PCIDB

Stephania yunnanensis H.S Lo

Species

KNApSAcK Entry

Organism name Stephania yunnanensis H.S Lo
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025630 External link 512 Stephanine
/ l-Stephanine
/ (-)-Stephanine
/ (R)-(-)-Stephanine
CHEMBL601020
C054160
1 / 0 / 0 No. 20 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00026094 External link 512 Stepholidine
/ (-)-Stepholidine
CHEMBL487387
CHEMBL2334890
C010513
7 / 4 / 0 0 / 1 No. 37 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00026048 External link 512 Stepharanin
/ Stepharanine
CHEMBL251229
1 / 0 / 1 No. 155 No. 4
C00026124 External link 512 Dehydrocorydalmine
CHEMBL1618061
No. 155 No. 4
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00025272 External link 512 Stepharine
/ (+)-Stepharine
CHEMBL463957
CHEMBL1975436
C009320
No. 688

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00025252 C00026094 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00025252 C00026094 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00025252 C00026094 2 / 0
P13726 Tissue factor Membrane receptor C00025241 C00025252 C00026094 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00025252 C00026094 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 C00026048 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00025629 C00025630 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
P21918 D(1B) dopamine receptor Dopamine receptor C00026094 1 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
O75496 Geminin Unclassified protein C00025625 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00026094 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P00734 Prothrombin S1A C00025629 4 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00025629 0 / 0
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025625 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025625 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
O00255 Menin Unclassified protein C00025625 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025625 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#606798 Blepharospasm, benign essential P21918
#114500 Colorectal cancer; crc P84022
#615363 Estrogen resistance; estrr P03372
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#614674 Periodic fever, menstrual cycle-dependent P08908
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (17)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D004409 Dyskinesia, Drug-Induced C00026094