KCF-S cluster No. 37 (89 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (89)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	338
Magnoliophyta	74
rosids	14
asterids	1

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Cumulative family count

class name	count
Papaveraceae	206
Menispermaceae	105
Annonaceae	54
Ranunculaceae	24
Lauraceae	20
Rutaceae	9
Pieridae	4
Berberidaceae	3
Euphorbiaceae	3
Fabaceae	2
Cornaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	10

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metabolites link (11)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C03329	C00001827
Isoquinoline alkaloids	C09371	C00001829
Isoquinoline alkaloids	C09377	C00001832
Isoquinoline alkaloids	C09671	C00001929
Isoquinoline alkaloids	C02890	C00025252
Isoquinoline alkaloids	C04118	C00025632
Isoquinoline alkaloids	C05174	C00026087
Isoquinoline alkaloids	C02106	C00026092
Isoquinoline alkaloids	C05175	C00026095
Isoquinoline alkaloids	C15530	C00026115
Isoquinoline alkaloids	C03329	C00028005

Metabolite list (89)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001801	Amurensine
C00001809	(-)-Argemonine	CHEMBL486987 CHEMBL1964569
C00001827	Canadine / Xanthopuccine / Tetrahydroberberine / Tetrahydroumbellatine	CHEMBL275097 CHEMBL490533 CHEMBL476501	C004645	22 / 36 / 28
C00001829	Capaurine / l-Capaurine / (-)-Capaurine	CHEMBL478775	C030167
C00001832	Caseadine
C00001855	Eschscholtzidine / O-Methylcaryachine	CHEMBL1621815
C00001929	Xylopinine / O-Methylgovanine / S-(-)-Xylopinine / O,O-Dimethylgovadine	CHEMBL465824 CHEMBL2357282	C008672	1 / 0 / 0
C00025233	Coramine / Coreximin / Coreximine / (S)-Coreximine / (-)-Coreximine / Coramine(alkaloid)	CHEMBL1164087
C00025234	Corytenchin / Corytenchine / (-)-Corytenchine
C00025238	Discretine / (-)-Discretine	CHEMBL513084
C00025241	Kikemanin / Kikemanine / Corydalmine / Schefferine / (-)-Kikemanine / (-)-Corydalmine	CHEMBL448891 CHEMBL1209608 CHEMBL2334894	C058198	5 / 3 / 0
C00025243	NSC 148826 / Norargemonine / (-)-Norargemonine / O8-Demethylargemonine	CHEMBL1570385		2 / 2 / 0
C00025247	Stephabinamine / (-)-Stephabinamine
C00025252	Rotundine / l-Tetrahydropalmatine / (-)-Tetrahydropalmatine / (-)-Rotundine(Stephania)	CHEMBL187892 CHEMBL487182 CHEMBL2334889		8 / 5 / 2
C00025253	9-O-Desmethyl-L-THP / (-)-Tetrahydropalmatrubine	CHEMBL522746 CHEMBL2314745 CHEMBL2334884		5 / 3 / 0
C00025254	(-)-Tetrahydrostephabine	CHEMBL516695
C00025255	(-)-Thaicanine	CHEMBL465823
C00025296	Bisnorargemonine	CHEMBL518908 CHEMBL1494954		1 / 0 / 0
C00025337	O-Methylthaicanine / (-)-O-Methylthaicanine
C00025397	Rotundine / (-)-Bisnorargemonine	CHEMBL518908 CHEMBL1494954		1 / 0 / 0
C00025398	Caryachin / (-)-Caryachine	CHEMBL480663	C098741	1 / 1 / 0
C00025400	Isonorargemonine / (-)-Isonorargemonine
C00025401	Munitagine / (-)-Munitagine	CHEMBL1969644
C00025402	Norargemonine / (-)-Norargemonine / O2-Demetylargemonie / O8-Demethylargemonine	CHEMBL1570385		2 / 2 / 0
C00025403	Platycerine / (-)-Platycerine
C00025591	10-Demethyldiscretine / (-)-10-Demethyldiscretine / (-)-O10-Demethyldiscretine
C00025600	Capaurimine / (-)-Capaurimine
C00025609	(-)-Govadine	CHEMBL1962947 CHEMBL1963011	C103305
C00025610	(-)-Govanine
C00025632	Isocorypalmine / (-)-Isocorypalmine / Tetrahydrocolumbamine / O10-Methylstepholidine	CHEMBL2334891 CHEMBL2334892		4 / 3 / 0
C00026049	Stepharotine
C00026087	Cheilanthifoline / (-)-Cheilanthifoline
C00026088	(-)-Corypalmine	CHEMBL2334885 CHEMBL2334886		4 / 3 / 0
C00026090	(-)-Discretamine	CHEMBL320397 CHEMBL2334883		7 / 3 / 0
C00026091	(-)-Ophiocarpine	CHEMBL1556795	C012464	1 / 11 / 10
C00026092	Scoulerine / (-)-Scoulerine	CHEMBL191133 CHEMBL1235966 CHEMBL1395394		27 / 19 / 15
C00026093	(-)-Sinactine
C00026094	Stepholidine / (-)-Stepholidine	CHEMBL487387 CHEMBL2334890	C010513	7 / 4 / 0	0 / 1
C00026095	Stylopine / (-)-Stylopine / l-Tetrahydrocoptisine / (-)-Tetrahydrocoptisine	CHEMBL1922602
C00026096	(+)-Cavidine	CHEMBL453544	C011188
C00026097	(+)-Coreximine	CHEMBL1164087
C00026098	Corybulbine / (+)-Corybulbine
C00026100	(+)-Isocorypalmine	CHEMBL2334891 CHEMBL2334892		4 / 3 / 0
C00026102	(+)-Sinactine
C00026103	(+)-Stylopine	CHEMBL1922602
C00026104	(+)-Tetrahydropalmatine	CHEMBL187892 CHEMBL487182 CHEMBL2334889		8 / 5 / 2
C00026105	(+)-Thalictricavine
C00026106	(-)-13-beta-Hydroxystylopine
C00026108	Aequaline / Discretamine / (-)-Discretamine	CHEMBL320397 CHEMBL2334883		7 / 3 / 0
C00026112	Bharatamine / (+/-)-Bharatamine
C00026115	Corydaline / d-Corydaline / (+)-Corydaline	CHEMBL2165401	C452799
C00026117	Corypalmine / (-)-Corypalmine	CHEMBL2334885 CHEMBL2334886		4 / 3 / 0
C00026144	Sinactine / Tetrahydroepiberberine
C00026149	Corypalmine / Tetrahydrojatrorrhizine	CHEMBL2334885 CHEMBL2334886		4 / 3 / 0
C00026150	Tetrahydropalmatine / dl-Tetrahydropalmatine / (+/-)-Tetrahydropalmatine	CHEMBL187892 CHEMBL487182 CHEMBL2334889		8 / 5 / 2
C00026151	Tetrahydrothalifendine / (+/-)-Tetrahydrothalifendine	CHEMBL1330951 CHEMBL1457510 CHEMBL2334880		29 / 18 / 14
C00027144	Isocorybulbine / (+)-Isocorybulbine
C00027171	(-)-Isocaryachine
C00027174	(+)-Isocaryachine
C00027224	Neocaryachine
C00027246	10-O-Demethyldiscretine / (-)-O10-Demethyldiscretine
C00027308	Caseamine / (-)-Caseamine
C00027374	Hemiargyrine
C00027395	Isothalisopavine
C00027483	Spinosine / S-(-)-Spinosine
C00027487	dl-Stylopine / Tetrahydrocoptisine	CHEMBL1922602
C00027488	Tetrahydrocorysamine / (+)-Tetrahydrocorysamine
C00027489	Thaipetaline / (-)-Thaipetaline / 10-O-Demethylthaicanine
C00027584	Pessoine	CHEMBL463752
C00027730	2-O-Demethylthalimonine / (-)-2-Demethylthalimonine
C00027865	Anibacanine
C00027899	Argemonine	CHEMBL486987 CHEMBL1964569
C00028005	Canadine / (S)-(-)-Canadine	CHEMBL275097 CHEMBL490533 CHEMBL476501		22 / 36 / 28
C00028013	Cavidine	CHEMBL453544	C011188
C00028087	Corydalidzine
C00028089	Corytenchirine
C00028394	Isoapocavidine
C00028558	Malacitanine
C00028565	Manibacanine / (+)-Manibacanine
C00028774	Ophiocarpine / (-)-Ophiocarpine	CHEMBL1556795	C012464	1 / 11 / 10
C00028863	Pseudoanibacanine
C00028872	Pseudomanibacanine
C00029094	Xylopinine / Tetrahydropseudopalmatine	CHEMBL465824 CHEMBL2357282		1 / 0 / 0
C00029110	Thalimonine / (-)-Thalimonine		C482652
C00044029	(-)-Isocoreximine	CHEMBL1164088
C00045473	(+)-Caryachine	CHEMBL480663		1 / 1 / 0
C00045475	(+)-Eschscholtzidine	CHEMBL1621815
C00045864	dl-Caryachine	CHEMBL480663		1 / 1 / 0
C00049038	(+)-O-Methylcaryachine	CHEMBL1621815

Human Protein / Gene in interactions

57 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00001827 C00025241 C00025252 C00025253 C00025398 C00025632 C00026088 C00026090 C00026092 C00026094 C00026100 C00026104 C00026108 C00026117 C00026149 C00026150 C00026151 C00028005 C00045473 C00045864	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001827 C00025241 C00025252 C00025253 C00025632 C00026088 C00026090 C00026092 C00026094 C00026100 C00026104 C00026108 C00026117 C00026149 C00026150 C00026151 C00028005	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001827 C00025241 C00025252 C00025253 C00025632 C00026088 C00026090 C00026092 C00026094 C00026100 C00026104 C00026108 C00026117 C00026149 C00026150 C00026151 C00028005	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00001827 C00025241 C00025252 C00025253 C00025632 C00026088 C00026090 C00026092 C00026094 C00026100 C00026104 C00026108 C00026117 C00026149 C00026150 C00026151 C00028005	2 / 0
P13726	Tissue factor	Membrane receptor	C00001827 C00025241 C00025252 C00025253 C00026094 C00026104 C00026150 C00028005	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001827 C00025252 C00026092 C00026104 C00026150 C00026151 C00028005	0 / 1
O75496	Geminin	Unclassified protein	C00001827 C00025243 C00025402 C00026092 C00026151 C00028005	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001827 C00025243 C00025402 C00026151 C00028005	2 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001827 C00026091 C00026092 C00028005 C00028774	11 / 10
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001827 C00026092 C00026151 C00028005	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001827 C00026092 C00026151 C00028005	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001827 C00026092 C00026151 C00028005	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001827 C00026092 C00026151 C00028005	1 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00025252 C00026104 C00026150	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001827 C00026151 C00028005	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001827 C00026092 C00028005	1 / 1
P03372	Estrogen receptor	NR3A1	C00025252 C00026104 C00026150	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00025296 C00025397 C00026151	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001827 C00026151 C00028005	0 / 0
Q14654	ATP-sensitive inward rectifier potassium channel 11	K	C00001827 C00028005	3 / 4
P35348	Alpha-1A adrenergic receptor	Adrenergic receptor	C00026090 C00026108	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00026092 C00026151	0 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00026090 C00026108	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001827 C00028005	7 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001827 C00028005	1 / 2
Q9UNA4	DNA polymerase iota	Enzyme	C00026092 C00026151	0 / 0
Q09428	ATP-binding cassette sub-family C member 8	K	C00001827 C00028005	5 / 3
O00255	Menin	Unclassified protein	C00001827 C00028005	2 / 5
P24941	Cyclin-dependent kinase 2	Cdc2	C00001827 C00028005	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00026092 C00026151	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00026092 C00026151	0 / 0
P35368	Alpha-1B adrenergic receptor	Adrenergic receptor	C00026090 C00026108	0 / 0
P43351	DNA repair protein RAD52 homolog	Unclassified protein	C00001929 C00029094	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00026092	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00026151	3 / 3
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00026151	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00026092	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00026151	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00026092	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00026092	1 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00026151	4 / 3
O14727	Apoptotic protease-activating factor 1	Unclassified protein	C00026092	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00026092	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00026092	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00026094	0 / 0
P11413	Glucose-6-phosphate 1-dehydrogenase	Enzyme	C00026151	1 / 2
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00026151	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00026151	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00026151	2 / 2
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00026092	1 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00026092	0 / 0
P21918	D(1B) dopamine receptor	Dopamine receptor	C00026094	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00026151	0 / 0
P29466	Caspase-1	C14	C00026092	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00026151	1 / 1
P14618	Pyruvate kinase PKM	Enzyme	C00026151	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00026092	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions