PCIDB

KNApSAcK Metabolite C00025625

Metabolite

KNApSAcK Entry

id C00025625
Name Roemerine / (-)-Remerine / (-)-Aporheine / (-)-Roemerine
CAS RN 548-08-3
Standard InChI InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3/t14-/m1/s1
Standard InChI (Main Layer) InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 20

Link

ChEMBL

By standard InChI CHEMBL483825
By standard InChI Main Layer CHEMBL36654 CHEMBL483825

KEGG

By LinkDB

CTD

By CAS RN C030169

Species

Summary

Plant class

class name count
eudicotyledons 15
Magnoliophyta 7

Family

family name count
Papaveraceae 8
Menispermaceae 7
Annonaceae 5
Magnoliaceae 1
Lauraceae 1

List (22)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Annona senegalensis 306945 Annonaceae Magnoliophyta Viridiplantae
Anomianthus dulcis 174962 Annonaceae Magnoliophyta Viridiplantae
Artabotrys uncinatus 225832 Annonaceae Magnoliophyta Viridiplantae
Guatteria oliviformis 295178 Annonaceae Magnoliophyta Viridiplantae
Magnolia obovata 349509 Magnoliaceae Magnoliophyta Viridiplantae
Meconopsis cambrica 248829 Papaveraceae eudicotyledons Viridiplantae
Neolitsea sericea 128655 Lauraceae Magnoliophyta Viridiplantae
Papaver confine 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver dubium 357469 Papaveraceae eudicotyledons Viridiplantae
Papaver fugax 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver persicum Lindl. 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver rhoeas 33128 Papaveraceae eudicotyledons Viridiplantae
Papaver rhopalothece 3468 Papaveraceae eudicotyledons Viridiplantae
Roemeria refracta 72192 Papaveraceae eudicotyledons Viridiplantae
Rollinia leptopetala 301698 Annonaceae Magnoliophyta Viridiplantae
Stephania abyssinica Walp. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania discflora Hand.-Mazz. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania excentrica H.S.Lo 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania kwangsiensis H.S.Lo 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania kwangsiensis H.S.Lo. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania lincangensis 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania yunnanensis H.S Lo 147243 Menispermaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

23 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL36654 CHEMBL1738312 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL36654 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL36654 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL36654 CHEMBL1794585 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL36654 CHEMBL1614166 (1)
1 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme CHEMBL36654 CHEMBL812682 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL36654 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL36654 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL36654 CHEMBL2114843 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL36654 CHEMBL1613838 (1) CHEMBL1738042 (1)
CHEMBL1963956 (1) CHEMBL2114867 (1)
CHEMBL2114724 (1)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL36654 CHEMBL1738174 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL36654 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL36654 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL36654 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL483825 CHEMBL1614211 (1)
0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein CHEMBL36654 CHEMBL1794319 (1) CHEMBL1794383 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL483825 CHEMBL1794536 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL483825 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL36654 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL36654 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL483825 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL483825 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL36654 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (13)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)