KCF-S cluster No. 4235 (3 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	5

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Cumulative family count

class name	count
Papaveraceae	5

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C06174	C00001837
Isoquinoline alkaloids	C01516	C00001889
Isoquinoline alkaloids	C06171	C00027603

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001837	Codeine / (-)-Codeine	CHEMBL485 CHEMBL22662 CHEMBL612012 CHEMBL1907378	D003061	16 / 12 / 6	6 / 66
C00001889	Morphine / (-)-Morphine	CHEMBL70 CHEMBL1888905 CHEMBL2133708 CHEMBL2139208	D009020	32 / 17 / 11	71 / 199
C00027603	6-Oxocodeine / (-)-Codeinone	CHEMBL163490 CHEMBL257627	C046414	1 / 0 / 0	5 / 2

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P35372	Mu-type opioid receptor	Opioid receptor	C00001837 C00001889 C00027603	0 / 0
P16662	UDP-glucuronosyltransferase 2B7	Enzyme	C00001837 C00001889	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001837 C00001889	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001837 C00001889	2 / 2
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001837 C00001889	0 / 0
P35498	Sodium channel protein type 1 subunit alpha	SCN alpha, NaV1.x	C00001837 C00001889	3 / 2
P08183	Multidrug resistance protein 1	drug	C00001837 C00001889	1 / 0
Q99250	Sodium channel protein type 2 subunit alpha	SCN alpha, NaV1.x	C00001837 C00001889	2 / 2
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00001837 C00001889	3 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00001837 C00001889	0 / 0
Q9NY46	Sodium channel protein type 3 subunit alpha	SCN alpha, NaV1.x	C00001837 C00001889	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001837 C00001889	1 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00001837 C00001889	0 / 0
P06133	UDP-glucuronosyltransferase 2B4	Enzyme	C00001837 C00001889	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001837 C00001889	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00001837 C00001889	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001889	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001889	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001889	1 / 0
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00001889	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001889	0 / 0
P36537	UDP-glucuronosyltransferase 2B10	Enzyme	C00001889	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00001889	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001889	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001889	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001889	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00001889	5 / 1
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00001889	0 / 0
O75496	Geminin	Unclassified protein	C00001889	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001889	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001889	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001889	0 / 0

75 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
581	BAX, BCL2L4	BCL2-associated X protein	C00001889 C00027603
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001889 C00027603
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001889 C00027603
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00001889 C00027603
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00001889 C00027603
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00001837 C00001889
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00001837 C00001889
407056	MIR99B, MIRN99B	microRNA 99b	C00001889
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001837
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001837
3757	KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1	potassium voltage-gated channel, subfamily H (eag-related), member 2	C00001837
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00001889
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00001889
10550	ARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx	ADP-ribosylation-like factor 6 interacting protein 5	C00001889
409	ARRB2, ARB2, ARR2, BARR2	arrestin, beta 2	C00001889
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00001889
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00001889
10018	BCL2L11, BAM, BIM, BOD	BCL2-like 11 (apoptosis facilitator)	C00001889
8678	BECN1, ATG6, VPS30, beclin1	beclin 1, autophagy related	C00001889
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00001889
6355	CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8	chemokine (C-C motif) ligand 8	C00001889
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00001889
8824	CES2, CE-2, CES2A1, PCE-2, iCE	carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56)	C00001889
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00001889
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00001889
1643	DDB2, DDBB, UV-DDB2	damage-specific DNA binding protein 2, 48kDa	C00001889
1984	EIF5A, EIF-5A, EIF5A1, eIF5AI	eukaryotic translation initiation factor 5A	C00001889
2155	F7, SPCA	coagulation factor VII (serum prothrombin conversion accelerator) (EC:3.4.21.21)	C00001889
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00001889
2247	FGF2, BFGF, FGF-2, FGFB, HBGF-2	fibroblast growth factor 2 (basic)	C00001889
3557	IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4	interleukin 1 receptor antagonist	C00001889
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001889
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00001889
8609	KLF7, UKLF	Kruppel-like factor 7 (ubiquitous)	C00001889
4010	LMX1B, LMX1.2, NPS1	LIM homeobox transcription factor 1, beta	C00001889
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001889
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001889
406901	MIR107, MIRN107, miR-107	microRNA 107	C00001889
406921	MIR132, MIRN132, miRNA132	microRNA 132	C00001889
100302258	MIR1469, MIRN1469, hsa-mir-1469	microRNA 1469	C00001889
406938	MIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A	microRNA 146a	C00001889
406942	MIR150, MIRN150, miRNA150	microRNA 150	C00001889
406947	MIR155, MIRN155, miRNA155	microRNA 155	C00001889
406949	MIR15B, MIRN15B, hsa-mir-15b, miR-15b	microRNA 15b	C00001889
406966	MIR191, MIRN191, miR-191	microRNA 191	C00001889
100302129	MIR1915, MIRN1915, hsa-mir-1915	microRNA 1915	C00001889
406991	MIR21, MIRN21, hsa-mir-21, miR-21, miRNA21	microRNA 21	C00001889
407006	MIR221, MIRN221, miRNA221, mir-221	microRNA 221	C00001889
407010	MIR23A, MIRN23A, hsa-mir-23a, miRNA23A	microRNA 23a	C00001889
407011	MIR23B, MIRN23B, hsa-mir-23b, miRNA23B	microRNA 23b	C00001889
407015	MIR26A1, MIR26A, MIRN26A1	microRNA 26a-1	C00001889
407017	MIR26B, MIRN26B, hsa-mir-26b, miR-26b	microRNA 26b	C00001889
407037	MIR320A, MIRN320, MIRN320A, hsa-mir-320a	microRNA 320a	C00001889
494335	MIR423, MIRN423, hsa-mir-423	microRNA 423	C00001889
693223	MIR638, MIRN638, hsa-mir-638	microRNA 638	C00001889
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00001837
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00001889
4814	NINJ1, NIN1, NINJURIN	ninjurin 1	C00001889
4985	OPRD1, OPRD	opioid receptor, delta 1	C00001889
4988	OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM	opioid receptor, mu 1	C00001889
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00001889
5443	POMC, ACTH, CLIP, LPH, MSH, NPP, POC	proopiomelanocortin	C00001889
84152	PPP1R1B, DARPP-32, DARPP32	protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16)	C00001889
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001889
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00001889
6778	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C	signal transducer and activator of transcription 6, interleukin-4 induced	C00001889
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00001889
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001889
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00001889
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00001889
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00001889
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00001889
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00001889
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00001889
7364	UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9	UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17)	C00001889

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions