PCIDB

Meconopsis robusta

Species

KNApSAcK Entry

Organism name Meconopsis robusta
Genus Meconopsis
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Meconopsis
Linked NCBI taxonomy ID 72195
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00026118 External link 512 Corysamine
No. 155 No. 4
C00024668 External link 512 YHL II
/ Coptisine
CHEMBL362071
C034384
No. 155 No. 4
C00001885 External link 512 Escholin
/ Escholine
/ Thalictrin
/ Thalictrine
/ Magnoflorine
/ (+)-Magnoflorine
CHEMBL235428
C001670
No. 286 No. 4
C00025459 External link 512 Papaverrubine C
/ Epiporphyroxine
/ 14-Epiporphyroxine
No. 305
C00001911 External link 512 Rhoeadine
C019078
No. 305
C00025460 External link 512 Porphyroxine
/ Papaverrubine D
No. 305
C00025461 External link 512 Papaverrubine E
No. 305
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00027332 External link 512 Cryptopin
/ Cryptopine
/ Kryptopine
/ Kryptocavin
/ Cryptocavine
CHEMBL1339015
C007159
6 / 5 / 8 No. 820 No. 4

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001906 C00027332 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001906 C00027332 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00027332 1 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001906 C00027332 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00027332 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025655 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001906 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001799 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
O00255 Menin Unclassified protein C00027332 2 / 5
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (12)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)