PCIDB

KNApSAcK Metabolite C00001799

Metabolite

KNApSAcK Entry

id C00001799
Name Thalictrimine / Allocryptopine / alpha-Fagarine / beta-Homochelidonine / alpha-Allocryptopine
CAS RN 485-91-6
Standard InChI InChI=1S/C21H23NO5/c1-22-7-6-14-9-19-20(27-12-26-19)10-15(14)17(23)8-13-4-5-18(24-2)21(25-3)16(13)11-22/h4-5,9-10H,6-8,11-12H2,1-3H3
Standard InChI (Main Layer) InChI=1S/C21H23NO5/c1-22-7-6-14-9-19-20(27-12-26-19)10-15(14)17(23)8-13-4-5-18(24-2)21(25-3)16(13)11-22/h4-5,9-10H,6-8,11-12H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 820

Link

ChEMBL

By standard InChI CHEMBL520043
By standard InChI Main Layer CHEMBL520043

KEGG

By LinkDB C02134

CTD

By CAS RN C109505

Species

Summary

Plant class

class name count
eudicotyledons 45
rosids 9

Family

family name count
Papaveraceae 42
Rutaceae 9
Ranunculaceae 2
Berberidaceae 1

List (54)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aegle marmelos Correa 23513 Rutaceae rosids Viridiplantae
Arctomecon californica 99305 Papaveraceae eudicotyledons Viridiplantae
Arctomecon humilis 99306 Papaveraceae eudicotyledons Viridiplantae
Arctomecon merrianii 99305 Papaveraceae eudicotyledons Viridiplantae
Argemone mexicana L. 54796 Papaveraceae eudicotyledons Viridiplantae
Berberis densiflora 22774 Berberidaceae eudicotyledons Viridiplantae
Bocconia arborea 72181 Papaveraceae eudicotyledons Viridiplantae
Bocconia cordata Willd. 72181 Papaveraceae eudicotyledons Viridiplantae
Bocconia frutescens L. 72182 Papaveraceae eudicotyledons Viridiplantae
Bocconia spp. 72181 Papaveraceae eudicotyledons Viridiplantae
Chelidonium majus L. 71251 Papaveraceae eudicotyledons Viridiplantae
Chelidonium spp. 3465 Papaveraceae eudicotyledons Viridiplantae
Corydalis caseana A.Gray. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis caucasia 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis intermedia 54425 Papaveraceae eudicotyledons Viridiplantae
Corydalis ledebouriana K.et K. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis nobilis 38909 Papaveraceae eudicotyledons Viridiplantae
Corydalis omeiensis 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis ophiocarpa 38929 Papaveraceae eudicotyledons Viridiplantae
Corydalis pallida 38903 Papaveraceae eudicotyledons Viridiplantae
Corydalis sewerzovii 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis solida 38914 Papaveraceae eudicotyledons Viridiplantae
Corydalis spp. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis ternata 3463 Papaveraceae eudicotyledons Viridiplantae
Dicentra oregana Eastwood. 22680 Papaveraceae eudicotyledons Viridiplantae
Dicentra spp. 22680 Papaveraceae eudicotyledons Viridiplantae
Eomecon chionantha 72185 Papaveraceae eudicotyledons Viridiplantae
Eschscholzia spp. 3466 Papaveraceae eudicotyledons Viridiplantae
Fagara coca 23513 Rutaceae rosids Viridiplantae
Glaucium arabicum 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium corniculatum 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium fimbrilligerum Boiss. 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium flavum 56853 Papaveraceae eudicotyledons Viridiplantae
Glaucium spp. 56852 Papaveraceae eudicotyledons Viridiplantae
Haplophyllum bucharicum Litv. 1006069 Rutaceae rosids Viridiplantae
Haplophyllum pedicellatum Bge. 266078 Rutaceae rosids Viridiplantae
Haplophyllum robustum Bge. 266078 Rutaceae rosids Viridiplantae
Hypecoum leptocarpum 72180 Papaveraceae eudicotyledons Viridiplantae
Hypecoum procumbens 391933 Papaveraceae eudicotyledons Viridiplantae
Meconopsis cambrica 248829 Papaveraceae eudicotyledons Viridiplantae
Meconopsis robusta 72195 Papaveraceae eudicotyledons Viridiplantae
Papaver confine 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver curviscapum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver pinnatifidum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver rhoeas chelidonides 3468 Papaveraceae eudicotyledons Viridiplantae
Sanguinaria canadensis L. 3471 Papaveraceae eudicotyledons Viridiplantae
Sanguinaria spp. 3471 Papaveraceae eudicotyledons Viridiplantae
Stylophorum lasiocarpum 72189 Papaveraceae eudicotyledons Viridiplantae
Thalictrum symplex 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum triternatum 46968 Ranunculaceae eudicotyledons Viridiplantae
Zanthoxylum avicennae 354527 Rutaceae rosids Viridiplantae
Zanthoxylum brachyacanthum 1056464 Rutaceae rosids Viridiplantae
Zanthoxylum integrifolium 67937 Rutaceae rosids Viridiplantae
Zanthoxylum spp. 67937 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL520043 CHEMBL1614410 (1)
1 / 3
Q9UNA4 DNA polymerase iota Enzyme CHEMBL520043 CHEMBL1794483 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL520043 CHEMBL2354287 (1)
1 / 1

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C109505 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) allocryptopine results in increased expression of CYP1A1 mRNA increases expression
mRNA 21419197
C109505 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) allocryptopine results in increased expression of CYP1A2 mRNA increases expression
mRNA 21419197

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164

KEGG DISEASE (3)

KEGG disease name UniProt
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)