PCIDB

KCF-S cluster No. 254 (23 metabolites)

Corresponding Phytochemical cluster No. 4

Plant Species

Cumulative plant class count

class name count
eudicotyledons 94
rosids 52

Cumulative family count

class name count
Papaveraceae 91
Rutaceae 51
Meliaceae 1
Ranunculaceae 1
Berberidaceae 1
Menispermaceae 1

Metabolite list (23)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001821 External link 512 Bocconine
/ Chelirubine
C033476
C00001856 External link 512 Fagaridine
/ Fararidine
/ 8-O-Demethylchelerythrine
CHEMBL305942
C00001857 External link 512 Fagaronine
CHEMBL121087
C00001883 External link 512 Macarpine
C00001894 External link 512 Nitidine
CHEMBL176008
C013615
C00001917 External link 512 Sanguinarine
/ Pseudochelerythrine
CHEMBL417799
C005705
55 / 55 / 77 23 / 6
C00024634 External link 512 Chelerythrine
CHEMBL13045
C016299
282 / 150 / 116 14 / 3
C00024635 External link 512 Chelilutine
C00024636 External link 512 Chelirubine
C033476
C00024652 External link 512 Isodecarine
C00024654 External link 512 Decarine
/ Rutaceline
CHEMBL458702
C00024655 External link 512 Norchelerythrine
/ O-Methyldecarine
/ N-Norchelerythrine
/ De-N-methylchelerythrine
/ Des-N-methylchelerythrine
CHEMBL1182694
C00024656 External link 512 Nornitidine
/ N-Nornitidine
/ N-Demethylnitidine
CHEMBL521226
C00024657 External link 512 Norsanguinarine
/ N-Norsanguinarine
/ 13-Demethylsanguinarine
C00024660 External link 512 Chelerythrine
CHEMBL13045
C016299
282 / 150 / 116 14 / 3
C00024663 External link 512 Sanguinarin
/ Sanguinarine
/ Sanguinarium
/ Pseudochelerythrine
CHEMBL417799
C005705
55 / 55 / 77 23 / 6
C00026122 External link 512 Hexadehydrocavidine
/ Dehydrocheilanthifoline
/ Hexadehydrothalictrifoline
C00027503 External link 512 Zanthoxyline
C00027653 External link 512 10-Hydroxysanguinarine
C00027672 External link 512 12-Hydroxychelirubine
C00028710 External link 512 N-Nornitidine
CHEMBL521226
C00028903 External link 512 Rhoifoline A
C00028904 External link 512 Rhoifoline B

Human Protein / Gene in interactions

299 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001917 C00024634 C00024660 C00024663 1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001917 C00024634 C00024660 C00024663 1 / 2
O00255 Menin Unclassified protein C00001917 C00024634 C00024660 C00024663 2 / 5
P04637 Cellular tumor antigen p53 Transcription Factor C00001917 C00024634 C00024660 C00024663 7 / 37
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
P40225 Thrombopoietin Unclassified protein C00001917 C00024634 C00024660 C00024663 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001917 C00024634 C00024660 C00024663 4 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001917 C00024634 C00024660 C00024663 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001917 C00024634 C00024660 C00024663 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001917 C00024634 C00024660 C00024663 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00001917 C00024634 C00024660 C00024663 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00001917 C00024634 C00024660 C00024663 4 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001917 C00024634 C00024660 C00024663 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001917 C00024634 C00024660 C00024663 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001917 C00024634 C00024660 C00024663 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001917 C00024634 C00024660 C00024663 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001917 C00024634 C00024660 C00024663 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001917 C00024634 C00024660 C00024663 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001917 C00024634 C00024660 C00024663 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001917 C00024634 C00024660 C00024663 2 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001917 C00024634 C00024660 C00024663 1 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00001917 C00024634 C00024660 C00024663 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001917 C00024634 C00024660 C00024663 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001917 C00024634 C00024660 C00024663 2 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001917 C00024634 C00024660 C00024663 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001917 C00024634 C00024660 C00024663 3 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001917 C00024634 C00024660 C00024663 0 / 0
Q8N568 Serine/threonine-protein kinase DCLK2 CAMK serine/threonine protein kinase DCAMK1 C00024634 C00024660 0 / 0
O14965 Aurora kinase A Aur C00024634 C00024660 0 / 0
Q7KZI7 Serine/threonine-protein kinase MARK2 CAMK serine/threonine protein kinase MARK subfamily C00024634 C00024660 0 / 0
Q13882 Protein-tyrosine kinase 6 Src C00024634 C00024660 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00024634 C00024660 0 / 0
Q9UHD2 Serine/threonine-protein kinase TBK1 Ikk C00024634 C00024660 1 / 0
P21709 Ephrin type-A receptor 1 Eph C00024634 C00024660 0 / 0
Q9P0L2 Serine/threonine-protein kinase MARK1 CAMK serine/threonine protein kinase MARK subfamily C00024634 C00024660 0 / 0
Q15303 Receptor tyrosine-protein kinase erbB-4 TK tyrosine-protein kinase EGFR subfamily C00024634 C00024660 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001917 C00024663 11 / 10
O14924 Regulator of G-protein signaling 12 Unclassified protein C00001917 C00024663 0 / 0
Q96PF2 Testis-specific serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase TSSK subfamily C00024634 C00024660 0 / 0
P51956 Serine/threonine-protein kinase Nek3 Nek1 C00024634 C00024660 0 / 0
P37840 Alpha-synuclein Unclassified protein C00001917 C00024663 4 / 2
P00519 Tyrosine-protein kinase ABL1 Abl C00024634 C00024660 1 / 2
Q04759 Protein kinase C theta type Delta C00024634 C00024660 0 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00024634 C00024660 3 / 1
Q05513 Protein kinase C zeta type Iota C00024634 C00024660 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00024634 C00024660 0 / 0
Q02156 Protein kinase C epsilon type Eta C00024634 C00024660 0 / 0
P41743 Protein kinase C iota type Iota C00024634 C00024660 0 / 0
Q9UK32 Ribosomal protein S6 kinase alpha-6 Rskb C00024634 C00024660 0 / 0
Q04912 Macrophage-stimulating protein receptor TK tyrosine-protein kinase MET subfamily C00024634 C00024660 0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 C00024634 C00024660 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00024634 C00024660 0 / 0
P80192 Mitogen-activated protein kinase kinase kinase 9 TKL dual-specificity kinase MLK C00024634 C00024660 0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk C00024634 C00024660 1 / 2
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00024634 C00024660 2 / 1
P19784 Casein kinase II subunit alpha' Ck2 C00024634 C00024660 0 / 0
Q05655 Protein kinase C delta type Delta C00024634 C00024660 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00024634 C00024660 0 / 0
Q9UQB9 Aurora kinase C Aur C00024634 C00024660 1 / 1
P49761 Dual specificity protein kinase CLK3 Clk C00024634 C00024660 0 / 0
P51813 Cytoplasmic tyrosine-protein kinase BMX Tec C00024634 C00024660 0 / 0
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00024634 C00024660 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00024634 C00024660 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00024634 C00024660 0 / 0
Q06187 Tyrosine-protein kinase BTK Tec C00024634 C00024660 2 / 2
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00024634 C00024660 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00024634 C00024660 0 / 0
Q9UBE8 Serine/threonine-protein kinase NLK CMGC serine/threonine protein kinase NMO subfamily C00024634 C00024660 0 / 0
Q12866 Tyrosine-protein kinase Mer TK tyrosine-protein kinase AXL C00024634 C00024660 1 / 1
Q00535 Cyclin-dependent kinase 5 Cdk5 C00024634 C00024660 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00024634 C00024660 0 / 0
Q9Y5S2 Serine/threonine-protein kinase MRCK beta AGC serine/threonine protein kinase GEK subfamily C00024634 C00024660 0 / 0
Q8N4C8 Misshapen-like kinase 1 STE serine/threonine protein kinase MSN subfamily C00024634 C00024660 0 / 0
Q9NYY3 Serine/threonine-protein kinase PLK2 Plk2 C00024634 C00024660 0 / 0
P43250 G protein-coupled receptor kinase 6 AGC serine/threonine protein kinase GRK subfamily C00024634 C00024660 0 / 0
Q96BR1 Serine/threonine-protein kinase Sgk3 AGC serine/threonine protein kinase SGK subfamily C00024634 C00024660 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00024634 C00024660 1 / 8
P04629 High affinity nerve growth factor receptor Trk C00024634 C00024660 2 / 3
O43293 Death-associated protein kinase 3 Dapk C00024634 C00024660 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00024634 C00024660 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00024634 C00024660 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00024634 C00024660 2 / 2
Q9Y243 RAC-gamma serine/threonine-protein kinase Akt C00024634 C00024660 1 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00024634 C00024660 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00024634 C00024660 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00024634 C00024660 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00024634 C00024660 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00024634 C00024660 0 / 0
Q15349 Ribosomal protein S6 kinase alpha-2 Rskb C00024634 C00024660 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00024634 C00024660 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00024634 C00024660 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00024634 C00024660 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00024634 C00024660 1 / 1
P07947 Tyrosine-protein kinase Yes Src C00024634 C00024660 0 / 0
P51617 Interleukin-1 receptor-associated kinase 1 Irak C00024634 C00024660 0 / 0
Q9NWZ3 Interleukin-1 receptor-associated kinase 4 Irak C00024634 C00024660 2 / 1
O43353 Receptor-interacting serine/threonine-protein kinase 2 Ripk C00024634 C00024660 0 / 0
P29320 Ephrin type-A receptor 3 Eph C00024634 C00024660 1 / 0
P54764 Ephrin type-A receptor 4 Eph C00024634 C00024660 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00024634 C00024660 0 / 0
P17252 Protein kinase C alpha type Alpha C00024634 C00024660 0 / 0
Q16620 BDNF/NT-3 growth factors receptor Trk C00024634 C00024660 1 / 1
P42680 Tyrosine-protein kinase Tec Tec C00024634 C00024660 0 / 0
P42681 Tyrosine-protein kinase TXK Tec C00024634 C00024660 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00024634 C00024660 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00024634 C00024660 0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer C00024634 C00024660 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00024634 C00024660 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00024634 C00024660 0 / 0
P54760 Ephrin type-B receptor 4 Eph C00024634 C00024660 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00024634 C00024660 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00024634 C00024660 0 / 0
Q09013 Myotonin-protein kinase AGC serine/threonine protein kinase GEK subfamily C00024634 C00024660 1 / 1
Q16832 Discoidin domain-containing receptor 2 Ddr C00024634 C00024660 1 / 1
Q8IYT8 Serine/threonine-protein kinase ULK2 ULK serine/threonine protein kinase C00024634 C00024660 0 / 0
P42858 Huntingtin Unclassified protein C00001917 C00024663 1 / 1
Q9BYT3 Serine/threonine-protein kinase 33 Unique CAMK serine/threonine protein kinase C00024634 C00024660 0 / 0
P57059 Serine/threonine-protein kinase SIK1 CAMK serine/threonine protein kinase QIK subfamily C00024634 C00024660 0 / 0
P78362 SRSF protein kinase 2 Srpk C00024634 C00024660 0 / 0
Q9HBY8 Serine/threonine-protein kinase Sgk2 AGC serine/threonine protein kinase SGK subfamily C00024634 C00024660 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001917 C00024663 2 / 0
Q9UIK4 Death-associated protein kinase 2 Dapk C00024634 C00024660 0 / 0
Q86Y07 Serine/threonine-protein kinase VRK2 Enzyme C00024634 C00024660 0 / 0
Q9Y3S1 Serine/threonine-protein kinase WNK2 WNK serine/threonine protein kinase subfamily C00024634 C00024660 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00024634 C00024660 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00024634 C00024660 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00024634 C00024660 0 / 0
P42684 Abelson tyrosine-protein kinase 2 Abl C00024634 C00024660 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00024634 C00024660 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00024634 C00024660 0 / 1
P29323 Ephrin type-B receptor 2 Eph C00024634 C00024660 2 / 0
O75914 Serine/threonine-protein kinase PAK 3 STE serine/threonine protein kinase PAKA subfamily C00024634 C00024660 1 / 1
P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phk C00024634 C00024660 1 / 1
Q02763 Angiopoietin-1 receptor Tie C00024634 C00024660 1 / 1
P29317 Ephrin type-A receptor 2 Eph C00024634 C00024660 1 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek C00024634 C00024660 0 / 0
Q15375 Ephrin type-A receptor 7 Eph C00024634 C00024660 0 / 0
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 C00024634 C00024660 0 / 0
Q9H4B4 Serine/threonine-protein kinase PLK3 PLK serine/threonine protein kinase subfamily C00024634 C00024660 0 / 0
P54753 Ephrin type-B receptor 3 Eph C00024634 C00024660 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00024634 C00024660 1 / 1
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00001917 C00024663 0 / 0
O15146 Muscle, skeletal receptor tyrosine-protein kinase Musk C00024634 C00024660 1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily C00024634 C00024660 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00024634 C00024660 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001917 C00024663 0 / 0
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00024634 C00024660 9 / 3
Q16539 Mitogen-activated protein kinase 14 p38 C00024634 C00024660 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001917 C00024663 0 / 0
Q96RG2 PAS domain-containing serine/threonine-protein kinase Pask C00024634 C00024660 0 / 0
P34947 G protein-coupled receptor kinase 5 AGC serine/threonine protein kinase GRK subfamily C00024634 C00024660 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00001917 C00024663 0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00024634 C00024660 5 / 4
P09619 Platelet-derived growth factor receptor beta Pdgfr C00024634 C00024660 5 / 1
P52564 Dual specificity mitogen-activated protein kinase kinase 6 Ste7 C00024634 C00024660 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00024634 C00024660 1 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00024634 C00024660 0 / 0
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha Other serine/threonine protein kinase C00024634 C00024660 1 / 1
Q96GD4 Aurora kinase B Aur C00024634 C00024660 0 / 0
O75676 Ribosomal protein S6 kinase alpha-4 CAMK serine/threonine protein kinase MSKB subfamily C00024634 C00024660 0 / 0
P05129 Protein kinase C gamma type Alpha C00024634 C00024660 1 / 1
O60674 Tyrosine-protein kinase JAK2 Jakb C00024634 C00024660 5 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00024634 C00024660 1 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00024634 C00024660 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00024634 C00024660 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00024634 C00024660 2 / 3
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily C00024634 C00024660 1 / 3
P35916 Vascular endothelial growth factor receptor 3 Vegfr C00024634 C00024660 2 / 1
P22455 Fibroblast growth factor receptor 4 Fgfr C00024634 C00024660 0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr C00024634 C00024660 14 / 6
P45983 Mitogen-activated protein kinase 8 Jnk C00024634 C00024660 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001917 C00024663 0 / 0
O94804 Serine/threonine-protein kinase 10 STE serine/threonine protein kinase SLK subfamily C00024634 C00024660 1 / 0
P53667 LIM domain kinase 1 Limk C00024634 C00024660 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00001917 C00024663 0 / 0
Q13177 Serine/threonine-protein kinase PAK 2 STE serine/threonine protein kinase PAKA subfamily C00024634 C00024660 0 / 0
Q06418 Tyrosine-protein kinase receptor TYRO3 TK tyrosine-protein kinase AXL C00024634 C00024660 0 / 0
Q6PHR2 Serine/threonine-protein kinase ULK3 ULK serine/threonine protein kinase C00024634 C00024660 0 / 0
Q7L7X3 Serine/threonine-protein kinase TAO1 STE serine/threonine protein kinase TAO subfamily C00024634 C00024660 0 / 0
P14616 Insulin receptor-related protein TK tyrosine-protein kinase INSR C00024634 C00024660 0 / 0
O43318 Mitogen-activated protein kinase kinase kinase 7 Tak1 C00024634 C00024660 0 / 0
Q9BXA7 Testis-specific serine/threonine-protein kinase 1 Tssk C00024634 C00024660 0 / 0
Q9H2K8 Serine/threonine-protein kinase TAO3 STE serine/threonine protein kinase TAO subfamily C00024634 C00024660 0 / 0
Q9BYP7 Serine/threonine-protein kinase WNK3 WNK serine/threonine protein kinase subfamily C00024634 C00024660 0 / 0
Q15831 Serine/threonine-protein kinase STK11 Lkb C00024634 C00024660 2 / 2
P08922 Proto-oncogene tyrosine-protein kinase ROS TK tyrosine-protein kinase SEV C00024634 C00024660 0 / 1
Q8NG66 Serine/threonine-protein kinase Nek11 Nek11 C00024634 C00024660 0 / 0
Q8WTQ7 G protein-coupled receptor kinase 7 AGC serine/threonine protein kinase GRK subfamily C00024634 C00024660 0 / 0
Q8TF76 Serine/threonine-protein kinase haspin Haspin C00024634 C00024660 0 / 0
P11362 Fibroblast growth factor receptor 1 Fgfr C00024634 C00024660 4 / 5
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00024634 C00024660 0 / 0
Q08881 Tyrosine-protein kinase ITK/TSK Tec C00024634 C00024660 1 / 1
P49840 Glycogen synthase kinase-3 alpha Gsk C00024634 C00024660 0 / 0
Q13976 cGMP-dependent protein kinase 1 Pkg C00024634 C00024660 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00024634 C00024660 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00024634 C00024660 0 / 0
Q14289 Protein-tyrosine kinase 2-beta Fak C00024634 C00024660 0 / 0
P05771 Protein kinase C beta type Alpha C00024634 C00024660 0 / 0
P08631 Tyrosine-protein kinase HCK Src C00024634 C00024660 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00024634 C00024660 0 / 0
Q5VT25 Serine/threonine-protein kinase MRCK alpha AGC serine/threonine protein kinase GEK subfamily C00024634 C00024660 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00024634 C00024660 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00024634 C00024660 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00024634 C00024660 2 / 2
P07333 Macrophage colony-stimulating factor 1 receptor Pdgfr C00024634 C00024660 1 / 1
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00024634 C00024660 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00024634 C00024660 0 / 0
P16591 Tyrosine-protein kinase Fer Fer C00024634 C00024660 0 / 0
Q8IU85 Calcium/calmodulin-dependent protein kinase type 1D Camk1 C00024634 C00024660 0 / 0
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00024634 C00024660 0 / 0
Q9UEE5 Serine/threonine-protein kinase 17A Dapk C00024634 C00024660 0 / 0
P07949 Proto-oncogene tyrosine-protein kinase receptor Ret Ret C00024634 C00024660 9 / 4
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00024634 C00024660 0 / 0
P36896 Activin receptor type-1B TKL serine/threonine protein kinase STKR type 1 subfamily C00024634 C00024660 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001917 C00024663 0 / 0
Q86UE8 Serine/threonine-protein kinase tousled-like 2 TLK serine/threonine protein kinase C00024634 C00024660 0 / 0
Q86Z02 Homeodomain-interacting protein kinase 1 CMGC serine/threonine protein kinase HIPK subfamily C00024634 C00024660 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00024634 C00024660 0 / 0
Q13043 Serine/threonine-protein kinase 4 STE serine/threonine protein kinase MST subfamily C00024634 C00024660 1 / 0
P42685 Tyrosine-protein kinase FRK Src C00024634 C00024660 0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00024634 C00024660 4 / 3
Q92934 Bcl2 antagonist of cell death Other cytosolic protein C00001917 C00024663 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00024634 C00024660 0 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00024634 C00024660 0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 C00024634 C00024660 0 / 0
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00024634 C00024660 4 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb C00024634 C00024660 1 / 1
P04049 RAF proto-oncogene serine/threonine-protein kinase Raf C00024634 C00024660 2 / 0
P43405 Tyrosine-protein kinase SYK Syk C00024634 C00024660 0 / 0
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00024634 C00024660 0 / 0
Q16566 Calcium/calmodulin-dependent protein kinase type IV Camk1 C00024634 C00024660 0 / 0
P53355 Death-associated protein kinase 1 Dapk C00024634 C00024660 0 / 1
P24723 Protein kinase C eta type Eta C00024634 C00024660 1 / 0
P51451 Tyrosine-protein kinase Blk Src C00024634 C00024660 1 / 1
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00024634 C00024660 0 / 0
O14733 Dual specificity mitogen-activated protein kinase kinase 7 Ste7 C00024634 C00024660 0 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00024634 C00024660 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00024634 C00024660 0 / 0
P35557 Glucokinase Enzyme C00024634 C00024660 3 / 3
P49760 Dual specificity protein kinase CLK2 Clk C00024634 C00024660 0 / 0
P54756 Ephrin type-A receptor 5 Eph C00024634 C00024660 0 / 0
P54762 Ephrin type-B receptor 1 Eph C00024634 C00024660 0 / 0
Q07912 Activated CDC42 kinase 1 TK tyrosine-protein kinase ACK subfamily C00024634 C00024660 0 / 0
P30530 Tyrosine-protein kinase receptor UFO TK tyrosine-protein kinase AXL subfamily C00024634 C00024660 0 / 0
Q9BZL6 Serine/threonine-protein kinase D2 Pkd C00024634 C00024660 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00024634 C00024660 0 / 0
Q9UPE1 SRSF protein kinase 3 Srpk C00024634 C00024660 0 / 0
Q9Y6E0 Serine/threonine-protein kinase 24 STE serine/threonine protein kinase YSK subfamily C00024634 C00024660 0 / 0
Q9Y6M4 Casein kinase I isoform gamma-3 Ck1-g C00024634 C00024660 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00024634 C00024660 0 / 0
Q8TDC3 Serine/threonine-protein kinase BRSK1 CAMK serine/threonine protein kinase BRSK subfamily C00024634 C00024660 0 / 0
P51817 cAMP-dependent protein kinase catalytic subunit PRKX Pka C00024634 C00024660 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001917 C00024663 0 / 0
P29322 Ephrin type-A receptor 8 Eph C00024634 C00024660 0 / 0
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 C00024634 C00024660 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00024634 C00024660 1 / 1
Q9UL54 Serine/threonine-protein kinase TAO2 STE serine/threonine protein kinase TAO subfamily C00024634 C00024660 0 / 0
P36897 TGF-beta receptor type-1 TKL dual-specificity kinase STKR type 1 subfamily C00024634 C00024660 3 / 2
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00024634 C00024660 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001917 C00024663 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001917 C00024663 1 / 4
P51946 Cyclin-H Other cytosolic protein C00024634 C00024660 0 / 0
P50613 Cyclin-dependent kinase 7 Cdk7 C00024634 C00024660 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00024634 C00024660 0 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00024634 C00024660 0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein C00024634 C00024660 0 / 2
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00024634 C00024660 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00024634 C00024660 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00024634 C00024660 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00024634 C00024660 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00024634 C00024660 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00024634 C00024660 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00024634 C00024660 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00024634 C00024660 0 / 0
P54619 5'-AMP-activated protein kinase subunit gamma-1 REG serine/threonine protein kinase family C00024634 C00024660 0 / 0
Q9Y478 5'-AMP-activated protein kinase subunit beta-1 REG serine/threonine protein kinase family C00024634 C00024660 0 / 0
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00024634 C00024660 0 / 0
Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 Ampk C00024634 C00024660 0 / 0
O43741 5'-AMP-activated protein kinase subunit beta-2 REG serine/threonine protein kinase family C00024634 C00024660 0 / 0
Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 REG serine/threonine protein kinase family C00024634 C00024660 3 / 3
O60563 Cyclin-T1 Other cytosolic protein C00024634 C00024660 0 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00024634 C00024660 0 / 0
Q00526 Cyclin-dependent kinase 3 Cdc2 C00024634 C00024660 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00024634 C00024660 1 / 0
P30281 G1/S-specific cyclin-D3 Other cytosolic protein C00024634 C00024660 0 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001917 C00024663 0 / 0
P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A Isomerase C00024634 C00024660 0 / 0
Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 Kinase C00024634 C00024660 0 / 0

34 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001917 C00024634 C00024660 C00024663
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001917 C00024634 C00024660 C00024663
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001917 C00024634 C00024660 C00024663
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001917 C00024663
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001917 C00024663
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001917 C00024663
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001917 C00024663
9075 CLDN2 claudin 2 C00001917 C00024663
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00001917 C00024663
1364 CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R claudin 4 C00001917 C00024663
7122 CLDN5, AWAL, BEC1, CPETRL1, TMVCF claudin 5 C00001917 C00024663
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001917 C00024663
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001917 C00024663
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00001917 C00024663
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001917 C00024663
581 BAX, BCL2L4 BCL2-associated X protein C00001917 C00024663
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001917 C00024663
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001917 C00024663
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001917 C00024663
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00001917 C00024663
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00001917 C00024663
6615 SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 snail family zinc finger 1 C00001917 C00024663
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001917 C00024663
846 CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1 calcium-sensing receptor C00024634 C00024660
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00024634 C00024660
1950 EGF, HOMG4, URG epidermal growth factor C00024634 C00024660
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00024634 C00024660
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00024634 C00024660
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00024634 C00024660
3752 KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22 potassium voltage-gated channel, Shal-related subfamily, member 3 C00024634 C00024660
5581 PRKCE, PKCE, nPKC-epsilon protein kinase C, epsilon (EC:2.7.11.13) C00024634 C00024660
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00024634 C00024660
8884 SLC5A6, SMVT solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 C00024634 C00024660
7082 TJP1, ZO-1 tight junction protein 1 C00024634 C00024660

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (168)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100800 Achondroplasia; ach P22607
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#300755 Agammaglobulinemia, x-linked; xla Q06187
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#101200 Apert syndrome P21802
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#109800 Bladder cancer P22607
#114480 Breast cancer O96017
P31749
#600880 Budd-chiari syndrome; bdchs O60674
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#600858 Cardiomyopathy, familial hypertrophic, 6; cmh6 Q9UGJ0
#116600 Cataract 6, multiple types; ctrct6 P29317
#209880 Central hypoventilation syndrome, congenital; cchs P07949
#603956 Cervical cancer P22607
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#613630 Cocoon syndrome O15111
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P07949
P18054
P29320
P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#123500 Crouzon syndrome P21802
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#127750 Dementia, lewy body; dlb P37840
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
P31751
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
P16234
#177700 Glaucoma 1, open angle, p; glc1p Q9UHD2
#613027 Glycogen storage disease ixc; gsd9c P15735
#261740 Glycogen storage disease of heart, lethal congenital Q9UGJ0
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#602089 Hemangioma, capillary infantile P35916
P35968
#114550 Hepatocellular carcinoma P08581
#142623 Hirschsprung disease, susceptibility to, 1; hscr1 P07949
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 P35557
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146000 Hypochondroplasia; hch P22607
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#256800 Insensitivity to pain, congenital, with anhidrosis; cipa P04629
#270450 Insulin-like growth factor i, resistance to P08069
#610799 Invasive pneumococcal disease, recurrent isolated, 1; ipd1 Q9NWZ3
#607676 Irak4 deficiency Q9NWZ3
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#123150 Jackson-weiss syndrome; jws P21802
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
P22607
#611554 Leopard syndrome 2 P04049
#601626 Leukemia, acute myeloid; aml O60674
P09619
P10721
P36888
#608232 Leukemia, chronic myeloid; cml P00519
#221820 Leukoencephalopathy, diffuse hereditary, with spheroids; hdls P07333
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#609192 Loeys-dietz syndrome, type 1a; lds1a P36897
#608967 Loeys-dietz syndrome, type 2a; lds2a P36897
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#153100 Lymphedema, hereditary, ia P35916
#613011 Lymphoproliferative syndrome 1; lpfs1 Q08881
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613375 Maturity-onset diabetes of the young, type 11; mody11 P51451
#125851 Maturity-onset diabetes of the young, type 2; mody2 P35557
#606391 Maturity-onset diabetes of the young; mody P35557
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph Q9Y243
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300558 Mental retardation, x-linked 30; mrx30 O75914
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#602849 Muenke syndrome; mnkes P22607
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#171400 Multiple endocrine neoplasia, type iia; men2a P07949
#162300 Multiple endocrine neoplasia, type iib; men2b P07949
#132800 Multiple self-healing squamous epithelioma, susceptibility to; msse P36897
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency O15146
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#254450 Myelofibrosis O60674
#254500 Myeloma, multiple P22607
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q09013
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#162900 Nevus, epidermal P22607
#257220 Niemann-pick disease, type c1; npc1 O15118
#611553 Noonan syndrome 5; ns5 P04049
#613886 Obesity, hyperphagia, and developmental delay Q16620
#259500 Osteogenic sarcoma O96017
#166250 Osteoglophonic dysplasia; ogd P11362
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#175200 Peutz-jeghers syndrome; pjs Q15831
#101600 Pfeiffer syndrome P11362
P21802
#171300 Pheochromocytoma P07949
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#263300 Polycythemia vera; pv O60674
#176807 Prostate cancer O96017
P29323
#603688 Prostate cancer/brain cancer susceptibility P29323
#176920 Proteus syndrome P31749
#191830 Renal adysplasia P07949
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#613862 Retinitis pigmentosa 38; rp38 Q12866
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#269840 Selective t-cell defect; stcd P43403
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#271665 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#614868 T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations; tiiac Q13043
#273300 Testicular germ cell tumor; tgct O94804
P10721
P22607
Q15831
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#187950 Thrombocythemia 1; thcyt1 P40225
#614521 Thrombocythemia 3; thcyt3 O60674
#155240 Thyroid carcinoma, familial medullary; mtc P07949
#188550 Thyroid carcinoma, papillary P04629
P07949
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190440 Trigonocephaly 1; trigno1 P11362
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#194200 Wolff-parkinson-white syndrome Q9UGJ0

KEGG DISEASE (129)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00882 Cocoon syndrome O15111 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00770 Congenital myasthenic syndrome O15146 (related)
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00480 Non-syndromic X-linked mental retardation O75914 (related)
P51812 (related)
Q99714 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
P04637 (related)
H00018 Gastric cancer O96020 (related)
P00533 (related)
P04637 (related)
P08581 (related)
P21802 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P24864 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
P04637 (related)
Q01196 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00022 Bladder cancer P00533 (related)
P04637 (related)
P22607 (related)
P53355 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
P07333 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P09619 (related)
P16234 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00032 Thyroid cancer P04629 (related)
P04637 (related)
P07949 (related)
P07949 (marker)
H00043 Neuroblastoma P04629 (related)
P04629 (marker)
Q16620 (related)
H00265 Hereditary sensory and autonomic neuropathy (HSAN) P04629 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P43403 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
P22607 (related)
P30281 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
P08922 (related)
Q9UM73 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
P08069 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
Q15831 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P31751 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
P08581 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
P35557 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
P43403 (related)
H00822 Renal agenesis and Renal adysplasia P07949 (related)
H00910 Hirschsprung disease (HD) P07949 (related)
H00916 Congenital central hypoventilation syndrome (CCHS) P07949 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
P22607 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00069 Glycogen storage diseases (GSD) P15735 (related)
Q9UGJ0 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
P22607 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H01202 Cataract P29317 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00410 Maturity onset diabetes of the young (MODY) P35557 (related)
P51451 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) P35557 (related)
H00535 Lymphedemas P35916 (related)
H00800 Loeys-Dietz syndrome (LDS) P36897 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) P36897 (related)
Q15746 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00531 Venous malformations Q02763 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00107 Other well-defined immunodeficiency syndromes Q08881 (related)
H00568 Myotonic dystrophy (DM) Q09013 (related)
H00527 Retinitis pigmentosa (RP) Q12866 (related)
H00666 Peutz-Jeghers syndrome Q15831 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00777 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00096 Defects of toll-like receptor signaling Q9NWZ3 (related)
H00292 Hypertrophic cardiomyopathy (HCM) Q9UGJ0 (related)
H01154 Wolff-Parkinson-White (WPW) syndrome Q9UGJ0 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D020964 Embryo Loss C00001917
C00024663
D005317 Fetal Growth Retardation C00001917
C00024663
D009336 Necrosis C00001917
C00024663
D009369 Neoplasms C00001917
C00024663
D009374 Neoplasms, Experimental C00001917
C00024663
D012878 Skin Neoplasms C00001917
C00024663
D000138 Acidosis C00024634
C00024660
D056486 Drug-Induced Liver Injury C00024634
C00024660
D006930 Hyperalgesia C00024634
C00024660