PCIDB

KNApSAcK Metabolite C00001867

Metabolite

KNApSAcK Entry

id C00001867
Name alpha-Hydrastine / (-)-alpha-Hydrastine
CAS RN 4370-85-8
Standard InChI InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19-/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 605

Link

ChEMBL

By standard InChI CHEMBL475536
By standard InChI Main Layer CHEMBL475536 CHEMBL462731 CHEMBL1256868 CHEMBL1256919 CHEMBL1408680 CHEMBL1412842 CHEMBL1441048

KEGG

By LinkDB C09462

CTD

By CAS RN

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL475536 CHEMBL1256919 CHEMBL1614110 (1) CHEMBL1741321 (2)
CHEMBL1743404 (1)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL475536 CHEMBL2114784 (1)
1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1256868 CHEMBL1794573 (1)
2 / 2
P04062 Glucosylceramidase Enzyme CHEMBL1256868 CHEMBL1613818 (1)
6 / 4
P02545 Prelamin-A/C Unclassified protein CHEMBL1408680 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL475536 CHEMBL1614281 (1) CHEMBL1614361 (2)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL475536 CHEMBL1256919 CHEMBL1614027 (4) CHEMBL1741325 (2)
CHEMBL1743400 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL1408680 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL475536 CHEMBL1256868 CHEMBL1738606 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1256868 CHEMBL2114843 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL475536 CHEMBL960411 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL475536 CHEMBL1741322 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1256868 CHEMBL1408680 CHEMBL1613910 (2)
3 / 3
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL1412842 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1256868 CHEMBL1738588 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL475536 CHEMBL1256919 CHEMBL1613777 (4) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL475536 CHEMBL462731 CHEMBL1256868 CHEMBL1256919 CHEMBL1408680 CHEMBL1614108 (5) CHEMBL1613886 (5)
CHEMBL1741324 (2) CHEMBL1743471 (2)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1256868 CHEMBL1794483 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1256868 CHEMBL1613914 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL475536 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1408680 CHEMBL1738442 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#168600 Parkinson disease, late-onset; pd P04062
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#187950 Thrombocythemia 1; thcyt1 P40225

KEGG DISEASE (30)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)