PCIDB

KCF-S cluster No. 233 (21 metabolites)

Corresponding Phytochemical cluster No. 4

Plant Species

Cumulative plant class count

class name count
eudicotyledons 50
Magnoliophyta 3
asterids 2

Cumulative family count

class name count
Papaveraceae 50
Lauraceae 3
Caprifoliaceae 2

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Isoquinoline alkaloids 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Isoquinoline alkaloids C12242 C00024623

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00024620 External link 512 (-)-Chelidonine
CHEMBL436279
CHEMBL496867
CHEMBL1394506
CHEMBL2009780
8 / 19 / 21
C00024621 External link 512 (-)-Norchelidonine
CHEMBL1922603
C00024623 External link 512 Chelidonin
/ Stylophorine
/ (+)-Chelidonine
CHEMBL436279
CHEMBL496867
CHEMBL1394506
CHEMBL2009780
C062047
8 / 19 / 21 1 / 2
C00024624 External link 512 Corynoline
/ (+)-Corynoline
C487644
C00024638 External link 512 Corynolamine
C00024639 External link 512 Corynoloxine
C00024658 External link 512 Acetylcorynoline
/ O-Acetylcorynoline
/ (+)-Corynoline acetate
C00025399 External link 512 Crychin
/ Crychine
/ Californin
/ Californine
/ Eschscholtzin
/ (-)-Eschscholtzine
CHEMBL165903
CHEMBL481839
C084233
2 / 1 / 1
C00027249 External link 512 12-Hydroxycrychine
/ (-)-12-Hydroxycrychine
C00027259 External link 512 6-Oxocorynoline
/ 13-Methyl-6-oxochelidonine
C00027344 External link 512 Dihydroleptopine
CHEMBL1209456
C00027420 External link 512 N-Demethylcrychine
/ (-)-N-Demethylcrychine
CHEMBL349696
C00027616 External link 512 (+)-14-Epichelidonine
CHEMBL436279
CHEMBL496867
CHEMBL1394506
CHEMBL2009780
8 / 19 / 21
C00028039 External link 512 Chelamine
C00028090 External link 512 Coryximine
CHEMBL1209456
C00028351 External link 512 Homochelidonine
/ (+)-Homochelidonine
C00028730 External link 512 Norribasine
/ N-Demethylribasine
C00028906 External link 512 Ribasidine
C00028907 External link 512 Ribasine
C00028941 External link 512 Roelactamine
C00029005 External link 512 Severzinine

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024620 C00024623 C00025399 C00027616 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00024620 C00024623 C00027616 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00024620 C00024623 C00027616 3 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00024620 C00024623 C00027616 0 / 0
P02545 Prelamin-A/C Unclassified protein C00024620 C00024623 C00027616 11 / 10
O00255 Menin Unclassified protein C00024620 C00024623 C00027616 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00024620 C00024623 C00027616 1 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00024620 C00024623 C00027616 1 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025399 1 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00024623

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#614674 Periodic fever, menstrual cycle-dependent P08908
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (21)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00024623
D009069 Movement Disorders C00024623