PCIDB

Corydalis yanhusuo

Species

KNApSAcK Entry

Organism name Corydalis yanhusuo
Genus Corydalis
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Corydalis yanhusuo
Linked NCBI taxonomy ID 458692
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001827 External link 512 Canadine
/ Xanthopuccine
/ Tetrahydroberberine
/ Tetrahydroumbellatine
CHEMBL275097
CHEMBL490533
CHEMBL476501
C004645
22 / 36 / 28 No. 37 No. 4
C00026115 External link 512 Corydaline
/ d-Corydaline
/ (+)-Corydaline
CHEMBL2165401
C452799
No. 37 No. 4
C00025632 External link 512 Isocorypalmine
/ (-)-Isocorypalmine
/ Tetrahydrocolumbamine
/ O10-Methylstepholidine
CHEMBL2334891
CHEMBL2334892
4 / 3 / 0 No. 37 No. 4
C00027144 External link 512 Isocorybulbine
/ (+)-Isocorybulbine
No. 37 No. 4
C00026123 External link 512 Dehydrocorydaline
/ 13-Methylpalmatine
CHEMBL1917176
C007232
No. 155 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00026026 External link 512 Saulatine
No. 1098

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001827 C00001906 1 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001827 C00025632 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001827 C00001906 0 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00001827 C00025632 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001827 C00001906 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001827 C00025632 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001827 C00025632 2 / 0
P13726 Tissue factor Membrane receptor C00001827 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001827 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001827 2 / 0
O75496 Geminin Unclassified protein C00001827 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001827 7 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001827 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001827 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
P02545 Prelamin-A/C Unclassified protein C00001827 11 / 10
Q99700 Ataxin-2 Unclassified protein C00001827 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00001827 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001827 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001906 0 / 0
O00255 Menin Unclassified protein C00001827 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001827 1 / 2
Q14654 ATP-sensitive inward rectifier potassium channel 11 K C00001827 3 / 4
Q09428 ATP-binding cassette sub-family C member 8 K C00001827 5 / 3

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#240800 Hypoglycemia, leucine-induced; lih Q09428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#166350 Osseous heteroplasia, progressive; poh P63092
#614674 Periodic fever, menstrual cycle-dependent P08908
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)