjoinine Ib
/ Norisocorydine |
CHEMBL465212
|
|
|||
|
C00027441
|
Nornuciferine
/ Sanjoinine Ia / Daechualkaloid E |
CHEMBL36496
CHEMBL325416 CHEMBL1164391 |
1 / 0 / 0 |
|
||
|
C00027447
|
Ocotein
/ Ocoteine / Thalicmin / Thalicmine |
CHEMBL443099
|
|
|||
|
C00027448
|
Oliveridine
/ (-)-Oliveridine |
CHEMBL506088
|
|
|||
|
C00027450
|
O-Methylbulbocapnine
|
CHEMBL464955
|
|
|||
|
C00027453
|
O-Methylisopiline
|
|
||||
|
C00027492
|
Thalicsimidine
|
|
||||
|
C00027510
|
3-Hydroxynuciferine
|
|
||||
|
C00027551
|
Isodomesticine
/ (+)-1-Methoxy-2-hydroxy-9,10-methylenedioxyaporphine |
|
||||
|
C00027566
|
Nandigerine
/ Hernangerine / (+)-Nandigerine / (+)-Hernangerine |
CHEMBL1190170
|
|
|||
|
C00027569
|
N-Formylnornantenine
|
|
||||
|
C00027576
|
Nuciferine
/ D-(-)-Nuciferine |
CHEMBL464529
|
C008692
|
0 / 1 |
|
|
|
C00027587
|
Preocoteine
|
|
||||
|
C00027589
|
Purpureine
/ Thalicsimidin / (+)-Purpureine / Thalicsimidine |
|
||||
|
C00027632
|
(+)-Kreysigine
|
|
||||
|
C00027748
|
3-Hydroxynornuciferine
|
CHEMBL461698
|
|
|||
|
C00027749
|
3-Methoxynordomesticine
|
|
||||
|
C00027750
|
O-Methyllirinine
/ O-Methylliridinine / 3-Methoxynuciferine / N,O-Dimethylisopiline |
|
||||
|
C00027807
|
Acutifolidine
|
|
||||
|
C00027856
|
Androbine
|
|
||||
|
C00027857
|
Androcine
/ (+)-Androcine |
|
||||
|
C00027920
|
Baytopine
/ (+)-Baytopine |
|
||||
|
C00028092
|
Crabbine
|
|
||||
|
C00028217
|
Domesticine
/ (+)-Domesticine |
CHEMBL1808240
|
|
|||
|
C00028239
|
Elmerillicine
|
CHEMBL461697
|
|
|||
|
C00028432
|
Kreysigine N-oxide
|
|
||||
|
C00028450
|
Lastourvilline
|
|
||||
|
C00028475
|
Lirioferine
|
|
||||
|
C00028572
|
Merenderine
|
|
||||
|
C00028673
|
Neolitsine
|
CHEMBL404684
|
|
|||
|
C00028698
|
N-Methyldanguyelline
|
|
||||
|
C00028701
|
N-Methylhernovine
/ (-)-N-Methylhernovine |
CHEMBL1183924
|
|
|||
|
C00028712
|
Norandrobine
|
|
||||
|
C00028720
|
Norguattevaline
/ (+)-Norguattevaline |
CHEMBL470272
|
|
|||
|
C00028722
|
Norisocorytuberine
|
|
||||
|
C00028723
|
Norisodomesticine
/ (+)-Norisodomesticine |
|
||||
|
C00028724
|
Norlirioferine
|
|
||||
|
C00028727
|
Nornantenine
|
CHEMBL1254951
|
1 / 0 / 0 |
|
||
|
C00028751
|
O,O-Dimethylcorytuberine
|
CHEMBL206505
CHEMBL486381 |
C013897
|
1 / 1 / 0 |
|
|
|
C00028766
|
O-Methylkreysigine
|
|
||||
|
C00028886
|
Pulchine
|
|
||||
|
C00028905
|
Rhopalotine
|
|
||||
|
C00029069
|
Szovitsamine
/ (+)-Szovitsamine |
|
||||
|
C00029258
|
Zenkerine
|
|
||||
|
C00033252
|
N-Methylhernangerine
/ (+)-N-Methylhernangerine |
CHEMBL1482066
|
C073417
|
7 / 12 / 10 |
|
|
|
C00034982
|
(+)-1,2-Dimethoxy-3-hydroxy-9,10-methylenedioxynoraporphine
|
CHEMBL1618043
|
|
|||
|
C00034984
|
(+)-10,11-Dihydroxy-1,2-dimethoxynoraporphine
|
|
||||
|
C00034986
|
(+)-Noroconovine
|
|
||||
|
C00035705
|
Norisoboldine
|
CHEMBL375902
|
|
|||
|
C00036281
|
(-)-Isocorydine
|
CHEMBL489525
CHEMBL1376826 |
14 / 7 / 10 |
|
||
|
C00038711
|
Cassythic acid
/ (+)-Cassythic acid |
CHEMBL404685
|
|
|||
|
C00038994
|
Desmorostratine
/ (-)-Desmorostratine |
CHEMBL456407
|
|
|||
|
C00039867
|
Norpredicentrine
|
|
||||
|
C00039904
|
O-Methylcassythine
|
|
||||
|
C00041045
|
Lirinidine
|
CHEMBL109473
CHEMBL2316500 |
C054613
|
|
||
|
C00044392
|
(-)-Boldine
|
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
34 / 32 / 35 |
|
||
|
C00045468
|
(-)-Cissaglaberrimine
|
|
||||
|
C00046539
|
(-)-Norboldine
|
CHEMBL487388
|
|
|||
|
C00046981
|
(-)-Lirinidine
|
CHEMBL109473
CHEMBL2316500 |
|
|||
|
C00046983
|
(+)-Apoglaziovine
|
|
||||
|
C00049908
|
(-)-Glaucine
|
CHEMBL36536
CHEMBL228082 |
14 / 8 / 6 |
|
||
|
C00050251
|
Thalbaicalidine
|
CHEMBL518061
|
|
Human Protein / Gene in interactions
107 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001790 C00001822 C00001823 C00001861 C00001869 C00001872 C00025607 C00025658 C00027238 C00027304 C00027305 C00033252 C00036281 C00044392 C00049908 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001790 C00001822 C00001823 C00001861 C00001869 C00001872 C00027238 C00027304 C00027305 C00036281 C00044392 C00049908 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001790 C00001822 C00001823 C00001861 C00001869 C00025607 C00025658 C00027238 C00027304 C00027305 C00044392 C00049908 | 4 / 3 |
| O75496 | Geminin | Unclassified protein | C00001790 C00001822 C00001861 C00001872 C00025607 C00025625 C00025658 C00027304 C00036281 C00044392 C00049908 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001822 C00001823 C00001861 C00001869 C00001872 C00027238 C00027304 C00027305 C00036281 C00044392 C00049908 | 3 / 3 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001790 C00001822 C00001861 C00025607 C00025625 C00025658 C00027304 C00033252 C00044392 C00049908 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001822 C00001823 C00001869 C00001872 C00027238 C00027304 C00027305 C00036281 C00044392 | 1 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001790 C00001822 C00001861 C00025607 C00025625 C00025658 C00027304 C00044392 C00049908 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001822 C00001823 C00001869 C00001872 C00027238 C00027304 C00027305 C00036281 C00044392 | 0 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001790 C00001822 C00001869 C00025607 C00025625 C00025658 C00027238 C00027304 C00044392 | 1 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001790 C00001822 C00001823 C00001869 C00025625 C00027238 C00027304 C00027305 C00044392 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001822 C00001823 C00001869 C00001872 C00027238 C00027304 C00027305 C00036281 C00044392 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001790 C00001822 C00001823 C00001869 C00027238 C00027304 C00027305 C00044392 | 2 / 2 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001872 C00025235 C00025607 C00025630 C00025655 C00025658 C00025827 C00036281 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001822 C00001823 C00001869 C00001872 C00027304 C00027305 C00036281 C00044392 | 0 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001790 C00001822 C00025607 C00025625 C00025658 C00027304 C00044392 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001822 C00001869 C00001872 C00025625 C00027304 C00036281 C00044392 | 1 / 4 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001790 C00001822 C00001869 C00025625 C00027238 C00027304 C00044392 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001790 C00001822 C00001861 C00025625 C00027304 C00044392 C00049908 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001790 C00001822 C00025607 C00025658 C00027304 C00033252 C00044392 | 11 / 10 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001822 C00001869 C00001872 C00025625 C00027304 C00036281 C00044392 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00001822 C00001869 C00025625 C00027238 C00027304 C00044392 | 2 / 5 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001790 C00001872 C00025607 C00025658 C00033252 C00036281 | 1 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001790 C00001822 C00025625 C00027304 C00033252 C00044392 | 0 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00001807 C00001861 C00025625 C00027281 C00027441 C00049908 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001822 C00001872 C00027304 C00036281 C00044392 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001790 C00001822 C00027304 C00033252 C00044392 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001790 C00001822 C00025625 C00027304 C00044392 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001790 C00001822 C00027304 C00033252 C00044392 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00025269 C00025953 C00027150 C00028727 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001823 C00025953 C00027150 C00027305 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001790 C00025607 C00025625 C00025658 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001790 C00001822 C00027304 C00044392 | 1 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001790 C00001822 C00027304 C00044392 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00001823 C00001869 C00027238 C00027305 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001823 C00001869 C00027238 C00027305 | 7 / 37 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001822 C00025625 C00027304 C00044392 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001790 C00025607 C00025625 C00025658 | 0 / 0 |
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00001861 C00025607 C00025658 C00049908 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001822 C00027304 C00044392 | 0 / 0 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00001822 C00027304 C00044392 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00001822 C00027304 C00044392 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001822 C00027304 C00044392 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001790 C00025607 C00025658 | 2 / 1 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00001822 C00027304 C00044392 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001872 C00025625 C00036281 | 0 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00025953 C00027150 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00025953 C00027150 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00025953 C00027150 | 0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00025953 C00027150 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00025953 C00027150 | 2 / 0 |
| Q9H3N8 | Histamine H4 receptor | Histamine receptor | C00025953 C00027150 | 0 / 0 |
| Q9GZR1 | Sentrin-specific protease 6 | Enzyme | C00001861 C00049908 | 0 / 0 |
| Q9BQF6 | Sentrin-specific protease 7 | Enzyme | C00001861 C00049908 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00025953 C00027150 | 0 / 0 |
| Q9Y5N1 | Histamine H3 receptor | Histamine receptor | C00025953 C00027150 | 0 / 0 |
| Q96LD8 | Sentrin-specific protease 8 | Enzyme | C00001861 C00049908 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00025953 C00027150 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00025953 C00027150 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00025953 C00027150 | 2 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00025953 C00027150 | 1 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00025953 C00027150 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001790 C00025625 | 2 / 0 |
| P42574 | Caspase-3 | C14 | C00001861 C00049908 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| P28566 | 5-hydroxytryptamine receptor 1E | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00025231 C00028751 | 1 / 0 |
| P21918 | D(1B) dopamine receptor | Dopamine receptor | C00025953 C00027150 | 1 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00025953 C00027150 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00025953 C00027150 | 0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00001869 C00027238 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00025953 C00027150 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00025953 C00027150 | 0 / 0 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | C00025953 C00027150 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00025953 C00027150 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00025953 C00027150 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00025607 C00025658 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00025953 C00027150 | 1 / 1 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00025675 | 1 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00025625 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00027238 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025625 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00027238 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00027238 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00027238 | 3 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001869 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00001790 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025625 | 1 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00027238 | 1 / 2 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001790 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001790 | 4 / 1 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00001790 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025625 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00001790 | 1 / 1 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001790 | 2 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (69)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #606798 | Blepharospasm, benign essential |
P21918
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (80)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|