KNApSAcK Metabolite C00027603
Metabolite
KNApSAcK Entry
| id | C00027603 |
|---|---|
| Name | 6-Oxocodeine / (-)-Codeinone |
| CAS RN | 467-13-0 |
| Standard InChI | InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-12,17H,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-12,17H,7-9H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 4235 |
Link
ChEMBL
| By standard InChI | CHEMBL257627 |
|---|---|
| By standard InChI Main Layer | CHEMBL163490 CHEMBL257627 |
KEGG
| By LinkDB | C06171 |
|---|
CTD
| By CAS RN | C046414 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| eudicotyledons | 1 |
Family
| family name | count |
|---|---|
| Papaveraceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Papaver somniferum | 3469 | Papaveraceae | eudicotyledons | Viridiplantae |
Human Protein / Gene in interaction
1 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL257627 |
CHEMBL925794
(1)
CHEMBL925795
(1)
CHEMBL925796 (1) |
0 / 0 |
CTD interaction (5)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C046414 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | 6-codeinone results in increased expression of BAX protein |
increases expression
|
protein |
12894543
|
| C046414 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | 6-codeinone results in decreased expression of BCL2 protein |
decreases expression
|
protein |
12894543
|
| C046414 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | 6-codeinone results in increased activity of CASP3 protein |
increases activity
|
protein |
12894543
|
| C046414 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | 6-codeinone results in increased activity of CASP9 protein |
increases activity
|
protein |
12894543
|
| C046414 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | 6-codeinone affects the localization of CYCS protein |
affects localization
|
protein |
12894543
|