PCIDB

Meconopsis cambrica

Species

KNApSAcK Entry

Organism name Meconopsis cambrica
Genus Meconopsis
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Meconopsis cambrica
Linked NCBI taxonomy ID 248829
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025626 External link 512 Remeroline
/ (R)-Roemeroline
/ (-)-Roemeroline
/ N-Methylanolobine
CHEMBL499835
No. 20 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00001887 External link 512 (+)-Mecambroline
No. 20 No. 4
C00001885 External link 512 Escholin
/ Escholine
/ Thalictrin
/ Thalictrine
/ Magnoflorine
/ (+)-Magnoflorine
CHEMBL235428
C001670
No. 286 No. 4
C00025459 External link 512 Papaverrubine C
/ Epiporphyroxine
/ 14-Epiporphyroxine
No. 305
C00025460 External link 512 Porphyroxine
/ Papaverrubine D
No. 305
C00027366 External link 512 Flavinantine
/ (-)-Flavinantine
CHEMBL463084
1 / 4 / 2 No. 426 No. 4
C00001862 External link 512 Glaziovine
/ L-Glaziovine
/ N-Methylcrotsparine
/ L-(-)-N-Methylcrotsparine
CHEMBL1980854
C007847
No. 688
C00001886 External link 512 Mecambrine
/ (-)-Fugapavine
/ (-)-Mecambrine
No. 688
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00025625 1 / 2
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00025625 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00025655 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
O75496 Geminin Unclassified protein C00025625 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001906 1 / 0
P00734 Prothrombin S1A C00027366 4 / 2
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001906 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001906 0 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025625 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001906 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
O00255 Menin Unclassified protein C00025625 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (20)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)