PCIDB

KNApSAcK Metabolite C00001917

Metabolite

KNApSAcK Entry

id C00001917
Name Sanguinarine / Pseudochelerythrine
CAS RN 2447-54-3
Standard InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
Standard InChI (Main Layer) InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 254

Link

ChEMBL

By standard InChI CHEMBL417799
By standard InChI Main Layer CHEMBL417799

KEGG

By LinkDB C06162

CTD

By CAS RN C005705

Human Protein / Gene in interaction

55 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL417799 CHEMBL1614110 (2) CHEMBL1741321 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL417799 CHEMBL1614009 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL417799 CHEMBL1613992 (2) CHEMBL1613995 (2)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL417799 CHEMBL1613842 (2)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL417799 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL417799 CHEMBL2169431 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL417799 CHEMBL1794367 (1) CHEMBL2114784 (2)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL417799 CHEMBL1794499 (2)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL417799 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL417799 CHEMBL2114744 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL417799 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL417799 CHEMBL1614544 (1)
11 / 10
O14924 Regulator of G-protein signaling 12 Unclassified protein CHEMBL417799 CHEMBL1613902 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL417799 CHEMBL2354282 (2)
4 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL417799 CHEMBL1614281 (2) CHEMBL1614361 (2)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL417799 CHEMBL1614027 (1) CHEMBL1741325 (2)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL417799 CHEMBL1794311 (3)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL417799 CHEMBL1613800 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL417799 CHEMBL1614458 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL417799 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL417799 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL417799 CHEMBL1738606 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL417799 CHEMBL1613918 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL417799 CHEMBL1794584 (1)
2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL417799 CHEMBL1613838 (1)
0 / 0
P42226 Signal transducer and activator of transcription 6 Unclassified protein CHEMBL417799 CHEMBL1614338 (1) CHEMBL1613945 (1)
CHEMBL1614070 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL417799 CHEMBL1738610 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL417799 CHEMBL1963863 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL417799 CHEMBL2169430 (1)
1 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL417799 CHEMBL1963893 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL417799 CHEMBL1794467 (1)
0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein CHEMBL417799 CHEMBL1614448 (1)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL417799 CHEMBL1614252 (2)
2 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL417799 CHEMBL1614521 (1) CHEMBL1613808 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL417799 CHEMBL1741322 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL417799 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL417799 CHEMBL1614038 (2)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL417799 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL417799 CHEMBL1738675 (1) CHEMBL1737868 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL417799 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL417799 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL417799 CHEMBL1613777 (2) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL417799 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL417799 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL417799 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL417799 CHEMBL1737980 (1)
0 / 0
Q92934 Bcl2 antagonist of cell death Other cytosolic protein CHEMBL417799 CHEMBL1035860 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL417799 CHEMBL1613914 (2)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL417799 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL417799 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL417799 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL417799 CHEMBL1614257 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL417799 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL417799 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL417799 CHEMBL2114738 (1)
0 / 0

CTD interaction (40)

compound gene gene name gene description interaction interaction type form reference
pmid
C005705 196 AHR
bHLHe76
aryl hydrocarbon receptor sanguinarine promotes the reaction [AHR protein binds to ARNT protein] affects binding
/ increases reaction
protein 15993743
C005705 196 AHR
bHLHe76
aryl hydrocarbon receptor sanguinarine results in increased activity of and affects the localization of AHR protein affects localization
/ increases activity
protein 15993743
C005705 196 AHR
bHLHe76
aryl hydrocarbon receptor sanguinarine results in increased localization of and results in increased activity of AHR protein increases activity
/ increases localization
protein 15993743
C005705 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator sanguinarine promotes the reaction [AHR protein binds to ARNT protein] affects binding
/ increases reaction
protein 15993743
C005705 581 BAX
BCL2L4
BCL2-associated X protein sanguinarine results in increased expression of BAX protein increases expression
protein 22215411
C005705 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 sanguinarine results in decreased expression of BCL2 protein decreases expression
protein 22215411
C005705 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) sanguinarine results in decreased expression of CASP3 protein alternative form decreases expression
protein 19135517
C005705 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) sanguinarine results in increased activity of CASP3 protein increases activity
protein 19135517
19346183
20150630
22215411
C005705 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) sanguinarine results in increased activity of CASP8 protein increases activity
protein 19346183
C005705 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) sanguinarine results in decreased expression of CASP9 protein alternative form decreases expression
protein 19135517
C005705 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) sanguinarine results in increased activity of CASP9 protein increases activity
protein 19346183
22215411
C005705 9075 CLDN2
claudin 2 sanguinarine results in decreased expression of CLDN2 protein decreases expression
protein 19063874
C005705 1365 CLDN3
C7orf1
CPE-R2
CPETR2
HRVP1
RVP1
claudin 3 sanguinarine results in decreased expression of CLDN3 protein decreases expression
protein 19063874
C005705 1364 CLDN4
CPE-R
CPER
CPETR
CPETR1
WBSCR8
hCPE-R
claudin 4 sanguinarine results in decreased expression of CLDN4 protein decreases expression
protein 19063874
C005705 7122 CLDN5
AWAL
BEC1
CPETRL1
TMVCF
claudin 5 sanguinarine results in decreased expression of CLDN5 protein decreases expression
protein 19063874
C005705 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) sanguinarine results in decreased activity of CYP1A1 protein decreases activity
protein 15993743
C005705 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) sanguinarine results in increased activity of CYP1A1 protein increases activity
protein 15993743
C005705 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) sanguinarine results in increased expression of CYP1A1 mRNA increases expression
mRNA 15993743
C005705 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) sanguinarine results in increased activity of CYP1B1 protein increases activity
protein 15993743
C005705 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) sanguinarine results in increased expression of CYP1B1 mRNA increases expression
mRNA 15993743
C005705 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) sanguinarine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
mRNA 15313406
C005705 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
mRNA 15313406
C005705 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) sanguinarine results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 19135517
C005705 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) sanguinarine results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 19135517
C005705 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) sanguinarine results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 19135517
C005705 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 19135517
C005705 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) sanguinarine results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 19135517
C005705 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) sanguinarine results in decreased expression of MMP2 mRNA decreases expression
mRNA 19063874
C005705 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) sanguinarine results in decreased expression of MMP2 protein decreases expression
protein 19063874
C005705 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) sanguinarine results in decreased expression of MMP9 mRNA decreases expression
mRNA 19063874
C005705 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) sanguinarine results in decreased expression of MMP9 protein decreases expression
protein 19063874
C005705 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) sanguinarine results in decreased expression of NQO1 mRNA decreases expression
mRNA 22021338
C005705 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) sanguinarine results in decreased expression of NQO1 protein decreases expression
protein 22021338
C005705 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 sanguinarine results in decreased expression of SNAI1 protein decreases expression
protein 19063874
C005705 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
protein 15313406

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (55)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (77)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

6 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D020964 C005705 Embryo Loss marker/mechanism
21722720
D005317 C005705 Fetal Growth Retardation marker/mechanism
21722720
D009336 C005705 Necrosis marker/mechanism
19346183
D009369 C005705 Neoplasms marker/mechanism
20691676
D009374 C005705 Neoplasms, Experimental marker/mechanism
20691676
D012878 C005705 Skin Neoplasms marker/mechanism
20691676