PCIDB

KNApSAcK Metabolite C00001827

Metabolite

KNApSAcK Entry

id C00001827
Name Canadine / Xanthopuccine / Tetrahydroberberine / Tetrahydroumbellatine
CAS RN 522-97-4
Standard InChI InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3/t16-/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 37

Link

ChEMBL

By standard InChI CHEMBL490533
By standard InChI Main Layer CHEMBL275097 CHEMBL490533 CHEMBL476501

KEGG

By LinkDB C03329

CTD

By CAS RN C004645

Human Protein / Gene in interaction

22 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL476501 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL275097 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL476501 CHEMBL2114784 (1)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL490533 CHEMBL476501 CHEMBL2343280 (2) CHEMBL2343284 (2)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL476501 CHEMBL1614544 (1)
11 / 10
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL275097 CHEMBL1067148 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL476501 CHEMBL1741325 (1)
0 / 1
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL490533 CHEMBL476501 CHEMBL2343279 (2) CHEMBL2343283 (2)
2 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL476501 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL476501 CHEMBL2114843 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL275097 CHEMBL2114810 (1)
7 / 3
P13726 Tissue factor Membrane receptor CHEMBL275097 CHEMBL2319887 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL476501 CHEMBL1741322 (1)
0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL490533 CHEMBL476501 CHEMBL2343277 (2) CHEMBL2343281 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL476501 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL476501 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL476501 CHEMBL1737991 (1)
0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL490533 CHEMBL476501 CHEMBL2343278 (2) CHEMBL2343282 (2)
1 / 0
O00255 Menin Unclassified protein CHEMBL275097 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL275097 CHEMBL1614257 (1)
1 / 3
Q14654 ATP-sensitive inward rectifier potassium channel 11 K CHEMBL490533 CHEMBL868377 (1)
3 / 4
Q09428 ATP-binding cassette sub-family C member 8 K CHEMBL490533 CHEMBL868377 (1)
5 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#145000 Hyperparathyroidism 1; hrpt1 O00255
#240800 Hypoglycemia, leucine-induced; lih Q09428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#166350 Osseous heteroplasia, progressive; poh P63092
#614674 Periodic fever, menstrual cycle-dependent P08908
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (28)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)