KCF-S cluster No. 1165 (8 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	11
asterids	1

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Cumulative family count

class name	count
Papaveraceae	7
Berberidaceae	2
Apocynaceae	1
Ranunculaceae	1
Menispermaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C06533	C00001899

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001899	Papaverine	CHEMBL19224	D010208	121 / 66 / 52	5 / 50
C00027343	Densiberine	CHEMBL1621723
C00027467	Papavarine	CHEMBL19224		121 / 66 / 52
C00027495	Thalprzewalskiinone
C00027591	Setigeridine
C00027592	Setigerine
C00033438	Tetradehydroreticuline
C00037598	Xanthaline / Papaveraldine	CHEMBL205040	C039655	15 / 10 / 5

Human Protein / Gene in interactions

135 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22303	Acetylcholinesterase	Hydrolase	C00001899 C00027467 C00037598	1 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00001899 C00027467	2 / 1
P35498	Sodium channel protein type 1 subunit alpha	SCN alpha, NaV1.x	C00001899 C00027467	3 / 2
Q99250	Sodium channel protein type 2 subunit alpha	SCN alpha, NaV1.x	C00001899 C00027467	2 / 2
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001899 C00027467	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001899 C00027467	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001899 C00027467	2 / 2
P08246	Neutrophil elastase	S1A	C00001899 C00027467	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00001899 C00027467	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001899 C00027467	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00001899 C00027467	0 / 0
Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE_3B	C00001899 C00027467	0 / 0
P29466	Caspase-1	C14	C00001899 C00027467	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001899 C00027467	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00001899 C00027467	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00001899 C00027467	2 / 2
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001899 C00027467	0 / 0
Q92793	CREB-binding protein	Enzyme	C00001899 C00027467	1 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001899 C00027467	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001899 C00027467	11 / 10
Q9NY46	Sodium channel protein type 3 subunit alpha	SCN alpha, NaV1.x	C00001899 C00027467	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001899 C00027467	3 / 2
Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE_4C	C00001899 C00027467	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00001899 C00027467	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001899 C00027467	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00001899 C00027467	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001899 C00027467	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001899 C00027467	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00001899 C00027467	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00001899 C00027467	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001899 C00027467	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00001899 C00027467	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001899 C00027467	0 / 1
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE_4B	C00001899 C00027467	0 / 0
Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE_4D	C00001899 C00027467	1 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001899 C00027467	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00001899 C00027467	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001899 C00027467	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00001899 C00027467	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00001899 C00027467	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00001899 C00027467	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00001899 C00027467	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00001899 C00027467	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00001899 C00027467	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00001899 C00027467	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00001899 C00027467	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001899 C00027467	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001899 C00027467	2 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001899 C00027467	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001899 C00027467	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00001899 C00027467	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001899 C00027467	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001899 C00027467	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00001899 C00027467	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001899 C00027467	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001899 C00027467	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00001899 C00027467	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001899 C00027467	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00001899 C00027467	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00001899 C00027467	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00001899 C00027467	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00001899 C00027467	0 / 0
P08311	Cathepsin G	S1A	C00001899 C00027467	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001899 C00027467	1 / 0
P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE_4A	C00001899 C00027467	0 / 0
P03956	Interstitial collagenase	M10A	C00001899 C00027467	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00001899 C00027467	0 / 0
Q01064	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE_1B	C00001899 C00027467	0 / 0
Q9Y233	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE_10A	C00001899 C00027467	0 / 0
P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE_1A	C00001899 C00027467	0 / 0
Q14123	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE_1C	C00001899 C00027467	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001899 C00027467	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001899 C00027467	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00001899 C00027467	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00001899 C00027467	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00001899 C00027467	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001899 C00027467	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00001899 C00027467	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00001899 C00027467	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00001899 C00027467	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00001899 C00027467	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00001899 C00027467	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001899 C00027467	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001899 C00027467	2 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00001899 C00027467	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001899 C00027467	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001899 C00027467	4 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001899 C00027467	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001899 C00027467	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00001899 C00027467	0 / 0
P03372	Estrogen receptor	NR3A1	C00001899 C00027467	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001899 C00027467	1 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001899 C00027467	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001899 C00027467	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001899 C00027467	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001899 C00027467	0 / 0
O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE_2A	C00001899 C00027467	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00001899 C00027467	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00001899 C00027467	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00001899 C00027467	1 / 1
P33032	Melanocortin receptor 5	Melanocortin receptor	C00001899 C00027467	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00001899 C00027467	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001899 C00027467	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001899 C00027467	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001899 C00027467	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001899 C00027467	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001899 C00027467	0 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00001899 C00027467	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001899 C00027467	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001899 C00027467	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00001899 C00027467	0 / 0
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE_3A	C00001899 C00027467	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001899 C00027467	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00001899 C00027467	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00001899 C00027467	0 / 1
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00001899 C00027467	0 / 0
O14727	Apoptotic protease-activating factor 1	Unclassified protein	C00037598	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00037598	0 / 0
P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	Ser_Thr	C00037598	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00037598	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00037598	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00037598	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00037598	7 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00037598	0 / 0
Q9GZR1	Sentrin-specific protease 6	Enzyme	C00037598	0 / 0
Q9BQF6	Sentrin-specific protease 7	Enzyme	C00037598	0 / 0
P42574	Caspase-3	C14	C00037598	0 / 0
Q96LD8	Sentrin-specific protease 8	Enzyme	C00037598	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00037598	1 / 1
Q9BPW0	Serine/threonine-protein phosphatase	Enzyme	C00037598	0 / 0

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001899
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001899
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001899
5150	PDE7A, HCP1, PDE7	phosphodiesterase 7A (EC:3.1.4.17)	C00001899
6581	SLC22A3, EMT, EMTH, OCT3	solute carrier family 22 (organic cation transporter), member 3	C00001899

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions