Species

KNApSAcK Entry

Organism name Papaver somniferum
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver somniferum
Linked NCBI taxonomy ID 3469
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (32)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005411 External link 512 Quercetin 3-gentiobioside
CHEMBL1097317
C088177
No. 1 No. 15
C00026087 External link 512 Cheilanthifoline
/ (-)-Cheilanthifoline
No. 37 No. 4
C00015402 External link 512 alpha-Thebaol
/ 3,6-Dimethoxy-4-hydroxyphenanthrene
No. 104 No. 27
C00015423 External link 512 3,7-Dimethoxy-5-hydroxyphenanthrene
No. 104 No. 27
C00034613 External link 512 Norcoclaurine
/ (S)-(-)-Higenamine
CHEMBL19344
CHEMBL501778
CHEMBL470491
2 / 2 / 0 No. 253 No. 4
C00001917 External link 512 Sanguinarine
/ Pseudochelerythrine
CHEMBL417799
C005705
55 / 55 / 77 23 / 6 No. 254 No. 4
C00024663 External link 512 Sanguinarin
/ Sanguinarine
/ Sanguinarium
/ Pseudochelerythrine
CHEMBL417799
C005705
55 / 55 / 77 23 / 6 No. 254 No. 4
C00001875 External link 512 Tritopin
/ Tritopine
/ Laudanidine
/ (-)-Laudanidine
CHEMBL251625
CHEMBL1425007
2 / 0 / 0 No. 345 No. 4
C00001876 External link 512 Laudanosine
/ L-Laudanosine
/ O-Methylcodamine
/ L-(+)-Laudanosine
CHEMBL1407
CHEMBL519894
CHEMBL1613
C001522
18 / 26 / 21 0 / 1 No. 345 No. 4
C00028453 External link 512 Laudanine
CHEMBL251625
CHEMBL1425007
2 / 0 / 0 No. 345 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00001916 External link 512 Salutaridine
/ (+)-Salutaridine
CHEMBL402782
CHEMBL404097
C009270
3 / 4 / 2 No. 426 No. 4
C00001891 External link 512 Noscapine
/ alpha-Narcotine
/ O-Methylnarcotoline
CHEMBL364713
CHEMBL402487
CHEMBL1403892
CHEMBL1570261
CHEMBL1623561
D009665
105 / 43 / 42 11 / 5 No. 605 No. 4
C00001892 External link 512 Narcotoline
C059402
No. 605 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00027332 External link 512 Cryptopin
/ Cryptopine
/ Kryptopine
/ Kryptocavin
/ Cryptocavine
CHEMBL1339015
C007159
6 / 5 / 8 No. 820 No. 4
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00001408 External link 512 Dopamine
CHEMBL59
D004298
69 / 40 / 56 51 / 52 No. 1114 No. 6
C00001899 External link 512 Papaverine
CHEMBL19224
D010208
121 / 66 / 52 5 / 50 No. 1165 No. 4
C00027467 External link 512 Papavarine
CHEMBL19224
121 / 66 / 52 No. 1165 No. 4
C00001893 External link 512 Neopine
No. 1983 No. 4
C00001924 External link 512 Thebaine
/ (-)-Thebaine
/ Paramorphine
CHEMBL403893
CHEMBL1318110
D013797
4 / 0 / 0 No. 1983 No. 4
C00001890 External link 512 Narceine
CHEMBL486305
No. 2202 No. 4
C00028646 External link 512 Narceinone
No. 2202 No. 4
C00001915 External link 512 Salsolinol
/ (-)-Salsolinol
CHEMBL416732
CHEMBL1193327
CHEMBL1195032
14 / 11 / 9 No. 2962 No. 4
C00000118 External link 512 N-Malonyltryptophan
No. 2986
C00000117 External link 512 Indole-3-acetyl-L-aspartic acid
C026984
No. 2986
C00001889 External link 512 Morphine
/ (-)-Morphine
CHEMBL70
CHEMBL1888905
CHEMBL2133708
CHEMBL2139208
D009020
32 / 17 / 11 71 / 199 No. 4235 No. 4
C00001837 External link 512 Codeine
/ (-)-Codeine
CHEMBL485
CHEMBL22662
CHEMBL612012
CHEMBL1907378
D003061
16 / 12 / 6 6 / 66 No. 4235 No. 4
C00027603 External link 512 6-Oxocodeine
/ (-)-Codeinone
CHEMBL163490
CHEMBL257627
C046414
1 / 0 / 0 5 / 2 No. 4235 No. 4
C00027193 External link 512 Bismorphine B
No. 7388
C00034467 External link 512 Codeine N-oxide
No. 8425

Human Protein / Gene in interactions

230 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 C00001408 C00001837 C00001876 C00001889 C00001891 C00001899 C00001906 C00001915 C00001917 C00024663 C00027332 C00027467 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 C00001408 C00001876 C00001889 C00001891 C00001899 C00001906 C00001915 C00001917 C00024663 C00027332 C00027467 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 C00001408 C00001876 C00001889 C00001891 C00001899 C00001906 C00001915 C00001917 C00024663 C00027467 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 C00001408 C00001876 C00001889 C00001891 C00001899 C00001915 C00001917 C00024663 C00027467 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 C00001408 C00001876 C00001889 C00001891 C00001899 C00001915 C00001917 C00024663 C00027467 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001837 C00001889 C00001891 C00001899 C00001910 C00001916 C00001924 C00027467 C00027603 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 C00001408 C00001876 C00001906 C00001915 C00001917 C00024663 C00027332 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00001408 C00001891 C00001899 C00001915 C00001917 C00024663 C00027467 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000615 C00001408 C00001876 C00001891 C00001899 C00001917 C00024663 C00027467 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001876 C00001889 C00001891 C00001899 C00001917 C00024663 C00027332 C00027467 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 C00001408 C00001875 C00001876 C00001889 C00001917 C00024663 C00028453 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00001408 C00001876 C00001899 C00001917 C00024663 C00027467 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 C00001408 C00001899 C00001915 C00001917 C00024663 C00027467 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00001899 C00001906 C00001915 C00001917 C00024663 C00027467 3 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 C00001408 C00001876 C00001915 C00001917 C00024663 3 / 3
P02545 Prelamin-A/C Unclassified protein C00000615 C00001876 C00001899 C00001917 C00024663 C00027467 11 / 10
P14416 D(2) dopamine receptor Dopamine receptor C00001408 C00001891 C00001899 C00001915 C00027467 C00034613 2 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001408 C00001891 C00001899 C00001915 C00027467 C00034613 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001408 C00001891 C00001899 C00001917 C00024663 C00027467 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001408 C00001876 C00001889 C00001917 C00001924 C00024663 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 C00001837 C00001889 C00001891 C00001899 C00027467 2 / 2
O00255 Menin Unclassified protein C00000615 C00001891 C00001917 C00024663 C00027332 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00001891 C00001917 C00024663 C00027332 1 / 2
P00918 Carbonic anhydrase 2 Lyase C00000615 C00001408 C00001891 C00001899 C00027467 1 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001891 C00001899 C00001917 C00024663 C00027467 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001837 C00001889 C00001891 C00001899 C00027467 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001837 C00001889 C00001891 C00001899 C00027467 0 / 0
P40225 Thrombopoietin Unclassified protein C00001408 C00001899 C00001917 C00024663 C00027467 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001408 C00001899 C00001917 C00024663 C00027467 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 C00001899 C00001917 C00024663 C00027467 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001408 C00001889 C00001891 C00001899 C00027467 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00001891 C00001899 C00001917 C00024663 C00027467 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00001408 C00001837 C00001889 C00001899 C00027467 0 / 0
O75496 Geminin Unclassified protein C00001875 C00001889 C00001891 C00001924 C00028453 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001408 C00001891 C00001915 C00001917 C00024663 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00000615 C00001891 C00001899 C00027467 2 / 2
P03372 Estrogen receptor NR3A1 C00000615 C00001891 C00001899 C00027467 1 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00001876 C00001891 C00001917 C00024663 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001408 C00001891 C00001899 C00027467 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001408 C00001891 C00001899 C00027467 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000615 C00001408 C00001899 C00027467 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001408 C00001891 C00001899 C00027467 1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001408 C00001891 C00001899 C00027467 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001899 C00001917 C00024663 C00027467 2 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00001408 C00001917 C00024663 4 / 3
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001889 C00001891 C00001899 C00027467 1 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001408 C00001891 C00001899 C00027467 1 / 0
P03956 Interstitial collagenase M10A C00000615 C00001891 C00001899 C00027467 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000615 C00001891 C00001899 C00027467 0 / 3
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001408 C00001891 C00001899 C00027467 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001889 C00001891 C00001899 C00027467 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00001876 C00001891 C00001899 C00027467 2 / 2
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001837 C00001889 C00001899 C00027467 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001408 C00001891 C00001899 C00027467 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001876 C00001891 C00001899 C00027467 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001408 C00001891 C00001899 C00027467 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001837 C00001889 C00001899 C00027467 2 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 C00001891 C00001899 C00027467 0 / 0
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001837 C00001889 C00001899 C00027467 3 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001899 C00001917 C00024663 C00027467 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001899 C00001917 C00024663 C00027467 4 / 1
P31645 Sodium-dependent serotonin transporter Serotonin C00001408 C00001891 C00001899 C00027467 2 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001408 C00001891 C00001899 C00027467 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000615 C00001891 C00001899 C00027467 1 / 8
P06239 Tyrosine-protein kinase Lck Src C00001891 C00001899 C00027467 0 / 1
P25105 Platelet-activating factor receptor PAF receptor C00001891 C00001899 C00027467 0 / 0
P16662 UDP-glucuronosyltransferase 2B7 Enzyme C00001408 C00001837 C00001889 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001891 C00001899 C00027467 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001891 C00001899 C00027467 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001891 C00001899 C00027467 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001891 C00001899 C00027467 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001408 C00001917 C00024663 7 / 37
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001891 C00001899 C00027467 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001891 C00001899 C00027467 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001891 C00001899 C00027467 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001891 C00001899 C00027467 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001891 C00001899 C00027467 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001891 C00001899 C00027467 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001891 C00001899 C00027467 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001891 C00001899 C00027467 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001891 C00001899 C00027467 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001891 C00001899 C00027467 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001891 C00001899 C00027467 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001891 C00001899 C00027467 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001891 C00001899 C00027467 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00001891 C00001899 C00027467 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 C00001408 C00001915 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001891 C00001899 C00027467 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001891 C00001899 C00027467 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001891 C00001899 C00027467 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001891 C00001899 C00027467 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001408 C00001917 C00024663 0 / 0
P17252 Protein kinase C alpha type Alpha C00001891 C00001899 C00027467 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 C00001917 C00024663 2 / 2
P29466 Caspase-1 C14 C00001891 C00001899 C00027467 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001891 C00001899 C00027467 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001891 C00001899 C00027467 1 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001891 C00001899 C00027467 2 / 1
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001891 C00001899 C00027467 1 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00001408 C00001837 C00001889 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001891 C00001899 C00027467 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001891 C00001899 C00027467 0 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00001408 C00001837 C00001889 3 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001891 C00001899 C00027467 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001891 C00001899 C00027467 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001408 C00001917 C00024663 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001891 C00001899 C00027467 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001891 C00001899 C00027467 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001891 C00001899 C00027467 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001891 C00001899 C00027467 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001891 C00001899 C00027467 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001891 C00001899 C00027467 1 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001891 C00001899 C00027467 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001891 C00001899 C00027467 0 / 0
P08311 Cathepsin G S1A C00001891 C00001899 C00027467 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001891 C00001899 C00027467 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001891 C00001899 C00027467 3 / 0
P08246 Neutrophil elastase S1A C00001891 C00001899 C00027467 2 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001891 C00001899 C00027467 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001891 C00001899 C00027467 0 / 0
P21452 Substance-K receptor Neurokinin receptor C00001891 C00001899 C00027467 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001891 C00001899 C00027467 1 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001891 C00001899 C00027467 5 / 9
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00001408 C00001837 C00001889 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001891 C00001917 C00024663 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001891 C00001899 C00027467 0 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001891 C00001899 C00027467 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001891 C00001899 C00027467 2 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001876 C00001917 C00024663 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001891 C00001899 C00027467 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00001917 C00024663 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001917 C00024663 2 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00001917 C00024663 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00001917 C00024663 0 / 0
P14679 Tyrosinase Oxidoreductase C00000615 C00001408 4 / 2
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001917 C00024663 1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter C00001408 C00001891 0 / 0
Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE_4C C00001899 C00027467 0 / 0
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00001917 C00024663 0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A C00001899 C00027467 0 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B C00001899 C00027467 0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D C00001899 C00027467 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00000615 C00001408 0 / 0
P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE_4A C00001899 C00027467 0 / 0
Q01064 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE_1B C00001899 C00027467 0 / 0
P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE_1A C00001899 C00027467 0 / 0
Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C PDE_1C C00001899 C00027467 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001917 C00024663 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00001917 C00024663 0 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00001408 1 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001917 C00024663 1 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000615 C00001408 0 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000615 C00001408 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000615 C00001408 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001917 C00024663 2 / 0
P22748 Carbonic anhydrase 4 Lyase C00000615 C00001408 1 / 1
P43166 Carbonic anhydrase 7 Lyase C00000615 C00001408 0 / 0
P42858 Huntingtin Unclassified protein C00001917 C00024663 1 / 1
O15118 Niemann-Pick C1 protein Unclassified protein C00001917 C00024663 1 / 1
O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE_2A C00001899 C00027467 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001917 C00024663 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000615 C00001408 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00001837 C00001889 0 / 0
Q92934 Bcl2 antagonist of cell death Other cytosolic protein C00001917 C00024663 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00001837 C00001889 0 / 0
Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE_3B C00001899 C00027467 0 / 0
Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE_3A C00001899 C00027467 0 / 0
Q92793 CREB-binding protein Enzyme C00001899 C00027467 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00000615 C00001408 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00000615 C00001408 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001917 C00024663 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000615 C00001408 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001917 C00024663 2 / 3
O14924 Regulator of G-protein signaling 12 Unclassified protein C00001917 C00024663 0 / 0
P37840 Alpha-synuclein Unclassified protein C00001917 C00024663 4 / 2
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001917 C00024663 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00001408 C00001889 5 / 1
P08183 Multidrug resistance protein 1 drug C00001837 C00001889 1 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000615 1 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00001408 1 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000615 3 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000615 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000615 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 1 / 1
O95622 Adenylate cyclase type 5 Enzyme C00001408 1 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001408 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00001889 0 / 0
O43704 Sulfotransferase family cytosolic 1B member 1 Enzyme C00001408 0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00001408 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000615 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 4 / 2
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000615 0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00001889 0 / 0
P49286 Melatonin receptor type 1B Melatonin receptor C00001408 0 / 1
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00001889 0 / 0
Q86VL8 Multidrug and toxin extrusion protein 2 Cation antiporter C00001891 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000615 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001891 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
Q16853 Membrane primary amine oxidase Enzyme C00001408 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001916 0 / 0
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001408 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 1 / 1
P06746 DNA polymerase beta Enzyme C00000615 0 / 0
P50225 Sulfotransferase 1A1 Enzyme C00001408 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000615 3 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00001889 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001408 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001408 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 0 / 0
P15121 Aldose reductase Enzyme C00000615 0 / 0
P48039 Melatonin receptor type 1A Melatonin receptor C00001408 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000615 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001891 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001876 7 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001924 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
P50224 Sulfotransferase 1A3/1A4 Enzyme C00001408 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000615 0 / 0
P00734 Prothrombin S1A C00001916 4 / 2
Q96FL8 Multidrug and toxin extrusion protein 1 Cation antiporter C00001891 0 / 0

134 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00001408 C00001889 C00001891 C00001917
C00024663 C00027603
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001408 C00001889 C00001891 C00001917
C00024663 C00027603
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001408 C00001889 C00001891 C00001917
C00024663 C00027603
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001408 C00001891 C00001899 C00001906
C00001917 C00024663
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001889 C00001891 C00001917 C00024663
C00027603
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001408 C00001889 C00001917 C00024663
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001408 C00001889 C00001917 C00024663
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001408 C00001917 C00024663
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001408 C00001889 C00001891
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001889 C00001917 C00024663
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00001408 C00001917 C00024663
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00001408 C00001837 C00001889
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001917 C00024663
7122 CLDN5, AWAL, BEC1, CPETRL1, TMVCF claudin 5 C00001917 C00024663
1364 CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R claudin 4 C00001917 C00024663
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00001917 C00024663
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001917 C00024663
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001917 C00024663
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001917 C00024663
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001917 C00024663
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00001917 C00024663
6615 SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 snail family zinc finger 1 C00001917 C00024663
9075 CLDN2 claudin 2 C00001917 C00024663
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001899 C00001906
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001889 C00027603
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001889 C00001891
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00001837 C00001889
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001917 C00024663
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001408 C00001837
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00001917 C00024663
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001408 C00001891
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00001408 C00001889
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00001408 C00001889
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00001408 C00001891
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001408 C00001889
100302129 MIR1915, MIRN1915, hsa-mir-1915 microRNA 1915 C00001889
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001408
1812 DRD1, DADR, DRD1A dopamine receptor D1 C00001408
1813 DRD2, D2DR, D2R dopamine receptor D2 C00001408
2152 F3, CD142, TF, TFA coagulation factor III (thromboplastin, tissue factor) C00001408
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00001408
2668 GDNF, ATF1, ATF2, HFB1-GDNF, HSCR3 glial cell derived neurotrophic factor C00001408
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00001408
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00001408
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00001408
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00001408
3359 HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic C00001408
9177 HTR3B, 5-HT3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic C00001408
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001408
183 AGT, ANHU, SERPINA8 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) C00001408
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00001408
2475 MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) C00001408
4548 MTR, HMAG, MS, cblG 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) C00001408
5071 PARK2, AR-JP, LPRS2, PDJ, PRKN parkin RBR E3 ubiquitin protein ligase C00001408
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00001837
5617 PRL prolactin C00001408
5998 RGS3, C2PA, RGP3 regulator of G-protein signaling 3 C00001408
6198 RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) C00001408
6343 SCT secretin C00001408
6570 SLC18A1, CGAT, VAT1, VMAT1 solute carrier family 18 (vesicular monoamine transporter), member 1 C00001408
6571 SLC18A2, SVAT, SVMT, VAT2, VMAT2 solute carrier family 18 (vesicular monoamine transporter), member 2 C00001408
85413 SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1 solute carrier family 22 (organic cation/carnitine transporter), member 16 C00001408
9016 SLC25A14, BMCP1, UCP5 solute carrier family 25 (mitochondrial carrier, brain), member 14 C00001408
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001408
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001408
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001408
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00001408
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00001408
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001408
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001408
7054 TH, DYT14, DYT5b, TYH tyrosine hydroxylase (EC:1.14.16.2) C00001408
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001837
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00001889
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001889
10550 ARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx ADP-ribosylation-like factor 6 interacting protein 5 C00001889
409 ARRB2, ARB2, ARR2, BARR2 arrestin, beta 2 C00001889
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00001889
10018 BCL2L11, BAM, BIM, BOD BCL2-like 11 (apoptosis facilitator) C00001889
8678 BECN1, ATG6, VPS30, beclin1 beclin 1, autophagy related C00001889
6355 CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8 chemokine (C-C motif) ligand 8 C00001889
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001837
8824 CES2, CE-2, CES2A1, PCE-2, iCE carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) C00001889
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001889
1643 DDB2, DDBB, UV-DDB2 damage-specific DNA binding protein 2, 48kDa C00001889
1984 EIF5A, EIF-5A, EIF5A1, eIF5AI eukaryotic translation initiation factor 5A C00001889
2155 F7, SPCA coagulation factor VII (serum prothrombin conversion accelerator) (EC:3.4.21.21) C00001889
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001889
2247 FGF2, BFGF, FGF-2, FGFB, HBGF-2 fibroblast growth factor 2 (basic) C00001889
3557 IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4 interleukin 1 receptor antagonist C00001889
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001889
8609 KLF7, UKLF Kruppel-like factor 7 (ubiquitous) C00001889
4010 LMX1B, LMX1.2, NPS1 LIM homeobox transcription factor 1, beta C00001889
406901 MIR107, MIRN107, miR-107 microRNA 107 C00001889
406921 MIR132, MIRN132, miRNA132 microRNA 132 C00001889
100302258 MIR1469, MIRN1469, hsa-mir-1469 microRNA 1469 C00001889
406938 MIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A microRNA 146a C00001889
406942 MIR150, MIRN150, miRNA150 microRNA 150 C00001889
406947 MIR155, MIRN155, miRNA155 microRNA 155 C00001889
406949 MIR15B, MIRN15B, hsa-mir-15b, miR-15b microRNA 15b C00001889
406966 MIR191, MIRN191, miR-191 microRNA 191 C00001889
847 CAT catalase (EC:1.11.1.6) C00001408
406991 MIR21, MIRN21, hsa-mir-21, miR-21, miRNA21 microRNA 21 C00001889
407006 MIR221, MIRN221, miRNA221, mir-221 microRNA 221 C00001889
407010 MIR23A, MIRN23A, hsa-mir-23a, miRNA23A microRNA 23a C00001889
407011 MIR23B, MIRN23B, hsa-mir-23b, miRNA23B microRNA 23b C00001889
407015 MIR26A1, MIR26A, MIRN26A1 microRNA 26a-1 C00001889
407017 MIR26B, MIRN26B, hsa-mir-26b, miR-26b microRNA 26b C00001889
407037 MIR320A, MIRN320, MIRN320A, hsa-mir-320a microRNA 320a C00001889
494335 MIR423, MIRN423, hsa-mir-423 microRNA 423 C00001889
693223 MIR638, MIRN638, hsa-mir-638 microRNA 638 C00001889
407056 MIR99B, MIRN99B microRNA 99b C00001889
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00001889
4814 NINJ1, NIN1, NINJURIN ninjurin 1 C00001889
4985 OPRD1, OPRD opioid receptor, delta 1 C00001889
4988 OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM opioid receptor, mu 1 C00001889
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00001889
5443 POMC, ACTH, CLIP, LPH, MSH, NPP, POC proopiomelanocortin C00001889
84152 PPP1R1B, DARPP-32, DARPP32 protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16) C00001889
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001889
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00001889
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00001889
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00001889
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00001889
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00001889
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00001889
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00001889
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00001889
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00001889
7364 UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) C00001889
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001891
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001891
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00001899
5150 PDE7A, HCP1, PDE7 phosphodiesterase 7A (EC:3.1.4.17) C00001899
6581 SLC22A3, EMT, EMTH, OCT3 solute carrier family 22 (organic cation transporter), member 3 C00001899

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (146)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#606798 Blepharospasm, benign essential P21918
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#606703 Dyskinesia, familial, with facial myokymia; fdfm O95622
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (119)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00409 Type II diabetes mellitus P49286 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

286 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012640 Seizures C00001876
C00027603
C00001837
C00001408
C00001889
D002375 Catalepsy C00001837
C00001408
C00001889
C00001899
D009336 Necrosis C00001917
C00024663
C00001408
C00001889
D007022 Hypotension C00001837
C00001408
C00001889
C00001899
D009369 Neoplasms C00001917
C00024663
C00027603
D013610 Tachycardia C00001837
C00001408
C00001889
D013375 Substance Withdrawal Syndrome C00001837
C00001408
C00001889
D013035 Spasm C00001837
C00001889
C00001899
D007024 Hypotension, Orthostatic C00001837
C00001408
C00001889
D004409 Dyskinesia, Drug-Induced C00001408
C00001889
C00001899
D018476 Hypokinesia C00001837
C00001408
C00001889
D007008 Hypokalemia C00001837
C00001408
C00001889
D001919 Bradycardia C00001837
C00001889
C00001899
D006973 Hypertension C00001837
C00001408
C00001889
D001145 Arrhythmias, Cardiac C00001408
C00001889
C00001899
D006930 Hyperalgesia C00001837
C00001408
C00001889
D003128 COMA C00001837
C00001889
C00001899
D004244 Dizziness C00001837
C00001889
C00001899
D003371 Cough C00001837
C00001889
C00001891
D017202 Myocardial Ischemia C00001408
C00001889
D003693 Delirium C00001837
C00001889
D006940 Hyperemia C00001889
C00001899
D003967 Diarrhea C00001837
C00001889
D003248 Constipation C00001837
C00001889
D006429 Hemiplegia C00001889
C00001899
D005094 Exophthalmos C00001889
C00001899
D004487 Edema C00001889
C00001899
D002637 Chest Pain C00001889
C00001899
D054537 Atrioventricular Block C00001889
C00001899
D005076 Exanthema C00001837
C00001889
D005334 Fever C00001837
C00001889
D018487 Ventricular Dysfunction, Left C00001408
C00001889
D005767 Gastrointestinal Diseases C00001837
C00001889
D006261 Headache C00001837
C00001889
D020301 Vasospasm, Intracranial C00001408
C00001899
D018908 Muscle Weakness C00001889
C00001899
D016171 Torsades de Pointes C00001408
C00001899
D015878 Mydriasis C00001889
C00001899
D010291 Paresis C00001889
C00001899
D001049 Apnea C00001837
C00001889
D000860 Anoxia C00001837
C00001889
D012131 Respiratory Insufficiency C00001889
C00001899
D013226 Status Epilepticus C00001408
C00001889
D007674 Kidney Diseases C00001837
C00001889
D012769 Shock C00001408
C00001889
D011595 Psychomotor Agitation C00001408
C00001889
D009120 Muscle Cramp C00001837
C00001889
D009207 Myoclonus C00001837
C00001889
D009325 Nausea C00001837
C00001889
D009357 Neonatal Abstinence Syndrome C00001837
C00001889
D009461 Neurologic Manifestations C00001837
C00001899
D009846 Oliguria C00001408
C00001889
D010146 Pain C00001837
C00001889
D010149 Pain, Postoperative C00001837
C00001889
D009422 Nervous System Diseases C00001408
C00001889
D011297 Prenatal Exposure Delayed Effects C00001837
C00001889
D011537 Pruritus C00001837
C00001889
D019586 Intracranial Hypertension C00001889
C00001899
D008133 Long QT Syndrome C00001408
C00001899
D007859 Learning Disorders C00001408
C00001889
D006948 Hyperkinesis C00001408
C00001889
D006556 Heroin Dependence C00001408
C00001889
D006331 Heart Diseases C00001408
C00001889
D015746 Abdominal Pain C00001837
C00001889
D046628 Sphincter of Oddi Dysfunction C00001837
C00001889
D004417 Dyspnea C00001408
C00001889
D019966 Substance-Related Disorders C00001837
C00001889
D012878 Skin Neoplasms C00001917
C00024663
D009374 Neoplasms, Experimental C00001917
C00024663
D005317 Fetal Growth Retardation C00001917
C00024663
D062787 Drug Overdose C00001408
C00001889
D014839 Vomiting C00001837
C00001889
D058186 Acute Kidney Injury C00001408
C00001889
D004342 Drug Hypersensitivity C00001408
C00001889
D020964 Embryo Loss C00001917
C00024663
D001480 Basal Ganglia Diseases C00001408
C00001889
D002389 Catatonia C00001408
C00001889
D016055 Urinary Retention C00001889
D002493 Central Nervous System Diseases C00001408
D019970 Cocaine-Related Disorders C00001408
D000788 Angina Pectoris, Variant C00001408
D014806 Vitamin B 12 Deficiency C00001837
D014517 Ureteral Obstruction C00001837
D020521 Stroke C00001837
D004802 Eosinophilia C00001408
D006323 Heart Arrest C00001408
D012891 Sleep Apnea Syndromes C00001837
D006333 Heart Failure C00001408
D012871 Skin Diseases C00001837
D012216 Rheumatic Diseases C00001837
D012185 Retroperitoneal Fibrosis C00001837
D011776 Pyuria C00001837
D020149 Manganese Poisoning C00001408
D048629 Micronuclei, Chromosome-Defective C00001408
D011695 Purpura, Schoenlein-Henoch C00001837
D009205 Myocarditis C00001408
D009410 Nerve Degeneration C00001408
D010195 Pancreatitis C00001837
D009771 Obsessive-Compulsive Disorder C00001837
D010300 Parkinson Disease C00001408
D020734 Parkinsonian Disorders C00001408
D010547 Persistent Fetal Circulation Syndrome C00001408
D007681 Kidney Papillary Necrosis C00001837
D012127 Respiratory Distress Syndrome, Newborn C00001408
D007680 Kidney Neoplasms C00001837
D012770 Shock, Cardiogenic C00001408
D012772 Shock, Septic C00001408
D007232 Infant, Newborn, Diseases C00001837
D013616 Tachycardia, Sinus C00001408
D006967 Hypersensitivity C00001837
D014202 Tremor C00001408
D006330 Heart Defects, Congenital C00001837
D005494 Folic Acid Deficiency C00001837
D000014 Abnormalities, Drug-Induced C00001889
D000142 Acidosis, Respiratory C00001889
D056586 Acute Chest Syndrome C00001889
D000219 Adams-Stokes Syndrome C00001889
D000307 Adrenal Gland Diseases C00001889
D019973 Alcohol-Related Disorders C00001889
D000647 Amnesia C00001889
D000707 Anaphylaxis C00001889
D000855 Anorexia C00001889
D001002 Anuria C00001889
D001008 Anxiety Disorders C00001889
D001281 Atrial Fibrillation C00001889
D053159 Dysuria C00001837
D001284 Atrophy C00001889
D001416 Back Pain C00001889
D001714 Bipolar Disorder C00001889
D001927 Brain Diseases C00001889
D002545 Brain Ischemia C00001889
D002056 Burns C00001889
D002194 Capgras Syndrome C00001889
D002311 Cardiomyopathy, Dilated C00001889
D004421 Dystonia C00001837
D002764 Cholecystitis C00001889
D002769 Cholelithiasis C00001889
D002779 Cholestasis C00001889
D003072 Cognition Disorders C00001889
D003110 Colonic Neoplasms C00001889
D003137 Common Bile Duct Diseases C00001889
D020918 Complex Regional Pain Syndromes C00001889
D003221 Confusion C00001889
D003244 Consciousness Disorders C00001889
D003327 Coronary Disease C00001889
D055191 Delayed Emergence from Anesthesia C00001889
D003731 Dental Caries C00001889
D003919 Diabetes Insipidus C00001889
D004108 Dilatation, Pathologic C00001889
D004172 Diplopia C00001889
D018450 Disease Progression C00001889
D006970 Disorders of Excessive Somnolence C00001889
D004213 Dissociative Disorders C00001889
D056486 Drug-Induced Liver Injury C00001889
D064420 Drug-Related Side Effects and Adverse Reactions C00001889
D004415 Dyspepsia C00001837
D004673 Encephalomyelitis, Acute Disseminated C00001889
D004831 Epilepsies, Myoclonic C00001889
D004827 Epilepsy C00001889
D004830 Epilepsy, Tonic-Clonic C00001889
D003875 Drug Eruptions C00001837
D005157 Facial Pain C00001889
D005221 Fatigue C00001889
D005242 Fecal Incontinence C00001889
D042882 Gallstones C00001889
D006099 Granuloma C00001889
D006212 Hallucinations C00001889
D006417 Hematuria C00001889
D004310 Double Outlet Right Ventricle C00001837
D006470 Hemorrhage C00001889
D006501 Hepatic Encephalopathy C00001889
D006526 Hepatitis C C00001889
D006560 Herpes Labialis C00001889
D006606 Hiccup C00001889
D006819 Hyaline Membrane Disease C00001889
D006869 Hydronephrosis C00001889
D006935 Hypercapnia C00001889
D003866 Depressive Disorder C00001837
D006941 Hyperesthesia C00001889
D006987 Hypesthesia C00001889
D007006 Hypogonadism C00001889
D007018 Hypopituitarism C00001889
D007035 Hypothermia C00001889
D002534 Hypoxia, Brain C00001889
D003490 Cyanosis C00001837
D048949 Labor Pain C00001889
D007826 Laryngismus C00001889
D053609 Lethargy C00001889
D017116 Low Back Pain C00001889
D008175 Lung Neoplasms C00001889
D008305 Malignant Hyperthermia C00001889
D008569 Memory Disorders C00001889
D015877 Miosis C00001889
D009021 Morphine Dependence C00001889
D009069 Movement Disorders C00001889
D052016 Mucositis C00001889
D009122 Muscle Hypertonia C00001889
D009123 Muscle Hypotonia C00001889
D009127 Muscle Rigidity C00001889
D009128 Muscle Spasticity C00001889
D003085 Colic C00001837
D002295 Carcinoma, Transitional Cell C00001837
D009203 Myocardial Infarction C00001889
D015428 Myocardial Reperfusion Injury C00001889
D009290 Narcolepsy C00001889
D009437 Neuralgia C00001889
D009436 Neural Tube Defects C00001889
D020258 Neurotoxicity Syndromes C00001889
D009759 Nystagmus, Pathologic C00001889
D009293 Opioid-Related Disorders C00001889
D010148 Pain, Intractable C00001889
D010243 Paralysis C00001889
D010259 Paranoid Disorders C00001889
D020335 Paraparesis C00001889
D020336 Paraparesis, Spastic C00001889
D001660 Biliary Tract Diseases C00001837
D010523 Peripheral Nervous System Diseases C00001889
D010538 Peritonitis C00001889
D010554 Personality Disorders C00001889
D020250 Postoperative Nausea and Vomiting C00001889
D011596 Psychomotor Disorders C00001889
D011605 Psychoses, Substance-Induced C00001889
D011654 Pulmonary Edema C00001889
D011681 Pupil Disorders C00001889
D012021 Reflex, Abnormal C00001889
D001405 Reflex, Babinski C00001889
D051437 Renal Insufficiency C00001889
D015427 Reperfusion Injury C00001889
D012120 Respiration Disorders C00001889
D000740 Anemia C00001837
D012206 Rhabdomyolysis C00001889
D012585 Sciatica C00001889
D020182 Sleep Apnea, Central C00001889
D020181 Sleep Apnea, Obstructive C00001889
D012892 Sleep Deprivation C00001889
D012893 Sleep Disorders C00001889
D013064 Speech Disorders C00001889
D013117 Spinal Cord Compression C00001889
D013118 Spinal Cord Diseases C00001889
D013203 Staphylococcal Infections C00001889
D019956 Stereotypic Movement Disorder C00001889
D053608 Stupor C00001889
D013705 Temporomandibular Joint Disorders C00001889
D018677 Tooth Injuries C00001889
D016388 Tooth Loss C00001889
D014474 Unconsciousness C00001889
D053201 Urinary Bladder, Overactive C00001889
D014549 Urinary Incontinence C00001889
D002303 Cardiac Output, Low C00001408
D014555 Urination Disorders C00001889
D018879 Ventricular Premature Complexes C00001889
D014717 Vertigo C00001889
D014786 Vision Disorders C00001889
D015431 Weight Loss C00001889
D014987 Xerostomia C00001889
D003711 Demyelinating Diseases C00001891
D005910 Glioma C00001891
D015473 Leukemia, Promyelocytic, Acute C00001891
D015458 Leukemia, T-Cell C00001891
D001037 Aphasia C00001899
D001157 Arterial Occlusive Diseases C00001899
D001766 Blindness C00001899
D002539 Cerebral Arterial Diseases C00001899
D015862 Choroid Diseases C00001899
D004414 Dyspareunia C00001899
D007172 Erectile Dysfunction C00001899
D005155 Facial Nerve Diseases C00001899
D005158 Facial Paralysis C00001899
D005355 Fibrosis C00001899
D006319 Hearing Loss, Sensorineural C00001899
D006406 Hematoma C00001899
D006505 Hepatitis C00001899
D006521 Hepatitis, Chronic C00001899
D018783 Impotence, Vasculogenic C00001899
D007238 Infarction C00001899
D020766 Intracranial Embolism C00001899
D007565 Jaundice C00001899
D008103 Liver Cirrhosis C00001899
D010411 Penile Induration C00001899
D011183 Postoperative Complications C00001899
D011317 Priapism C00001899
D054138 Sinus Arrest, Cardiac C00001899
D017180 Tachycardia, Ventricular C00001899
D013927 Thrombosis C00001899
D014693 Ventricular Fibrillation C00001899
D000160 Vestibulocochlear Nerve Diseases C00001899