PCIDB

KNApSAcK Metabolite C00001899

Metabolite

KNApSAcK Entry

id C00001899
Name Papaverine
CAS RN 58-74-2
Standard InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
Standard InChI (Main Layer) InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1165

Link

ChEMBL

By standard InChI CHEMBL19224
By standard InChI Main Layer CHEMBL19224

KEGG

By LinkDB C06533

CTD

By CAS RN D010208

Human Protein / Gene in interaction

121 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL19224 CHEMBL1614110 (3) CHEMBL1741321 (2)
CHEMBL1909136 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL19224 CHEMBL1613842 (1)
4 / 2
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL19224 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL19224 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL19224 CHEMBL1676103 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL19224 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL19224 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL19224 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL19224 CHEMBL1909176 (2)
0 / 0
Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE_3B CHEMBL19224 CHEMBL762675 (1) CHEMBL909388 (1)
CHEMBL1827311 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL19224 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL19224 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL19224 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL19224 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL19224 CHEMBL993349 (1)
0 / 0
Q92793 CREB-binding protein Enzyme CHEMBL19224 CHEMBL1614162 (2) CHEMBL1614333 (2)
CHEMBL1614040 (2) CHEMBL1614026 (2)
1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL19224 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL19224 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL19224 CHEMBL1614281 (2) CHEMBL1614361 (3)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL19224 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL19224 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL19224 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL19224 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL19224 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL19224 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL19224 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL19224 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL19224 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL19224 CHEMBL1614027 (2) CHEMBL1741325 (2)
CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL19224 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL19224 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL19224 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL19224 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL19224 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL19224 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL19224 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL19224 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL19224 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL19224 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL19224 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL19224 CHEMBL1614458 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL19224 CHEMBL943086 (1)
2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL19224 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL19224 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL19224 CHEMBL1613838 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL19224 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL19224 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL19224 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL19224 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL19224 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL19224 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL19224 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL19224 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL19224 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL19224 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL19224 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL19224 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL19224 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL19224 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL19224 CHEMBL1909119 (2)
0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A CHEMBL19224 CHEMBL1119709 (2) CHEMBL1629232 (1)
CHEMBL1646316 (1) CHEMBL1780568 (1)
CHEMBL1827309 (1) CHEMBL1960211 (1)
CHEMBL2187842 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL19224 CHEMBL1738610 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL19224 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL19224 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL19224 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL19224 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL19224 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL19224 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL19224 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL19224 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL19224 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL19224 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL19224 CHEMBL1909108 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL19224 CHEMBL1614252 (1)
2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL19224 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL19224 CHEMBL1613808 (2) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL19224 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL19224 CHEMBL1741322 (2) CHEMBL1909132 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL19224 CHEMBL822071 (1) CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL19224 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL19224 CHEMBL866857 (1) CHEMBL866858 (1)
CHEMBL866863 (1) CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL19224 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL19224 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL19224 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL19224 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL19224 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL19224 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL19224 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL19224 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL19224 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL19224 CHEMBL1613777 (3) CHEMBL1741323 (2)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL19224 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL19224 CHEMBL1909137 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL19224 CHEMBL1737980 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL19224 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL19224 CHEMBL1909213 (2)
0 / 0
Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE_3A CHEMBL19224 CHEMBL762675 (1) CHEMBL909386 (1)
CHEMBL1827310 (1) CHEMBL2187831 (1)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL19224 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL19224 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL19224 CHEMBL1909206 (2)
0 / 1
O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE_2A CHEMBL19224 CHEMBL759849 (1) CHEMBL768902 (1)
0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL19224 CHEMBL1909128 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL19224 CHEMBL1794536 (2)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL19224 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL19224 CHEMBL1738442 (2)
0 / 0
Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C PDE_1C CHEMBL19224 CHEMBL760919 (1) CHEMBL822070 (1)
0 / 0
P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE_1A CHEMBL19224 CHEMBL760919 (1) CHEMBL822070 (1)
0 / 0
Q01064 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE_1B CHEMBL19224 CHEMBL760919 (1) CHEMBL822070 (1)
0 / 0
P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE_4A CHEMBL19224 CHEMBL762675 (1)
0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D CHEMBL19224 CHEMBL762675 (1)
1 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B CHEMBL19224 CHEMBL762675 (1)
0 / 0
Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE_4C CHEMBL19224 CHEMBL762675 (1)
0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL19224 CHEMBL806153 (1) CHEMBL806154 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL19224 CHEMBL806153 (1) CHEMBL806154 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL19224 CHEMBL806153 (1) CHEMBL806154 (1)
3 / 2

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
D010208 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides] affects secretion
/ increases reaction
protein 12714375
D010208 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Papaverine results in increased activity of CFTR protein increases activity
protein 12714375
D010208 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 18493746
D010208 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] decreases reaction
/ increases activity
protein 18493746
D010208 5150 PDE7A
HCP1
PDE7
phosphodiesterase 7A (EC:3.1.4.17) Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] decreases reaction
/ increases hydrolysis
protein 10618442
D010208 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases uptake
protein 12411423

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (66)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (52)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)

Diseases related to CTD interactions

50 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001037 D010208 Aphasia marker/mechanism
8613866
D001145 D010208 Arrhythmias, Cardiac marker/mechanism
therapeutic
2461650
18858160
D001157 D010208 Arterial Occlusive Diseases marker/mechanism
3809473
8451424
D054537 D010208 Atrioventricular Block marker/mechanism
1422403
D001766 D010208 Blindness marker/mechanism
19901231
D001919 D010208 Bradycardia marker/mechanism
19961315
D002375 D010208 Catalepsy marker/mechanism
1033561
D002539 D010208 Cerebral Arterial Diseases therapeutic
9726476
D002637 D010208 Chest Pain marker/mechanism
2750660
D015862 D010208 Choroid Diseases marker/mechanism
19901231
D003128 D010208 COMA marker/mechanism
3366170
D004244 D010208 Dizziness marker/mechanism
3366170
D004409 D010208 Dyskinesia, Drug-Induced therapeutic
1172755
D004414 D010208 Dyspareunia marker/mechanism
1296038
1719248
D004487 D010208 Edema marker/mechanism
11549511
D007172 D010208 Erectile Dysfunction therapeutic
1296038
1589286
1737261
1984099
2278150
2327828
2366292
2617964
2908935
2917481
3175561
3215253
3363769
3640652
3687629
7735362
9607891
10098948
14999218
D005094 D010208 Exophthalmos marker/mechanism
19901231
D005155 D010208 Facial Nerve Diseases marker/mechanism
12513030
D005158 D010208 Facial Paralysis marker/mechanism
9918178
12513030
17977279
D005355 D010208 Fibrosis marker/mechanism
11549511
D006319 D010208 Hearing Loss, Sensorineural marker/mechanism
18726058
D006406 D010208 Hematoma marker/mechanism
3762853
D006429 D010208 Hemiplegia marker/mechanism
8613866
D006505 D010208 Hepatitis marker/mechanism
4029887
D006521 D010208 Hepatitis, Chronic marker/mechanism
3949106
D006940 D010208 Hyperemia marker/mechanism
2358592
3881002
6240483
8287414
8601879
8892781
9840701
11249884
17351955
18568317
D007022 D010208 Hypotension marker/mechanism
999414
2835134
16984954
19604547
19961315
D018783 D010208 Impotence, Vasculogenic therapeutic
1719248
2038782
D007238 D010208 Infarction marker/mechanism
19901231
D020766 D010208 Intracranial Embolism marker/mechanism
16283980
D019586 D010208 Intracranial Hypertension marker/mechanism
9726476
D007565 D010208 Jaundice marker/mechanism
3949106
D008103 D010208 Liver Cirrhosis marker/mechanism
3949106
D008133 D010208 Long QT Syndrome marker/mechanism
2044564
2334953
2605630
7511988
D018908 D010208 Muscle Weakness marker/mechanism
3366170
D015878 D010208 Mydriasis marker/mechanism
12513030
D009461 D010208 Neurologic Manifestations marker/mechanism
7847211
D010291 D010208 Paresis therapeutic
3762853
11145478
D010411 D010208 Penile Induration marker/mechanism
therapeutic
1589286
2908935
3363769
7713130
D011183 D010208 Postoperative Complications marker/mechanism
9918178
18726058
D011317 D010208 Priapism marker/mechanism
1296038
1589286
1719248
1984077
2278150
2327828
2524805
2908935
2917481
7713130
14999218
D012131 D010208 Respiratory Insufficiency marker/mechanism
7847211
D054138 D010208 Sinus Arrest, Cardiac marker/mechanism
19961315
D013035 D010208 Spasm therapeutic
47907
D017180 D010208 Tachycardia, Ventricular marker/mechanism
2299067
7511988
8032075
8892781
D013927 D010208 Thrombosis marker/mechanism
8451424
D016171 D010208 Torsades de Pointes marker/mechanism
2044564
2605630
D020301 D010208 Vasospasm, Intracranial therapeutic
7847211
7900600
8010275
9726476
11145478
18726058
19057314
19901231
D014693 D010208 Ventricular Fibrillation marker/mechanism
1772671
D000160 D010208 Vestibulocochlear Nerve Diseases marker/mechanism
18726058