PCIDB

Corydalis solida

Species

KNApSAcK Entry

Organism name Corydalis solida
Genus Corydalis
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Corydalis solida
Linked NCBI taxonomy ID 38914
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (31)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00027150 External link 512 Nantenine
/ (+)-Domestine
/ (+)-Nantenine
CHEMBL179440
CHEMBL467094
C041615
38 / 10 / 2 No. 20 No. 4
C00001824 External link 512 Bulbocapnine
/ d-Bulbocapnine
CHEMBL157912
C083807
0 / 1 No. 20 No. 4
C00026144 External link 512 Sinactine
/ Tetrahydroepiberberine
No. 37 No. 4
C00028774 External link 512 Ophiocarpine
/ (-)-Ophiocarpine
CHEMBL1556795
C012464
1 / 11 / 10 No. 37 No. 4
C00028087 External link 512 Corydalidzine
No. 37 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00028005 External link 512 Canadine
/ (S)-(-)-Canadine
CHEMBL275097
CHEMBL490533
CHEMBL476501
22 / 36 / 28 No. 37 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00024775 External link 512 Oxosarcocapnine
No. 74
C00024773 External link 512 Oxocularine
CHEMBL510574
No. 74
C00027678 External link 512 13-Methylcolumbamine
No. 155 No. 4
C00026123 External link 512 Dehydrocorydaline
/ 13-Methylpalmatine
CHEMBL1917176
C007232
No. 155 No. 4
C00001819 External link 512 Thalsine
/ Majarine
/ Berberine
/ Umbellatin
CHEMBL295124
D001599
19 / 25 / 26 30 / 19 No. 155 No. 4
C00024657 External link 512 Norsanguinarine
/ N-Norsanguinarine
/ 13-Demethylsanguinarine
No. 254 No. 4
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00027369 External link 512 Fumarophycine
/ O-Acetylfumaritine
No. 512 No. 4
C00001900 External link 512 Parfumine
/ d-Parfumine
/ (+)-Parfumine
CHEMBL1968957
No. 512 No. 4
C00001838 External link 512 Corpaine
/ (-)-Corpaine
No. 512 No. 4
C00028283 External link 512 Fumaritine
No. 512 No. 4
C00027368 External link 512 Fumariline
C049095
No. 512 No. 4
C00029012 External link 512 Sibiricine
/ (+)-Sibiricine
No. 512 No. 4
C00001867 External link 512 alpha-Hydrastine
/ (-)-alpha-Hydrastine
CHEMBL475536
CHEMBL462731
CHEMBL1256868
CHEMBL1256919
CHEMBL1408680
CHEMBL1412842
CHEMBL1441048
21 / 35 / 30 No. 605 No. 4
C00001830 External link 512 Capnoidine
/ l-Adlumidine
/ l-Capnoidine
/ (-)-Adlumidine
/ (-)-Capnoidine
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
30 / 28 / 20 No. 605 No. 4
C00001820 External link 512 Bucuculline
/ Bicucullin
/ (+)-Bicuculline
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
D001640
30 / 28 / 20 0 / 21 No. 605 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4
C00028040 External link 512 Chelidimerine
C000467
No. 1563
C00027136 External link 512 Corydaldine
/ 3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolone
No. 2199

Human Protein / Gene in interactions

122 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001819 C00001820 C00001830 C00001867 C00001869 C00001872 C00001906 C00026092 C00026150 C00028005 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001819 C00001820 C00001830 C00001867 C00001869 C00001872 C00001906 C00026092 C00028005 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001819 C00001820 C00001830 C00001867 C00001869 C00001872 C00001906 C00026092 C00028005 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001819 C00001820 C00001830 C00001867 C00001869 C00001872 C00026092 C00028005 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001819 C00001820 C00001830 C00001867 C00001872 C00026092 C00028005 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001820 C00001830 C00001867 C00026092 C00028005 C00028774 11 / 10
O75496 Geminin Unclassified protein C00001820 C00001830 C00001867 C00001872 C00026092 C00028005 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00026092 C00026150 C00027150 C00028005 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001867 C00001869 C00001872 C00001906 C00026092 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00026092 C00026150 C00027150 C00028005 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00026092 C00026150 C00027150 C00028005 2 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001819 C00001820 C00001830 C00001867 C00001906 3 / 2
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001820 C00001830 C00001867 C00026092 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00026092 C00026150 C00028005 1 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00001819 C00001869 C00028005 1 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025629 C00028005 0 / 0
P13726 Tissue factor Membrane receptor C00025241 C00026150 C00028005 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001867 C00001869 C00001872 3 / 3
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00001867 C00026092 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001867 C00026092 C00028005 1 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001819 C00001869 C00001872 1 / 4
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001819 C00001820 C00001830 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001819 C00001869 C00001872 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001819 C00001869 C00001872 0 / 1
O00255 Menin Unclassified protein C00001819 C00001869 C00028005 2 / 5
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001820 C00001830 0 / 0
P29466 Caspase-1 C14 C00001869 C00026092 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001820 C00001830 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001820 C00001830 4 / 2
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001820 C00001830 1 / 0
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001820 C00001830 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001820 C00001830 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001820 C00001830 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001820 C00001830 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00026092 1 / 0
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001820 C00001830 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001819 C00001867 2 / 2
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001820 C00001830 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001820 C00001830 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001819 C00001869 4 / 3
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001820 C00001830 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001820 C00001830 1 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025629 C00027150 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001867 C00026092 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001820 C00001830 0 / 0
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 3 / 2
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001820 C00001830 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001820 C00001830 0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001820 C00001830 1 / 1
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00027150 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001819 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
P00734 Prothrombin S1A C00025629 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00001867 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00027150 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00027150 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00027150 2 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00027150 1 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00026092 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00028005 7 / 3
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00001867 5 / 2
Q9H3N8 Histamine H4 receptor Histamine receptor C00027150 0 / 0
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00027150 1 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00027150 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00027150 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00027150 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00027150 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00027150 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00027150 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00028005 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00027150 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00026092 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00027150 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00027150 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00027150 0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00027150 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00027150 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00027150 0 / 0
O14746 Telomerase reverse transcriptase Enzyme C00001819 5 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00001869 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00027150 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
P40225 Thrombopoietin Unclassified protein C00001867 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00028005 2 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001867 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
P39748 Flap endonuclease 1 Enzyme C00026092 0 / 0
P28566 5-hydroxytryptamine receptor 1E Serotonin receptor C00027150 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00027150 0 / 0
P54132 Bloom syndrome protein Enzyme C00001867 1 / 2
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00027150 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00027150 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00027150 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00027150 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00027150 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00027150 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00027150 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00027150 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00027150 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00027150 0 / 1
P04062 Glucosylceramidase Enzyme C00001867 6 / 4
Q9Y5N1 Histamine H3 receptor Histamine receptor C00027150 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001819 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00028005 0 / 0
Q14654 ATP-sensitive inward rectifier potassium channel 11 K C00028005 3 / 4
Q09428 ATP-binding cassette sub-family C member 8 K C00028005 5 / 3
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001819 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001819 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

31 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001819 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00001819
581 BAX, BCL2L4 BCL2-associated X protein C00001819
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001819
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00001819
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001819
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001819
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001819
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001819
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001819
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001819
894 CCND2, KIAK0002 cyclin D2 C00001819
898 CCNE1, CCNE cyclin E1 C00001819
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00001819
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001819
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00001819
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001819
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001819
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001819
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001819
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00001819
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001819
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001819
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001819
5027 P2RX7, P2X7 purinergic receptor P2X, ligand-gated ion channel, 7 C00001819
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001819
6476 SI sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) C00001819
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001819
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001819
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00001819

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (109)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
P47869
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#609135 Aplastic anemia O14746
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#606798 Blepharospasm, benign essential P21918
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240800 Hypoglycemia, leucine-induced; lih Q09428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (101)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P04637 (related)
H00024 Prostate cancer O14746 (marker)
H00783 Febrile seizures O14764 (related)
P18507 (related)
P35498 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00079 Asthma P07550 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

37 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001824
C00001820
D000647 Amnesia C00001819
C00001820
D006973 Hypertension C00001819
C00001820
D004487 Edema C00001819
C00001820
D010190 Pancreatic Neoplasms C00001819
D003920 Diabetes Mellitus C00001819
D003921 Diabetes Mellitus, Experimental C00001819
D003924 Diabetes Mellitus, Type 2 C00001819
D002471 Cell Transformation, Neoplastic C00001819
D006470 Hemorrhage C00001819
D006937 Hypercholesterolemia C00001819
D006943 Hyperglycemia C00001819
D006949 Hyperlipidemias C00001819
D001862 Bone Resorption C00001819
D007077 Ileal Diseases C00001819
D007333 Insulin Resistance C00001819
D007410 Intestinal Diseases C00001819
D009369 Neoplasms C00001819
D003556 Cystitis C00001819
D011471 Prostatic Neoplasms C00001819
D000648 Amnesia, Retrograde C00001820
D001008 Anxiety Disorders C00001820
D001919 Bradycardia C00001820
D004827 Epilepsy C00001820
D005119 Extravasation of Diagnostic and Therapeutic Materials C00001820
D006930 Hyperalgesia C00001820
D007022 Hypotension C00001820
D009069 Movement Disorders C00001820
D009207 Myoclonus C00001820
D009436 Neural Tube Defects C00001820
D020078 Neurogenic Inflammation C00001820
D020336 Paraparesis, Spastic C00001820
D010409 Penile Diseases C00001820
D049188 Prenatal Injuries C00001820
D012640 Seizures C00001820
D013035 Spasm C00001820
D013226 Status Epilepticus C00001820