KCF-S cluster No. 1114 (9 metabolites)

Corresponding Phytochemical cluster No. 6

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	6
eudicotyledons	4
asterids	3
Liliopsida	2
Magnoliophyta	2
Spermatophyta	1

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Cumulative family count

class name	count
Fabaceae	6
Solanaceae	2
Cactaceae	1
Musaceae	1
Montiaceae	1
Papaveraceae	1
Nyctaginaceae	1
Cupressaceae	1
Oleaceae	1
Piperaceae	1
Asparagaceae	1
Lauraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Tyramine derivatives	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Tyramine derivatives	C03758	C00001408

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001408	Dopamine	CHEMBL59	D004298	69 / 40 / 56	51 / 52
C00031551	3-(3,4-Dihydroxyphenyl)-1-propanol	CHEMBL485747		7 / 5 / 4
C00032635	3-Hydroxytyrosol / 3,4-Dihydroxyphenethyl alcohol	CHEMBL1950045	C005975		26 / 4
C00042101	3,4,5-Trihydroxyphenethylamine	CHEMBL30625	C027802		1 / 0
C00042758	N,N-Dimethyldopamine	CHEMBL347228	C041923
C00042774	N-Methyl-3,4,5-trihydroxyphenethylamine
C00042777	N-Methyldopamine	CHEMBL31088	D003846	23 / 25 / 52	1 / 0
C00044457	4-Allyl-pyrocatechol	CHEMBL111134	C051268		8 / 0
C00047668	4-Allylcatechol	CHEMBL111134	C051268		8 / 0

Human Protein / Gene in interactions

77 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10636	Microtubule-associated protein tau	Unclassified protein	C00001408 C00031551 C00042777	4 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001408 C00042777	0 / 1
P40225	Thrombopoietin	Unclassified protein	C00001408 C00042777	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00001408 C00042777	7 / 37
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001408 C00031551	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001408 C00042777	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001408 C00042777	1 / 1
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00001408 C00042777	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001408 C00042777	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001408 C00042777	1 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001408 C00042777	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001408 C00042777	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001408 C00042777	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001408 C00042777	3 / 3
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001408 C00042777	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001408 C00042777	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00031551 C00042777	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001408 C00042777	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001408 C00042777	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001408 C00031551	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001408 C00042777	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00031551	0 / 0
O95622	Adenylate cyclase type 5	Enzyme	C00001408	1 / 0
P21918	D(1B) dopamine receptor	Dopamine receptor	C00001408	1 / 0
P16662	UDP-glucuronosyltransferase 2B7	Enzyme	C00001408	0 / 0
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00001408	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00042777	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00001408	2 / 0
P23280	Carbonic anhydrase 6	Lyase	C00001408	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00001408	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001408	1 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001408	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001408	0 / 1
P00918	Carbonic anhydrase 2	Lyase	C00001408	1 / 2
O75496	Geminin	Unclassified protein	C00031551	0 / 0
P50225	Sulfotransferase 1A1	Enzyme	C00001408	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00001408	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001408	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001408	1 / 0
P00915	Carbonic anhydrase 1	Lyase	C00001408	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00042777	3 / 2
P50224	Sulfotransferase 1A3/1A4	Enzyme	C00001408	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00001408	4 / 2
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001408	2 / 0
P48039	Melatonin receptor type 1A	Melatonin receptor	C00001408	0 / 0
O43704	Sulfotransferase family cytosolic 1B member 1	Enzyme	C00001408	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001408	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00001408	0 / 1
Q16853	Membrane primary amine oxidase	Enzyme	C00001408	0 / 0
P49286	Melatonin receptor type 1B	Melatonin receptor	C00001408	0 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001408	1 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00042777	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00001408	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00001408	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00001408	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001408	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001408	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001408	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00001408	5 / 1
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00031551	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00042777	2 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001408	1 / 1
P07451	Carbonic anhydrase 3	Lyase	C00001408	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00001408	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001408	0 / 0
O15244	Solute carrier family 22 member 2	Drug uniporter	C00001408	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001408	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00001408	3 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001408	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001408	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
P35368	Alpha-1B adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
P35348	Alpha-1A adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001408	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001408	0 / 0

77 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00032635 C00044457 C00047668
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00001408 C00044457 C00047668
4166	CHST6, MCDC1	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	C00044457 C00047668
7172	TPMT	thiopurine S-methyltransferase (EC:2.1.1.67)	C00044457 C00047668
8520	HAT1, KAT1	histone acetyltransferase 1 (EC:2.3.1.48)	C00044457 C00047668
2953	GSTT2, GSTT2B	glutathione S-transferase theta 2 (EC:2.5.1.18)	C00044457 C00047668
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001408 C00032635
56548	CHST7, C6ST-2, GST-5	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 (EC:2.8.2.17)	C00044457 C00047668
5617	PRL	prolactin	C00001408 C00042777
23563	CHST5, I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	C00044457 C00047668
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00001408 C00042101
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001408 C00032635
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00001408 C00032635
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001408 C00032635
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001408 C00032635
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001408 C00032635
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00001408
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00032635
5862	RAB2A, LHX, RAB2	RAB2A, member RAS oncogene family	C00032635
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00032635
6119	RPA3, REPA3	replication protein A3, 14kDa	C00032635
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00032635
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00032635
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00032635
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00032635
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00032635
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00032635
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00032635
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00032635
1647	GADD45A, DDIT1, GADD45	growth arrest and DNA-damage-inducible, alpha	C00032635
10922	FASTK, FAST	Fas-activated serine/threonine kinase (EC:2.7.11.8)	C00032635
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00032635
37618			C00032635
993	CDC25A, CDC25A2	cell division cycle 25A (EC:3.1.3.48)	C00032635
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00032635
183	AGT, ANHU, SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	C00001408
581	BAX, BCL2L4	BCL2-associated X protein	C00001408
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00001408
664	BNIP3, NIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	C00001408
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00001408
847	CAT	catalase (EC:1.11.1.6)	C00001408
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001408
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001408
1812	DRD1, DADR, DRD1A	dopamine receptor D1	C00001408
1813	DRD2, D2DR, D2R	dopamine receptor D2	C00001408
2152	F3, CD142, TF, TFA	coagulation factor III (thromboplastin, tissue factor)	C00001408
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001408
2668	GDNF, ATF1, ATF2, HFB1-GDNF, HSCR3	glial cell derived neurotrophic factor	C00001408
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00001408
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00001408
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00001408
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00001408
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00001408
3359	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	C00001408
9177	HTR3B, 5-HT3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	C00001408
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001408
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00001408
4779	NFE2L1, LCR-F1, NRF1, TCF11	nuclear factor, erythroid 2-like 1	C00032635
4548	MTR, HMAG, MS, cblG	5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)	C00001408
5071	PARK2, AR-JP, LPRS2, PDJ, PRKN	parkin RBR E3 ubiquitin protein ligase	C00001408
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001408
5998	RGS3, C2PA, RGP3	regulator of G-protein signaling 3	C00001408
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00001408
6343	SCT	secretin	C00001408
6570	SLC18A1, CGAT, VAT1, VMAT1	solute carrier family 18 (vesicular monoamine transporter), member 1	C00001408
6571	SLC18A2, SVAT, SVMT, VAT2, VMAT2	solute carrier family 18 (vesicular monoamine transporter), member 2	C00001408
85413	SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1	solute carrier family 22 (organic cation/carnitine transporter), member 16	C00001408
9016	SLC25A14, BMCP1, UCP5	solute carrier family 25 (mitochondrial carrier, brain), member 14	C00001408
6530	SLC6A2, NAT1, NET, NET1, SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 2	C00001408
6531	SLC6A3, DAT, DAT1, PKDYS	solute carrier family 6 (neurotransmitter transporter), member 3	C00001408
6532	SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT	solute carrier family 6 (neurotransmitter transporter), member 4	C00001408
6622	SNCA, NACP, PARK1, PARK4, PD1	synuclein, alpha (non A4 component of amyloid precursor)	C00001408
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00001408
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00001408
134864	TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1	trace amine associated receptor 1	C00001408
7054	TH, DYT14, DYT5b, TYH	tyrosine hydroxylase (EC:1.14.16.2)	C00001408
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001408

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions