PCIDB

Hypecoum leptocarpum

Species

KNApSAcK Entry

Organism name Hypecoum leptocarpum
Genus Hypecoum
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hypecoum leptocarpum
Linked NCBI taxonomy ID 72180
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027344 External link 512 Dihydroleptopine
CHEMBL1209456
No. 233 No. 4
C00041037 External link 512 Leptopidinine
No. 605 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4
C00027557 External link 512 Leptocarpine
No. 820 No. 4
C00041036 External link 512 Leptopidine
No. 2440
C00041038 External link 512 Leptopine
No. 2440
C00041039 External link 512 Leptopinine
No. 2440
C00027458 External link 512 Oxyhydrastinine
/ N-Methylnoroxyhydrastinine
C048352
No. 3603
C00027531 External link 512 Corydamine
No. 4202 No. 4
C00027389 External link 512 Isohyperectine
No. 4816
C00027546 External link 512 Hyperectine
No. 4816
C00027410 External link 512 Leptocarpinine
No. 6461
C00027378 External link 512 Hypecoleptopine
No. 8150

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001906 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 1 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001906 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001906 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001799 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001906 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (7)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)