KCF-S cluster No. 605 (14 metabolites)
Corresponding Phytochemical cluster No. 4
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| eudicotyledons | 63 |
Cumulative family count
| class name | count |
|---|---|
| Papaveraceae | 61 |
| Ranunculaceae | 2 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Isoquinoline alkaloids | 6 |
metabolites link (6)
Metabolite list (14)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001792
|
Adlumine
/ (+)-Adlumine |
CHEMBL510121
|
|
|||
|
C00001820
|
Bucuculline
/ Bicucullin / (+)-Bicuculline |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
D001640
|
30 / 28 / 20 | 0 / 21 |
|
|
C00001830
|
Capnoidine
/ l-Adlumidine / l-Capnoidine / (-)-Adlumidine / (-)-Capnoidine |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
30 / 28 / 20 |
|
||
|
C00001867
|
alpha-Hydrastine
/ (-)-alpha-Hydrastine |
CHEMBL475536
CHEMBL462731 CHEMBL1256868 CHEMBL1256919 CHEMBL1408680 CHEMBL1412842 CHEMBL1441048 |
21 / 35 / 30 |
|
||
|
C00001891
|
Noscapine
/ alpha-Narcotine / O-Methylnarcotoline |
CHEMBL364713
CHEMBL402487 CHEMBL1403892 CHEMBL1570261 CHEMBL1623561 |
D009665
|
105 / 43 / 42 | 11 / 5 |
|
|
C00001892
|
Narcotoline
|
C059402
|
|
|||
|
C00027303
|
beta-Hydrastine
|
CHEMBL475536
CHEMBL462731 CHEMBL1256868 CHEMBL1256919 CHEMBL1408680 CHEMBL1412842 CHEMBL1441048 |
C013024
|
21 / 35 / 30 |
|
|
|
C00027328
|
Corlumidine
/ (+)-Corlumidine |
|
||||
|
C00027329
|
Corlumine
/ NSC 32983 / (+)-Carlumine / (+)-Corlumine |
CHEMBL510121
|
|
|||
|
C00027512
|
Adlumidine
/ (+)-Adlumidine |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
30 / 28 / 20 |
|
||
|
C00028647
|
Narlumicine
|
|
||||
|
C00028648
|
Narlumidine
|
|
||||
|
C00028800
|
Papraine
|
|
||||
|
C00041037
|
Leptopidinine
|
|
Human Protein / Gene in interactions
135 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001820 C00001830 C00001867 C00001891 C00027303 C00027512 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001820 C00001830 C00001867 C00027303 C00027512 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001820 C00001830 C00001867 C00027303 C00027512 | 3 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001820 C00001830 C00001891 C00027512 | 0 / 0 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 C00027512 | 3 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001820 C00001830 C00027512 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 C00027512 | 2 / 2 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 C00027512 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001820 C00001830 C00027512 | 1 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001820 C00001830 C00027512 | 0 / 0 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001820 C00001830 C00027512 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001820 C00001830 C00027512 | 4 / 2 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001820 C00001830 C00027512 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001820 C00001830 C00027512 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001820 C00001830 C00027512 | 1 / 1 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001820 C00001830 C00027512 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001820 C00001830 C00027512 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001820 C00001830 C00027512 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001820 C00001830 C00027512 | 0 / 0 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001820 C00001830 C00027512 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001867 C00001891 C00027303 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001820 C00001830 C00027512 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001820 C00001830 C00027512 | 1 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001820 C00001830 C00027512 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001867 C00001891 C00027303 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001867 C00001891 C00027303 | 2 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001867 C00001891 C00027303 | 0 / 1 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001820 C00001830 C00027512 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001867 C00027303 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001867 C00027303 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00001867 C00027303 | 5 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001867 C00027303 | 3 / 3 |
| P54132 | Bloom syndrome protein | Enzyme | C00001867 C00027303 | 1 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001867 C00027303 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00001867 C00027303 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00001867 C00027303 | 6 / 4 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001891 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001891 | 1 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001891 | 2 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001891 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001891 | 1 / 1 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001891 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001891 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00001891 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001891 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001891 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001891 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001891 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001891 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001891 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001891 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001891 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001891 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001891 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001891 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001891 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001891 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001891 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001891 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001891 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001891 | 0 / 3 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00001891 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001891 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001891 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001891 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001891 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001891 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001891 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001891 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001891 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001891 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001891 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001891 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001891 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001891 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001891 | 2 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001891 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001891 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001891 | 1 / 1 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001891 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001891 | 0 / 0 |
| Q86VL8 | Multidrug and toxin extrusion protein 2 | Cation antiporter | C00001891 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001891 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001891 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001891 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001891 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001891 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001891 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001891 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001891 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001891 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001891 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001891 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001891 | 2 / 0 |
| Q96FL8 | Multidrug and toxin extrusion protein 1 | Cation antiporter | C00001891 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001891 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001891 | 1 / 8 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001891 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001891 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001891 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001891 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001891 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001891 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00001891 | 2 / 1 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001891 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001891 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001891 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001891 | 1 / 2 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001891 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001891 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001891 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001891 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001891 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001891 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001891 | 1 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001891 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001891 | 1 / 2 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001891 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001891 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001891 | 2 / 2 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001891 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001891 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001891 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001891 | 0 / 0 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001891
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001891
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001891
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001891
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001891
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001891
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001891
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00001891
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001891
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001891
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001891
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (84)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 P47869 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #607208 | Dravet syndrome |
P18507
P35498 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (69)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) P35498 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
26 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00001820
|
| D000648 | Amnesia, Retrograde |
C00001820
|
| D001008 | Anxiety Disorders |
C00001820
|
| D001919 | Bradycardia |
C00001820
|
| D002375 | Catalepsy |
C00001820
|
| D004487 | Edema |
C00001820
|
| D004827 | Epilepsy |
C00001820
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00001820
|
| D006930 | Hyperalgesia |
C00001820
|
| D006973 | Hypertension |
C00001820
|
| D007022 | Hypotension |
C00001820
|
| D009069 | Movement Disorders |
C00001820
|
| D009207 | Myoclonus |
C00001820
|
| D009436 | Neural Tube Defects |
C00001820
|
| D020078 | Neurogenic Inflammation |
C00001820
|
| D020336 | Paraparesis, Spastic |
C00001820
|
| D010409 | Penile Diseases |
C00001820
|
| D049188 | Prenatal Injuries |
C00001820
|
| D012640 | Seizures |
C00001820
|
| D013035 | Spasm |
C00001820
|
| D013226 | Status Epilepticus |
C00001820
|
| D003371 | Cough |
C00001891
|
| D003711 | Demyelinating Diseases |
C00001891
|
| D005910 | Glioma |
C00001891
|
| D015473 | Leukemia, Promyelocytic, Acute |
C00001891
|
| D015458 | Leukemia, T-Cell |
C00001891
|