KCF-S cluster No. 820 (11 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	161
rosids	9
asterids	2

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Cumulative family count

class name	count
Papaveraceae	151
Rutaceae	9
Ranunculaceae	7
Rubiaceae	2
Berberidaceae	2
Menispermaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C02134	C00001799
Isoquinoline alkaloids	C05189	C00001906

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001799	Thalictrimine / Allocryptopine / alpha-Fagarine / beta-Homochelidonine / alpha-Allocryptopine	CHEMBL520043	C109505	3 / 2 / 3	2 / 0
C00001906	Fumarin / Biflorine / Protopine / Fumarine / Corydinine	CHEMBL453019	C009093	5 / 5 / 4	2 / 0
C00026099	(+)-Corycavine
C00026101	(+)-Ophiocarpinone
C00027323	Chilenine
C00027332	Cryptopin / Cryptopine / Kryptopine / Kryptocavin / Cryptocavine	CHEMBL1339015	C007159	6 / 5 / 8
C00027505	13-Oxo-allocryptopine
C00027557	Leptocarpine
C00027711	Oreonone / 1-Methoxy-13-oxoallocryptopine
C00027712	1-Methoxyallocryptopine / 13-Methoxyallocryptopine
C00028614	Muramine	CHEMBL1971249

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001906 C00027332	1 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001906 C00027332	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001799 C00027332	1 / 2
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001906 C00027332	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001906	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00027332	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001799	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001906	3 / 2
O00255	Menin	Unclassified protein	C00027332	2 / 5
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001799	1 / 1

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001799 C00001906
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions